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The map label for this gene is nuoM [H]

Identifier: 52140270

GI number: 52140270

Start: 5093320

End: 5094822

Strand: Reverse

Name: nuoM [H]

Synonym: BCZK4991

Alternate gene names: 52140270

Gene position: 5094822-5093320 (Counterclockwise)

Preceding gene: 52140269

Following gene: 52140271

Centisome position: 96.11

GC content: 41.78

Gene sequence:

>1503_bases
ATGAATGATTTGTTATTAACGTTCTTCATTTTTTCCCCGCTTTTAGGAATTCTCTTACTTGCATTAACACCGAAAAAAGA
ATCGCGTACAGTGCGAGCGCTCGGTTTATTTGGAACGGTGCTTCCATTTGGAATGGCTATCGTCCTCGCTTGTACATATG
CTTCTGGAAGGGATTTGTCTCTATTTGATGAAAAAGTGAAATGGATTAAATTCGGGGATTTTGCAGCGGTAGATAAAAGG
TGGTTTTCCATTTATTACGAACTTGGTATAGATGGTTTATCGCTCGTTATGATGGTGCTGACGGCCCTTCTAGCGATGCT
TGCAGCAATTGCGGCATTTACGATTAAAAGAAATTTGAAAGCATTTTATATGCTGTTACTCATGTTAGAAATAGGAATGC
TCGGCGTCTTCGCTGCTCAAAATTTAATGTTATTCTTTATCTTCTTTGAAATTACATTGCCGCCGATGTTTTTATTAATT
GGGAAGTGGGGGAAGTTGTCGAGTGAAAAGGCTGCTTATAGTTATTTAATATATAACGGTATTGGCTCCGCTATTTTACT
CATCGTTTTCTCGGTTTTATTTGCGAAAACGGGTACAACAAATATTACAGAACTGAAAGAAATATTAGCGAGTGTAGGTG
CTGGGGGAGGAATGGTTGTCCCAAGTAGCTTACAGTTCGGCTTGTTTCTTGCCATAGTGATTGCTTTCGCAATTAAATTA
CCCGTTTTCCCGTTACATCGCTGGATGGTCAATGTACATATTGAAGCGCATCCGGCTGTAGTGATGCTTCATGCAGGTGT
TTTACTGAAGATTGGAGCATACGGTATCATTCGCTTCGGGCAGGGGCTATTCCCGGAATACTTTCGCGAGTTTGCAATGC
TCATTGCGATTTTAGGAGTTATCAATTTATTGTACGGAGCCTTCTTAGCGCTCATTCAAACAGACTTTCGGAAGGTGCTT
GCTTACTCTAGTATTTCGCATATGGGTATTGTATTAATGGGCATTGCGGCGTTAAATGCACCAGGTACACAAGGGGCACT
ATTCCAAGTTGTGTCGCATGGCTTAATTGCAGCCTTACTCTTTTTCTTACTTGGTGTTATAGAACAGCGTTTTGGAACGT
CGGATATTACAGCGCTTGGCGGACTTGCAAAAAGTGTACCCGTACTTAGCGGTTTCTTCTTAGCGGGAGGAATGGCATCG
CTTGGATTGCCGGGAATGTCTGGATTTGTTAGCGAGTTTCTTGCCTTTCTCGGTTTATTCCAAGTAGAGCCAGTCATTGC
TGCGGCCGGAGTACTTGGCATCATTTTAACCGCTGTATACGTATTAAGAGCGACACTTCAAGTAACATTTGGTAAGAAAG
AGTGGGAAGCGAAAGCTGATATACACGGATGGGAGTATGTTCCTATATTGCTACTTATCTTCTGCATTATTGCAATTGGC
GTAATGCCAGAAATACTAGGGGATCCGCTTCAAAATACATTGAAAACATTGGGGGTGAAGTAG

Upstream 100 bases:

>100_bases
CTAGACTCCAAAACGGAAATGTACAAGTGTACGGGACTGTAACAGCTGTTTCACTTGCAGTACTCTTCATTATTTTGCTC
TATACGGGAGGGGATTTACG

Downstream 100 bases:

>100_bases
GATGGATATGAATACGTTACTTAGCTTATCGTGGCATCTCATGGTGCCAGAATTCATCATTCTCGGAGCTGCCATCCTTC
TTTCCATATGTGATTTGTTT

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MNDLLLTFFIFSPLLGILLLALTPKKESRTVRALGLFGTVLPFGMAIVLACTYASGRDLSLFDEKVKWIKFGDFAAVDKR
WFSIYYELGIDGLSLVMMVLTALLAMLAAIAAFTIKRNLKAFYMLLLMLEIGMLGVFAAQNLMLFFIFFEITLPPMFLLI
GKWGKLSSEKAAYSYLIYNGIGSAILLIVFSVLFAKTGTTNITELKEILASVGAGGGMVVPSSLQFGLFLAIVIAFAIKL
PVFPLHRWMVNVHIEAHPAVVMLHAGVLLKIGAYGIIRFGQGLFPEYFREFAMLIAILGVINLLYGAFLALIQTDFRKVL
AYSSISHMGIVLMGIAALNAPGTQGALFQVVSHGLIAALLFFLLGVIEQRFGTSDITALGGLAKSVPVLSGFFLAGGMAS
LGLPGMSGFVSEFLAFLGLFQVEPVIAAAGVLGIILTAVYVLRATLQVTFGKKEWEAKADIHGWEYVPILLLIFCIIAIG
VMPEILGDPLQNTLKTLGVK

Sequences:

>Translated_500_residues
MNDLLLTFFIFSPLLGILLLALTPKKESRTVRALGLFGTVLPFGMAIVLACTYASGRDLSLFDEKVKWIKFGDFAAVDKR
WFSIYYELGIDGLSLVMMVLTALLAMLAAIAAFTIKRNLKAFYMLLLMLEIGMLGVFAAQNLMLFFIFFEITLPPMFLLI
GKWGKLSSEKAAYSYLIYNGIGSAILLIVFSVLFAKTGTTNITELKEILASVGAGGGMVVPSSLQFGLFLAIVIAFAIKL
PVFPLHRWMVNVHIEAHPAVVMLHAGVLLKIGAYGIIRFGQGLFPEYFREFAMLIAILGVINLLYGAFLALIQTDFRKVL
AYSSISHMGIVLMGIAALNAPGTQGALFQVVSHGLIAALLFFLLGVIEQRFGTSDITALGGLAKSVPVLSGFFLAGGMAS
LGLPGMSGFVSEFLAFLGLFQVEPVIAAAGVLGIILTAVYVLRATLQVTFGKKEWEAKADIHGWEYVPILLLIFCIIAIG
VMPEILGDPLQNTLKTLGVK
>Mature_500_residues
MNDLLLTFFIFSPLLGILLLALTPKKESRTVRALGLFGTVLPFGMAIVLACTYASGRDLSLFDEKVKWIKFGDFAAVDKR
WFSIYYELGIDGLSLVMMVLTALLAMLAAIAAFTIKRNLKAFYMLLLMLEIGMLGVFAAQNLMLFFIFFEITLPPMFLLI
GKWGKLSSEKAAYSYLIYNGIGSAILLIVFSVLFAKTGTTNITELKEILASVGAGGGMVVPSSLQFGLFLAIVIAFAIKL
PVFPLHRWMVNVHIEAHPAVVMLHAGVLLKIGAYGIIRFGQGLFPEYFREFAMLIAILGVINLLYGAFLALIQTDFRKVL
AYSSISHMGIVLMGIAALNAPGTQGALFQVVSHGLIAALLFFLLGVIEQRFGTSDITALGGLAKSVPVLSGFFLAGGMAS
LGLPGMSGFVSEFLAFLGLFQVEPVIAAAGVLGIILTAVYVLRATLQVTFGKKEWEAKADIHGWEYVPILLLIFCIIAIG
VMPEILGDPLQNTLKTLGVK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=340, Percent_Identity=30, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI251831117, Length=363, Percent_Identity=25.8953168044077, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1788613, Length=463, Percent_Identity=35.85313174946, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1788614, Length=511, Percent_Identity=28.1800391389432, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788827, Length=312, Percent_Identity=28.525641025641, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788831, Length=286, Percent_Identity=28.6713286713287, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788829, Length=428, Percent_Identity=23.1308411214953, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI2367154, Length=354, Percent_Identity=25.1412429378531, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI145693160, Length=403, Percent_Identity=24.8138957816377, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54120; Mature: 54120

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA