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The map label for this gene is hmuR

Identifier: 51594695

GI number: 51594695

Start: 405228

End: 407258

Strand: Reverse

Name: hmuR

Synonym: YPTB0340

Alternate gene names: 51594695

Gene position: 407258-405228 (Counterclockwise)

Preceding gene: 51594696

Following gene: 51594694

Centisome position: 8.58

GC content: 50.81

Gene sequence:

>2031_bases
ATGCTTCGTTCCACTTCCGACCGTTTCCGCTGGTCCTCACTCAGTTTGGCAATCGCTTGTACCTTGCCCCTTGCTACTCA
AGCTGCTGATACCACAACCACTCAAACCAGCAGTAAAAAGCACAGCACCGACACCATGGTCGTCACAGCAACCGGTAATG
AGCGTAGCAGTTTTGAAGCGCCAATGATGGTAACGGTAATCGAAGGGAATGCCCCTACCAGCCAAACCGCCGCGACGGCC
GCAGATATGCTGCGACAAGTACCAGGGCTGACCGTCACTGGCAGCGGGCGTACCAACGGTCAAGATGTGGTGATGCGAGG
TTACGGTAAACAAGGCGTGTTGACACTGGTTGATGGTGTTCGTCAGGGGACCGATACCGGTCACTTGAACTCCACTTTCC
TCGATCCTGCGTTAGTCAAACGTATCGAAATCGTCCGTGGGCCAGCAGCACTGCTGTACGGCAGTGGCGCTCTCGGCGGG
GTTATTGCCTATGAAACCGTGGATGCAGCGGACATGCTGCAACCGGGCCAAAACAGTGGTTATCGGGTTTACAGCTCTGC
CGCAACGGGTGATCACAGCTTCGGTCTGGGAGCCAGCGCCTTTGGCCGCACCGATGATCTGGATGGTATCCTCTCTTTCG
GTACCCGTGATATCGGCAACATTCGTCAAAGCGACGGTTTTAATGCCCCGAATGATGAAACTATCAGTAATGTATTGGCA
AAAGGCACTTGGCAGATAGACTCGATTCAATCGTTAAGCGCCAATCTGCGTTATTACAACAACAGTGCAATAGAGCCAAA
GAATCCGCAAACCAGCGCACCATCCAGTACCAATGTCATGACCAATCGTTCAACGATCCAGCGTGATGCCCAGCTCAGAT
ATAATATTAAGCCTCTCGATCAAGAATGGTTGAATGCCACGGCACAGGTTTATTACTCCGAAGTGGAAATCAATGCCCGT
CCACAAGGTTCAGCCGAAGAAGGCCGCAAGCAGACAACCGAAGGTGTGAAGCTGGAAAACCGTACCCGTCTGTTTATCGA
AAGCCCAGCCTCCCACTTGCTGACCTATGGTACTGAAACCTATAAACAGGAACAGACCCCCGGTGGGGCAACGGAAAGTT
TCCCACAGGCCAAAATTCGGTTTAGTTCGGGCTGGCTACAAGATGAAATCACCTTACGCGACCTGCCTGTCTCCATATTA
GCCGGTACGCGTTATGACAATTACAGTGGTAGCAGCGATGGCTATGCCGATGTCGATGCCGATAAATGGTCATCACGTGG
TGCAATCAGCATTACACCAACTGATTGGCTGATGCTGTTTGGCTCCTATGCTCAGGCTTTCCGCGCCCCAACCATGGGTG
AGATGTATAACGATTCCAAACACTTTGCGATCCCTATCCGGCCTGGGTTGACACTCACCAACTATTGGGTCCCCAACCCA
AATCTGAAACCAGAAACCAATGAGACCCAGGAATACGGTTTTGGCCTACGTTTCAGTGATTTACTGATGGCTGAAGATGA
CCTGCAATTTAAAGTCAGTTACTTCGATACCAAGGCTAAAGACTACATCAGTACCCGCGTTGACATGCAAGCCATGACCA
CCACATCGGTGAATATCGATCAGGCAAAAATCTGGGGTTGGGATGCCAGCATGAGCTATAAAACGGCCTTGTTTAACTGG
GATCTGGCCTATAACCGCACCCGTGGTAAAAATCAGAATACCGATGAATGGCTCGACACCATCAACCCGGATACCGTCAC
CAGTATCGTTGATGTACCTGTCGCCAACAGTGGTTTCTCCGTCGGTTGGATTGGGACCTTCGCTAATCGCTCCAGCCGCG
TTTCCAGTTCAACACCGCAAGCCGGTTATGGCGTCAATGATTTCTATGTGAGCTATAAAGGCCAGGAAGCATTCAAAGGC
ATGACCACAACAATGTTATTGGGTAATGCCTTCGAAAAAGAGTATTACGCGCCACAAGGCATCCCACAAGATGGCCGTAA
CGTGAAATTTTTCGTGAGTTATCAGTGGTAG

