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The map label for this gene is hbd [H]

Identifier: 52140218

GI number: 52140218

Start: 5141508

End: 5142359

Strand: Reverse

Name: hbd [H]

Synonym: BCZK5043

Alternate gene names: 52140218

Gene position: 5142359-5141508 (Counterclockwise)

Preceding gene: 52140217

Following gene: 52140220

Centisome position: 97.01

GC content: 40.02

Gene sequence:

>852_bases
ATGGGTGTACAAAAAATTGTTGTAATTGGTGCAGGACAAATGGGGTCAGGAATTGCGCAAGTATGTGCAATGGCAGGATA
CGATGTGAAGGTACAAGATTTAAAACAGGAGCAATTAGATAGAGGATTGGCTATTATTACGAAAAACTTAGCACGCCAAG
TAGAAAAGGGGCGCATGAAGGAAGAAGAAAAGGAAGCGACATTAAACCGTCTTGCAGTAACGCTTGATTTAGATTGTGTG
AAGGAAGCGGATCTTATTATCGAAGCAGCTGTCGAGAAAATGGATATTAAAAAGAAAATCTTTGCGAATTTAGATGAAAT
TGCTCCAGAACACGCAATTTTAGCGACGAATACGTCATCCCTGCCAATTACAGAAATTGCCGCAGTAACGAAGCGCCCGG
AAAAAGTAATCGGTATGCACTTTATGAATCCCGTTCCGGTTATGAAACTTGTTGAAATCATTCGTGGTTTGGCTACAGAT
GATGCGGTATACGAAACAATTGAAGATATTACGAAGAAGATTGGGAAAGTACCAGTTGAAGTGAATGATTTCCCAGGATT
TGTATCGAACCGTATTTTATTACCGATGATTAACGAAGCGATCTATACGTTATATGAAGGTGTAGCGACGAAAGAAGCGA
TTGATGAAGTAATGAAACTTGGTATGAATCACCCGATGGGCCCTTTAACGCTCGCTGATTTTATCGGTTTAGATACATGT
TTATACATTATGGAAGTGTTGCATGAAGGCTTAGGTGATAGTAAATATCGCCCATGTCCATTGCTACGCAAGTACGTAAA
TGCAGGATGGTTAGGACGTAAAGCAGGTCGTGGTTTCTACGTTTATGAATAA

Upstream 100 bases:

>100_bases
ATTTGTAGTGGTGGCGGTCAAGGCGATGCAGTGATGATTGAAGTTCACTAATTAAGATTAGAAGATATATAGTTTATTAA
AAATTAAGGGGGAAGAAGAA

Downstream 100 bases:

>100_bases
ATTCCCCTTTGTTACAAAATAGTGGTCTTACCAAATTGTTAAAAGGATATATAGCAAATGGAGGCGGGGTATATGAACTT
TCGTTTTAATGAAGAGCAAC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MGVQKIVVIGAGQMGSGIAQVCAMAGYDVKVQDLKQEQLDRGLAIITKNLARQVEKGRMKEEEKEATLNRLAVTLDLDCV
KEADLIIEAAVEKMDIKKKIFANLDEIAPEHAILATNTSSLPITEIAAVTKRPEKVIGMHFMNPVPVMKLVEIIRGLATD
DAVYETIEDITKKIGKVPVEVNDFPGFVSNRILLPMINEAIYTLYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
LYIMEVLHEGLGDSKYRPCPLLRKYVNAGWLGRKAGRGFYVYE

Sequences:

>Translated_283_residues
MGVQKIVVIGAGQMGSGIAQVCAMAGYDVKVQDLKQEQLDRGLAIITKNLARQVEKGRMKEEEKEATLNRLAVTLDLDCV
KEADLIIEAAVEKMDIKKKIFANLDEIAPEHAILATNTSSLPITEIAAVTKRPEKVIGMHFMNPVPVMKLVEIIRGLATD
DAVYETIEDITKKIGKVPVEVNDFPGFVSNRILLPMINEAIYTLYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
LYIMEVLHEGLGDSKYRPCPLLRKYVNAGWLGRKAGRGFYVYE
>Mature_282_residues
GVQKIVVIGAGQMGSGIAQVCAMAGYDVKVQDLKQEQLDRGLAIITKNLARQVEKGRMKEEEKEATLNRLAVTLDLDCVK
EADLIIEAAVEKMDIKKKIFANLDEIAPEHAILATNTSSLPITEIAAVTKRPEKVIGMHFMNPVPVMKLVEIIRGLATDD
AVYETIEDITKKIGKVPVEVNDFPGFVSNRILLPMINEAIYTLYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTCL
YIMEVLHEGLGDSKYRPCPLLRKYVNAGWLGRKAGRGFYVYE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=42.9065743944637, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=41.3680781758958, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=39.0070921985816, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI261878539, Length=296, Percent_Identity=33.7837837837838, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI68989263, Length=296, Percent_Identity=33.7837837837838, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI115430219, Length=230, Percent_Identity=31.304347826087, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=42.0494699646643, Blast_Score=224, Evalue=4e-60,
Organism=Escherichia coli, GI1788682, Length=258, Percent_Identity=37.984496124031, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1790281, Length=265, Percent_Identity=33.9622641509434, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=40.9722222222222, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=40.0696864111498, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17563036, Length=290, Percent_Identity=39.6551724137931, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI25144276, Length=281, Percent_Identity=38.7900355871886, Blast_Score=180, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=38.7900355871886, Blast_Score=180, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17508953, Length=281, Percent_Identity=38.7900355871886, Blast_Score=180, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17558304, Length=281, Percent_Identity=37.7224199288256, Blast_Score=177, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71985923, Length=288, Percent_Identity=34.0277777777778, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=281, Percent_Identity=32.0284697508897, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI193203623, Length=194, Percent_Identity=27.8350515463918, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=194, Percent_Identity=27.8350515463918, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=40.2826855123675, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=40.2826855123675, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=40.2826855123675, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20129993, Length=229, Percent_Identity=29.6943231441048, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=27.5, Blast_Score=84, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31278; Mature: 31147

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVQKIVVIGAGQMGSGIAQVCAMAGYDVKVQDLKQEQLDRGLAIITKNLARQVEKGRMK
CCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCC
EEEKEATLNRLAVTLDLDCVKEADLIIEAAVEKMDIKKKIFANLDEIAPEHAILATNTSS
HHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEEECCCC
LPITEIAAVTKRPEKVIGMHFMNPVPVMKLVEIIRGLATDDAVYETIEDITKKIGKVPVE
CCHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCE
VNDFPGFVSNRILLPMINEAIYTLYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
ECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LYIMEVLHEGLGDSKYRPCPLLRKYVNAGWLGRKAGRGFYVYE
HHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEC
>Mature Secondary Structure 
GVQKIVVIGAGQMGSGIAQVCAMAGYDVKVQDLKQEQLDRGLAIITKNLARQVEKGRMK
CCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCC
EEEKEATLNRLAVTLDLDCVKEADLIIEAAVEKMDIKKKIFANLDEIAPEHAILATNTSS
HHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEEECCCC
LPITEIAAVTKRPEKVIGMHFMNPVPVMKLVEIIRGLATDDAVYETIEDITKKIGKVPVE
CCHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCE
VNDFPGFVSNRILLPMINEAIYTLYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
ECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LYIMEVLHEGLGDSKYRPCPLLRKYVNAGWLGRKAGRGFYVYE
HHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]