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The map label for this gene is cysC

Identifier: 51595117

GI number: 51595117

Start: 924095

End: 924736

Strand: Direct

Name: cysC

Synonym: YPTB0767

Alternate gene names: 51595117

Gene position: 924095-924736 (Clockwise)

Preceding gene: 51595116

Following gene: 51595118

Centisome position: 19.48

GC content: 50.16

Gene sequence:

>642_bases
GTGCCAGCCCATCAGTTAGATGACCATAACCAAGAAACGCGGTCAGACGATGAGAATATCGTCTGGCACCCCCATGCGAT
CACCCGACAGGATCGCGAACAACAGCACGGTCATCAGGGCGTAGTTCTTTGGTTTACCGGCCTGTCGGGTTCCGGGAAAT
CCACTCTGGCCGGTGCGCTGGAACAAGCGTTGTTCGCTCGCGGTGTCAGTACTTACTTACTGGATGGTGATAACGTGCGC
CATGGCCTCTGCCGCGATTTGGGCTTTTCTGACGCTGATCGTCGTGAAAATATCCGGCGGGTTGGCGAGGTGGCTAAACT
GATGGTTGATGCCGGTCTGGTGGTCTTGACGGCGTTTATTTCCCCTCATCGGGCTGAACGGAAAATGGTACAAGATATGC
TGGCATCGGGTCAGTTTATTGAGGTATTTGTCGATACGCCGTTAGCAATTTGTGAGGCCCGTGACCCGAAAGGCTTATAC
AAAAAAGCCCGTGCCGGAGAGCTTAAAAATTTTACAGGGATCGATTCAGTTTATGAATCGCCTGCGTCTCCTGATATCCA
TTTGCAGGGTGAACAATTAGTAACAAATTTGATTGAACAATTGTTAGACGTACTGCGTGGTAGAGCTATTATCAAATCCT
AA

Upstream 100 bases:

>100_bases
GAGAATCATGACTTCAGTACCTTTGAGCTGGAATTAAATGCCTTGGTTCGCCGTCATTTCCCACATTGGGGTGCGCGTGA
TCTGCTGGGGGGTAAATAGC

Downstream 100 bases:

>100_bases
ACGTATCCCCTTCGCACTTGACGCTACAGGGTCGTTCGCTGCAGGTATTCACTCGAATCACTGACGTTGTCAGCTCGCCG
TGATTTATTTGCAGCCTACC

Product: adenylylsulfate kinase

Products: NA

Alternate protein names: APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MPAHQLDDHNQETRSDDENIVWHPHAITRQDREQQHGHQGVVLWFTGLSGSGKSTLAGALEQALFARGVSTYLLDGDNVR
HGLCRDLGFSDADRRENIRRVGEVAKLMVDAGLVVLTAFISPHRAERKMVQDMLASGQFIEVFVDTPLAICEARDPKGLY
KKARAGELKNFTGIDSVYESPASPDIHLQGEQLVTNLIEQLLDVLRGRAIIKS

Sequences:

>Translated_213_residues
MPAHQLDDHNQETRSDDENIVWHPHAITRQDREQQHGHQGVVLWFTGLSGSGKSTLAGALEQALFARGVSTYLLDGDNVR
HGLCRDLGFSDADRRENIRRVGEVAKLMVDAGLVVLTAFISPHRAERKMVQDMLASGQFIEVFVDTPLAICEARDPKGLY
KKARAGELKNFTGIDSVYESPASPDIHLQGEQLVTNLIEQLLDVLRGRAIIKS
>Mature_212_residues
PAHQLDDHNQETRSDDENIVWHPHAITRQDREQQHGHQGVVLWFTGLSGSGKSTLAGALEQALFARGVSTYLLDGDNVRH
GLCRDLGFSDADRRENIRRVGEVAKLMVDAGLVVLTAFISPHRAERKMVQDMLASGQFIEVFVDTPLAICEARDPKGLYK
KARAGELKNFTGIDSVYESPASPDIHLQGEQLVTNLIEQLLDVLRGRAIIKS

Specific function: Catalyzes the synthesis of activated sulfate

COG id: COG0529

COG function: function code P; Adenylylsulfate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the APS kinase family

Homologues:

Organism=Homo sapiens, GI34447231, Length=213, Percent_Identity=46.9483568075117, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI62912492, Length=213, Percent_Identity=46.9483568075117, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI46094058, Length=200, Percent_Identity=49, Blast_Score=199, Evalue=2e-51,
Organism=Escherichia coli, GI1789107, Length=197, Percent_Identity=80.2030456852792, Blast_Score=332, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17542422, Length=200, Percent_Identity=49, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6322852, Length=176, Percent_Identity=52.2727272727273, Blast_Score=199, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24667040, Length=174, Percent_Identity=50, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24667032, Length=174, Percent_Identity=50, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24667028, Length=174, Percent_Identity=50, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24667036, Length=174, Percent_Identity=50, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI116007838, Length=174, Percent_Identity=50, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24667044, Length=174, Percent_Identity=50, Blast_Score=178, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSC_YERPE (Q8ZBP3)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AF0408
- RefSeq:   NP_668159.1
- RefSeq:   NP_991719.1
- RefSeq:   YP_002348257.1
- ProteinModelPortal:   Q8ZBP3
- SMR:   Q8ZBP3
- GeneID:   1145772
- GeneID:   1176181
- GeneID:   2763856
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO3364
- KEGG:   ypk:y0825
- KEGG:   ypm:YP_0323
- HOGENOM:   HBG309946
- OMA:   ITITAFV
- ProtClustDB:   PRK03846
- BioCyc:   YPES187410:Y0825-MONOMER
- BioCyc:   YPES214092:YPO3364-MONOMER
- BRENDA:   2.7.1.25
- HAMAP:   MF_00065
- InterPro:   IPR002891
- TIGRFAMs:   TIGR00455

Pfam domain/function: PF01583 APS_kinase

EC number: =2.7.1.25

Molecular weight: Translated: 23632; Mature: 23501

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: ACT_SITE 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAHQLDDHNQETRSDDENIVWHPHAITRQDREQQHGHQGVVLWFTGLSGSGKSTLAGAL
CCCCCCCCCCCHHCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHH
EQALFARGVSTYLLDGDNVRHGLCRDLGFSDADRRENIRRVGEVAKLMVDAGLVVLTAFI
HHHHHHHCCHHEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SPHRAERKMVQDMLASGQFIEVFVDTPLAICEARDPKGLYKKARAGELKNFTGIDSVYES
CCCHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHCC
PASPDIHLQGEQLVTNLIEQLLDVLRGRAIIKS
CCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PAHQLDDHNQETRSDDENIVWHPHAITRQDREQQHGHQGVVLWFTGLSGSGKSTLAGAL
CCCCCCCCCCHHCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHH
EQALFARGVSTYLLDGDNVRHGLCRDLGFSDADRRENIRRVGEVAKLMVDAGLVVLTAFI
HHHHHHHCCHHEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SPHRAERKMVQDMLASGQFIEVFVDTPLAICEARDPKGLYKKARAGELKNFTGIDSVYES
CCCHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHCC
PASPDIHLQGEQLVTNLIEQLLDVLRGRAIIKS
CCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430