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The map label for this gene is nrdZ [H]

Identifier: 51893898

GI number: 51893898

Start: 2978565

End: 2980895

Strand: Reverse

Name: nrdZ [H]

Synonym: STH2760

Alternate gene names: 51893898

Gene position: 2980895-2978565 (Counterclockwise)

Preceding gene: 51893899

Following gene: 51893897

Centisome position: 83.59

GC content: 67.65

Gene sequence:

>2331_bases
TTGGAACTGACGCATATTGCGAAGACCGTGATGGAAAAGCGGTACCTGCGCATGAAGGAGGACGGCACCCGGGAGACGCC
GGACGAGATGCTGCGCCGCGTGGCCAGGGTCATCGCCGCCGTCGAGGAGAAGTACGGGGCGAGCAAGAAGGAGATCCGGG
CGGTGGAGGAGCGGTTCTACCAGCTGATGGACCGCCAGGACTTCATGCCCAACAGTCCGACGTTCACCGGGGCCGGGACG
GCCCTGGGCCAGCTGTCGGCCTGCTTCGTCCTGCCCGTGGGGGACTCTCTGCCGGAGATCTACGAGACCATGAAGCAAGC
CGCCCTGATCCACCAGACCGGAGGCGGCACGGGCTTCGCCTTCTCCCGCCTGCGGCCGGCGGGCGACGTGGTGCGCTCCA
GCCAGGGCGTGGCCTCGGGCCCCGTGTCTTTCCTGCGGGTCTACAACGCCTCCACGGAGGCGATCAAGCAGGGGGGAACC
CGCCGCGGCGCCAACATGGGCATCCTGCGGGTGGACCACCCGGACATCCTGCAGTTCATCGAGTCCAAGGCCGACATCAC
GCAGATCACCAACTTCAACATCTCGGTGGCCATCACCGACGCCTTCATGGAGGCGCTGGAGAAGGGCACCGAGTACGAGC
TGATCAACCCCCGCAACGGCGAGGTCACCGGCAAGCTCTCCGCCAAGCTGGTGTGGGACAAGCTGGTGGAGAACGCGTGG
AAGACCGGCGAGCCCGGCATCGTCTTCATCGACCGGATCAACCGGCGCAATCCCAACAATCACGTGGAAGTCATCGAGGC
CACCAACCCGTGCGGCGAGCAACCGCTGCCGCCGTACGGCTCCTGCAACCTGGGTTCCATCAACCTGGCCAACTTCGTGA
AGAACCCGTACACCGACCGGGCGGAGGTGGACTGGGAACGGCTGGGCGAAGTGGCCCGCACCGCCACCCGCTTCCTGGAC
AACGTCATCGACGCCAACAAGTACCCGCTGCCGCAGATCGCCGAGAAGGCGCTGCGCGACCGGCGCATTGGCCTCGGCAT
CATGGGCTGGGCGGAGATGCTGGTGCAGATGGGGCTGCCCTATGACTCGGAAGAGGCGGTGGCCCTGGGGAACCGGGTGA
TGACCTTCATCAAGCAGAAGGCGCTGGAGGAGTCCATGGCGCTGGCCGAGGTCCGGGGACCCTACCCGGAGTGGGAGGGC
AGCCAGTGGCACAAGGCCGGGCTGAAGGTGCGCAACGCGACGCTGACCACGGTGGCGCCCACCGGCACCATCTCGCTGTT
CGCGGCGCGGCCGGACCTGCCGTGCTCCGGCGGCATCGAGCCGAAGTTTGCCCTGGTCTTCACCCGGAACCAGGCGGGCG
CGCTGATGCTGGATGTGGACGGCCAGTTCGCCTCCATCGCACGCCGGGAGGGCTGGTACTCGGACGAGCTGATGCAGCAG
GTGGCCGACCGGGGCACCGCCCGGGGCGTGTCCGGGGTGCCGGAGAAGTGGCAGCGCATCTTTGCCACCTCCCACGACAT
CACGCCGGAGTGGCACGTCCGCATGCAGGCCGCCTTCCAGGGCGGCGACGGGCTGCCGGTCGACCAGCAGCCGGTGGACG
CGGCGGTGTCGAAGACGATCAACTTCCCGCACCACGCGACCGTGGAGGACGTCGGCAAGTCCTACGCGCTGGCCTGGCAG
CTGGGCCTGAAGGGCATCACCGTCTACCGGGACGGCTCCCGTGCGTCCCAGGTGCTGACCACCGGCGACAAGACCAAGAA
GCAGGAGGAGCCGGCCGCACCGCCGGCGCCGCAGGGCCCGTCCCTCCGGCCCCGTCCCACTGAGGCGGTGGGCAAGATGT
TCGTCGTGCCCACGCACTTCGGCAAGATGACGCTGGACGTGCACATGGACGAAGACGGCGAGCCCTTCGAGATCATCGTG
AACGTGGGCGCCGTGGGCTCCGACCTGATGGCCGACGCCGTGGGCATGGGCATGCTGGTGTCCAAGATGCTGCGGCTGCG
CTCGGACGTGCCGGTGCGGGAGCGCATCGAAATCGTCATCGATACGTTGAAGAACATCGGCGGTTCCGGCTCGTACGGCT
TCGGTCCGAACCGCATTACGTCGCTGGCCTCGGCCATCGCCAAGGGGCTGCAGCGCTTCCTCGCCTGGAAGGACGCCAAC
GGCAAGCTCACGGAGGCCACCCCGGTGGAGGCGACGGCTCCGCAGCCGCAGATGAAGGGCGCACAGGTGGATTCCCCCGT
CGACCCGTGCCCCGAGTGCGGTTCCTTCACCCTGGTCATCGGCGAGGGCTGCGCGACCTGCCACAACTGCGGCTATTCGA
AGTGCAGCTAA

Upstream 100 bases:

>100_bases
GGGAGCAGCTGGAACAGCTCTTGAAGTCCCGCTGAAGCGGAGCGGCGCAGCGCGGAGGGAGCGCGCGCCCCGCGGACTCT
ACCAGAGGGGGGTTCCCGAC

Downstream 100 bases:

>100_bases
TGGGATCGGAGGGGCGCATCAACATGCGCCCCTCCGGTTTCTTTTGGCCATGAAAGGGCAGTCCCGGGCGATCTACCCGG
GACTGCCCTTTCATGGCGAT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 776; Mature: 776

Protein sequence:

>776_residues
MELTHIAKTVMEKRYLRMKEDGTRETPDEMLRRVARVIAAVEEKYGASKKEIRAVEERFYQLMDRQDFMPNSPTFTGAGT
ALGQLSACFVLPVGDSLPEIYETMKQAALIHQTGGGTGFAFSRLRPAGDVVRSSQGVASGPVSFLRVYNASTEAIKQGGT
RRGANMGILRVDHPDILQFIESKADITQITNFNISVAITDAFMEALEKGTEYELINPRNGEVTGKLSAKLVWDKLVENAW
KTGEPGIVFIDRINRRNPNNHVEVIEATNPCGEQPLPPYGSCNLGSINLANFVKNPYTDRAEVDWERLGEVARTATRFLD
NVIDANKYPLPQIAEKALRDRRIGLGIMGWAEMLVQMGLPYDSEEAVALGNRVMTFIKQKALEESMALAEVRGPYPEWEG
SQWHKAGLKVRNATLTTVAPTGTISLFAARPDLPCSGGIEPKFALVFTRNQAGALMLDVDGQFASIARREGWYSDELMQQ
VADRGTARGVSGVPEKWQRIFATSHDITPEWHVRMQAAFQGGDGLPVDQQPVDAAVSKTINFPHHATVEDVGKSYALAWQ
LGLKGITVYRDGSRASQVLTTGDKTKKQEEPAAPPAPQGPSLRPRPTEAVGKMFVVPTHFGKMTLDVHMDEDGEPFEIIV
NVGAVGSDLMADAVGMGMLVSKMLRLRSDVPVRERIEIVIDTLKNIGGSGSYGFGPNRITSLASAIAKGLQRFLAWKDAN
GKLTEATPVEATAPQPQMKGAQVDSPVDPCPECGSFTLVIGEGCATCHNCGYSKCS

Sequences:

>Translated_776_residues
MELTHIAKTVMEKRYLRMKEDGTRETPDEMLRRVARVIAAVEEKYGASKKEIRAVEERFYQLMDRQDFMPNSPTFTGAGT
ALGQLSACFVLPVGDSLPEIYETMKQAALIHQTGGGTGFAFSRLRPAGDVVRSSQGVASGPVSFLRVYNASTEAIKQGGT
RRGANMGILRVDHPDILQFIESKADITQITNFNISVAITDAFMEALEKGTEYELINPRNGEVTGKLSAKLVWDKLVENAW
KTGEPGIVFIDRINRRNPNNHVEVIEATNPCGEQPLPPYGSCNLGSINLANFVKNPYTDRAEVDWERLGEVARTATRFLD
NVIDANKYPLPQIAEKALRDRRIGLGIMGWAEMLVQMGLPYDSEEAVALGNRVMTFIKQKALEESMALAEVRGPYPEWEG
SQWHKAGLKVRNATLTTVAPTGTISLFAARPDLPCSGGIEPKFALVFTRNQAGALMLDVDGQFASIARREGWYSDELMQQ
VADRGTARGVSGVPEKWQRIFATSHDITPEWHVRMQAAFQGGDGLPVDQQPVDAAVSKTINFPHHATVEDVGKSYALAWQ
LGLKGITVYRDGSRASQVLTTGDKTKKQEEPAAPPAPQGPSLRPRPTEAVGKMFVVPTHFGKMTLDVHMDEDGEPFEIIV
NVGAVGSDLMADAVGMGMLVSKMLRLRSDVPVRERIEIVIDTLKNIGGSGSYGFGPNRITSLASAIAKGLQRFLAWKDAN
GKLTEATPVEATAPQPQMKGAQVDSPVDPCPECGSFTLVIGEGCATCHNCGYSKCS
>Mature_776_residues
MELTHIAKTVMEKRYLRMKEDGTRETPDEMLRRVARVIAAVEEKYGASKKEIRAVEERFYQLMDRQDFMPNSPTFTGAGT
ALGQLSACFVLPVGDSLPEIYETMKQAALIHQTGGGTGFAFSRLRPAGDVVRSSQGVASGPVSFLRVYNASTEAIKQGGT
RRGANMGILRVDHPDILQFIESKADITQITNFNISVAITDAFMEALEKGTEYELINPRNGEVTGKLSAKLVWDKLVENAW
KTGEPGIVFIDRINRRNPNNHVEVIEATNPCGEQPLPPYGSCNLGSINLANFVKNPYTDRAEVDWERLGEVARTATRFLD
NVIDANKYPLPQIAEKALRDRRIGLGIMGWAEMLVQMGLPYDSEEAVALGNRVMTFIKQKALEESMALAEVRGPYPEWEG
SQWHKAGLKVRNATLTTVAPTGTISLFAARPDLPCSGGIEPKFALVFTRNQAGALMLDVDGQFASIARREGWYSDELMQQ
VADRGTARGVSGVPEKWQRIFATSHDITPEWHVRMQAAFQGGDGLPVDQQPVDAAVSKTINFPHHATVEDVGKSYALAWQ
LGLKGITVYRDGSRASQVLTTGDKTKKQEEPAAPPAPQGPSLRPRPTEAVGKMFVVPTHFGKMTLDVHMDEDGEPFEIIV
NVGAVGSDLMADAVGMGMLVSKMLRLRSDVPVRERIEIVIDTLKNIGGSGSYGFGPNRITSLASAIAKGLQRFLAWKDAN
GKLTEATPVEATAPQPQMKGAQVDSPVDPCPECGSFTLVIGEGCATCHNCGYSKCS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=640, Percent_Identity=27.5, Blast_Score=217, Evalue=3e-56,
Organism=Escherichia coli, GI1789030, Length=571, Percent_Identity=25.9194395796848, Blast_Score=131, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17555242, Length=661, Percent_Identity=27.5340393343419, Blast_Score=225, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6320914, Length=681, Percent_Identity=25.5506607929515, Blast_Score=193, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6322123, Length=646, Percent_Identity=25.5417956656347, Blast_Score=190, Evalue=6e-49,
Organism=Drosophila melanogaster, GI17352481, Length=640, Percent_Identity=27.65625, Blast_Score=216, Evalue=6e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 84714; Mature: 84714

