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The map label for this gene is hom [H]

Identifier: 51893877

GI number: 51893877

Start: 2943259

End: 2944569

Strand: Reverse

Name: hom [H]

Synonym: STH2739

Alternate gene names: 51893877

Gene position: 2944569-2943259 (Counterclockwise)

Preceding gene: 51893878

Following gene: 51893876

Centisome position: 82.57

GC content: 68.42

Gene sequence:

>1311_bases
TTGGAGAAACAGACCATGCGGTTCGCCATTCTGGGACTCGGCACCGTCGGCAAAGGGGTGGTGAAGCTCCTGCAGGAGAG
CCGGGAGATGCTGCACCTGAAGACCGGCCTCAACCTGGAGCTGGCCAAGGTGCTGGTGCGCGATGCCTCCAAGCCGCGGC
CCGGTTTCGAGGGACTCCCGCTGACGGAGGACGTGAGCGAGATTCTGGACGATCCTTCCATCCGCATCGTGGTGGAGCTG
ATGGGCGGCATCGAGCCGGCCCGGACCTACCTGGTCGAGGCCCTGAGGCGCGGGAAGACCATCGTGACCGCCAACAAGGA
CGTGATGGCCGACTACGACAAGGACCTGTACGACGCCGGTGAGATCGGCGATGCCGAGATCTACTTCGAGGCGTCCGTGG
GGGGCGGCATCCCCATCATCCGGCCGCTGAAGGAGGCCCTGGCGGCCAACACGATGCGCCAGGTGATGGGCATCGTCAAT
GGGACGACCAACTACATCCTGACCCAGATGAGCCAGTACGGCAGGAGTTACGAGGAGGCCCTGCAGGAGGCGCAGGCCCT
GGGCTACGCCGAGCCCGACCCGACCAACGACGTCCAGGGATTCGACGCCGCCCGAAAGCTGGCCATCCTCTGCACCATCT
GCTTCCTCTCCCGGGTCAAGCCCGGGATGGTCTACACCGAGGGGATCACGCGCGTGACGCCGCGCGACATCGAGTACGGC
CGCCGGTTCGGCTGGGTGCTGAAGCTCCTGGCCATCGGGAAGGAGGTGGACGGCGAGATCGAGGCGCGGGTCCACCCGGC
GTTCATCCCCCACACCCATCCCCTGGCCAGCGTAGCCGGATCGTTCAACGCCATCTACACCGTGGGCGATCCGGTCGGCG
AGACGATGTTCTACGGGCGGGGCGCCGGCGCCGGACCCACCGCATCGGCCGTGGTCTCCGACCTGATCGCCGCCGCGCTG
TCCAAGCGGACGCCGGGGCGGCGCGCCGGCGATGCCCACACCGTCTACTTCGAGAAGCGGGTCCTGCCCATCGAGGAGAC
CCGCAGCCGCTACTACCTGCGGCTGCACGCGGTGGACGCGCCCGGCAGCCTGGCCCGGATCGCCGAGCGGTTCGGCGAGC
ACGGGGTCTCCCTGGCCGAGGTGGTGCAGGCCTCGGGCGGGCCAGACCATCCCGACGACGGCGGCGCAGCCGAGCTGGTG
CTGGTGACCCACACGGTGCAGGACGCCAACCTCCAGGCGGTGGTCCGCGACCTGAAGGAGATGCGGGACACGGTGCTCCG
GGTGGACAACGTGATCCGCGTGGAGGGTTAG

Upstream 100 bases:

>100_bases
CCGGCACCGGTCGAGGCTGAGGCGCCAGGCGCCGGGGCAGGAGGTCGGCGGTGGAACTCGAATTCATCGTTGCGGTAGAG
CGGTAAAGGAGGGGCTGTGG

Downstream 100 bases:

>100_bases
CCTTGGGCACGGCGCTTTTGCACGGACTGGTGCTTTCCTTCGGGCTGATCCTTCCGCTGGGCGCCCAGAACACGTTTGTG
CTCACACAGGGCGCGCTGCA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MEKQTMRFAILGLGTVGKGVVKLLQESREMLHLKTGLNLELAKVLVRDASKPRPGFEGLPLTEDVSEILDDPSIRIVVEL
MGGIEPARTYLVEALRRGKTIVTANKDVMADYDKDLYDAGEIGDAEIYFEASVGGGIPIIRPLKEALAANTMRQVMGIVN
GTTNYILTQMSQYGRSYEEALQEAQALGYAEPDPTNDVQGFDAARKLAILCTICFLSRVKPGMVYTEGITRVTPRDIEYG
RRFGWVLKLLAIGKEVDGEIEARVHPAFIPHTHPLASVAGSFNAIYTVGDPVGETMFYGRGAGAGPTASAVVSDLIAAAL
SKRTPGRRAGDAHTVYFEKRVLPIEETRSRYYLRLHAVDAPGSLARIAERFGEHGVSLAEVVQASGGPDHPDDGGAAELV
LVTHTVQDANLQAVVRDLKEMRDTVLRVDNVIRVEG

Sequences:

>Translated_436_residues
MEKQTMRFAILGLGTVGKGVVKLLQESREMLHLKTGLNLELAKVLVRDASKPRPGFEGLPLTEDVSEILDDPSIRIVVEL
MGGIEPARTYLVEALRRGKTIVTANKDVMADYDKDLYDAGEIGDAEIYFEASVGGGIPIIRPLKEALAANTMRQVMGIVN
GTTNYILTQMSQYGRSYEEALQEAQALGYAEPDPTNDVQGFDAARKLAILCTICFLSRVKPGMVYTEGITRVTPRDIEYG
RRFGWVLKLLAIGKEVDGEIEARVHPAFIPHTHPLASVAGSFNAIYTVGDPVGETMFYGRGAGAGPTASAVVSDLIAAAL
SKRTPGRRAGDAHTVYFEKRVLPIEETRSRYYLRLHAVDAPGSLARIAERFGEHGVSLAEVVQASGGPDHPDDGGAAELV
LVTHTVQDANLQAVVRDLKEMRDTVLRVDNVIRVEG
>Mature_436_residues
MEKQTMRFAILGLGTVGKGVVKLLQESREMLHLKTGLNLELAKVLVRDASKPRPGFEGLPLTEDVSEILDDPSIRIVVEL
MGGIEPARTYLVEALRRGKTIVTANKDVMADYDKDLYDAGEIGDAEIYFEASVGGGIPIIRPLKEALAANTMRQVMGIVN
GTTNYILTQMSQYGRSYEEALQEAQALGYAEPDPTNDVQGFDAARKLAILCTICFLSRVKPGMVYTEGITRVTPRDIEYG
RRFGWVLKLLAIGKEVDGEIEARVHPAFIPHTHPLASVAGSFNAIYTVGDPVGETMFYGRGAGAGPTASAVVSDLIAAAL
SKRTPGRRAGDAHTVYFEKRVLPIEETRSRYYLRLHAVDAPGSLARIAERFGEHGVSLAEVVQASGGPDHPDDGGAAELV
LVTHTVQDANLQAVVRDLKEMRDTVLRVDNVIRVEG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=190, Percent_Identity=33.1578947368421, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790376, Length=352, Percent_Identity=23.8636363636364, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=233, Percent_Identity=26.6094420600858, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47355; Mature: 47355

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKQTMRFAILGLGTVGKGVVKLLQESREMLHLKTGLNLELAKVLVRDASKPRPGFEGLP
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
LTEDVSEILDDPSIRIVVELMGGIEPARTYLVEALRRGKTIVTANKDVMADYDKDLYDAG
CHHHHHHHHCCCCCEEHHHHHCCCCHHHHHHHHHHHCCCEEEEECCHHHHHCCCCHHCCC
EIGDAEIYFEASVGGGIPIIRPLKEALAANTMRQVMGIVNGTTNYILTQMSQYGRSYEEA
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHH
LQEAQALGYAEPDPTNDVQGFDAARKLAILCTICFLSRVKPGMVYTEGITRVTPRDIEYG
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHH
RRFGWVLKLLAIGKEVDGEIEARVHPAFIPHTHPLASVAGSFNAIYTVGDPVGETMFYGR
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCEEEECCCCCCCHHEECC
GAGAGPTASAVVSDLIAAALSKRTPGRRAGDAHTVYFEKRVLPIEETRSRYYLRLHAVDA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHCCEEEEEEEEECC
PGSLARIAERFGEHGVSLAEVVQASGGPDHPDDGGAAELVLVTHTVQDANLQAVVRDLKE
CCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHH
MRDTVLRVDNVIRVEG
HHHHHHHHCCEEEECC
>Mature Secondary Structure
MEKQTMRFAILGLGTVGKGVVKLLQESREMLHLKTGLNLELAKVLVRDASKPRPGFEGLP
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
LTEDVSEILDDPSIRIVVELMGGIEPARTYLVEALRRGKTIVTANKDVMADYDKDLYDAG
CHHHHHHHHCCCCCEEHHHHHCCCCHHHHHHHHHHHCCCEEEEECCHHHHHCCCCHHCCC
EIGDAEIYFEASVGGGIPIIRPLKEALAANTMRQVMGIVNGTTNYILTQMSQYGRSYEEA
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHH
LQEAQALGYAEPDPTNDVQGFDAARKLAILCTICFLSRVKPGMVYTEGITRVTPRDIEYG
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHH
RRFGWVLKLLAIGKEVDGEIEARVHPAFIPHTHPLASVAGSFNAIYTVGDPVGETMFYGR
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCEEEECCCCCCCHHEECC
GAGAGPTASAVVSDLIAAALSKRTPGRRAGDAHTVYFEKRVLPIEETRSRYYLRLHAVDA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHCCEEEEEEEEECC
PGSLARIAERFGEHGVSLAEVVQASGGPDHPDDGGAAELVLVTHTVQDANLQAVVRDLKE
CCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHH
MRDTVLRVDNVIRVEG
HHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]