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The map label for this gene is ilvD

Identifier: 51893823

GI number: 51893823

Start: 2874168

End: 2875865

Strand: Reverse

Name: ilvD

Synonym: STH2685

Alternate gene names: 51893823

Gene position: 2875865-2874168 (Counterclockwise)

Preceding gene: 51893824

Following gene: 51893822

Centisome position: 80.64

GC content: 70.67

Gene sequence:

>1698_bases
ATGGAGGGATCGACGGTGCGCAGCGACCTGATCAAGAAGGGGCCCGACCGGGCCCCGCATCGAGCGCTGCTGAAGGCGAC
CGGCGTCACCGACGCCGACATGGGGAAACCCTTCATCGGCATCGCCAACAGCTACATCGACATCGTGCCGGGGCACGTCC
ACCTGAAGGAGTTCGGCGACCTGGTGAAGGAGGCCGTGCGGGAGGCGGGCGGCGTGCCCTTCATCTTCAACACCATCGGC
GTCGACGACGGCATCGCCATGGGTCACATCGGGATGCGCTACAGCCTCCCCAGCCGGGAGCTGATCGCCGACGCGGTGGA
GACGGTGATCGAGGCGCACCAGCTGGACGCGCTGATCTGCATCCCCAACTGCGACAAGATCACCCCGGGCATGCTCATGG
CGGCCATGCGGGTGAACATCCCGACGATCTTCATCTCCGGCGGCCCCATGGCCGCCGGCCGGCTCAAGGACGGCCGCAGG
GCCGACCTGATCACCATCTTCGAGGGGGTCGGCGCCCACAGCCGGGGGATGATCAGCGACGAGGAGCTGAAGGAGCTGGA
GGACCTGGCCTGCCCCAGCTGCGGCTCCTGCTCGGGCATGTTCACCGCCAACTCGATGAACTGCCTCTGCGAGGCCCTCG
GCCTGGCCTTGCCGGGCAACGGCACCGCCCTGGCGCGGTCGGCCGAGCGGGAGGCGCTGGCGCGGGCGGCGGCCCGGCGC
ATCGTGGAGATGGCCCTGGCCGGAGGCCCCAGGCCCCGGGACATCGTCACGCCCGAGGCCATCGACAACGCCTTTGCGCT
GGACATCGCGATGGGCGGATCCACCAACACCGTCCTGCACACCCTGGCCGTCGCCACCGAAGCGGGCATCGCGTACCCGC
TGGAGCGGATCAACGCGCTCTCCGCCCGGGTGCCGTACCTGTGCAAGGTCTCGCCCGCCACGGCCGAGGTGCACATCGAG
GACGTGCATGCCGCCGGCGGCGTGATGGCGATCCTGAAGGAGCTGTCCCGGAAGGAGGGGACGCTGCATCCCCACTGCCT
GACGGTGACGGGGAAGACGATCGGCGAGCTCTGGGCCGAGGCCGAGAACCGGAACCGGGAGGTCATCCGTCCGGTGGAGG
ACCCGTACGCCGAGACCGGCGGCCTGGCGATCCTCTTCGGCAACCTGGCCCCCGACGGCGCAGCGTTGAAGGTGGGGGCG
GTGGACCCGTCCATCACCACGTTCACCGGCCGGGCGATCTGCTTCGACTCCCAGGACGAGGCGCTGCAGGGGATCTTCGG
CGGCAGGGTGCAGCCGGGCCACGTGGTGGTGATCCGCTACGAGGGGCCCAAGGGCGGCCCCGGCATGCCGGAGATGCTGG
CGCCCACGTCGGCCATTGTGGGGATGGGCCTGGGGAAGGAGGTTGCCCTGATCACCGACGGCCGCTTCTCCGGCGGCACC
CGGGGCATCTGCCTGGGCCATATCTCGCCCGAGGCGGCCGAAGGGGGGCCCATCGCCCTGGTGCGGGACGGCGACGTGAT
CACCATCGACATCCCCGGCCGCCGGCTCACGCTGGAGGTGCCGGCGGATGAGCTGGAGCGGCGCCGGGCAGCCTGGGTCA
AGCCCGCGCCCAAGGTGCGGAAGGGCTGGCTGGGGCGCTATGCCGCCCTGGTCACGTCGGCCAACACCGGTGCGGTGCTG
CGCACGCCGGAAGAGTGA

Upstream 100 bases:

>100_bases
CCAGCCCGGCGAGATCACCAGGCAGCTCATCGCCGAGTTCCGCCGGCGGGTGCAGGTCGAAGGCACGCCGATCGGCTGAC
CAAAGTCCACGCAAGCGACG

Downstream 100 bases:

>100_bases
GCAAAGGAGGACGGGGAGATGGAGATGCAGGCGGCCCGCGCCCTGATGCGGGCATTGGAGGCGGAGGGGGTCGAGGTCAT
CTTCGGCTACCCCGGCGGGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MEGSTVRSDLIKKGPDRAPHRALLKATGVTDADMGKPFIGIANSYIDIVPGHVHLKEFGDLVKEAVREAGGVPFIFNTIG
VDDGIAMGHIGMRYSLPSRELIADAVETVIEAHQLDALICIPNCDKITPGMLMAAMRVNIPTIFISGGPMAAGRLKDGRR
ADLITIFEGVGAHSRGMISDEELKELEDLACPSCGSCSGMFTANSMNCLCEALGLALPGNGTALARSAEREALARAAARR
IVEMALAGGPRPRDIVTPEAIDNAFALDIAMGGSTNTVLHTLAVATEAGIAYPLERINALSARVPYLCKVSPATAEVHIE
DVHAAGGVMAILKELSRKEGTLHPHCLTVTGKTIGELWAEAENRNREVIRPVEDPYAETGGLAILFGNLAPDGAALKVGA
VDPSITTFTGRAICFDSQDEALQGIFGGRVQPGHVVVIRYEGPKGGPGMPEMLAPTSAIVGMGLGKEVALITDGRFSGGT
RGICLGHISPEAAEGGPIALVRDGDVITIDIPGRRLTLEVPADELERRRAAWVKPAPKVRKGWLGRYAALVTSANTGAVL
RTPEE

Sequences:

>Translated_565_residues
MEGSTVRSDLIKKGPDRAPHRALLKATGVTDADMGKPFIGIANSYIDIVPGHVHLKEFGDLVKEAVREAGGVPFIFNTIG
VDDGIAMGHIGMRYSLPSRELIADAVETVIEAHQLDALICIPNCDKITPGMLMAAMRVNIPTIFISGGPMAAGRLKDGRR
ADLITIFEGVGAHSRGMISDEELKELEDLACPSCGSCSGMFTANSMNCLCEALGLALPGNGTALARSAEREALARAAARR
IVEMALAGGPRPRDIVTPEAIDNAFALDIAMGGSTNTVLHTLAVATEAGIAYPLERINALSARVPYLCKVSPATAEVHIE
DVHAAGGVMAILKELSRKEGTLHPHCLTVTGKTIGELWAEAENRNREVIRPVEDPYAETGGLAILFGNLAPDGAALKVGA
VDPSITTFTGRAICFDSQDEALQGIFGGRVQPGHVVVIRYEGPKGGPGMPEMLAPTSAIVGMGLGKEVALITDGRFSGGT
RGICLGHISPEAAEGGPIALVRDGDVITIDIPGRRLTLEVPADELERRRAAWVKPAPKVRKGWLGRYAALVTSANTGAVL
RTPEE
>Mature_565_residues
MEGSTVRSDLIKKGPDRAPHRALLKATGVTDADMGKPFIGIANSYIDIVPGHVHLKEFGDLVKEAVREAGGVPFIFNTIG
VDDGIAMGHIGMRYSLPSRELIADAVETVIEAHQLDALICIPNCDKITPGMLMAAMRVNIPTIFISGGPMAAGRLKDGRR
ADLITIFEGVGAHSRGMISDEELKELEDLACPSCGSCSGMFTANSMNCLCEALGLALPGNGTALARSAEREALARAAARR
IVEMALAGGPRPRDIVTPEAIDNAFALDIAMGGSTNTVLHTLAVATEAGIAYPLERINALSARVPYLCKVSPATAEVHIE
DVHAAGGVMAILKELSRKEGTLHPHCLTVTGKTIGELWAEAENRNREVIRPVEDPYAETGGLAILFGNLAPDGAALKVGA
VDPSITTFTGRAICFDSQDEALQGIFGGRVQPGHVVVIRYEGPKGGPGMPEMLAPTSAIVGMGLGKEVALITDGRFSGGT
RGICLGHISPEAAEGGPIALVRDGDVITIDIPGRRLTLEVPADELERRRAAWVKPAPKVRKGWLGRYAALVTSANTGAVL
RTPEE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=611, Percent_Identity=50.5728314238953, Blast_Score=556, Evalue=1e-159,
Organism=Escherichia coli, GI1786464, Length=506, Percent_Identity=34.7826086956522, Blast_Score=209, Evalue=5e-55,
Organism=Escherichia coli, GI1788157, Length=522, Percent_Identity=31.8007662835249, Blast_Score=209, Evalue=5e-55,
Organism=Escherichia coli, GI2367371, Length=504, Percent_Identity=34.5238095238095, Blast_Score=199, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322476, Length=562, Percent_Identity=40.9252669039146, Blast_Score=411, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_SYMTH (Q67KX6)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076514.1
- GeneID:   2980170
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2685
- NMPDR:   fig|292459.1.peg.2573
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- BioCyc:   STHE292459:STH2685-MONOMER
- BRENDA:   4.2.1.9
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 59432; Mature: 59432

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGSTVRSDLIKKGPDRAPHRALLKATGVTDADMGKPFIGIANSYIDIVPGHVHLKEFGD
CCCCHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCEEEECCCEEEECCCEEEHHHHHH
LVKEAVREAGGVPFIFNTIGVDDGIAMGHIGMRYSLPSRELIADAVETVIEAHQLDALIC
HHHHHHHHCCCCCEEEEECCCCCCEEECCCCEEECCCHHHHHHHHHHHHHHHHHCCEEEE
IPNCDKITPGMLMAAMRVNIPTIFISGGPMAAGRLKDGRRADLITIFEGVGAHSRGMISD
CCCCCCCCHHHHHHHHCCCCCEEEECCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCH
EELKELEDLACPSCGSCSGMFTANSMNCLCEALGLALPGNGTALARSAEREALARAAARR
HHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
IVEMALAGGPRPRDIVTPEAIDNAFALDIAMGGSTNTVLHTLAVATEAGIAYPLERINAL
HHHHHHCCCCCCCCCCCHHHHCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHH
SARVPYLCKVSPATAEVHIEDVHAAGGVMAILKELSRKEGTLHPHCLTVTGKTIGELWAE
HCCCCEEEEECCCCEEEEEEEHHHCCHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHH
AENRNREVIRPVEDPYAETGGLAILFGNLAPDGAALKVGAVDPSITTFTGRAICFDSQDE
HCCCCCCEECCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCEEEECCHHH
ALQGIFGGRVQPGHVVVIRYEGPKGGPGMPEMLAPTSAIVGMGLGKEVALITDGRFSGGT
HHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHCCCHHHHHCCCCCEEEEEECCCCCCCC
RGICLGHISPEAAEGGPIALVRDGDVITIDIPGRRLTLEVPADELERRRAAWVKPAPKVR
CCEEEECCCCCCCCCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHCCCCCCHHH
KGWLGRYAALVTSANTGAVLRTPEE
HHHHHHHHHEEECCCCCCEEECCCC
>Mature Secondary Structure
MEGSTVRSDLIKKGPDRAPHRALLKATGVTDADMGKPFIGIANSYIDIVPGHVHLKEFGD
CCCCHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCEEEECCCEEEECCCEEEHHHHHH
LVKEAVREAGGVPFIFNTIGVDDGIAMGHIGMRYSLPSRELIADAVETVIEAHQLDALIC
HHHHHHHHCCCCCEEEEECCCCCCEEECCCCEEECCCHHHHHHHHHHHHHHHHHCCEEEE
IPNCDKITPGMLMAAMRVNIPTIFISGGPMAAGRLKDGRRADLITIFEGVGAHSRGMISD
CCCCCCCCHHHHHHHHCCCCCEEEECCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCH
EELKELEDLACPSCGSCSGMFTANSMNCLCEALGLALPGNGTALARSAEREALARAAARR
HHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
IVEMALAGGPRPRDIVTPEAIDNAFALDIAMGGSTNTVLHTLAVATEAGIAYPLERINAL
HHHHHHCCCCCCCCCCCHHHHCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHH
SARVPYLCKVSPATAEVHIEDVHAAGGVMAILKELSRKEGTLHPHCLTVTGKTIGELWAE
HCCCCEEEEECCCCEEEEEEEHHHCCHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHH
AENRNREVIRPVEDPYAETGGLAILFGNLAPDGAALKVGAVDPSITTFTGRAICFDSQDE
HCCCCCCEECCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCEEEECCHHH
ALQGIFGGRVQPGHVVVIRYEGPKGGPGMPEMLAPTSAIVGMGLGKEVALITDGRFSGGT
HHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHCCCHHHHHCCCCCEEEEEECCCCCCCC
RGICLGHISPEAAEGGPIALVRDGDVITIDIPGRRLTLEVPADELERRRAAWVKPAPKVR
CCEEEECCCCCCCCCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHCCCCCCHHH
KGWLGRYAALVTSANTGAVLRTPEE
HHHHHHHHHEEECCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA