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The map label for this gene is ilvB [H]

Identifier: 51893822

GI number: 51893822

Start: 2872434

End: 2874149

Strand: Reverse

Name: ilvB [H]

Synonym: STH2684

Alternate gene names: 51893822

Gene position: 2874149-2872434 (Counterclockwise)

Preceding gene: 51893823

Following gene: 51893821

Centisome position: 80.6

GC content: 70.92

Gene sequence:

>1716_bases
ATGGAGATGCAGGCGGCCCGCGCCCTGATGCGGGCATTGGAGGCGGAGGGGGTCGAGGTCATCTTCGGCTACCCCGGCGG
GGCGAGTCTGTACATCTACGACGCCCTCTATGACAGCCCCATCCACCACGTGCTGACCCGGCACGAGCAGGGGGCGATCC
ACGCGGCCGAGGGGTACGCCCGGGCCACGGGCAAGGTCGGGGTGGTGCTGGCCACCTCCGGCCCCGGCGCGACCAACCTG
GTGACCGGCCTGTGCGATGCCATGATGGACTCGACCCCGATCGTGGCCATCACGGGGCAGGTGACCCGTTCGCTCATCGG
CCGGGACGCGTTCCAGGAAGCCGACGTCACGGGCATAACGATGCCCGTCACGAAGCACAACTACCTGGTGACGGACCCGA
ACGACCTGCTCCGGGTGGTGCGCGAGGCCTTCTACATCGCCCGCACCGGCCGGCCCGGACCGGTCCTGATCGACATCCCC
AAGGACGTGACCAACGCCCAGGTGCGCTGGGAGTACCCGCCCAGGATCCACCTGCCGGGCTACCGGGTGCCGCGGGAGGC
CAGCCCGGAGGCGGTGGCGGCGGCCGCCGAGGCCATCCGGTCCGCGCGGCAGCCGGTCCTGATCTGCGGCGGCGGCGTGG
TCTCGTCCCCGGACGCCACCGGACCGTTCCGGACCTTGGCTGAGCGGATGGACGCCCCGGTGGTGGAGACGCTGATGGGG
CTCGGCGGCTTCCCCATGGACCATCCGCTGTGCCTGGGGCTTGTGGGCATGCACGGGACCTTTGCCGCCAACCGGGCGGT
GGCCAACTCCGACCTGGTGATCGCCTGCGGGATGCGCTTTGACGACCGGGTGACCGGCATGGCCTCCCGGTTTGCGCCCA
AGGCCCGGATCATCCACATCGACATCGACCCCGCGGAGATGTCCAAGAACCTGACGGCGCACATCCCGCTGGTGGGCGAC
TGCGGCCTGGTGCTCGCGCAGCTCAACGAGGCCCTGGGCGACTGGTCCCAGACCCTCCCCGAGTGGCGGGCGCAGGTGCA
GGGGTGGCAGGAGCAGTTCCCGCTCTGGGGCGTGCGCCGGGGCGAGGAGATCGCCACCGACCCGGACGGGGTGCCGAAGC
CGCAGCAGGTGATCCAGGCGGTGCAGGCGGCCTTCGGGCCGGAGGCCGTGGTCGCCACCGACGTCGGCCAGCACCAGATG
TGGGCGGCGCACTACTGCACCCGTACGGAGCCCCGGACGTGGCTTTCCTCCAGCGGGCTGGGCACGATGGGCTTCGGCCT
TCCGGCGGCCATCGGCGCCGCGATCGGTCGCCCCGACCGGGACGTGGTGCTCATCACCGGCGACGGCTCGTTCCAGATGT
GCATCCAGGAGCTGGCCACTGTGGTCCAGGAGCGGGTGCCGGTCAAGATCGTCCTGCTCAACAACGGCTACCTGGGCATG
GTGCGCCAGTGGCAGGAGATGTTCTACAAGGGCCGGTACAAGGAGGTCGACCTGCGGCCGGGCATGCCGGATTTCGTGAA
GCTGGCCGAGGCATATGGCATCAAGGGGCTGCGGGTGCGGCGGCTCGGCGAGCTGGAAGGGGCCGTGGCCGAGGCCCGGG
CGCACCAGGGTCCGGTGCTGCTGGAGGTCGTGGTGGAGGAGGAAGAGAACGTCTTCCCGATCGTGCCGCCCGGTGGGGCC
AACACCGAGGCGCTGTTGCCCGGGGCGGGGCGCTGA

Upstream 100 bases:

>100_bases
GCGGAAGGGCTGGCTGGGGCGCTATGCCGCCCTGGTCACGTCGGCCAACACCGGTGCGGTGCTGCGCACGCCGGAAGAGT
GAGCAAAGGAGGACGGGGAG

Downstream 100 bases:

>100_bases
GCGGGCTGGACGCCGGCTTCGGGCGCCCGCGTCCGGACAGCCTATCTGCGGTATTCAAAGAATCTATAGCTTCTCCGATA
GGAAGCAGCCCCACGGCTGG

Product: acetolactate synthase large subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS; Vegetative protein 105; VEG105 [H]

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MEMQAARALMRALEAEGVEVIFGYPGGASLYIYDALYDSPIHHVLTRHEQGAIHAAEGYARATGKVGVVLATSGPGATNL
VTGLCDAMMDSTPIVAITGQVTRSLIGRDAFQEADVTGITMPVTKHNYLVTDPNDLLRVVREAFYIARTGRPGPVLIDIP
KDVTNAQVRWEYPPRIHLPGYRVPREASPEAVAAAAEAIRSARQPVLICGGGVVSSPDATGPFRTLAERMDAPVVETLMG
LGGFPMDHPLCLGLVGMHGTFAANRAVANSDLVIACGMRFDDRVTGMASRFAPKARIIHIDIDPAEMSKNLTAHIPLVGD
CGLVLAQLNEALGDWSQTLPEWRAQVQGWQEQFPLWGVRRGEEIATDPDGVPKPQQVIQAVQAAFGPEAVVATDVGQHQM
WAAHYCTRTEPRTWLSSSGLGTMGFGLPAAIGAAIGRPDRDVVLITGDGSFQMCIQELATVVQERVPVKIVLLNNGYLGM
VRQWQEMFYKGRYKEVDLRPGMPDFVKLAEAYGIKGLRVRRLGELEGAVAEARAHQGPVLLEVVVEEEENVFPIVPPGGA
NTEALLPGAGR

Sequences:

>Translated_571_residues
MEMQAARALMRALEAEGVEVIFGYPGGASLYIYDALYDSPIHHVLTRHEQGAIHAAEGYARATGKVGVVLATSGPGATNL
VTGLCDAMMDSTPIVAITGQVTRSLIGRDAFQEADVTGITMPVTKHNYLVTDPNDLLRVVREAFYIARTGRPGPVLIDIP
KDVTNAQVRWEYPPRIHLPGYRVPREASPEAVAAAAEAIRSARQPVLICGGGVVSSPDATGPFRTLAERMDAPVVETLMG
LGGFPMDHPLCLGLVGMHGTFAANRAVANSDLVIACGMRFDDRVTGMASRFAPKARIIHIDIDPAEMSKNLTAHIPLVGD
CGLVLAQLNEALGDWSQTLPEWRAQVQGWQEQFPLWGVRRGEEIATDPDGVPKPQQVIQAVQAAFGPEAVVATDVGQHQM
WAAHYCTRTEPRTWLSSSGLGTMGFGLPAAIGAAIGRPDRDVVLITGDGSFQMCIQELATVVQERVPVKIVLLNNGYLGM
VRQWQEMFYKGRYKEVDLRPGMPDFVKLAEAYGIKGLRVRRLGELEGAVAEARAHQGPVLLEVVVEEEENVFPIVPPGGA
NTEALLPGAGR
>Mature_571_residues
MEMQAARALMRALEAEGVEVIFGYPGGASLYIYDALYDSPIHHVLTRHEQGAIHAAEGYARATGKVGVVLATSGPGATNL
VTGLCDAMMDSTPIVAITGQVTRSLIGRDAFQEADVTGITMPVTKHNYLVTDPNDLLRVVREAFYIARTGRPGPVLIDIP
KDVTNAQVRWEYPPRIHLPGYRVPREASPEAVAAAAEAIRSARQPVLICGGGVVSSPDATGPFRTLAERMDAPVVETLMG
LGGFPMDHPLCLGLVGMHGTFAANRAVANSDLVIACGMRFDDRVTGMASRFAPKARIIHIDIDPAEMSKNLTAHIPLVGD
CGLVLAQLNEALGDWSQTLPEWRAQVQGWQEQFPLWGVRRGEEIATDPDGVPKPQQVIQAVQAAFGPEAVVATDVGQHQM
WAAHYCTRTEPRTWLSSSGLGTMGFGLPAAIGAAIGRPDRDVVLITGDGSFQMCIQELATVVQERVPVKIVLLNNGYLGM
VRQWQEMFYKGRYKEVDLRPGMPDFVKLAEAYGIKGLRVRRLGELEGAVAEARAHQGPVLLEVVVEEEENVFPIVPPGGA
NTEALLPGAGR

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=560, Percent_Identity=26.6071428571429, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI21361361, Length=557, Percent_Identity=26.3913824057451, Blast_Score=160, Evalue=4e-39,
Organism=Escherichia coli, GI87081685, Length=578, Percent_Identity=44.9826989619377, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1790104, Length=560, Percent_Identity=45, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1786717, Length=571, Percent_Identity=35.9019264448336, Blast_Score=318, Evalue=5e-88,
Organism=Escherichia coli, GI1787096, Length=562, Percent_Identity=29.1814946619217, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1788716, Length=568, Percent_Identity=26.056338028169, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17531301, Length=572, Percent_Identity=27.0979020979021, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17531299, Length=572, Percent_Identity=27.0979020979021, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17542570, Length=514, Percent_Identity=27.2373540856031, Blast_Score=153, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6323755, Length=571, Percent_Identity=44.6584938704028, Blast_Score=453, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6320816, Length=495, Percent_Identity=24.6464646464646, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323163, Length=499, Percent_Identity=23.6472945891784, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321524, Length=506, Percent_Identity=22.5296442687747, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323073, Length=501, Percent_Identity=23.1536926147705, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19922626, Length=573, Percent_Identity=23.7347294938918, Blast_Score=143, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 61492; Mature: 61492

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMQAARALMRALEAEGVEVIFGYPGGASLYIYDALYDSPIHHVLTRHEQGAIHAAEGYA
CCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECHHCCHHHHHHHCCCCCCEECCCCHH
RATGKVGVVLATSGPGATNLVTGLCDAMMDSTPIVAITGQVTRSLIGRDAFQEADVTGIT
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCHHHHHCCCCEEE
MPVTKHNYLVTDPNDLLRVVREAFYIARTGRPGPVLIDIPKDVTNAQVRWEYPPRIHLPG
EEEECCCEEEECHHHHHHHHHHHHHHEECCCCCCEEEECCCCCCCCEEEECCCCEECCCC
YRVPREASPEAVAAAAEAIRSARQPVLICGGGVVSSPDATGPFRTLAERMDAPVVETLMG
CCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCCCCCCHHHHHHHHHCCHHHHHHHH
LGGFPMDHPLCLGLVGMHGTFAANRAVANSDLVIACGMRFDDRVTGMASRFAPKARIIHI
CCCCCCCCCHHHHHHCCCCCHHHCCEECCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEE
DIDPAEMSKNLTAHIPLVGDCGLVLAQLNEALGDWSQTLPEWRAQVQGWQEQFPLWGVRR
ECCHHHHCCCCEEECCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
GEEIATDPDGVPKPQQVIQAVQAAFGPEAVVATDVGQHQMWAAHYCTRTEPRTWLSSSGL
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHCCCCC
GTMGFGLPAAIGAAIGRPDRDVVLITGDGSFQMCIQELATVVQERVPVKIVLLNNGYLGM
CCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHH
VRQWQEMFYKGRYKEVDLRPGMPDFVKLAEAYGIKGLRVRRLGELEGAVAEARAHQGPVL
HHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCEE
LEVVVEEEENVFPIVPPGGANTEALLPGAGR
EEEEEECCCCEEEEECCCCCCCCEECCCCCC
>Mature Secondary Structure
MEMQAARALMRALEAEGVEVIFGYPGGASLYIYDALYDSPIHHVLTRHEQGAIHAAEGYA
CCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECHHCCHHHHHHHCCCCCCEECCCCHH
RATGKVGVVLATSGPGATNLVTGLCDAMMDSTPIVAITGQVTRSLIGRDAFQEADVTGIT
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCHHHHHCCCCEEE
MPVTKHNYLVTDPNDLLRVVREAFYIARTGRPGPVLIDIPKDVTNAQVRWEYPPRIHLPG
EEEECCCEEEECHHHHHHHHHHHHHHEECCCCCCEEEECCCCCCCCEEEECCCCEECCCC
YRVPREASPEAVAAAAEAIRSARQPVLICGGGVVSSPDATGPFRTLAERMDAPVVETLMG
CCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCCCCCCHHHHHHHHHCCHHHHHHHH
LGGFPMDHPLCLGLVGMHGTFAANRAVANSDLVIACGMRFDDRVTGMASRFAPKARIIHI
CCCCCCCCCHHHHHHCCCCCHHHCCEECCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEE
DIDPAEMSKNLTAHIPLVGDCGLVLAQLNEALGDWSQTLPEWRAQVQGWQEQFPLWGVRR
ECCHHHHCCCCEEECCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
GEEIATDPDGVPKPQQVIQAVQAAFGPEAVVATDVGQHQMWAAHYCTRTEPRTWLSSSGL
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHCCCCC
GTMGFGLPAAIGAAIGRPDRDVVLITGDGSFQMCIQELATVVQERVPVKIVLLNNGYLGM
CCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHH
VRQWQEMFYKGRYKEVDLRPGMPDFVKLAEAYGIKGLRVRRLGELEGAVAEARAHQGPVL
HHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCEE
LEVVVEEEENVFPIVPPGGANTEALLPGAGR
EEEEEECCCCEEEEECCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 1577690; 9298659 [H]