Upstream 100 bases:

>100_bases
GGTATGAATGACGCTTACTGCAAGCCACCCAGATTTTCGAATCAAGGCAGCCAGCAACCTATCGATATGTTTTTGAAAAA
AAATATGGAGAATTGCCGAC

Downstream 100 bases:

>100_bases
CTAATGAAAAAAAGTTAGTCTGAAATCATTCATCCGGTAATCCATTTTGTGGCTTGCCGGATTATCATTTGACAATGATT
ACCTGCATACAAAAAAACCA

Product: tonB dependent outer membrane hemin receptor, hmuR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 676; Mature: 676

Protein sequence:

>676_residues
MLRSTSDRFRWSSLSLAIACTLPLATQAADTTTTQTSSKKHSTDTMVVTATGNERSSFEAPMMVTVIEGNAPTSQTAATA
ADMLRQVPGLTVTGSGRTNGQDVVMRGYGKQGVLTLVDGVRQGTDTGHLNSTFLDPALVKRIEIVRGPAALLYGSGALGG
VIAYETVDAADMLQPGQNSGYRVYSSAATGDHSFGLGASAFGRTDDLDGILSFGTRDIGNIRQSDGFNAPNDETISNVLA
KGTWQIDSIQSLSANLRYYNNSAIEPKNPQTSAPSSTNVMTNRSTIQRDAQLRYNIKPLDQEWLNATAQVYYSEVEINAR
PQGSAEEGRKQTTEGVKLENRTRLFIESPASHLLTYGTETYKQEQTPGGATESFPQAKIRFSSGWLQDEITLRDLPVSIL
AGTRYDNYSGSSDGYADVDADKWSSRGAISITPTDWLMLFGSYAQAFRAPTMGEMYNDSKHFAIPIRPGLTLTNYWVPNP
NLKPETNETQEYGFGLRFSDLLMAEDDLQFKVSYFDTKAKDYISTRVDMQAMTTTSVNIDQAKIWGWDASMSYKTALFNW
DLAYNRTRGKNQNTDEWLDTINPDTVTSIVDVPVANSGFSVGWIGTFANRSSRVSSSTPQAGYGVNDFYVSYKGQEAFKG
MTTTMLLGNAFEKEYYAPQGIPQDGRNVKFFVSYQW

Sequences:

