Click here to switch to the map view.

The map label for this gene is ffh [H]

Identifier: 51598948

GI number: 51598948

Start: 737269

End: 738603

Strand: Direct

Name: ffh [H]

Synonym: BG0717

Alternate gene names: 51598948

Gene position: 737269-738603 (Clockwise)

Preceding gene: 51598947

Following gene: 51598949

Centisome position: 81.53

GC content: 31.91

Gene sequence:

>1335_bases
ATGCTTGAAAGTTTGGGGTCAAATTTTAAAAATTTTATAAACTATCTTTCTGGAAAATCTACAATAAATGATAAAAACAT
CTCAGAGGCTATTGAGATTATTAAGAATTCTTTAGTTGATGCTGATGTCAACTTAAGAGTTATAAGACGTTTTTTAAATT
CTATAATTGAAGAATCCAAGGGAGTAAAAGTTTTAAGAGGTGTTGATCCTAAATCTCAGTTTATTAAAATTGTCAACGAT
AATCTTGTTAAATTTTTGGGAGGCAAAAGTTATGAGCTTGGCTTACATCCTGTCAATAAGCAATCTTATATTCTTATGCT
CGGACTTCAAGGTTCTGGCAAAACTACAACATGTGCTAAGCTTTCTTTAAAGCTTAAAAAGGAAAATAGAAAAGTGCTTC
TTGTAGCTGCTGACACATTTAGAGCAGCAGCTATAGAGCAGTTAAAAATATTGGGCAGCCAAATAGGTGTTCCAGTATTT
TCACTTACAGGAGAAAAAGATCCTATTAAAATTGTTAAAGCATCTATAAAGTTTGCCGAGTCTGAGTTTTTTGATTCTGT
AATAGTTGATACTAGAGGACGGCTTGAAGTTGAATCTTTGTTAGTTGAAGAGATAAAAAAAATCAAGGATATTCTAAAAC
CCACAGAAACCATTTTGGTAGTAGACTCTATGATGGGACAAGTTGCGGTAAATATTGCTAAGGAATTTAATGAGAATGTT
GGACTTACTGGTGCAATATTCTCTAAATTTGATTCAGATACTAGGGGTGGGGCTGTGCTATCGTTCAAAAGTATTTGTGC
AGTTCCTATTAAATTTATTGGGGTTGGAGAAAGAGTTGAAGATCTTGATTCATTTTACCCGGAAAGAATTGCTTCTAGAA
TTCTTGGCATGGGGGATGTGGTTAGCCTTGTAGAGAAGGTTCAAAGCGTTGTTGACAAAGAAGAGGCTATTAAGCTTGAG
GAAAAAATTAATAAAGCTAGTTTTAATTTTGAAGACTATCTAAGTCAATTTAAGCGCATGAGGCAAATAGGGGGGGTTTC
TAATTTTGTAAGTTTTTTACCAGGTGTTTCAAAATCAATGTTGAATATCAATAATTTAACCGAAGAAAGTTTTAACAAAG
AAGAGGCTATTATTCTTTCTATGACTAAAAAAGAAAGAATAAATCCAGTTATTTTGAACAATCCCTCAAGGAAAAAAAGA
ATAGCTTTGGGTAGTGGAACAACTATTTTTGATGTTAATAAGCTTATAAAGAAGTTTAGTCAAACAACTTTAATTATGAA
AAAAATGAAAAATAAAGATTTTCAAAATAAGATTGCATCCCTTTTAGGGAAATAA

Upstream 100 bases:

>100_bases
TTAATAAATTTTATTTGACAGGAGGAGATATTGATTAATATTGCCTTTTTTTGTATCTTATATTTGATAAGATTATTTTT
GAGAATAAGGGTTGTTTTTA

Downstream 100 bases:

>100_bases
GGAGGAATAAATTTGAGTGTTAGGATAAGATTGAAGAGAATGGGTGCTAAAAAAAGACCTTATTATAGGATTGTAGTTAT
GAATTCTGCTTCTCCTAGAG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MLESLGSNFKNFINYLSGKSTINDKNISEAIEIIKNSLVDADVNLRVIRRFLNSIIEESKGVKVLRGVDPKSQFIKIVND
NLVKFLGGKSYELGLHPVNKQSYILMLGLQGSGKTTTCAKLSLKLKKENRKVLLVAADTFRAAAIEQLKILGSQIGVPVF
SLTGEKDPIKIVKASIKFAESEFFDSVIVDTRGRLEVESLLVEEIKKIKDILKPTETILVVDSMMGQVAVNIAKEFNENV
GLTGAIFSKFDSDTRGGAVLSFKSICAVPIKFIGVGERVEDLDSFYPERIASRILGMGDVVSLVEKVQSVVDKEEAIKLE
EKINKASFNFEDYLSQFKRMRQIGGVSNFVSFLPGVSKSMLNINNLTEESFNKEEAIILSMTKKERINPVILNNPSRKKR
IALGSGTTIFDVNKLIKKFSQTTLIMKKMKNKDFQNKIASLLGK

Sequences:

>Translated_444_residues
MLESLGSNFKNFINYLSGKSTINDKNISEAIEIIKNSLVDADVNLRVIRRFLNSIIEESKGVKVLRGVDPKSQFIKIVND
NLVKFLGGKSYELGLHPVNKQSYILMLGLQGSGKTTTCAKLSLKLKKENRKVLLVAADTFRAAAIEQLKILGSQIGVPVF
SLTGEKDPIKIVKASIKFAESEFFDSVIVDTRGRLEVESLLVEEIKKIKDILKPTETILVVDSMMGQVAVNIAKEFNENV
GLTGAIFSKFDSDTRGGAVLSFKSICAVPIKFIGVGERVEDLDSFYPERIASRILGMGDVVSLVEKVQSVVDKEEAIKLE
EKINKASFNFEDYLSQFKRMRQIGGVSNFVSFLPGVSKSMLNINNLTEESFNKEEAIILSMTKKERINPVILNNPSRKKR
IALGSGTTIFDVNKLIKKFSQTTLIMKKMKNKDFQNKIASLLGK
>Mature_444_residues
MLESLGSNFKNFINYLSGKSTINDKNISEAIEIIKNSLVDADVNLRVIRRFLNSIIEESKGVKVLRGVDPKSQFIKIVND
NLVKFLGGKSYELGLHPVNKQSYILMLGLQGSGKTTTCAKLSLKLKKENRKVLLVAADTFRAAAIEQLKILGSQIGVPVF
SLTGEKDPIKIVKASIKFAESEFFDSVIVDTRGRLEVESLLVEEIKKIKDILKPTETILVVDSMMGQVAVNIAKEFNENV
GLTGAIFSKFDSDTRGGAVLSFKSICAVPIKFIGVGERVEDLDSFYPERIASRILGMGDVVSLVEKVQSVVDKEEAIKLE
EKINKASFNFEDYLSQFKRMRQIGGVSNFVSFLPGVSKSMLNINNLTEESFNKEEAIILSMTKKERINPVILNNPSRKKR
IALGSGTTIFDVNKLIKKFSQTTLIMKKMKNKDFQNKIASLLGK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=438, Percent_Identity=30.5936073059361, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI226371618, Length=338, Percent_Identity=33.7278106508876, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=34.375, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI23308697, Length=221, Percent_Identity=29.4117647058824, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI295424842, Length=221, Percent_Identity=29.4117647058824, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1788963, Length=422, Percent_Identity=41.9431279620853, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1789874, Length=188, Percent_Identity=42.5531914893617, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=442, Percent_Identity=28.0542986425339, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI193206261, Length=296, Percent_Identity=28.3783783783784, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=404, Percent_Identity=34.9009900990099, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6320498, Length=208, Percent_Identity=32.6923076923077, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17647949, Length=439, Percent_Identity=30.9794988610478, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24641198, Length=318, Percent_Identity=25.7861635220126, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49331; Mature: 49331

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLESLGSNFKNFINYLSGKSTINDKNISEAIEIIKNSLVDADVNLRVIRRFLNSIIEESK
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
GVKVLRGVDPKSQFIKIVNDNLVKFLGGKSYELGLHPVNKQSYILMLGLQGSGKTTTCAK
CCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCCCEEEH
LSLKLKKENRKVLLVAADTFRAAAIEQLKILGSQIGVPVFSLTGEKDPIKIVKASIKFAE
EEEEEECCCCEEEEEEECHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHH
SEFFDSVIVDTRGRLEVESLLVEEIKKIKDILKPTETILVVDSMMGQVAVNIAKEFNENV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHEEHHHHHHHHHHHHHHHHHCCCC
GLTGAIFSKFDSDTRGGAVLSFKSICAVPIKFIGVGERVEDLDSFYPERIASRILGMGDV
CCHHHHHHHCCCCCCCCEEEEHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCCCHHH
VSLVEKVQSVVDKEEAIKLEEKINKASFNFEDYLSQFKRMRQIGGVSNFVSFLPGVSKSM
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHH
LNINNLTEESFNKEEAIILSMTKKERINPVILNNPSRKKRIALGSGTTIFDVNKLIKKFS
HHHHHHHHHHCCCCCEEEEEECHHHCCCCEEECCCCCCCEEEECCCCEEHHHHHHHHHHH
QTTLIMKKMKNKDFQNKIASLLGK
HHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure
MLESLGSNFKNFINYLSGKSTINDKNISEAIEIIKNSLVDADVNLRVIRRFLNSIIEESK
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
GVKVLRGVDPKSQFIKIVNDNLVKFLGGKSYELGLHPVNKQSYILMLGLQGSGKTTTCAK
CCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCCCEEEH
LSLKLKKENRKVLLVAADTFRAAAIEQLKILGSQIGVPVFSLTGEKDPIKIVKASIKFAE
EEEEEECCCCEEEEEEECHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHH
SEFFDSVIVDTRGRLEVESLLVEEIKKIKDILKPTETILVVDSMMGQVAVNIAKEFNENV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHEEHHHHHHHHHHHHHHHHHCCCC
GLTGAIFSKFDSDTRGGAVLSFKSICAVPIKFIGVGERVEDLDSFYPERIASRILGMGDV
CCHHHHHHHCCCCCCCCEEEEHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCCCHHH
VSLVEKVQSVVDKEEAIKLEEKINKASFNFEDYLSQFKRMRQIGGVSNFVSFLPGVSKSM
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHH
LNINNLTEESFNKEEAIILSMTKKERINPVILNNPSRKKRIALGSGTTIFDVNKLIKKFS
HHHHHHHHHHCCCCCEEEEEECHHHCCCCEEECCCCCCCEEEECCCCEEHHHHHHHHHHH
QTTLIMKKMKNKDFQNKIASLLGK
HHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]