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The map label for this gene is guaB [H]

Identifier: 52783864

GI number: 52783864

Start: 15884

End: 17350

Strand: Direct

Name: guaB [H]

Synonym: BLi00014

Alternate gene names: 52783864

Gene position: 15884-17350 (Clockwise)

Preceding gene: 52783862

Following gene: 52783865

Centisome position: 0.38

GC content: 46.63

Gene sequence:

>1467_bases
ATGTGGGAAAGCAAATTTTCAAAAGAAGGCTTAACATTTGATGATGTATTGCTCGTTCCGGCTAAATCGGAGGTACTTCC
GCGCGACGTCGATTTATCGGTAGAGCTTACACCGTCTCTCAAGCTGAATGTTCCAATTATTAGTGCAGGCATGGATACAG
TTACAGAAGCTCAAATGGCCATCGCGATGGCAAGGCAGGGCGGACTGGGTATTATCCACAAAAACATGTCAATTGAACAG
CAGGCTGAGCAGGTTGACAAAGTCAAACGTTCAGAGCGCGGCGTCATTACAAATCCGTTTTTCCTGACACCAGAGCACCA
AGTTTTTGATGCAGAGCATTTGATGGGCAAATACAGAATTTCCGGTGTTCCGATTGTTGACAATGAAGAGGATCAGAAGC
TGGTTGGAATCATTACAAACCGTGATCTGCGATTTATTTCTGATTACTCCATGAAAATCAGCGATGTTATGACAAAAGAA
GAGCTTGTTACGGCTCCTGTTGGTACAACCCTGGATGAAGCAGAAAAAATTCTTCAAAAATACAAGATCGAAAAACTCCC
TCTTTTAGATGATCAAGGTGTTTTAAAAGGGCTAATTACGATTAAAGACATTGAAAAAGTAATCGAATTCCCGAATTCAG
CGAAAGATGTTCACGGCCGCCTATTGGTTGGAGCAGCGGTTGGTGTAACAGGCGACACAATGACACGCGTCAGAAAGCTT
GTGGAAGCCAATGTCGATGTGATCGTCGTTGATACCGCGCACGGCCATTCACAAGGAGTATTGGATACCGTTAAGAAAAT
CCGCGACACTTATCCTGAATTAAATATCATTGCCGGTAACGTCGCAACTGCCGAAGGAACAAAAGCGCTTATCGAAGCTG
GAGCAAATGTAGTTAAAGTCGGTATCGGACCGGGGTCAATTTGTACAACCCGCGTAGTAGCCGGTGTCGGTGTTCCGCAA
GTGACAGCGATTTACGATTGTGCGACTGAAGCAAGAAAACACGGCGCTGCGATTATTGCAGACGGCGGCATCAAGTATTC
CGGAGATATTGTCAAAGCCTTGGCTGCCGGCGGTCATGCCGTCATGCTAGGAAGCCTTCTTGCCGGAACATCTGAAAGCC
CGGGCGAGACTGAAATCTATCAAGGCAGACGCTTTAAAGTTTATCGCGGCATGGGTTCTGTAGCTGCGATGGAAAAAGGA
AGCAAAGACCGCTACTTCCAAGAGGAAAACAAAAAATTCGTTCCTGAAGGCATTGAAGGCCGTACGCCTTATAAAGGCCC
TGTTGCTGATACCGTTTATCAGCTTGTCGGCGGCTTGAAATCCGGCATGGGCTACTGCGGAACGAAAGATTTGCACGCAT
TGAGGGAAGATGCGCAGTTCATCCGCATGACAGGAGCAGGCCTGCGGGAAAGCCATCCTCACGATGTGCAAATTACCAAA
GAATCGCCTAACTATACCATTTCCTAA

Upstream 100 bases:

>100_bases
TATTTTCTAAAAATTACAACTGTTTCTCGCTTTCTTGACAGTGGGTATTCAAGTTGATAATCTACATATAATATTTTGCC
GAAAAGAGGGGGATTTACTA

Downstream 100 bases:

>100_bases
TCAAATATGACAAAAATTAAACCGTAGACAGAGTGATACTCTGTCTATTTTTTTTTGCTTCATTATGATAAAATTTATAA
TGTTGTGTTTGAAAAATGTC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH; Superoxide-inducible protein 12; SOI12 [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTPSLKLNVPIISAGMDTVTEAQMAIAMARQGGLGIIHKNMSIEQ
QAEQVDKVKRSERGVITNPFFLTPEHQVFDAEHLMGKYRISGVPIVDNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE
ELVTAPVGTTLDEAEKILQKYKIEKLPLLDDQGVLKGLITIKDIEKVIEFPNSAKDVHGRLLVGAAVGVTGDTMTRVRKL
VEANVDVIVVDTAHGHSQGVLDTVKKIRDTYPELNIIAGNVATAEGTKALIEAGANVVKVGIGPGSICTTRVVAGVGVPQ
VTAIYDCATEARKHGAAIIADGGIKYSGDIVKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMGSVAAMEKG
SKDRYFQEENKKFVPEGIEGRTPYKGPVADTVYQLVGGLKSGMGYCGTKDLHALREDAQFIRMTGAGLRESHPHDVQITK
ESPNYTIS

Sequences:

>Translated_488_residues
MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTPSLKLNVPIISAGMDTVTEAQMAIAMARQGGLGIIHKNMSIEQ
QAEQVDKVKRSERGVITNPFFLTPEHQVFDAEHLMGKYRISGVPIVDNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE
ELVTAPVGTTLDEAEKILQKYKIEKLPLLDDQGVLKGLITIKDIEKVIEFPNSAKDVHGRLLVGAAVGVTGDTMTRVRKL
VEANVDVIVVDTAHGHSQGVLDTVKKIRDTYPELNIIAGNVATAEGTKALIEAGANVVKVGIGPGSICTTRVVAGVGVPQ
VTAIYDCATEARKHGAAIIADGGIKYSGDIVKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMGSVAAMEKG
SKDRYFQEENKKFVPEGIEGRTPYKGPVADTVYQLVGGLKSGMGYCGTKDLHALREDAQFIRMTGAGLRESHPHDVQITK
ESPNYTIS
>Mature_488_residues
MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTPSLKLNVPIISAGMDTVTEAQMAIAMARQGGLGIIHKNMSIEQ
QAEQVDKVKRSERGVITNPFFLTPEHQVFDAEHLMGKYRISGVPIVDNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE
ELVTAPVGTTLDEAEKILQKYKIEKLPLLDDQGVLKGLITIKDIEKVIEFPNSAKDVHGRLLVGAAVGVTGDTMTRVRKL
VEANVDVIVVDTAHGHSQGVLDTVKKIRDTYPELNIIAGNVATAEGTKALIEAGANVVKVGIGPGSICTTRVVAGVGVPQ
VTAIYDCATEARKHGAAIIADGGIKYSGDIVKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMGSVAAMEKG
SKDRYFQEENKKFVPEGIEGRTPYKGPVADTVYQLVGGLKSGMGYCGTKDLHALREDAQFIRMTGAGLRESHPHDVQITK
ESPNYTIS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=455, Percent_Identity=45.2747252747253, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI156616279, Length=455, Percent_Identity=45.2747252747253, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI34328928, Length=455, Percent_Identity=45.2747252747253, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI34328930, Length=455, Percent_Identity=45.2747252747253, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI66933016, Length=453, Percent_Identity=43.046357615894, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=45.1901565995526, Blast_Score=351, Evalue=8e-97,
Organism=Homo sapiens, GI217035148, Length=455, Percent_Identity=44.3956043956044, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI217035150, Length=455, Percent_Identity=42.4175824175824, Blast_Score=324, Evalue=9e-89,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=39.4308943089431, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=39.4308943089431, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=39.4308943089431, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=39.4308943089431, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=39.4308943089431, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=54.1152263374486, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1786293, Length=256, Percent_Identity=37.5, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71994385, Length=473, Percent_Identity=37.2093023255814, Blast_Score=292, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=38.8625592417062, Blast_Score=277, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI17560440, Length=287, Percent_Identity=35.191637630662, Blast_Score=175, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6322012, Length=467, Percent_Identity=39.4004282655246, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6323585, Length=461, Percent_Identity=40.997830802603, Blast_Score=336, Evalue=6e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=467, Percent_Identity=41.3276231263383, Blast_Score=335, Evalue=9e-93,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=39.9408284023669, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=41.3793103448276, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641071, Length=479, Percent_Identity=42.1711899791232, Blast_Score=349, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24641073, Length=479, Percent_Identity=42.1711899791232, Blast_Score=349, Evalue=3e-96,
Organism=Drosophila melanogaster, GI28571163, Length=437, Percent_Identity=42.1052631578947, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52715; Mature: 52715

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTPSLKLNVPIISAGMDTVTEAQMA
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCEEECCEEEECCCHHHHHHHHH
IAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFLTPEHQVFDAEHLMGKYRI
HHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHCCHHHHHHHEEE
SGVPIVDNEEDQKLVGIITNRDLRFISDYSMKISDVMTKEELVTAPVGTTLDEAEKILQK
CCCCEECCCCCCEEEEEEECCCEEEECCCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHH
YKIEKLPLLDDQGVLKGLITIKDIEKVIEFPNSAKDVHGRLLVGAAVGVTGDTMTRVRKL
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEEEEEECCCCHHHHHHHHH
VEANVDVIVVDTAHGHSQGVLDTVKKIRDTYPELNIIAGNVATAEGTKALIEAGANVVKV
HHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCEECCCCHHHHHHCCCCEEEE
GIGPGSICTTRVVAGVGVPQVTAIYDCATEARKHGAAIIADGGIKYSGDIVKALAAGGHA
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECCHHHHHHHCCCHH
VMLGSLLAGTSESPGETEIYQGRRFKVYRGMGSVAAMEKGSKDRYFQEENKKFVPEGIEG
HHHHHHHCCCCCCCCCCHHHCCCEEEEECCCCCHHHHCCCCCCCCHHHCCCEECCCCCCC
RTPYKGPVADTVYQLVGGLKSGMGYCGTKDLHALREDAQFIRMTGAGLRESHPHDVQITK
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEE
ESPNYTIS
CCCCCCCC
>Mature Secondary Structure
MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTPSLKLNVPIISAGMDTVTEAQMA
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCEEECCEEEECCCHHHHHHHHH
IAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFLTPEHQVFDAEHLMGKYRI
HHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHCCHHHHHHHEEE
SGVPIVDNEEDQKLVGIITNRDLRFISDYSMKISDVMTKEELVTAPVGTTLDEAEKILQK
CCCCEECCCCCCEEEEEEECCCEEEECCCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHH
YKIEKLPLLDDQGVLKGLITIKDIEKVIEFPNSAKDVHGRLLVGAAVGVTGDTMTRVRKL
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEEEEEECCCCHHHHHHHHH
VEANVDVIVVDTAHGHSQGVLDTVKKIRDTYPELNIIAGNVATAEGTKALIEAGANVVKV
HHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCEECCCCHHHHHHCCCCEEEE
GIGPGSICTTRVVAGVGVPQVTAIYDCATEARKHGAAIIADGGIKYSGDIVKALAAGGHA
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECCHHHHHHHCCCHH
VMLGSLLAGTSESPGETEIYQGRRFKVYRGMGSVAAMEKGSKDRYFQEENKKFVPEGIEG
HHHHHHHCCCCCCCCCCHHHCCCEEEEECCCCCHHHHCCCCCCCCHHHCCCEECCCCCCC
RTPYKGPVADTVYQLVGGLKSGMGYCGTKDLHALREDAQFIRMTGAGLRESHPHDVQITK
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCEEEEE
ESPNYTIS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1979163; 7584024; 9384377; 9298659 [H]