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELTHIAKTVMEKRYLRMKEDGTRETPDEMLRRVARVIAAVEEKYGASKKEIRAVEERFY
CCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QLMDRQDFMPNSPTFTGAGTALGQLSACFVLPVGDSLPEIYETMKQAALIHQTGGGTGFA
HHHHHHCCCCCCCCCCCCCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHEECCCCCCCH
FSRLRPAGDVVRSSQGVASGPVSFLRVYNASTEAIKQGGTRRGANMGILRVDHPDILQFI
HHHCCCHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHCCCCCCCCCCCEEECCCHHHHHHH
ESKADITQITNFNISVAITDAFMEALEKGTEYELINPRNGEVTGKLSAKLVWDKLVENAW
HCCCCHHEEECCEEEEEEHHHHHHHHHCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHC
KTGEPGIVFIDRINRRNPNNHVEVIEATNPCGEQPLPPYGSCNLGSINLANFVKNPYTDR
CCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCC
AEVDWERLGEVARTATRFLDNVIDANKYPLPQIAEKALRDRRIGLGIMGWAEMLVQMGLP
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
YDSEEAVALGNRVMTFIKQKALEESMALAEVRGPYPEWEGSQWHKAGLKVRNATLTTVAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEECCEEEEECC
TGTISLFAARPDLPCSGGIEPKFALVFTRNQAGALMLDVDGQFASIARREGWYSDELMQQ
CCCEEEEEECCCCCCCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHCCCCHHHHHHH
VADRGTARGVSGVPEKWQRIFATSHDITPEWHVRMQAAFQGGDGLPVDQQPVDAAVSKTI
HHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHC
NFPHHATVEDVGKSYALAWQLGLKGITVYRDGSRASQVLTTGDKTKKQEEPAAPPAPQGP
CCCCCCCHHHHCCCEEEEEEECCCEEEEEECCCHHHHHEECCCCCCCCCCCCCCCCCCCC
SLRPRPTEAVGKMFVVPTHFGKMTLDVHMDEDGEPFEIIVNVGAVGSDLMADAVGMGMLV
CCCCCCHHHHCCEEEEEECCCEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
SKMLRLRSDVPVRERIEIVIDTLKNIGGSGSYGFGPNRITSLASAIAKGLQRFLAWKDAN
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCC
GKLTEATPVEATAPQPQMKGAQVDSPVDPCPECGSFTLVIGEGCATCHNCGYSKCS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCCC
>Mature Secondary Structure
MELTHIAKTVMEKRYLRMKEDGTRETPDEMLRRVARVIAAVEEKYGASKKEIRAVEERFY
CCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QLMDRQDFMPNSPTFTGAGTALGQLSACFVLPVGDSLPEIYETMKQAALIHQTGGGTGFA
HHHHHHCCCCCCCCCCCCCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHEECCCCCCCH
FSRLRPAGDVVRSSQGVASGPVSFLRVYNASTEAIKQGGTRRGANMGILRVDHPDILQFI
HHHCCCHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHCCCCCCCCCCCEEECCCHHHHHHH
ESKADITQITNFNISVAITDAFMEALEKGTEYELINPRNGEVTGKLSAKLVWDKLVENAW
HCCCCHHEEECCEEEEEEHHHHHHHHHCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHC
KTGEPGIVFIDRINRRNPNNHVEVIEATNPCGEQPLPPYGSCNLGSINLANFVKNPYTDR
CCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCC
AEVDWERLGEVARTATRFLDNVIDANKYPLPQIAEKALRDRRIGLGIMGWAEMLVQMGLP
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
YDSEEAVALGNRVMTFIKQKALEESMALAEVRGPYPEWEGSQWHKAGLKVRNATLTTVAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEECCEEEEECC
TGTISLFAARPDLPCSGGIEPKFALVFTRNQAGALMLDVDGQFASIARREGWYSDELMQQ
CCCEEEEEECCCCCCCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHCCCCHHHHHHH
VADRGTARGVSGVPEKWQRIFATSHDITPEWHVRMQAAFQGGDGLPVDQQPVDAAVSKTI
HHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHC
NFPHHATVEDVGKSYALAWQLGLKGITVYRDGSRASQVLTTGDKTKKQEEPAAPPAPQGP
CCCCCCCHHHHCCCEEEEEEECCCEEEEEECCCHHHHHEECCCCCCCCCCCCCCCCCCCC
SLRPRPTEAVGKMFVVPTHFGKMTLDVHMDEDGEPFEIIVNVGAVGSDLMADAVGMGMLV
CCCCCCHHHHCCEEEEEECCCEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
SKMLRLRSDVPVRERIEIVIDTLKNIGGSGSYGFGPNRITSLASAIAKGLQRFLAWKDAN
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCC
GKLTEATPVEATAPQPQMKGAQVDSPVDPCPECGSFTLVIGEGCATCHNCGYSKCS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]