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The map label for this gene is gyrA [H]

Identifier: 52783862

GI number: 52783862

Start: 6900

End: 9368

Strand: Direct

Name: gyrA [H]

Synonym: BLi00007

Alternate gene names: 52783862

Gene position: 6900-9368 (Clockwise)

Preceding gene: 52783861

Following gene: 52783864

Centisome position: 0.16

GC content: 46.58

Gene sequence:

>2469_bases
ATGAGTGAACAACATAAGCCCCAAGTTCAGGAAGTCAATATCAGTCAGGAAATGCGCACATCTTTTTTAGATTACGCAAT
GAGTGTTATTGTTTCCCGCGCTCTTCCGGACGTAAGAGACGGTCTGAAGCCGGTGCACAGAAGAATATTGTATGCGATGA
ACGACCTTGGGATGACAAGTGATAAGCCGTATAAAAAATCCGCGCGTATTGTCGGCGAAGTTATCGGTAAGTACCACCCT
CACGGTGATTCTGCTGTTTACGAAGCCATGGTCAGAATGGCGCAGGATTTTAACTATCGGTACATGCTCGTTCAAGGCCA
TGGAAACTTCGGTTCTGTTGACGGCGACTCGGCTGCGGCCATGCGTTACACAGAAGCGAGAATGTCTAAAATATCAATGG
AAATTCTGCGCGACATCAATAAAGACACAATCGATTACCAGGACAACTATGACGGTTCGGAAAAAGAGCCGGTTGTTATG
CCTGCGAGATTTCCGAACTTGCTTGTCAACGGAGCGGCCGGTATTGCTGTAGGTATGGCCACAAACATCCCGCCGCATCA
GCTCGGTGAAGTCATTGACGGTGTTTTGGCGGTCAGCAAAAACCCTGATATCACGCTTCCGGAATTGATGGAGATCATTC
CTGGACCCGACTTCCCTACAGCAGGGCTGATCTTGGGAAGAAGCGGTATCCGAAAGGCCTATGAAACAGGCCGGGGATCA
ATTACGCTTCGAGCCAAAGCTCAAATCGAAGAAACATCTTCCGGCAAACCGGTAATCATTATTACGGAAATACCGTACCA
AGTGAATAAAGCAAGGCTGATCGAAAAAATCGCCGATCTAGTGCGCGATAAGAAAATCGACGGCATTACGGATCTCCGCG
ATGAATCAGACCGAAACGGAATGCGCATCGTCATTGAACTGAGAAGGGATGCAAATGCCAATGTACTGTTAAATAACTTG
TACAAGCAGACCGCTCTTCAAACATCATTCGGCATTAATCTTTTGGCGCTTGTTGACGGCCAGCCGAAAGTATTGAGCTT
GAAGCAGTGTCTGGAGCATTATCTCGACCATCAAAAAGTCGTGATCAGAAGGCGTACTGCATTCGAGCTTCGCAAAGCGG
AAGCGCGGGCCCATATTCTTGAGGGCTTGAGAGTGGCGCTTGATCACCTTGATGAAGTTATTTCCCTAATTAGAAATTCG
CAAACGGCTGAAATCGCAAAAAACGGATTGATTGAGAAGTTTTCTTTGACTGAAAAACAGGCCCAGGCGATTTTGGACAT
GCGTCTCCAGCGTTTAACAGGGCTGGAACGCGAAAAAATCGAAGAGGAATATCAAAGCCTTGTTGAGCTGATTGCAGAGC
TAAAAGCAATCTTAGCAGACGAAGAGAAAGTTCTTGAAATCATTCGGGAAGAGCTCACAGAAGTTAAAGAGCGCTTTAAT
GATGAGCGCCGTACTGAAATCGTGACATCGGGCCTTGAGACGATTGAGGATGAAGATCTCATCACGCGCGAGAATATCGT
TGTGACTTTAACTCATAACGGATATATCAAACGTCTGCCTTCTTCCACTTACCGCAGCCAAAAACGGGGCGGGAAAGGCA
TTCAGGGCATGGGTACAAATGAAGACGACTTCGTTGAACACCTGATTTCAACATCCACCCATGACACCATTCTCTTCTTC
TCGAATAAAGGGAAGGTGTACCGTGCGAAAGGATATGAGATCCCTGAATTCGGACGGACAGCGAAGGGAATTCCGATTAT
TAACCTGCTTGAAGTGGAAAAAGGAGAATGGATCAACGCGATTATTCCGGTAGGCGAATTTGATGACGAGTCTTATTTGT
TCTTCACGACAAAACACGGAATATCAAAACGCACACCGCTTTCTCAATTCGCGAATATCCGCAATAATGGATTGATCGCC
TTAAGCCTCCGCGATGAGGATGAATTGATCGCTGTCCGCCTGACGGATGGAAATAAACAAATTATTATCGGCACGAAGAA
CGGTCTGCTCATCCGTTTCCCTGAAACAGATGTAAGGCAAATGGGAAGAACAGCAGCCGGCGTTAAGGGCATCAATCTGA
CAGATGACGATGTTGTTGTCGGCATGGAGATTTTGGAAGAGGATTCACACGTGCTAATCGTAACTGAAAAGGGCTACGGA
AAACTGACGCCCGCTTCAGAATACAGGGTGCAAAGCCGCGGAGGAAAAGGGCTGAAAACCTGCAAAATCACAGAAAATAA
CGGATCTCTTGTGACAGTGAAAGCAACGACAGGAGAAGAAGATTTAATGATCATCACAGCAAGCGGCGTGATCATTCGGA
TGGATATTAAAGATATCTCCACGACCGGACGCGTCACTCAAGGTGTGCGACTTATCCGCTTAGGTGAACAAGAGCATGTC
GCGACTGTCGCTTTAGTTGAAAAAGATGAAGAGAACGATTCAGAAGAACAGGAAGCGGATGAATCATAA

Upstream 100 bases:

>100_bases
AAGATTATTGATATAATGGAGAATAGCCTAATTCGTTGAAGAGTATAAATACAAATCTACTCCCACACAACTCATGTAGA
TTCTCCAGGGAGGTTTTTTA

Downstream 100 bases:

>100_bases
AAACATGCAGCCAAATGGCTGCATGTTTTTCTATTCAATCTTTCAAATATAATCTTTTCATCAGGAACATAATGTGCTAT
AATTTCTCTTGGTCGCTTAT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 822; Mature: 821

Protein sequence:

>822_residues
MSEQHKPQVQEVNISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHP
HGDSAVYEAMVRMAQDFNYRYMLVQGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDINKDTIDYQDNYDGSEKEPVVM
PARFPNLLVNGAAGIAVGMATNIPPHQLGEVIDGVLAVSKNPDITLPELMEIIPGPDFPTAGLILGRSGIRKAYETGRGS
ITLRAKAQIEETSSGKPVIIITEIPYQVNKARLIEKIADLVRDKKIDGITDLRDESDRNGMRIVIELRRDANANVLLNNL
YKQTALQTSFGINLLALVDGQPKVLSLKQCLEHYLDHQKVVIRRRTAFELRKAEARAHILEGLRVALDHLDEVISLIRNS
QTAEIAKNGLIEKFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVELIAELKAILADEEKVLEIIREELTEVKERFN
DERRTEIVTSGLETIEDEDLITRENIVVTLTHNGYIKRLPSSTYRSQKRGGKGIQGMGTNEDDFVEHLISTSTHDTILFF
SNKGKVYRAKGYEIPEFGRTAKGIPIINLLEVEKGEWINAIIPVGEFDDESYLFFTTKHGISKRTPLSQFANIRNNGLIA
LSLRDEDELIAVRLTDGNKQIIIGTKNGLLIRFPETDVRQMGRTAAGVKGINLTDDDVVVGMEILEEDSHVLIVTEKGYG
KLTPASEYRVQSRGGKGLKTCKITENNGSLVTVKATTGEEDLMIITASGVIIRMDIKDISTTGRVTQGVRLIRLGEQEHV
ATVALVEKDEENDSEEQEADES

Sequences:

>Translated_822_residues
MSEQHKPQVQEVNISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHP
HGDSAVYEAMVRMAQDFNYRYMLVQGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDINKDTIDYQDNYDGSEKEPVVM
PARFPNLLVNGAAGIAVGMATNIPPHQLGEVIDGVLAVSKNPDITLPELMEIIPGPDFPTAGLILGRSGIRKAYETGRGS
ITLRAKAQIEETSSGKPVIIITEIPYQVNKARLIEKIADLVRDKKIDGITDLRDESDRNGMRIVIELRRDANANVLLNNL
YKQTALQTSFGINLLALVDGQPKVLSLKQCLEHYLDHQKVVIRRRTAFELRKAEARAHILEGLRVALDHLDEVISLIRNS
QTAEIAKNGLIEKFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVELIAELKAILADEEKVLEIIREELTEVKERFN
DERRTEIVTSGLETIEDEDLITRENIVVTLTHNGYIKRLPSSTYRSQKRGGKGIQGMGTNEDDFVEHLISTSTHDTILFF
SNKGKVYRAKGYEIPEFGRTAKGIPIINLLEVEKGEWINAIIPVGEFDDESYLFFTTKHGISKRTPLSQFANIRNNGLIA
LSLRDEDELIAVRLTDGNKQIIIGTKNGLLIRFPETDVRQMGRTAAGVKGINLTDDDVVVGMEILEEDSHVLIVTEKGYG
KLTPASEYRVQSRGGKGLKTCKITENNGSLVTVKATTGEEDLMIITASGVIIRMDIKDISTTGRVTQGVRLIRLGEQEHV
ATVALVEKDEENDSEEQEADES
>Mature_821_residues
SEQHKPQVQEVNISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPH
GDSAVYEAMVRMAQDFNYRYMLVQGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDINKDTIDYQDNYDGSEKEPVVMP
ARFPNLLVNGAAGIAVGMATNIPPHQLGEVIDGVLAVSKNPDITLPELMEIIPGPDFPTAGLILGRSGIRKAYETGRGSI
TLRAKAQIEETSSGKPVIIITEIPYQVNKARLIEKIADLVRDKKIDGITDLRDESDRNGMRIVIELRRDANANVLLNNLY
KQTALQTSFGINLLALVDGQPKVLSLKQCLEHYLDHQKVVIRRRTAFELRKAEARAHILEGLRVALDHLDEVISLIRNSQ
TAEIAKNGLIEKFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVELIAELKAILADEEKVLEIIREELTEVKERFND
ERRTEIVTSGLETIEDEDLITRENIVVTLTHNGYIKRLPSSTYRSQKRGGKGIQGMGTNEDDFVEHLISTSTHDTILFFS
NKGKVYRAKGYEIPEFGRTAKGIPIINLLEVEKGEWINAIIPVGEFDDESYLFFTTKHGISKRTPLSQFANIRNNGLIAL
SLRDEDELIAVRLTDGNKQIIIGTKNGLLIRFPETDVRQMGRTAAGVKGINLTDDDVVVGMEILEEDSHVLIVTEKGYGK
LTPASEYRVQSRGGKGLKTCKITENNGSLVTVKATTGEEDLMIITASGVIIRMDIKDISTTGRVTQGVRLIRLGEQEHVA
TVALVEKDEENDSEEQEADES

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=356, Percent_Identity=25, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI19913406, Length=356, Percent_Identity=25.2808988764045, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1788562, Length=842, Percent_Identity=52.2565320665083, Blast_Score=864, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=731, Percent_Identity=36.5253077975376, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17535065, Length=171, Percent_Identity=30.9941520467836, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=26.2247838616715, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136538, Length=166, Percent_Identity=31.3253012048193, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91833; Mature: 91702

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQHKPQVQEVNISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMNDLGMTS
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
DKPYKKSARIVGEVIGKYHPHGDSAVYEAMVRMAQDFNYRYMLVQGHGNFGSVDGDSAAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHH
MRYTEARMSKISMEILRDINKDTIDYQDNYDGSEKEPVVMPARFPNLLVNGAAGIAVGMA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEECCCCEEEEEE
TNIPPHQLGEVIDGVLAVSKNPDITLPELMEIIPGPDFPTAGLILGRSGIRKAYETGRGS
CCCCHHHHHHHHHHHEEECCCCCCCHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCC
ITLRAKAQIEETSSGKPVIIITEIPYQVNKARLIEKIADLVRDKKIDGITDLRDESDRNG
EEEEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
MRIVIELRRDANANVLLNNLYKQTALQTSFGINLLALVDGQPKVLSLKQCLEHYLDHQKV
CEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCHHE
VIRRRTAFELRKAEARAHILEGLRVALDHLDEVISLIRNSQTAEIAKNGLIEKFSLTEKQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHCCHHH
AQAILDMRLQRLTGLEREKIEEEYQSLVELIAELKAILADEEKVLEIIREELTEVKERFN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
DERRTEIVTSGLETIEDEDLITRENIVVTLTHNGYIKRLPSSTYRSQKRGGKGIQGMGTN
HHHHHHHHHHHHHHCCCCCCEEECCEEEEEECCCEEEECCCHHHHHHHCCCCCCCCCCCC
EDDFVEHLISTSTHDTILFFSNKGKVYRAKGYEIPEFGRTAKGIPIINLLEVEKGEWINA
HHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCCEEEE
IIPVGEFDDESYLFFTTKHGISKRTPLSQFANIRNNGLIALSLRDEDELIAVRLTDGNKQ
EEECCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCEE
IIIGTKNGLLIRFPETDVRQMGRTAAGVKGINLTDDDVVVGMEILEEDSHVLIVTEKGYG
EEEECCCCEEEECCCHHHHHCCCHHCCCCCCCCCCCCEEEEHHHHCCCCEEEEEEECCCC
KLTPASEYRVQSRGGKGLKTCKITENNGSLVTVKATTGEEDLMIITASGVIIRMDIKDIS
CCCCCHHHEECCCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEECCEEEEEECHHCC
TTGRVTQGVRLIRLGEQEHVATVALVEKDEENDSEEQEADES
CCCHHHHCEEEEEECCHHHEEEEEEEECCCCCCCHHHHCCCC
>Mature Secondary Structure 
SEQHKPQVQEVNISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMNDLGMTS
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
DKPYKKSARIVGEVIGKYHPHGDSAVYEAMVRMAQDFNYRYMLVQGHGNFGSVDGDSAAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHH
MRYTEARMSKISMEILRDINKDTIDYQDNYDGSEKEPVVMPARFPNLLVNGAAGIAVGMA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEECCCCEEEEEE
TNIPPHQLGEVIDGVLAVSKNPDITLPELMEIIPGPDFPTAGLILGRSGIRKAYETGRGS
CCCCHHHHHHHHHHHEEECCCCCCCHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCC
ITLRAKAQIEETSSGKPVIIITEIPYQVNKARLIEKIADLVRDKKIDGITDLRDESDRNG
EEEEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
MRIVIELRRDANANVLLNNLYKQTALQTSFGINLLALVDGQPKVLSLKQCLEHYLDHQKV
CEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCHHE
VIRRRTAFELRKAEARAHILEGLRVALDHLDEVISLIRNSQTAEIAKNGLIEKFSLTEKQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHCCHHH
AQAILDMRLQRLTGLEREKIEEEYQSLVELIAELKAILADEEKVLEIIREELTEVKERFN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
DERRTEIVTSGLETIEDEDLITRENIVVTLTHNGYIKRLPSSTYRSQKRGGKGIQGMGTN
HHHHHHHHHHHHHHCCCCCCEEECCEEEEEECCCEEEECCCHHHHHHHCCCCCCCCCCCC
EDDFVEHLISTSTHDTILFFSNKGKVYRAKGYEIPEFGRTAKGIPIINLLEVEKGEWINA
HHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCCEEEE
IIPVGEFDDESYLFFTTKHGISKRTPLSQFANIRNNGLIALSLRDEDELIAVRLTDGNKQ
EEECCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCEE
IIIGTKNGLLIRFPETDVRQMGRTAAGVKGINLTDDDVVVGMEILEEDSHVLIVTEKGYG
EEEECCCCEEEECCCHHHHHCCCHHCCCCCCCCCCCCEEEEHHHHCCCCEEEEEEECCCC
KLTPASEYRVQSRGGKGLKTCKITENNGSLVTVKATTGEEDLMIITASGVIIRMDIKDIS
CCCCCHHHEECCCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEECCEEEEEECHHCC
TTGRVTQGVRLIRLGEQEHVATVALVEKDEENDSEEQEADES
CCCHHHHCEEEEEECCHHHEEEEEEEECCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2987847; 7584024; 9384377 [H]