>Translated_676_residues
MLRSTSDRFRWSSLSLAIACTLPLATQAADTTTTQTSSKKHSTDTMVVTATGNERSSFEAPMMVTVIEGNAPTSQTAATA
ADMLRQVPGLTVTGSGRTNGQDVVMRGYGKQGVLTLVDGVRQGTDTGHLNSTFLDPALVKRIEIVRGPAALLYGSGALGG
VIAYETVDAADMLQPGQNSGYRVYSSAATGDHSFGLGASAFGRTDDLDGILSFGTRDIGNIRQSDGFNAPNDETISNVLA
KGTWQIDSIQSLSANLRYYNNSAIEPKNPQTSAPSSTNVMTNRSTIQRDAQLRYNIKPLDQEWLNATAQVYYSEVEINAR
PQGSAEEGRKQTTEGVKLENRTRLFIESPASHLLTYGTETYKQEQTPGGATESFPQAKIRFSSGWLQDEITLRDLPVSIL
AGTRYDNYSGSSDGYADVDADKWSSRGAISITPTDWLMLFGSYAQAFRAPTMGEMYNDSKHFAIPIRPGLTLTNYWVPNP
NLKPETNETQEYGFGLRFSDLLMAEDDLQFKVSYFDTKAKDYISTRVDMQAMTTTSVNIDQAKIWGWDASMSYKTALFNW
DLAYNRTRGKNQNTDEWLDTINPDTVTSIVDVPVANSGFSVGWIGTFANRSSRVSSSTPQAGYGVNDFYVSYKGQEAFKG
MTTTMLLGNAFEKEYYAPQGIPQDGRNVKFFVSYQW
>Mature_676_residues
MLRSTSDRFRWSSLSLAIACTLPLATQAADTTTTQTSSKKHSTDTMVVTATGNERSSFEAPMMVTVIEGNAPTSQTAATA
ADMLRQVPGLTVTGSGRTNGQDVVMRGYGKQGVLTLVDGVRQGTDTGHLNSTFLDPALVKRIEIVRGPAALLYGSGALGG
VIAYETVDAADMLQPGQNSGYRVYSSAATGDHSFGLGASAFGRTDDLDGILSFGTRDIGNIRQSDGFNAPNDETISNVLA
KGTWQIDSIQSLSANLRYYNNSAIEPKNPQTSAPSSTNVMTNRSTIQRDAQLRYNIKPLDQEWLNATAQVYYSEVEINAR
PQGSAEEGRKQTTEGVKLENRTRLFIESPASHLLTYGTETYKQEQTPGGATESFPQAKIRFSSGWLQDEITLRDLPVSIL
AGTRYDNYSGSSDGYADVDADKWSSRGAISITPTDWLMLFGSYAQAFRAPTMGEMYNDSKHFAIPIRPGLTLTNYWVPNP
NLKPETNETQEYGFGLRFSDLLMAEDDLQFKVSYFDTKAKDYISTRVDMQAMTTTSVNIDQAKIWGWDASMSYKTALFNW
DLAYNRTRGKNQNTDEWLDTINPDTVTSIVDVPVANSGFSVGWIGTFANRSSRVSSSTPQAGYGVNDFYVSYKGQEAFKG
MTTTMLLGNAFEKEYYAPQGIPQDGRNVKFFVSYQW

Specific function: This protein is involved in the initial step of iron uptake by binding hemin, an iron chelatin siderophore that allows the bacteria to extract iron from the environment [H]

COG id: COG1629

COG function: function code P; Outer membrane receptor proteins, mostly Fe transport

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1790405, Length=689, Percent_Identity=23.22206095791, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786798, Length=166, Percent_Identity=32.5301204819277, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1788478, Length=151, Percent_Identity=33.112582781457, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR011276
- InterPro:   IPR010949 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 74173; Mature: 74173

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSTSDRFRWSSLSLAIACTLPLATQAADTTTTQTSSKKHSTDTMVVTATGNERSSFEA
CCCCCCCCCEEECEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCC
PMMVTVIEGNAPTSQTAATAADMLRQVPGLTVTGSGRTNGQDVVMRGYGKQGVLTLVDGV
CEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHH
RQGTDTGHLNSTFLDPALVKRIEIVRGPAALLYGSGALGGVIAYETVDAADMLQPGQNSG
HCCCCCCCCCCHHCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCHHHHCCCCCCCC
YRVYSSAATGDHSFGLGASAFGRTDDLDGILSFGTRDIGNIRQSDGFNAPNDETISNVLA
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHH
KGTWQIDSIQSLSANLRYYNNSAIEPKNPQTSAPSSTNVMTNRSTIQRDAQLRYNIKPLD
CCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCCEEECHHHHHCCCEEEECCCCCC
QEWLNATAQVYYSEVEINARPQGSAEEGRKQTTEGVKLENRTRLFIESPASHLLTYGTET
HHHHCCEEEEEEEEEEEECCCCCCHHHHHHHCCCCCEECCCEEEEEECCHHHHHHCCCHH
YKQEQTPGGATESFPQAKIRFSSGWLQDEITLRDLPVSILAGTRYDNYSGSSDGYADVDA
HHHCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCC
DKWSSRGAISITPTDWLMLFGSYAQAFRAPTMGEMYNDSKHFAIPIRPGLTLTNYWVPNP
CCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEEECCCCEEEEEECCCC
NLKPETNETQEYGFGLRFSDLLMAEDDLQFKVSYFDTKAKDYISTRVDMQAMTTTSVNID
CCCCCCCCHHHHCCCCCHHHHEEECCCCEEEEEEECCCHHHHHHHHCCEEEEEEEECCCC
QAKIWGWDASMSYKTALFNWDLAYNRTRGKNQNTDEWLDTINPDTVTSIVDVPVANSGFS
CEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCHHHHHHCCCCCHHHHEEECCCCCCCCC
VGWIGTFANRSSRVSSSTPQAGYGVNDFYVSYKGQEAFKGMTTTMLLGNAFEKEYYAPQG
EEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHCCCEEEHHHCCHHHHHHCCCCC
IPQDGRNVKFFVSYQW
CCCCCCCEEEEEEECC
>Mature Secondary Structure
MLRSTSDRFRWSSLSLAIACTLPLATQAADTTTTQTSSKKHSTDTMVVTATGNERSSFEA
CCCCCCCCCEEECEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCC
PMMVTVIEGNAPTSQTAATAADMLRQVPGLTVTGSGRTNGQDVVMRGYGKQGVLTLVDGV
CEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHH
RQGTDTGHLNSTFLDPALVKRIEIVRGPAALLYGSGALGGVIAYETVDAADMLQPGQNSG
HCCCCCCCCCCHHCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCHHHHCCCCCCCC
YRVYSSAATGDHSFGLGASAFGRTDDLDGILSFGTRDIGNIRQSDGFNAPNDETISNVLA
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHH
KGTWQIDSIQSLSANLRYYNNSAIEPKNPQTSAPSSTNVMTNRSTIQRDAQLRYNIKPLD
CCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCCEEECHHHHHCCCEEEECCCCCC
QEWLNATAQVYYSEVEINARPQGSAEEGRKQTTEGVKLENRTRLFIESPASHLLTYGTET
HHHHCCEEEEEEEEEEEECCCCCCHHHHHHHCCCCCEECCCEEEEEECCHHHHHHCCCHH
YKQEQTPGGATESFPQAKIRFSSGWLQDEITLRDLPVSILAGTRYDNYSGSSDGYADVDA
HHHCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCC
DKWSSRGAISITPTDWLMLFGSYAQAFRAPTMGEMYNDSKHFAIPIRPGLTLTNYWVPNP
CCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEEECCCCEEEEEECCCC
NLKPETNETQEYGFGLRFSDLLMAEDDLQFKVSYFDTKAKDYISTRVDMQAMTTTSVNID
CCCCCCCCHHHHCCCCCHHHHEEECCCCEEEEEEECCCHHHHHHHHCCEEEEEEEECCCC
QAKIWGWDASMSYKTALFNWDLAYNRTRGKNQNTDEWLDTINPDTVTSIVDVPVANSGFS
CEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCHHHHHHCCCCCHHHHEEECCCCCCCCC
VGWIGTFANRSSRVSSSTPQAGYGVNDFYVSYKGQEAFKGMTTTMLLGNAFEKEYYAPQG
EEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHCCCEEEHHHCCHHHHHHCCCCC
IPQDGRNVKFFVSYQW
CCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]