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The map label for this gene is nth [C]

Identifier: 51893804

GI number: 51893804

Start: 2857029

End: 2857820

Strand: Reverse

Name: nth [C]

Synonym: STH2666

Alternate gene names: 51893804

Gene position: 2857820-2857029 (Counterclockwise)

Preceding gene: 51893805

Following gene: 51893803

Centisome position: 80.14

GC content: 74.37

Gene sequence:

>792_bases
GTGGTTCGGCCTGAGCCCCCGGAGGGCTGGGCGCGGTGGGTGGCGGAGGTGTACCGGCGGCTGCTGGAGGCGTTCGGCCC
GCGCCACTGGTGGCCGTCCGCCCTGGAGCCCCCGCCGGCCAAGGCTCAGCCCTTCGAGATGATCGCCGGGGCCATCCTGG
TGCAGAACGTGGCCTGGAGCAACGCAGCCAAGGCGGTGCGGGCCCTGGCGGAAGCGGGGCTGCTGGACGTGGCCGCGATG
GACGCGGCCCCGGCTGAGGCGGTGGAGCCGCTGATCCGGCCCGCGGCCTACTTCCGGCAGAAGGCGCAGCGGTTGAAGGG
GTTTGCCGCGCACGTGATGAACCGCTACGGCGGCGACCTCCCGGCGATGCTGCGCCGGCCCGCGGACGAGCTGAGGGCCG
AGCTCCTGGCCTTGCCCGGGATCGGCCCCGAAACCGCGGACTGCATCCTCTGCTACGCCGCGGGCCGTCCCGTGATGGCC
ATGGACGCCTATACCCGCCGGATCTTCGCCCGCCTGGGGGTCTTCGCGCCGGATGCCCGGTACGAGGCGATGCAGGCGTT
CTTCCACGGCTGGACCCCGGCCGACGCTCAGCTGCGGGGCGAGTACCACGCGCTGATCGACACCCTGGGCAACCGGCTCT
GCCTGAAGCGGAACCCGCGCTGCGGCCAGTGCCCGCTGGCGGACCTGTGTCCCCGGGTGGGGGTCGTGGAGGAGGCGGGC
GGCGCAGCCGGCCGGGCCCGAACCGTGGACGGGCGGGGAAGGGGGCCTTGCTGCGAGGCGGGGCGACCTTGA

Upstream 100 bases:

>100_bases
GTCGGTGGAGGTGCGGCAGGGGAACAGCTTCGACCCGGTGCCCTCCACTCCCGTGAATCCGCCCGTCATCCGGAAAGTGA
CCATTGCGGAGGAGTAGGCG

Downstream 100 bases:

>100_bases
CTGCCGCGTCCGCGTGCGCAGCGGGGCCTGGGAAACGGCGCGGAGGGGGAAGGGAGAGGGTCTCCGTGCGGATCGTCTTC
AAGGACAAGAAGCACTCGTC

Product: putative endonuclease III

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MVRPEPPEGWARWVAEVYRRLLEAFGPRHWWPSALEPPPAKAQPFEMIAGAILVQNVAWSNAAKAVRALAEAGLLDVAAM
DAAPAEAVEPLIRPAAYFRQKAQRLKGFAAHVMNRYGGDLPAMLRRPADELRAELLALPGIGPETADCILCYAAGRPVMA
MDAYTRRIFARLGVFAPDARYEAMQAFFHGWTPADAQLRGEYHALIDTLGNRLCLKRNPRCGQCPLADLCPRVGVVEEAG
GAAGRARTVDGRGRGPCCEAGRP

Sequences:

>Translated_263_residues
MVRPEPPEGWARWVAEVYRRLLEAFGPRHWWPSALEPPPAKAQPFEMIAGAILVQNVAWSNAAKAVRALAEAGLLDVAAM
DAAPAEAVEPLIRPAAYFRQKAQRLKGFAAHVMNRYGGDLPAMLRRPADELRAELLALPGIGPETADCILCYAAGRPVMA
MDAYTRRIFARLGVFAPDARYEAMQAFFHGWTPADAQLRGEYHALIDTLGNRLCLKRNPRCGQCPLADLCPRVGVVEEAG
GAAGRARTVDGRGRGPCCEAGRP
>Mature_263_residues
MVRPEPPEGWARWVAEVYRRLLEAFGPRHWWPSALEPPPAKAQPFEMIAGAILVQNVAWSNAAKAVRALAEAGLLDVAAM
DAAPAEAVEPLIRPAAYFRQKAQRLKGFAAHVMNRYGGDLPAMLRRPADELRAELLALPGIGPETADCILCYAAGRPVMA
MDAYTRRIFARLGVFAPDARYEAMQAFFHGWTPADAQLRGEYHALIDTLGNRLCLKRNPRCGQCPLADLCPRVGVVEEAG
GAAGRARTVDGRGRGPCCEAGRP

Specific function: Has Both An Apurinic And/Or Apyrimidinic Endonuclease Activity And A DNA N-Glycosylase Activity. Incises Damaged DNA At Cytosines, Thymines And Guanines. Acts On A Damaged Strand, 5' From The Damaged Site. Required For The Repair Of Both Oxidative DNA Da

COG id: COG2231

COG function: function code L; Uncharacterized protein related to Endonuclease III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=212, Percent_Identity=28.3018867924528, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1787920, Length=189, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45550361, Length=196, Percent_Identity=27.5510204081633, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 4.2.99.18

Molecular weight: Translated: 28621; Mature: 28621

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRPEPPEGWARWVAEVYRRLLEAFGPRHWWPSALEPPPAKAQPFEMIAGAILVQNVAWS
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
NAAKAVRALAEAGLLDVAAMDAAPAEAVEPLIRPAAYFRQKAQRLKGFAAHVMNRYGGDL
HHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAMLRRPADELRAELLALPGIGPETADCILCYAAGRPVMAMDAYTRRIFARLGVFAPDAR
HHHHHCCHHHHHHHHHHCCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHH
YEAMQAFFHGWTPADAQLRGEYHALIDTLGNRLCLKRNPRCGQCPLADLCPRVGVVEEAG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCHHHHCCCCCCHHHCC
GAAGRARTVDGRGRGPCCEAGRP
CCCCCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MVRPEPPEGWARWVAEVYRRLLEAFGPRHWWPSALEPPPAKAQPFEMIAGAILVQNVAWS
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
NAAKAVRALAEAGLLDVAAMDAAPAEAVEPLIRPAAYFRQKAQRLKGFAAHVMNRYGGDL
HHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAMLRRPADELRAELLALPGIGPETADCILCYAAGRPVMAMDAYTRRIFARLGVFAPDAR
HHHHHCCHHHHHHHHHHCCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHH
YEAMQAFFHGWTPADAQLRGEYHALIDTLGNRLCLKRNPRCGQCPLADLCPRVGVVEEAG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCHHHHCCCCCCHHHCC
GAAGRARTVDGRGRGPCCEAGRP
CCCCCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Carbon-Oxygen Lyase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]