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The map label for this gene is hom [H]

Identifier: 52142886

GI number: 52142886

Start: 2487147

End: 2488190

Strand: Direct

Name: hom [H]

Synonym: BCZK2354

Alternate gene names: 52142886

Gene position: 2487147-2488190 (Clockwise)

Preceding gene: 52142888

Following gene: 52142885

Centisome position: 46.92

GC content: 33.62

Gene sequence:

>1044_bases
ATGAAAGTTAAAGTTGTATTATCAGGATATGGAACAGTAGGAAAAGAGTTTATAAAATTATTAAACGAAAAATATTTATA
TATAAATGAAACGTATGGAATAGATTTAGTGGTAAGCGGTGTATTAGGCAGAAATGTCGCAATACATAATGAAGATGGAT
TATCTATTCATCATTTATTAAGAAATGGTGGCGGTAGCTGTGCAATTGAAAAATATATTGAACATCATCCAGAAGAACGT
GCAACAGATAACATAAGTGGTACAGTGCTGGTAGAATCAACAGTTACAAACCTTAAAGATGGAAATCCAGGGAAACAATA
TATAAAACAAGCGATTGAGAAAAAAATGGATATAGTAGCAATTTCAAAAGGTGCGCTAGTTACAAACTGGAGAGAAATAA
ATGAAGCTGCAAAAATCGCAAATGTACGAATTCGATACAGTGGGGCAACTGCTGCGGCATTACCAACACTTGATATTGGT
CAATTTAGTTTAGCTGGTTGCCATATTGAAAAAATAGAAGGAATATTAAACGGGACAACAAATTATATTCTTTCGAAAAT
GAATGAGGAAGATATTACATTTGAAGAAGCACTGAAAGAAGCGCAAAGTAAAGGAATTGCTGAAACGAACCCAATATTAG
ATGTAAGTGGTTCTGATAGTGCGTGTAAATTGTTACTTTTGACAAACAGTTTAATGGGAACAGAAAATACGCTTACCGAT
TTACATATAAAAGGAATCGAACATGTTACAAAACAAGACATTGGAAATGCGAAGGAACAAAATAAATATATTAAATTAAT
TGCATCAGCATATAAAGATGAGGATGGCAATGTGAATTTAAATGTTGAACCGTGCGAAATAGATAAAGATCATCCGCTAG
CAAAAGTAAATGGGACGGAAAAAGGGATTACGTTCTTTACAGATACGATGGGGCAAGTTACTACAATTGGTGGTGCTTCT
AATCCACGTGGAGCCGCAGCAGCAGCTTTAAAAGATATAATTAATTTATATCGTAAAGATTTGTCACGTATTAACGGGGA
ATAA

Upstream 100 bases:

>100_bases
TTTACCGAAATAGATAATAATAAAGCGCTCTCGATAGAATTCGGGGGCGCTTTATTATATATTAAAAGAGGGATTGGATA
GAAAAATATGGGGGGATATT

Downstream 100 bases:

>100_bases
AGTTACTAATTGATTAAAGTTGTATTTTATAAAACCGTACCGCCCTTTATAAAAAATACATATGCAGTGGACCTTTTGAG
AATGAAATAAATATGCAAAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKVKVVLSGYGTVGKEFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLLRNGGGSCAIEKYIEHHPEER
ATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVAISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIG
QFSLAGCHIEKIEGILNGTTNYILSKMNEEDITFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENTLTD
LHIKGIEHVTKQDIGNAKEQNKYIKLIASAYKDEDGNVNLNVEPCEIDKDHPLAKVNGTEKGITFFTDTMGQVTTIGGAS
NPRGAAAAALKDIINLYRKDLSRINGE

Sequences:

>Translated_347_residues
MKVKVVLSGYGTVGKEFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLLRNGGGSCAIEKYIEHHPEER
ATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVAISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIG
QFSLAGCHIEKIEGILNGTTNYILSKMNEEDITFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENTLTD
LHIKGIEHVTKQDIGNAKEQNKYIKLIASAYKDEDGNVNLNVEPCEIDKDHPLAKVNGTEKGITFFTDTMGQVTTIGGAS
NPRGAAAAALKDIINLYRKDLSRINGE
>Mature_347_residues
MKVKVVLSGYGTVGKEFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLLRNGGGSCAIEKYIEHHPEER
ATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVAISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIG
QFSLAGCHIEKIEGILNGTTNYILSKMNEEDITFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENTLTD
LHIKGIEHVTKQDIGNAKEQNKYIKLIASAYKDEDGNVNLNVEPCEIDKDHPLAKVNGTEKGITFFTDTMGQVTTIGGAS
NPRGAAAAALKDIINLYRKDLSRINGE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=200, Percent_Identity=27, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 37652; Mature: 37652

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKVVLSGYGTVGKEFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLL
CEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHCCCEEEECCCCCHHHHHH
RNGGGSCAIEKYIEHHPEERATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVA
HCCCCCHHHHHHHHHCCHHHCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHHCCCEEE
ISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIGQFSLAGCHIEKIEGILNGTT
EECCCEEECHHHHHHHHHHEEEEEEECCCCCHHCCCCCCCCEEECCCHHHHHHHHHCCHH
NYILSKMNEEDITFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENTLTD
HHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCHHH
LHIKGIEHVTKQDIGNAKEQNKYIKLIASAYKDEDGNVNLNVEPCEIDKDHPLAKVNGTE
EEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEECCCC
KGITFFTDTMGQVTTIGGASNPRGAAAAALKDIINLYRKDLSRINGE
CCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVKVVLSGYGTVGKEFIKLLNEKYLYINETYGIDLVVSGVLGRNVAIHNEDGLSIHHLL
CEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHCCCEEEECCCCCHHHHHH
RNGGGSCAIEKYIEHHPEERATDNISGTVLVESTVTNLKDGNPGKQYIKQAIEKKMDIVA
HCCCCCHHHHHHHHHCCHHHCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHHCCCEEE
ISKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIGQFSLAGCHIEKIEGILNGTT
EECCCEEECHHHHHHHHHHEEEEEEECCCCCHHCCCCCCCCEEECCCHHHHHHHHHCCHH
NYILSKMNEEDITFEEALKEAQSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENTLTD
HHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCHHH
LHIKGIEHVTKQDIGNAKEQNKYIKLIASAYKDEDGNVNLNVEPCEIDKDHPLAKVNGTE
EEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEECCCC
KGITFFTDTMGQVTTIGGASNPRGAAAAALKDIINLYRKDLSRINGE
CCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]