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The map label for this gene is glyA [H]

Identifier: 51598854

GI number: 51598854

Start: 626934

End: 628187

Strand: Direct

Name: glyA [H]

Synonym: BG0614

Alternate gene names: 51598854

Gene position: 626934-628187 (Clockwise)

Preceding gene: 51598853

Following gene: 51598855

Centisome position: 69.33

GC content: 33.49

Gene sequence:

>1254_bases
ATGAGAGATGATCAAATATTTAATTTAATTGAGAAAGAGAAATTAAGAGAAAAAGAACATATTAAGCTTATTGCATCTGA
AAATTTTACATCTTTAGAGATAAGGCAAGCTGTTGGGAGTATTTTAACTAATAAATATGCGGAAGGATACCCTTTGAATC
GATATTATGGTGGATGTTCTTTTGTTGATGAGATTGAAAGTTTAGCAATTTTAAGGGCAAAAGAGCTTTTTGGTGCAAAG
TATGCCAATGTTCAGCCTCATAGCGGATCTCAGGCTAATATGGCTGCTATAATGGCTCTTATTAACCCTGGTGACAGGAT
TCTTGGTATGCAATTGTCTCATGGAGGGCATTTAACACATGGTAGTAGGGTAAATTTTTCTGGCATATTTTTTAACACTT
ATTTTTATGGCGTTTCTAGAGATTCTGAGTTGATTGATTATGATGAGGTTCTTAAAATAGCTAGAGATTGTAGACCAAAT
TTAATAATAGCTGGAGCTTCTTCTTATTCAAGAGAAATTGATTTTAAAAAATTTAGGGAAATAGCAGACGATGTTTCTGC
TTATCTTTTGTGTGATATTGCCCATATTGCGGGCCTTATTGTTGCCGGTTTTCATAATTCTTCGATTGATGTAGCACATC
TTACTACAAGTACTACCCATAAAACTTTAAGAGGGCCAAGAGGTGGAATAATACTTTCTGGAAAAGATTTTGACAAATTG
GTAACCTTTAATGGAAAAGAGAAAGCTTTGTTTAATGCTGTAAATTCTACAGTTTTCCCCGGCACTCAAGGAGGTCCTTT
AGTTCATGTTATTGCAGGGAAGGCTATTGCATTCAGAGAGGCTCTTCAAGAAAGTTTTAGAGAATACATTGCTAACGTAA
TAAAAAATACTAAAGTTATGGCTGAATATTTCAAATCGGAAGGATTTAGGATTGTCAGTGGAGGTACAGACAATCATTTA
TTTTTGGTTGATCTTAGTAATTTGGATCTTACAGGTGCCGATGCTGAGAAATTGCTTGAGGGTGTAAATATTACTTTAAA
TAAAAATGCCATTCCTTTTGATAAAAAAAGTCCTTCTTTAGCTTCTGGTATTAGAATTGGAGGCGCTGCTATTACTTCCA
GAGGTTTAAATGAAAATGATTCTTTAAATGTTGCTAAATTTATTGTTAGAGCTTTAAAGACAAGGTCTGACATCGAATTA
AAACAAATCAAAAAGGAAGTTGTAAGATTTATTAGAGATTTTGACATGCCTTAA

Upstream 100 bases:

>100_bases
TTTTTGATGGATACCTAGATTCTAGGTTTTTGAAGTATAAAAGCTTGACAAACGGATCGTATTCTTTAATGCATAGGTTT
GTTTTGGAGGATAATTTTTG

Downstream 100 bases:

>100_bases
TTATGTTTGGAGGTTATGATCAATAAATGCCAAGCTTAATTAGAACGTTTTTTTTAGTGTTGCTACTTATTTTCATTTTT
AATCCCATTTTAATAGGAAT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MRDDQIFNLIEKEKLREKEHIKLIASENFTSLEIRQAVGSILTNKYAEGYPLNRYYGGCSFVDEIESLAILRAKELFGAK
YANVQPHSGSQANMAAIMALINPGDRILGMQLSHGGHLTHGSRVNFSGIFFNTYFYGVSRDSELIDYDEVLKIARDCRPN
LIIAGASSYSREIDFKKFREIADDVSAYLLCDIAHIAGLIVAGFHNSSIDVAHLTTSTTHKTLRGPRGGIILSGKDFDKL
VTFNGKEKALFNAVNSTVFPGTQGGPLVHVIAGKAIAFREALQESFREYIANVIKNTKVMAEYFKSEGFRIVSGGTDNHL
FLVDLSNLDLTGADAEKLLEGVNITLNKNAIPFDKKSPSLASGIRIGGAAITSRGLNENDSLNVAKFIVRALKTRSDIEL
KQIKKEVVRFIRDFDMP

Sequences:

>Translated_417_residues
MRDDQIFNLIEKEKLREKEHIKLIASENFTSLEIRQAVGSILTNKYAEGYPLNRYYGGCSFVDEIESLAILRAKELFGAK
YANVQPHSGSQANMAAIMALINPGDRILGMQLSHGGHLTHGSRVNFSGIFFNTYFYGVSRDSELIDYDEVLKIARDCRPN
LIIAGASSYSREIDFKKFREIADDVSAYLLCDIAHIAGLIVAGFHNSSIDVAHLTTSTTHKTLRGPRGGIILSGKDFDKL
VTFNGKEKALFNAVNSTVFPGTQGGPLVHVIAGKAIAFREALQESFREYIANVIKNTKVMAEYFKSEGFRIVSGGTDNHL
FLVDLSNLDLTGADAEKLLEGVNITLNKNAIPFDKKSPSLASGIRIGGAAITSRGLNENDSLNVAKFIVRALKTRSDIEL
KQIKKEVVRFIRDFDMP
>Mature_417_residues
MRDDQIFNLIEKEKLREKEHIKLIASENFTSLEIRQAVGSILTNKYAEGYPLNRYYGGCSFVDEIESLAILRAKELFGAK
YANVQPHSGSQANMAAIMALINPGDRILGMQLSHGGHLTHGSRVNFSGIFFNTYFYGVSRDSELIDYDEVLKIARDCRPN
LIIAGASSYSREIDFKKFREIADDVSAYLLCDIAHIAGLIVAGFHNSSIDVAHLTTSTTHKTLRGPRGGIILSGKDFDKL
VTFNGKEKALFNAVNSTVFPGTQGGPLVHVIAGKAIAFREALQESFREYIANVIKNTKVMAEYFKSEGFRIVSGGTDNHL
FLVDLSNLDLTGADAEKLLEGVNITLNKNAIPFDKKSPSLASGIRIGGAAITSRGLNENDSLNVAKFIVRALKTRSDIEL
KQIKKEVVRFIRDFDMP

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=448, Percent_Identity=42.6339285714286, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI261862350, Length=448, Percent_Identity=42.6339285714286, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI261862348, Length=448, Percent_Identity=42.6339285714286, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI19923315, Length=448, Percent_Identity=42.6339285714286, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI22547186, Length=420, Percent_Identity=44.5238095238095, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI261862346, Length=448, Percent_Identity=41.7410714285714, Blast_Score=322, Evalue=4e-88,
Organism=Homo sapiens, GI22547189, Length=417, Percent_Identity=40.5275779376499, Blast_Score=281, Evalue=1e-75,
Organism=Escherichia coli, GI1788902, Length=395, Percent_Identity=53.9240506329114, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI25144732, Length=429, Percent_Identity=43.1235431235431, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI25144729, Length=429, Percent_Identity=43.1235431235431, Blast_Score=332, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6319739, Length=409, Percent_Identity=43.2762836185819, Blast_Score=335, Evalue=9e-93,
Organism=Saccharomyces cerevisiae, GI6323087, Length=423, Percent_Identity=41.8439716312057, Blast_Score=324, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24640005, Length=451, Percent_Identity=43.4589800443459, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221329721, Length=451, Percent_Identity=43.4589800443459, Blast_Score=360, Evalue=1e-99,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46031; Mature: 46031

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDDQIFNLIEKEKLREKEHIKLIASENFTSLEIRQAVGSILTNKYAEGYPLNRYYGGCS
CCCHHHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCH
FVDEIESLAILRAKELFGAKYANVQPHSGSQANMAAIMALINPGDRILGMQLSHGGHLTH
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHEEECCCCEEEEEEECCCCCCCC
GSRVNFSGIFFNTYFYGVSRDSELIDYDEVLKIARDCRPNLIIAGASSYSREIDFKKFRE
CCEEEEEEEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHH
IADDVSAYLLCDIAHIAGLIVAGFHNSSIDVAHLTTSTTHKTLRGPRGGIILSGKDFDKL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHCCCCCCEEECCCCCCCE
VTFNGKEKALFNAVNSTVFPGTQGGPLVHVIAGKAIAFREALQESFREYIANVIKNTKVM
EEECCCHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AEYFKSEGFRIVSGGTDNHLFLVDLSNLDLTGADAEKLLEGVNITLNKNAIPFDKKSPSL
HHHHHCCCCEEEECCCCCEEEEEECCCCCCCCCCHHHHHCCCCEEECCCCCCCCCCCCCH
ASGIRIGGAAITSRGLNENDSLNVAKFIVRALKTRSDIELKQIKKEVVRFIRDFDMP
HHCCEECCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRDDQIFNLIEKEKLREKEHIKLIASENFTSLEIRQAVGSILTNKYAEGYPLNRYYGGCS
CCCHHHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCH
FVDEIESLAILRAKELFGAKYANVQPHSGSQANMAAIMALINPGDRILGMQLSHGGHLTH
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHEEECCCCEEEEEEECCCCCCCC
GSRVNFSGIFFNTYFYGVSRDSELIDYDEVLKIARDCRPNLIIAGASSYSREIDFKKFRE
CCEEEEEEEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHH
IADDVSAYLLCDIAHIAGLIVAGFHNSSIDVAHLTTSTTHKTLRGPRGGIILSGKDFDKL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHCCCCCCEEECCCCCCCE
VTFNGKEKALFNAVNSTVFPGTQGGPLVHVIAGKAIAFREALQESFREYIANVIKNTKVM
EEECCCHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AEYFKSEGFRIVSGGTDNHLFLVDLSNLDLTGADAEKLLEGVNITLNKNAIPFDKKSPSL
HHHHHCCCCEEEECCCCCEEEEEECCCCCCCCCCHHHHHCCCCEEECCCCCCCCCCCCCH
ASGIRIGGAAITSRGLNENDSLNVAKFIVRALKTRSDIELKQIKKEVVRFIRDFDMP
HHCCEECCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA