BacMap

Definition	Symbiobacterium thermophilum IAM 14863 chromosome, complete genome.
Accession	NC_006177
Length	3,566,135

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The map label for this gene is ppiB [H]

Identifier: 51893805

GI number: 51893805

Start: 2857824

End: 2858435

Strand: Reverse

Name: ppiB [H]

Synonym: STH2667

Alternate gene names: 51893805

Gene position: 2858435-2857824 (Counterclockwise)

Preceding gene: 51893807

Following gene: 51893804

Centisome position: 80.15

GC content: 67.48

Gene sequence:

>612_bases
GTGTACAACAACCGGTCGCCGGCAGGTCAGCAGGGCGGCGCCGGTCAGGGCGGTGCGGACCAGGCGGGCCACAAGCAGTG
GGACAAGCCGCCGGAGATGATCATCGACCCCGCCAAGCGCTACACCGCGACCATGGAGACCAGCCTGGGCACGATGACGT
TCGAGCTCTTCGCCGACGAGGTGCCCCAGACGGTCAACAACTTCGTGTTCCTGGCGCGGGAGGGCTTCTACGACGGGGTG
ACCTTCCATCGGATCATCAAGGATTTCATGATCCAGGGCGGCGATCCGACGGGCACCGGCACCGGCGGGCCCGGCTACAC
CATCCCGGACGAGTACCCGGTGACCCGGCCGTACCAGCGGGGCACCCTGGCCATGGCCCGCACGACGGCGCCCAACTCCG
CGGGCAGCCAGTTCTTCATCTGCACGGGCCTCTCCTGCGGGGGCCTCGACCAGCAGCCGGTCTACGTGATCTTCGGCCAG
CTGATCGAGGGGGATGACGTGCTGACCCAGCTGGAGTCGGTGGAGGTGCGGCAGGGGAACAGCTTCGACCCGGTGCCCTC
CACTCCCGTGAATCCGCCCGTCATCCGGAAAGTGACCATTGCGGAGGAGTAG

Upstream 100 bases:

>100_bases
GAGGGAATGGCGGATGCAGAGTCGAGGCTGGAAGGCGGCCGCCGGCGCGCTGGCGTTGCTCCTGGTGCTGGCCGGGTGCG
GCGGCCGCAGCCCGCAGGAT

Downstream 100 bases:

>100_bases
GCGGTGGTTCGGCCTGAGCCCCCGGAGGGCTGGGCGCGGTGGGTGGCGGAGGTGTACCGGCGGCTGCTGGAGGCGTTCGG
CCCGCGCCACTGGTGGCCGT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MYNNRSPAGQQGGAGQGGADQAGHKQWDKPPEMIIDPAKRYTATMETSLGTMTFELFADEVPQTVNNFVFLAREGFYDGV
TFHRIIKDFMIQGGDPTGTGTGGPGYTIPDEYPVTRPYQRGTLAMARTTAPNSAGSQFFICTGLSCGGLDQQPVYVIFGQ
LIEGDDVLTQLESVEVRQGNSFDPVPSTPVNPPVIRKVTIAEE

Sequences:

