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The map label for this gene is lsrK [H]

Identifier: 52142544

GI number: 52142544

Start: 2816961

End: 2818529

Strand: Direct

Name: lsrK [H]

Synonym: BCZK2698

Alternate gene names: 52142544

Gene position: 2816961-2818529 (Clockwise)

Preceding gene: 52142545

Following gene: 52142542

Centisome position: 53.14

GC content: 40.09

Gene sequence:

>1569_bases
TTGTTAATGTCCAATTTATTAGCTTTCGATGCTGGTACAGGAAGTATTCGAGCAGTTCTTTTTGATTTACATGGTAATCA
AATTGCAGTAAGTCAAAAAGAATGGATTCACAAATCTGACCCACGTTACCCTGGTTCTATGAACTTTGATGTAATAGAAA
ATTGGAAGCTTGTACAAGAATGCACGAAAGAGGTTCTTCAAAAAAGCAATACTCTTGCCTCTTCTATTCTTGCTATTAGC
GCTACAAGTATGCGGGAAGGGTTTGTTTTATACGATCAAGATGGGCAAGAAATATGGGCATGTGCAAATGTTGATGGGCG
CGCATCCGCCGAGGTTAGTGAACTAAAAGAAATTCGGTCACATCTTGAAAAAGATTTATATACAAAGTCTGGTCAAACTT
TTTCATTAGGTGCTTTACCTCGCCTACTTTGGATAAAAAAACATGAACCCGACGTCTATAATTCTATTCACTCTTTTACA
ATGTTAAACGATTGGATTTTATATAAACTAAGCGGCGTGCTGCAAATTGATCCTTCAAACGGATGTACGTCAGGTATTTT
TGACTTGCAAAATAGAGTGTGGGATAACGATGTTGCTAAGGAGTGCGGTCTATCTTTACCATTTTCACCAAAAGTAAATG
AAGCTGGCACTGTGATTGGTAATGTTACAAAAGAATGTGCAGCATTAACTGGATTACGAGAAGGAATTCCTGTCGTATCC
GGGGGCGGAGATGCTCAAATGGCATCGCTCGGAACTGGAGTTGTGAAACCGAATCAAACATTAATATGCGGAGGTAGTTT
TTGGCAACAAGAAGTGAATGTTACTGAGCCAATAACGGATCCATGTGCTGCAATTCGTATAAATTGTCACGTCGTACGTA
ACCTATGGCAATATGAAACGATTGCCTTTTTCCCAGGCCTCGTTATGCGCTGGTTTCGAGACGCTTTTTGCCAAGAGGAA
AAGAAACTTGCTGACAAACTCGGTGTAGATGCTTATGAATTACTAGAAGAACAAGCGAAAGACGTACCTGTCGGTTCACA
TGGCATTATCCCTACTTTTTCAAACGTTATGAACTACATTTCTTGGCGTCATGCCGCACCTTCTTTTTTAAATTTAAGTT
TAGACACTGACAAATGCGGAAAAAAAGAACTGTTTCGTGCTATTGAAGAAAATGCCGCCTTCGTTACACTTGGAAACTTA
AAATTAATAGAAAATCTAACTGGTATATTCCCTTCTGAAGTTATTTTTGCTGGTGGTGCCGCTAAAGGAAAACTATGGCC
ACAAATTCTATCAGACGTCCTTGGTATTCCTGTAAAAGTACCTGTTGTGAAAGAAGCAGCTGCTTTAGGAACTGCGATTG
CTGCAGGAGTTGGTGCTGGCATATATTCATCTATGGAAGAGACTGCCGAACAGTTTGTACAGTGGGAGCAAACATTCGAA
CCAGTTACTGAAAATCACGAACTATATAAAGAGTTCTATGAAACATGGAAAACTGTGTATGACAGTCAGCTCGCTTTAGC
TGATAACGGGCTCACCTCACACATGTGGATTGCGCCTGGTGCACTGTAA

Upstream 100 bases:

>100_bases
AAAAGATAAATGCAATTTATGGTGCCTTAAAAGGAAAGTTTATTCATACATTAATTACCGATGAGGAAACTGCCCTTTCC
TTATTACGAAAGGATGGTGA

Downstream 100 bases:

>100_bases
CACATTACATAAAGGAGTGGAATGTATGTTAAAAGTGAATGAAAATGACTTCTCCTATCGCTTCGGTGATAACGGGCCGA
AATATTTAATACAAGGTCCG

Product: autoinducer-2 (AI-2) kinase

Products: NA

Alternate protein names: AI-2 kinase [H]

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MLMSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQECTKEVLQKSNTLASSILAIS
ATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNSIHSFT
MLNDWILYKLSGVLQIDPSNGCTSGIFDLQNRVWDNDVAKECGLSLPFSPKVNEAGTVIGNVTKECAALTGLREGIPVVS
GGGDAQMASLGTGVVKPNQTLICGGSFWQQEVNVTEPITDPCAAIRINCHVVRNLWQYETIAFFPGLVMRWFRDAFCQEE
KKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISWRHAAPSFLNLSLDTDKCGKKELFRAIEENAAFVTLGNL
KLIENLTGIFPSEVIFAGGAAKGKLWPQILSDVLGIPVKVPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFE
PVTENHELYKEFYETWKTVYDSQLALADNGLTSHMWIAPGAL

Sequences:

>Translated_522_residues
MLMSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQECTKEVLQKSNTLASSILAIS
ATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNSIHSFT
MLNDWILYKLSGVLQIDPSNGCTSGIFDLQNRVWDNDVAKECGLSLPFSPKVNEAGTVIGNVTKECAALTGLREGIPVVS
GGGDAQMASLGTGVVKPNQTLICGGSFWQQEVNVTEPITDPCAAIRINCHVVRNLWQYETIAFFPGLVMRWFRDAFCQEE
KKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISWRHAAPSFLNLSLDTDKCGKKELFRAIEENAAFVTLGNL
KLIENLTGIFPSEVIFAGGAAKGKLWPQILSDVLGIPVKVPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFE
PVTENHELYKEFYETWKTVYDSQLALADNGLTSHMWIAPGAL
>Mature_522_residues
MLMSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQECTKEVLQKSNTLASSILAIS
ATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNSIHSFT
MLNDWILYKLSGVLQIDPSNGCTSGIFDLQNRVWDNDVAKECGLSLPFSPKVNEAGTVIGNVTKECAALTGLREGIPVVS
GGGDAQMASLGTGVVKPNQTLICGGSFWQQEVNVTEPITDPCAAIRINCHVVRNLWQYETIAFFPGLVMRWFRDAFCQEE
KKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISWRHAAPSFLNLSLDTDKCGKKELFRAIEENAAFVTLGNL
KLIENLTGIFPSEVIFAGGAAKGKLWPQILSDVLGIPVKVPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFE
PVTENHELYKEFYETWKTVYDSQLALADNGLTSHMWIAPGAL

Specific function: Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=529, Percent_Identity=22.4952741020794, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1787789, Length=516, Percent_Identity=54.6511627906977, Blast_Score=599, Evalue=1e-172,
Organism=Escherichia coli, GI1789168, Length=494, Percent_Identity=23.8866396761134, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790361, Length=517, Percent_Identity=25.3384912959381, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1789987, Length=506, Percent_Identity=24.5059288537549, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1789138, Length=334, Percent_Identity=24.251497005988, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790005, Length=252, Percent_Identity=27.7777777777778, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17535599, Length=468, Percent_Identity=23.5042735042735, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: NA

Molecular weight: Translated: 57467; Mature: 57467

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQE
CCHHHCEEECCCCCCEEEEEEEECCCEEEECHHHHCCCCCCCCCCCCCCHHHHCCHHHHH
CTKEVLQKSNTLASSILAISATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRS
HHHHHHHHCHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHH
HLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNSIHSFTMLNDWILYKLSGVLQIDPSN
HHHHHHHHCCCCEEECCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHEEECCEEEECCCC
GCTSGIFDLQNRVWDNDVAKECGLSLPFSPKVNEAGTVIGNVTKECAALTGLREGIPVVS
CCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEE
GGGDAQMASLGTGVVKPNQTLICGGSFWQQEVNVTEPITDPCAAIRINCHVVRNLWQYET
CCCCCHHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCCHHEEEHHHHHHHHHHHHH
IAFFPGLVMRWFRDAFCQEEKKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
SWRHAAPSFLNLSLDTDKCGKKELFRAIEENAAFVTLGNLKLIENLTGIFPSEVIFAGGA
HHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCHHEEECCC
AKGKLWPQILSDVLGIPVKVPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFE
CCCCHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PVTENHELYKEFYETWKTVYDSQLALADNGLTSHMWIAPGAL
CCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEECCCCC
>Mature Secondary Structure
MLMSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQE
CCHHHCEEECCCCCCEEEEEEEECCCEEEECHHHHCCCCCCCCCCCCCCHHHHCCHHHHH
CTKEVLQKSNTLASSILAISATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRS
HHHHHHHHCHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHH
HLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNSIHSFTMLNDWILYKLSGVLQIDPSN
HHHHHHHHCCCCEEECCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHEEECCEEEECCCC
GCTSGIFDLQNRVWDNDVAKECGLSLPFSPKVNEAGTVIGNVTKECAALTGLREGIPVVS
CCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEE
GGGDAQMASLGTGVVKPNQTLICGGSFWQQEVNVTEPITDPCAAIRINCHVVRNLWQYET
CCCCCHHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCCHHEEEHHHHHHHHHHHHH
IAFFPGLVMRWFRDAFCQEEKKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
SWRHAAPSFLNLSLDTDKCGKKELFRAIEENAAFVTLGNLKLIENLTGIFPSEVIFAGGA
HHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCHHEEECCC
AKGKLWPQILSDVLGIPVKVPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFE
CCCCHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PVTENHELYKEFYETWKTVYDSQLALADNGLTSHMWIAPGAL
CCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA