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The map label for this gene is fmt

Identifier: 51597956

GI number: 51597956

Start: 4378265

End: 4379212

Strand: Direct

Name: fmt

Synonym: YPTB3666

Alternate gene names: 51597956

Gene position: 4378265-4379212 (Clockwise)

Preceding gene: 51597955

Following gene: 51597957

Centisome position: 92.28

GC content: 47.05

Gene sequence:

>948_bases
GTGTCTGATTCTTTGCGGATTATTTTTGCCGGAACTCCTGATTTTGCAGCGCGCCATTTAGGCGCGTTGCTCTCTTCTCA
ACATAAGATTGTTGGTGTGTTCACTCAACCAGACCGCCCGGCTGGCCGAGGTAATAAACTCACCCCCAGCCCAGTTAAAA
TATTGGCAGAACACCACGGCATCCCTGTTTTTCAGCCCAAGTCATTAAGACCTGAAGAGAACCAACATTTAGTTGCCGAC
CTCAATGCTGACATCATGGTCGTAGTGGCTTATGGCTTAATACTACCTGCAGCGGTGTTAGCGATGCCACGTTTAGGCTG
CATCAATGTTCATGGTTCGTTACTCCCACGTTGGCGTGGTGCAGCACCGATCCAACGTTCAGTATGGGCGGGTGACGAAA
AAACGGGGATTACTATCATGCAGATGGATATCGGGTTAGATACCGGTGCTATGCTGCATAAAATTGAATGTGCCATTCAA
CCAGAAGATACCAGTGCGACACTGTATGATAAATTAGCACAATTGGGGCCTCAAGGGCTGTTGATAACATTACAACAGCT
AGCCGCAGGCACAGCCCTAGCAGAAGTTCAAAATGAAACACAAGCAACCTATGCGGAGAAGCTAAGTAAAGAGGAAGCCA
AATTAGATTGGACACTTTCTGCAACTCAGTTAGAACGCTGTATCCGTGCATTTAACCCTTGGCCTGTCAGCTATTTTATT
GTTGATGAACAGCCAATCAAAGTTTGGCAAGCGCAGGTACTCCCTGCTGGCGAGGATGCAGAACCAGGCACCATTATCCA
TGCAGATAAGCATGGTATCCAAGTTGCAACTGCTGATGGCGTTTTGAATATCACACAACTCCAGCCTGCAGGGAAAAAAG
CAATGTCAGCCGCTGACTTATTAAACTCTCGGCGAGAATGGTTTATACCAGGTAGTCAACTAGTGTAA

Upstream 100 bases:

>100_bases
TCTGTCACCACTCAAGCGTCAGCGTATCCGCCAAAAGCTGGAGAAAATGGCCAAGCTCAATGCCCGCGCCAACTAAACTT
TTCTAACGCAGGAAACCAAC

Downstream 100 bases:

>100_bases
TCGTTCGGCTCCAATAATACCTTTCATCGCCCAATACTTCGTCATTGGGCTACTTCTCCCTTTATTTGCTGGCGTTTGTC
AGCTTTTTTGGTTATGAAAA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSDSLRIIFAGTPDFAARHLGALLSSQHKIVGVFTQPDRPAGRGNKLTPSPVKILAEHHGIPVFQPKSLRPEENQHLVAD
LNADIMVVVAYGLILPAAVLAMPRLGCINVHGSLLPRWRGAAPIQRSVWAGDEKTGITIMQMDIGLDTGAMLHKIECAIQ
PEDTSATLYDKLAQLGPQGLLITLQQLAAGTALAEVQNETQATYAEKLSKEEAKLDWTLSATQLERCIRAFNPWPVSYFI
VDEQPIKVWQAQVLPAGEDAEPGTIIHADKHGIQVATADGVLNITQLQPAGKKAMSAADLLNSRREWFIPGSQLV

Sequences:

>Translated_315_residues
MSDSLRIIFAGTPDFAARHLGALLSSQHKIVGVFTQPDRPAGRGNKLTPSPVKILAEHHGIPVFQPKSLRPEENQHLVAD
LNADIMVVVAYGLILPAAVLAMPRLGCINVHGSLLPRWRGAAPIQRSVWAGDEKTGITIMQMDIGLDTGAMLHKIECAIQ
PEDTSATLYDKLAQLGPQGLLITLQQLAAGTALAEVQNETQATYAEKLSKEEAKLDWTLSATQLERCIRAFNPWPVSYFI
VDEQPIKVWQAQVLPAGEDAEPGTIIHADKHGIQVATADGVLNITQLQPAGKKAMSAADLLNSRREWFIPGSQLV
>Mature_314_residues
SDSLRIIFAGTPDFAARHLGALLSSQHKIVGVFTQPDRPAGRGNKLTPSPVKILAEHHGIPVFQPKSLRPEENQHLVADL
NADIMVVVAYGLILPAAVLAMPRLGCINVHGSLLPRWRGAAPIQRSVWAGDEKTGITIMQMDIGLDTGAMLHKIECAIQP
EDTSATLYDKLAQLGPQGLLITLQQLAAGTALAEVQNETQATYAEKLSKEEAKLDWTLSATQLERCIRAFNPWPVSYFIV
DEQPIKVWQAQVLPAGEDAEPGTIIHADKHGIQVATADGVLNITQLQPAGKKAMSAADLLNSRREWFIPGSQLV

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=259, Percent_Identity=32.046332046332, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI238814322, Length=322, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI164663775, Length=336, Percent_Identity=27.9761904761905, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1789683, Length=315, Percent_Identity=75.8730158730159, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1788589, Length=295, Percent_Identity=30.8474576271186, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI133930964, Length=322, Percent_Identity=28.2608695652174, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319458, Length=167, Percent_Identity=32.3353293413174, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550868, Length=305, Percent_Identity=29.5081967213115, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI28571984, Length=227, Percent_Identity=31.2775330396476, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24585660, Length=334, Percent_Identity=29.3413173652695, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_YERP3 (A7FNK3)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001402831.1
- ProteinModelPortal:   A7FNK3
- SMR:   A7FNK3
- STRING:   A7FNK3
- GeneID:   5384364
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_3883
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- ProtClustDB:   PRK00005
- BioCyc:   YPSE349747:YPSIP31758_3883-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 34141; Mature: 34010

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSLRIIFAGTPDFAARHLGALLSSQHKIVGVFTQPDRPAGRGNKLTPSPVKILAEHHG
CCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCC
IPVFQPKSLRPEENQHLVADLNADIMVVVAYGLILPAAVLAMPRLGCINVHGSLLPRWRG
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCC
AAPIQRSVWAGDEKTGITIMQMDIGLDTGAMLHKIECAIQPEDTSATLYDKLAQLGPQGL
CCCCHHHHCCCCCCCCEEEEEEECCCCCCHHEEEEEEEECCCCCCHHHHHHHHHHCCCCC
LITLQQLAAGTALAEVQNETQATYAEKLSKEEAKLDWTLSATQLERCIRAFNPWPVSYFI
EEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHCCCCCEEEEE
VDEQPIKVWQAQVLPAGEDAEPGTIIHADKHGIQVATADGVLNITQLQPAGKKAMSAADL
ECCCCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEECCCEEEEEECCCCCHHHHHHHHH
LNSRREWFIPGSQLV
HHCCCEEECCCCCCC
>Mature Secondary Structure 
SDSLRIIFAGTPDFAARHLGALLSSQHKIVGVFTQPDRPAGRGNKLTPSPVKILAEHHG
CCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCC
IPVFQPKSLRPEENQHLVADLNADIMVVVAYGLILPAAVLAMPRLGCINVHGSLLPRWRG
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCC
AAPIQRSVWAGDEKTGITIMQMDIGLDTGAMLHKIECAIQPEDTSATLYDKLAQLGPQGL
CCCCHHHHCCCCCCCCEEEEEEECCCCCCHHEEEEEEEECCCCCCHHHHHHHHHHCCCCC
LITLQQLAAGTALAEVQNETQATYAEKLSKEEAKLDWTLSATQLERCIRAFNPWPVSYFI
EEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHCCCCCEEEEE
VDEQPIKVWQAQVLPAGEDAEPGTIIHADKHGIQVATADGVLNITQLQPAGKKAMSAADL
ECCCCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEECCCEEEEEECCCCCHHHHHHHHH
LNSRREWFIPGSQLV
HHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA