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The map label for this gene is mvaB [H]

Identifier: 52142952

GI number: 52142952

Start: 2425766

End: 2426677

Strand: Direct

Name: mvaB [H]

Synonym: BCZK2288

Alternate gene names: 52142952

Gene position: 2425766-2426677 (Clockwise)

Preceding gene: 52142951

Following gene: 52142950

Centisome position: 45.76

GC content: 36.73

Gene sequence:

>912_bases
TTGAAACTACCTAATTTTGCTGTCATTAAAGAAGTCGGGCCACGTGATGGCTTACAAAATGAAAAAAAGATTGTTGGCAC
AAAAGATAAAGTAAAATGGATCCAACTACTTACAGAGGCGGGATTATCGTACGTTGAAGTTTCCTCATTCGTTCACCCTA
AATGGGTCCCTGCATTAGCAGATGCAAATGATGTGTTTTCAGAGCTGAAAAGGGACCCAAATGTTACATATGCAGCGCTT
GTTCCAAATCAAAATGGTTTGGAACGAGCTTTTTTGCAAAATGTAGATGAGGTGAATGTTTTTTTATCAGCAAGTGAATC
TCATAATAAAAGTAATATTAATAAATCAGTTAAAGAAGCATTAGTTGTAATTGAAGATATAACAAAACAGGCGTTATTTG
AAGGTAAAAAGGTAAGAGGCTATGTTTCTACTGTATTTGGATGTCCTTATGAAGGAGATATAAGTGCCATAGCAGTTGAC
GAATTATGTGATCAACTATTTTCATACGGCATTTATGAAGTGTCTCTTGGCGACACAATCGGAGTAGCGAATCCGTTACA
AGTAGAGCGAGTATTAGAGCATTTATTAAAGAAATATGATGCTTCGCAGTTTGCAATGCACTTCCATAATACGTACGGAA
TGGCTCTTGCGAATGTAGTAAAGTCTTTAGAATATGGTATTACAACATTTGATAGTTCTTGTGGTGGTCTTGGCGGCTGT
CCATATGCACCAGGAGCATCAGGTAATGTTGCAACTGATGACTTAGTTCATATGCTCCATAAGTTAGGGGTCCAAACGAA
TATTGATGAAGAGAAGTTATTGAGAGCGAGTCAATTTATTCAAAGTAAATTAAATATCCAATTACCGAGTCATGTGTATA
GAGCGCTTCAACATAAAACGATAAGTAGGTGA

Upstream 100 bases:

>100_bases
AGCTGGCACAGTTATGAAAATTAATGTGCAAGAAGGCGATTTTGTAAATGAAGGAGATGTATTACTAGAAATTGAATAGG
GAGATATAGGGGGAAGCGAA

Downstream 100 bases:

>100_bases
GAAGATGCTACAATTACAAAATATTTCAGTTGATTATGTAACACCGCACGTTGTAAAGATTTCATTAAATCGTGAAAGAC
AAGCAAACTCATTATCTTTA

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYVEVSSFVHPKWVPALADANDVFSELKRDPNVTYAAL
VPNQNGLERAFLQNVDEVNVFLSASESHNKSNINKSVKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISAIAVD
ELCDQLFSYGIYEVSLGDTIGVANPLQVERVLEHLLKKYDASQFAMHFHNTYGMALANVVKSLEYGITTFDSSCGGLGGC
PYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQSKLNIQLPSHVYRALQHKTISR

Sequences:

>Translated_303_residues
MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYVEVSSFVHPKWVPALADANDVFSELKRDPNVTYAAL
VPNQNGLERAFLQNVDEVNVFLSASESHNKSNINKSVKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISAIAVD
ELCDQLFSYGIYEVSLGDTIGVANPLQVERVLEHLLKKYDASQFAMHFHNTYGMALANVVKSLEYGITTFDSSCGGLGGC
PYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQSKLNIQLPSHVYRALQHKTISR
>Mature_303_residues
MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYVEVSSFVHPKWVPALADANDVFSELKRDPNVTYAAL
VPNQNGLERAFLQNVDEVNVFLSASESHNKSNINKSVKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISAIAVD
ELCDQLFSYGIYEVSLGDTIGVANPLQVERVLEHLLKKYDASQFAMHFHNTYGMALANVVKSLEYGITTFDSSCGGLGGC
PYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQSKLNIQLPSHVYRALQHKTISR

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=293, Percent_Identity=47.7815699658703, Blast_Score=281, Evalue=5e-76,
Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=46.7576791808874, Blast_Score=278, Evalue=6e-75,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=46.7576791808874, Blast_Score=277, Evalue=7e-75,
Organism=Homo sapiens, GI260654708, Length=131, Percent_Identity=48.0916030534351, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17510563, Length=292, Percent_Identity=44.8630136986301, Blast_Score=251, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24582381, Length=289, Percent_Identity=44.2906574394464, Blast_Score=265, Evalue=4e-71,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 33401; Mature: 33401

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYVEVSSFVHPKWVPALA
CCCCCHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHC
DANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSASESHNKSNINKSVKEA
CHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCHHEEEEECCCCCCHHHHHHHHHHH
LVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISAIAVDELCDQLFSYGIYEVSLGDTI
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCC
GVANPLQVERVLEHLLKKYDASQFAMHFHNTYGMALANVVKSLEYGITTFDSSCGGLGGC
CCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQSKLNIQLPSHVYRALQHKT
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ISR
CCC
>Mature Secondary Structure
MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYVEVSSFVHPKWVPALA
CCCCCHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHC
DANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSASESHNKSNINKSVKEA
CHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCHHEEEEECCCCCCHHHHHHHHHHH
LVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISAIAVDELCDQLFSYGIYEVSLGDTI
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCC
GVANPLQVERVLEHLLKKYDASQFAMHFHNTYGMALANVVKSLEYGITTFDSSCGGLGGC
CCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQSKLNIQLPSHVYRALQHKT
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ISR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]