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The map label for this gene is cobB

Identifier: 51893900

GI number: 51893900

Start: 2981552

End: 2982307

Strand: Reverse

Name: cobB

Synonym: STH2762

Alternate gene names: 51893900

Gene position: 2982307-2981552 (Counterclockwise)

Preceding gene: 51893901

Following gene: 51893899

Centisome position: 83.63

GC content: 69.71

Gene sequence:

>756_bases
ATGCTGGAACAGATCCAGGACTTCGCTCGTGCTCTGCAGGCGTCGCGGTACGCGGTGGCCCTGACGGGCGCCGGCGCCTC
CACCGAGTCGGGACTGCCGGACTTCCGGTCCAACACCGGGCTCTGGAAGGACGTGGACCCGGTGTCGCTCATCTCGATGA
CCGCGCTGCGCAGGCGGCCGGTGGACTTCTACAGGTTCTACCGGATGCGCTTCTCGCACCTGTGGGGCGCGCAGCCCAAC
CCCGTGCACAAGGTGCTGGCGGCGCTGCAGCGTGAAGGGCTGCTGAAGCGGCTGATCACGCAGAATGTGGACGGCCTGCA
CCAGGCGGCCGGGTCGCCGGACGTCATCGAGCTGCACGGGTCGCTCCGGGAGTGCCAGTGCCTCCGCTGCGGCCGCCGGT
TCCCCAGCCGGCTGATCGACGTCGAGGTGGAGACGGAGGCGGACATCCCCCGTTGCCCGGAGTGCGGCGGCGTCCTCAAA
CCCGGCGTCGTCCTCTTCGAGGAGGCGTTGCCGGCGGACGCCATCGAGGCGGCCATCGAGGCCGCCATGAAGGCTGACCT
GTTCCTGGTGGTGGGCTCCTCCCTTGAGGTGGGGCCGGCGAACCAGCTGCCGGTCCTGGCCGTGCAGCACGGAGGGCGAC
TCGCCATCTTCAACCTCACGCCCACCTTCCTGGATCCCCGTGCGACCTGGATCTTCCGGGAGAAGGCGGGGCAGGCGCTG
GGCGCCCTCGCTGCGGAGTTGGGGATCTCCCTGTAA

Upstream 100 bases:

>100_bases
TCACCCATGCGTGACGGGTTCATGGTTCTTTCCGGACGGCCACCGCTAGAGGTGGCCGTTTCTGCATGGCGAAGAAAAGA
ATGGTCAGGGGGTGACACGT

Downstream 100 bases:

>100_bases
GGTAGAAATTCGAAGCAAGAGGGAACTAGCGGGAGCACCGCGCGCCAAAGGTGCAAATTTGGCACCTGATCATGGTTGTC
CCACCCCACATATGGTGGTA

Product: Sir2 family transcriptional regulator

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MLEQIQDFARALQASRYAVALTGAGASTESGLPDFRSNTGLWKDVDPVSLISMTALRRRPVDFYRFYRMRFSHLWGAQPN
PVHKVLAALQREGLLKRLITQNVDGLHQAAGSPDVIELHGSLRECQCLRCGRRFPSRLIDVEVETEADIPRCPECGGVLK
PGVVLFEEALPADAIEAAIEAAMKADLFLVVGSSLEVGPANQLPVLAVQHGGRLAIFNLTPTFLDPRATWIFREKAGQAL
GALAAELGISL

Sequences:

>Translated_251_residues
MLEQIQDFARALQASRYAVALTGAGASTESGLPDFRSNTGLWKDVDPVSLISMTALRRRPVDFYRFYRMRFSHLWGAQPN
PVHKVLAALQREGLLKRLITQNVDGLHQAAGSPDVIELHGSLRECQCLRCGRRFPSRLIDVEVETEADIPRCPECGGVLK
PGVVLFEEALPADAIEAAIEAAMKADLFLVVGSSLEVGPANQLPVLAVQHGGRLAIFNLTPTFLDPRATWIFREKAGQAL
GALAAELGISL
>Mature_251_residues
MLEQIQDFARALQASRYAVALTGAGASTESGLPDFRSNTGLWKDVDPVSLISMTALRRRPVDFYRFYRMRFSHLWGAQPN
PVHKVLAALQREGLLKRLITQNVDGLHQAAGSPDVIELHGSLRECQCLRCGRRFPSRLIDVEVETEADIPRCPECGGVLK
PGVVLFEEALPADAIEAAIEAAMKADLFLVVGSSLEVGPANQLPVLAVQHGGRLAIFNLTPTFLDPRATWIFREKAGQAL
GALAAELGISL

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain

Homologues:

Organism=Homo sapiens, GI6912662, Length=268, Percent_Identity=32.089552238806, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI6912660, Length=210, Percent_Identity=37.6190476190476, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI63054862, Length=191, Percent_Identity=38.7434554973822, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI7657575, Length=233, Percent_Identity=31.3304721030043, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI6912664, Length=259, Percent_Identity=31.2741312741313, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI13787215, Length=241, Percent_Identity=31.9502074688797, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI300795542, Length=250, Percent_Identity=31.2, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI300797577, Length=259, Percent_Identity=30.5019305019305, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI13775602, Length=248, Percent_Identity=30.241935483871, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI13775600, Length=248, Percent_Identity=30.241935483871, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI300797705, Length=205, Percent_Identity=30.7317073170732, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI7706712, Length=264, Percent_Identity=29.5454545454545, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI215982798, Length=177, Percent_Identity=30.5084745762712, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI308199517, Length=209, Percent_Identity=34.9282296650718, Blast_Score=95, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17541892, Length=206, Percent_Identity=33.9805825242718, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17567771, Length=241, Percent_Identity=30.7053941908714, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71990482, Length=257, Percent_Identity=29.5719844357977, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71990487, Length=259, Percent_Identity=29.3436293436293, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17505510, Length=253, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6324504, Length=255, Percent_Identity=27.4509803921569, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325242, Length=210, Percent_Identity=30.952380952381, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320163, Length=257, Percent_Identity=26.8482490272374, Blast_Score=102, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324599, Length=276, Percent_Identity=26.8115942028986, Blast_Score=95, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320397, Length=238, Percent_Identity=28.1512605042017, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137536, Length=231, Percent_Identity=31.1688311688312, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24648389, Length=193, Percent_Identity=32.1243523316062, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24645650, Length=261, Percent_Identity=29.8850574712644, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28571445, Length=202, Percent_Identity=34.6534653465347, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571443, Length=150, Percent_Identity=32.6666666666667, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571441, Length=150, Percent_Identity=32.6666666666667, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NPD_SYMTH (Q67KQ0)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076591.1
- ProteinModelPortal:   Q67KQ0
- SMR:   Q67KQ0
- GeneID:   2982124
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2762
- NMPDR:   fig|292459.1.peg.2639
- HOGENOM:   HBG641281
- OMA:   YDIDAFL
- BioCyc:   STHE292459:STH2762-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01121
- InterPro:   IPR003000
- PANTHER:   PTHR11085

Pfam domain/function: PF02146 SIR2

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27338; Mature: 27338

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS50305 SIRTUIN

Important sites: ACT_SITE 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQIQDFARALQASRYAVALTGAGASTESGLPDFRSNTGLWKDVDPVSLISMTALRRRP
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
VDFYRFYRMRFSHLWGAQPNPVHKVLAALQREGLLKRLITQNVDGLHQAAGSPDVIELHG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECC
SLRECQCLRCGRRFPSRLIDVEVETEADIPRCPECGGVLKPGVVLFEEALPADAIEAAIE
CHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHH
AAMKADLFLVVGSSLEVGPANQLPVLAVQHGGRLAIFNLTPTFLDPRATWIFREKAGQAL
HHHHCCEEEEECCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCHHEEEHHHHHHHH
GALAAELGISL
HHHHHHHCCCC
>Mature Secondary Structure
MLEQIQDFARALQASRYAVALTGAGASTESGLPDFRSNTGLWKDVDPVSLISMTALRRRP
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
VDFYRFYRMRFSHLWGAQPNPVHKVLAALQREGLLKRLITQNVDGLHQAAGSPDVIELHG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECC
SLRECQCLRCGRRFPSRLIDVEVETEADIPRCPECGGVLKPGVVLFEEALPADAIEAAIE
CHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHH
AAMKADLFLVVGSSLEVGPANQLPVLAVQHGGRLAIFNLTPTFLDPRATWIFREKAGQAL
HHHHCCEEEEECCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCHHEEEHHHHHHHH
GALAAELGISL
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA