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The map label for this gene is sugE

Identifier: 51594761

GI number: 51594761

Start: 487988

End: 488302

Strand: Direct

Name: sugE

Synonym: YPTB0409

Alternate gene names: 51594761

Gene position: 487988-488302 (Clockwise)

Preceding gene: 51594760

Following gene: 51594766

Centisome position: 10.28

GC content: 50.79

Gene sequence:

>315_bases
ATGGCTTGGATTATTCTGGTTATTGCAGGTTTATTAGAGGTTATTTGGGCTATTGGCCTGAAGTATTCTCATGGTTTTTC
GCGGCTGACGCCGAGCATTATTACCCTCGTCGCAATGGCTGCCAGTGTTTTTCTATTGGCCTATGCGATGAAAAGTTTGC
CAGCAGGCACGGCTTACGCGGTCTGGACCGGCATTGGTGCGGTAGGTACGGCCATTTTAGGCATTGTGCTACTGGGGGAA
TCGGCCAGTCTGGCGCGGATACTAAGCTTGGGGCTGATTCTGGCAGGGATTATCGGCTTGAAGTTGGCGTCATAA

Upstream 100 bases:

>100_bases
TGAGCATGATAATGTATCGCGCTTATCTCTCTGCTGGCTGGGACGACCCAGTTACGCATCTGTTTTTCGGGGACGGCCCC
GCCTGAGCGAGGTGGTTACC

Downstream 100 bases:

>100_bases
CGCTTGAGTTATAACGTTATGTGCCATAAGGGGGCTGCGCCCTTCGCCGGTTGGCCTACGGAGGTCAAATGAGTCGTAAA
ATTTGGGCAACCGAACTGAG

Product: quaternary ammonium compound-resistance protein SugE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MAWIILVIAGLLEVIWAIGLKYSHGFSRLTPSIITLVAMAASVFLLAYAMKSLPAGTAYAVWTGIGAVGTAILGIVLLGE
SASLARILSLGLILAGIIGLKLAS

Sequences:

>Translated_104_residues
MAWIILVIAGLLEVIWAIGLKYSHGFSRLTPSIITLVAMAASVFLLAYAMKSLPAGTAYAVWTGIGAVGTAILGIVLLGE
SASLARILSLGLILAGIIGLKLAS
>Mature_103_residues
AWIILVIAGLLEVIWAIGLKYSHGFSRLTPSIITLVAMAASVFLLAYAMKSLPAGTAYAVWTGIGAVGTAILGIVLLGES
ASLARILSLGLILAGIIGLKLAS

Specific function: Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. SugE (TC 2.A.7.1.4) subfamily

Homologues:

Organism=Escherichia coli, GI87082378, Length=104, Percent_Identity=75.9615384615385, Blast_Score=150, Evalue=2e-38,
Organism=Escherichia coli, GI1786755, Length=94, Percent_Identity=39.3617021276596, Blast_Score=65, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SUGE_YERPE (Q8D1E4)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AC0044
- RefSeq:   NP_667950.1
- RefSeq:   NP_991904.1
- RefSeq:   YP_002345433.1
- ProteinModelPortal:   Q8D1E4
- GeneID:   1145560
- GeneID:   1173200
- GeneID:   2766845
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO0355
- KEGG:   ypk:y0613
- KEGG:   ypm:YP_0511
- HOGENOM:   HBG740972
- OMA:   DMSWIIL
- BioCyc:   YPES187410:Y0613-MONOMER
- BioCyc:   YPES214092:YPO0355-MONOMER
- GO:   GO:0006810
- InterPro:   IPR000390

Pfam domain/function: PF00893 Multi_Drug_Res

EC number: NA

Molecular weight: Translated: 10651; Mature: 10520

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1872e4dc)-; HASH(0x18211d60)-; HASH(0x184e1ee8)-; HASH(0x18076f20)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWIILVIAGLLEVIWAIGLKYSHGFSRLTPSIITLVAMAASVFLLAYAMKSLPAGTAYA
CHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VWTGIGAVGTAILGIVLLGESASLARILSLGLILAGIIGLKLAS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
AWIILVIAGLLEVIWAIGLKYSHGFSRLTPSIITLVAMAASVFLLAYAMKSLPAGTAYA
HHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VWTGIGAVGTAILGIVLLGESASLARILSLGLILAGIIGLKLAS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430