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The map label for this gene is sul [H]

Identifier: 52783934

GI number: 52783934

Start: 90376

End: 91233

Strand: Direct

Name: sul [H]

Synonym: BLi00093

Alternate gene names: 52783934

Gene position: 90376-91233 (Clockwise)

Preceding gene: 52783933

Following gene: 52783935

Centisome position: 2.14

GC content: 47.67

Gene sequence:

>858_bases
ATGGCGCTTCAAACAGCGGTGCGTTCAAAGCAACTGATCGCAAAGCAATACACGTTGTCTTATGAAGATAAAACATTGAT
CATGGGAATTTTAAATGTGACGCCCGATTCTTTTTCAGACGGCGGAAAATATAACAGCATCGATCGCGCCGTCATTCATG
CAAAACAAATGATCGAAGACGGCGCCCATATCCTTGATATCGGAGGAGAATCGACGAGGCCGGGGGCGGAAAAGGTTTCT
CTTGATGAAGAGCTGTCAAGAGTCATACCTGTAATTGAAAAACTTGTTCAGGAAATCGACGTCCCGATTTCCGTTGACAC
TTATAAAGCGCAAGTGGCAGATGAAGCCATTAAGGCCGGTGCAGCCATCATCAATGATGTCTGGGGAGCAAAAGCAGATC
CTGACATGGCCCGAGTTGCGGCCGCTCATAATGTGCCGATTATCTTGATGCATAACCGCGAGGAACGGAATTATAAGGAT
TTGATCCCGGACATGCTGTCTGATTTGATGGAATGTGTGAGCATTGCAAAATCAGCAGGCGTTCAGGATCATCACATCGT
ACTTGATCCCGGCATCGGCTTTGCCAAAACGTATCATGACAATTTGGCGGTCATGAATCAGCTCGAGAAGTTCAGCGAAC
CGGGATACCCGGTTTTATTGGGGACGTCACGAAAAAAATTTATCGGCCGAGTCCTGGATCTGCCGCCTGAAGAAAGAGCG
GAAGGCACGGGGGCGACAGTATGCCTCGGTATTCAAAAGGGGTGCGATATCGTCAGGGTGCATGACGTCAAGCAAATCTC
CAGGATGGCAAAAATGATGGATGCCATGATTGATAAAGGAGGCGTTTATCATCGATAA

Upstream 100 bases:

>100_bases
ATTTCCGGGAAAGGATGGAAATTTGTCGAAACGTCTGCAAGAGGCATACACTAATGATAGGAAAGCAGCAAAAGAATATT
TGAGTTAAAGGGTGAAGGAT

Downstream 100 bases:

>100_bases
AGTGCATGTAGAGGGCATGGAGTTTTACGGATATCACGGTGTTTTCAAAGAAGAAAACAAACTCGGCCAGAGATTCCGCG
TTGATCTGACAGCATTTCTA

Product: Sul

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MALQTAVRSKQLIAKQYTLSYEDKTLIMGILNVTPDSFSDGGKYNSIDRAVIHAKQMIEDGAHILDIGGESTRPGAEKVS
LDEELSRVIPVIEKLVQEIDVPISVDTYKAQVADEAIKAGAAIINDVWGAKADPDMARVAAAHNVPIILMHNREERNYKD
LIPDMLSDLMECVSIAKSAGVQDHHIVLDPGIGFAKTYHDNLAVMNQLEKFSEPGYPVLLGTSRKKFIGRVLDLPPEERA
EGTGATVCLGIQKGCDIVRVHDVKQISRMAKMMDAMIDKGGVYHR

Sequences:

>Translated_285_residues
MALQTAVRSKQLIAKQYTLSYEDKTLIMGILNVTPDSFSDGGKYNSIDRAVIHAKQMIEDGAHILDIGGESTRPGAEKVS
LDEELSRVIPVIEKLVQEIDVPISVDTYKAQVADEAIKAGAAIINDVWGAKADPDMARVAAAHNVPIILMHNREERNYKD
LIPDMLSDLMECVSIAKSAGVQDHHIVLDPGIGFAKTYHDNLAVMNQLEKFSEPGYPVLLGTSRKKFIGRVLDLPPEERA
EGTGATVCLGIQKGCDIVRVHDVKQISRMAKMMDAMIDKGGVYHR
>Mature_284_residues
ALQTAVRSKQLIAKQYTLSYEDKTLIMGILNVTPDSFSDGGKYNSIDRAVIHAKQMIEDGAHILDIGGESTRPGAEKVSL
DEELSRVIPVIEKLVQEIDVPISVDTYKAQVADEAIKAGAAIINDVWGAKADPDMARVAAAHNVPIILMHNREERNYKDL
IPDMLSDLMECVSIAKSAGVQDHHIVLDPGIGFAKTYHDNLAVMNQLEKFSEPGYPVLLGTSRKKFIGRVLDLPPEERAE
GTGATVCLGIQKGCDIVRVHDVKQISRMAKMMDAMIDKGGVYHR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=259, Percent_Identity=42.4710424710425, Blast_Score=210, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=34.1772151898734, Blast_Score=148, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31259; Mature: 31128

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQTAVRSKQLIAKQYTLSYEDKTLIMGILNVTPDSFSDGGKYNSIDRAVIHAKQMIED
CCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GAHILDIGGESTRPGAEKVSLDEELSRVIPVIEKLVQEIDVPISVDTYKAQVADEAIKAG
CCEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AAIINDVWGAKADPDMARVAAAHNVPIILMHNREERNYKDLIPDMLSDLMECVSIAKSAG
HHHHHHHCCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
VQDHHIVLDPGIGFAKTYHDNLAVMNQLEKFSEPGYPVLLGTSRKKFIGRVLDLPPEERA
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCHHHC
EGTGATVCLGIQKGCDIVRVHDVKQISRMAKMMDAMIDKGGVYHR
CCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ALQTAVRSKQLIAKQYTLSYEDKTLIMGILNVTPDSFSDGGKYNSIDRAVIHAKQMIED
CCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GAHILDIGGESTRPGAEKVSLDEELSRVIPVIEKLVQEIDVPISVDTYKAQVADEAIKAG
CCEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AAIINDVWGAKADPDMARVAAAHNVPIILMHNREERNYKDLIPDMLSDLMECVSIAKSAG
HHHHHHHCCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
VQDHHIVLDPGIGFAKTYHDNLAVMNQLEKFSEPGYPVLLGTSRKKFIGRVLDLPPEERA
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCHHHC
EGTGATVCLGIQKGCDIVRVHDVKQISRMAKMMDAMIDKGGVYHR
CCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]