>Translated_203_residues
MYNNRSPAGQQGGAGQGGADQAGHKQWDKPPEMIIDPAKRYTATMETSLGTMTFELFADEVPQTVNNFVFLAREGFYDGV
TFHRIIKDFMIQGGDPTGTGTGGPGYTIPDEYPVTRPYQRGTLAMARTTAPNSAGSQFFICTGLSCGGLDQQPVYVIFGQ
LIEGDDVLTQLESVEVRQGNSFDPVPSTPVNPPVIRKVTIAEE
>Mature_203_residues
MYNNRSPAGQQGGAGQGGADQAGHKQWDKPPEMIIDPAKRYTATMETSLGTMTFELFADEVPQTVNNFVFLAREGFYDGV
TFHRIIKDFMIQGGDPTGTGTGGPGYTIPDEYPVTRPYQRGTLAMARTTAPNSAGSQFFICTGLSCGGLDQQPVYVIFGQ
LIEGDDVLTQLESVEVRQGNSFDPVPSTPVNPPVIRKVTIAEE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=163, Percent_Identity=38.0368098159509, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI7706339, Length=135, Percent_Identity=45.1851851851852, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI24308049, Length=142, Percent_Identity=44.3661971830986, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI4758950, Length=137, Percent_Identity=43.7956204379562, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI10863927, Length=140, Percent_Identity=43.5714285714286, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI5031987, Length=140, Percent_Identity=43.5714285714286, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI22547212, Length=135, Percent_Identity=47.4074074074074, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI7657473, Length=135, Percent_Identity=47.4074074074074, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI22547215, Length=135, Percent_Identity=47.4074074074074, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI64276486, Length=160, Percent_Identity=35, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4505991, Length=145, Percent_Identity=42.7586206896552, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI20911035, Length=162, Percent_Identity=30.8641975308642, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI169164185, Length=140, Percent_Identity=38.5714285714286, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI169163623, Length=140, Percent_Identity=38.5714285714286, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI5454154, Length=141, Percent_Identity=42.5531914893617, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI169163387, Length=140, Percent_Identity=38.5714285714286, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI310129267, Length=140, Percent_Identity=40.7142857142857, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI310120620, Length=140, Percent_Identity=40.7142857142857, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI310127646, Length=161, Percent_Identity=37.888198757764, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI310114371, Length=161, Percent_Identity=37.888198757764, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI310119221, Length=161, Percent_Identity=37.888198757764, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI4826932, Length=144, Percent_Identity=40.9722222222222, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI178057341, Length=161, Percent_Identity=36.6459627329193, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI256017253, Length=161, Percent_Identity=36.6459627329193, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI221139811, Length=161, Percent_Identity=36.6459627329193, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI256017251, Length=161, Percent_Identity=36.6459627329193, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI310110104, Length=140, Percent_Identity=38.5714285714286, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI45439316, Length=134, Percent_Identity=41.7910447761194, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI209417936, Length=161, Percent_Identity=36.0248447204969, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI30102944, Length=161, Percent_Identity=36.0248447204969, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI219842199, Length=161, Percent_Identity=36.0248447204969, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI303305009, Length=131, Percent_Identity=41.9847328244275, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI5174637, Length=139, Percent_Identity=40.2877697841727, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI27735045, Length=140, Percent_Identity=40.7142857142857, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI310132444, Length=140, Percent_Identity=37.8571428571429, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI310113152, Length=140, Percent_Identity=37.8571428571429, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI169214050, Length=140, Percent_Identity=38.5714285714286, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI239751853, Length=140, Percent_Identity=38.5714285714286, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI113428306, Length=140, Percent_Identity=38.5714285714286, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI6631100, Length=142, Percent_Identity=36.6197183098592, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI42560244, Length=139, Percent_Identity=35.9712230215827, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786736, Length=167, Percent_Identity=37.125748502994, Blast_Score=94, Evalue=5e-21,
Organism=Escherichia coli, GI1789763, Length=151, Percent_Identity=38.4105960264901, Blast_Score=85, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17532641, Length=137, Percent_Identity=43.0656934306569, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17506311, Length=136, Percent_Identity=42.6470588235294, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71980594, Length=159, Percent_Identity=35.8490566037736, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71980590, Length=148, Percent_Identity=37.8378378378378, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17539496, Length=135, Percent_Identity=41.4814814814815, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71997782, Length=122, Percent_Identity=38.5245901639344, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17506307, Length=140, Percent_Identity=42.8571428571429, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17566266, Length=137, Percent_Identity=40.8759124087591, Blast_Score=83, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17559074, Length=138, Percent_Identity=42.0289855072464, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17552780, Length=133, Percent_Identity=43.609022556391, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539498, Length=131, Percent_Identity=43.5114503816794, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32563659, Length=138, Percent_Identity=34.7826086956522, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17552782, Length=155, Percent_Identity=40, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17565860, Length=148, Percent_Identity=40.5405405405405, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17551282, Length=154, Percent_Identity=37.6623376623377, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17551284, Length=154, Percent_Identity=37.6623376623377, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17552784, Length=152, Percent_Identity=33.5526315789474, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=181, Percent_Identity=34.8066298342541, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=133, Percent_Identity=43.609022556391, Blast_Score=88, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6323562, Length=134, Percent_Identity=44.0298507462687, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321848, Length=138, Percent_Identity=39.1304347826087, Blast_Score=82, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320510, Length=144, Percent_Identity=36.8055555555556, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323246, Length=149, Percent_Identity=36.241610738255, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19922376, Length=136, Percent_Identity=44.1176470588235, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=40.3614457831325, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI45549139, Length=169, Percent_Identity=37.8698224852071, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24652460, Length=143, Percent_Identity=38.4615384615385, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664125, Length=145, Percent_Identity=41.3793103448276, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21357783, Length=145, Percent_Identity=41.3793103448276, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI20130249, Length=154, Percent_Identity=42.2077922077922, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357249, Length=99, Percent_Identity=42.4242424242424, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24586038, Length=172, Percent_Identity=37.2093023255814, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17647301, Length=137, Percent_Identity=40.8759124087591, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24650807, Length=143, Percent_Identity=39.8601398601399, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355677, Length=154, Percent_Identity=31.1688311688312, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19922912, Length=134, Percent_Identity=43.2835820895522, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21944; Mature: 21944

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNNRSPAGQQGGAGQGGADQAGHKQWDKPPEMIIDPAKRYTATMETSLGTMTFELFADE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEECCHHHHHHHHHHCCCHHHHHHHHHH
VPQTVNNFVFLAREGFYDGVTFHRIIKDFMIQGGDPTGTGTGGPGYTIPDEYPVTRPYQR
HHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GTLAMARTTAPNSAGSQFFICTGLSCGGLDQQPVYVIFGQLIEGDDVLTQLESVEVRQGN
CEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCEEEEECHHCCHHHHHHHHHHHCCCCC
SFDPVPSTPVNPPVIRKVTIAEE
CCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MYNNRSPAGQQGGAGQGGADQAGHKQWDKPPEMIIDPAKRYTATMETSLGTMTFELFADE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEECCHHHHHHHHHHCCCHHHHHHHHHH
VPQTVNNFVFLAREGFYDGVTFHRIIKDFMIQGGDPTGTGTGGPGYTIPDEYPVTRPYQR
HHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GTLAMARTTAPNSAGSQFFICTGLSCGGLDQQPVYVIFGQLIEGDDVLTQLESVEVRQGN
CEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCEEEEECHHCCHHHHHHHHHHHCCCCC
SFDPVPSTPVNPPVIRKVTIAEE
CCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9317025; 9665876 [H]