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The map label for this gene is iclR [H]

Identifier: 51597944

GI number: 51597944

Start: 4359638

End: 4360480

Strand: Direct

Name: iclR [H]

Synonym: YPTB3654

Alternate gene names: 51597944

Gene position: 4359638-4360480 (Clockwise)

Preceding gene: 51597942

Following gene: 51597949

Centisome position: 91.88

GC content: 52.67

Gene sequence:

>843_bases
ATGGCGTTACCGATTCCGATTAAACGGGGAAAGAAACCCAAGGCAGCCACACAGAATACACCTGCAGCAACGGGCCAAGT
TCAATCATTGACTCGCGGCCTTAAATTGCTGGAATATATTTCCGAATCTGATGGGAACGTCGCCCTGACTGATTTAGCCC
AACAGGCGGGATTACCCAATTCGACCACCCACCGTTTACTCACGACCATGCAACAGCAGGGTTTTGTTCGTCAGGTCGGC
GATTTAGGGCTATGGACCATGGGGGCCCACGCCTTTATTGTCGGGAGCAGTTTCCTGCAAAGCCGTAATTTACTGGCGAT
GGTCCACCCAATGTTACGCCGTTTAATGGATGAATCTGGCGAAACCGTCAATTTGGCGGTACTCGATCACAGCGATTACC
AGGCAATAATTATCGATCAAGTGCAATGTACCGCGCTGATGCGGATGTCCGCACCAATTGGAGGCAAGCTCCCCATGCAT
GCCTCCGGGGCAGGCAAAGCCTTTCTCTCCACCCTGCCGGACGATCAACTGGTTCAGTTGTTACATAAAAAGGGGTTGCA
CGCTTACACCCAGCACACCCGTACCAATCCAACCAGCCTGAAAGAAAATCTAGCGCTGATCCGCAAGCAAGGTTATTCAT
TTGATGATGAAGAGCACGCCCTCGGCCTACGTTGTATCGCCGCCTGCTTGTTCGATGAGCACCACGAAGCCTTCGCCGCG
ATTTCTATCTCCGGCCCAATATCACGGATCACCGACGATCGCGTCACCGAGCTGGGTGCACTGGTTATCCACGCGGCGAA
AGAGATTACCCAATCTTACGGTGGGGGAACCGGGGTTAAATAA

Upstream 100 bases:

>100_bases
AGGTAGAAAAGTCGACTCATCGGATGAGTATTTTTAGCGGTTTACATGCATAATTGAAAAACGAAAATGAATTCCATAAA
AATATTTGAGGGGCTGATTT

Downstream 100 bases:

>100_bases
TAGAATGAAAAATAAAGGAAAAATTTGTCGTTCGGCGAGAACAGGCCGATCGTAAAGACGCGATAAATAGAGGCGTAGCG
AGCTACGTTAATCTGAGTAC

Product: transcriptional repressor IclR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MALPIPIKRGKKPKAATQNTPAATGQVQSLTRGLKLLEYISESDGNVALTDLAQQAGLPNSTTHRLLTTMQQQGFVRQVG
DLGLWTMGAHAFIVGSSFLQSRNLLAMVHPMLRRLMDESGETVNLAVLDHSDYQAIIIDQVQCTALMRMSAPIGGKLPMH
ASGAGKAFLSTLPDDQLVQLLHKKGLHAYTQHTRTNPTSLKENLALIRKQGYSFDDEEHALGLRCIAACLFDEHHEAFAA
ISISGPISRITDDRVTELGALVIHAAKEITQSYGGGTGVK

Sequences:

>Translated_280_residues
MALPIPIKRGKKPKAATQNTPAATGQVQSLTRGLKLLEYISESDGNVALTDLAQQAGLPNSTTHRLLTTMQQQGFVRQVG
DLGLWTMGAHAFIVGSSFLQSRNLLAMVHPMLRRLMDESGETVNLAVLDHSDYQAIIIDQVQCTALMRMSAPIGGKLPMH
ASGAGKAFLSTLPDDQLVQLLHKKGLHAYTQHTRTNPTSLKENLALIRKQGYSFDDEEHALGLRCIAACLFDEHHEAFAA
ISISGPISRITDDRVTELGALVIHAAKEITQSYGGGTGVK
>Mature_279_residues
ALPIPIKRGKKPKAATQNTPAATGQVQSLTRGLKLLEYISESDGNVALTDLAQQAGLPNSTTHRLLTTMQQQGFVRQVGD
LGLWTMGAHAFIVGSSFLQSRNLLAMVHPMLRRLMDESGETVNLAVLDHSDYQAIIIDQVQCTALMRMSAPIGGKLPMHA
SGAGKAFLSTLPDDQLVQLLHKKGLHAYTQHTRTNPTSLKENLALIRKQGYSFDDEEHALGLRCIAACLFDEHHEAFAAI
SISGPISRITDDRVTELGALVIHAAKEITQSYGGGTGVK

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=275, Percent_Identity=78.1818181818182, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1786715, Length=268, Percent_Identity=39.9253731343284, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1788131, Length=248, Percent_Identity=29.8387096774194, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789999, Length=244, Percent_Identity=33.1967213114754, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786468, Length=226, Percent_Identity=29.2035398230088, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788581, Length=257, Percent_Identity=28.7937743190661, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790752, Length=251, Percent_Identity=25.8964143426295, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30269; Mature: 30138

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALPIPIKRGKKPKAATQNTPAATGQVQSLTRGLKLLEYISESDGNVALTDLAQQAGLPN
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCC
STTHRLLTTMQQQGFVRQVGDLGLWTMGAHAFIVGSSFLQSRNLLAMVHPMLRRLMDESG
CHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHEEHHHHHHHHCCHHHHHHHHHHHHHHCCC
ETVNLAVLDHSDYQAIIIDQVQCTALMRMSAPIGGKLPMHASGAGKAFLSTLPDDQLVQL
CEEEEEEEECCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHH
LHKKGLHAYTQHTRTNPTSLKENLALIRKQGYSFDDEEHALGLRCIAACLFDEHHEAFAA
HHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEE
ISISGPISRITDDRVTELGALVIHAAKEITQSYGGGTGVK
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ALPIPIKRGKKPKAATQNTPAATGQVQSLTRGLKLLEYISESDGNVALTDLAQQAGLPN
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCC
STTHRLLTTMQQQGFVRQVGDLGLWTMGAHAFIVGSSFLQSRNLLAMVHPMLRRLMDESG
CHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHEEHHHHHHHHCCHHHHHHHHHHHHHHCCC
ETVNLAVLDHSDYQAIIIDQVQCTALMRMSAPIGGKLPMHASGAGKAFLSTLPDDQLVQL
CEEEEEEEECCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHH
LHKKGLHAYTQHTRTNPTSLKENLALIRKQGYSFDDEEHALGLRCIAACLFDEHHEAFAA
HHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEE
ISISGPISRITDDRVTELGALVIHAAKEITQSYGGGTGVK
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]