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The map label for this gene is uppS1 [H]

Identifier: 50842050

GI number: 50842050

Start: 624666

End: 625487

Strand: Reverse

Name: uppS1 [H]

Synonym: PPA0564

Alternate gene names: 50842050

Gene position: 625487-624666 (Counterclockwise)

Preceding gene: 50842054

Following gene: 50842048

Centisome position: 24.43

GC content: 61.56

Gene sequence:

>822_bases
ATGAGCAGCCTGGACCACCGCCTGTCGAAGGTCAGTGAGACCCTCGACCGCATGCACCCGTCCGGTCTGCTGTACACCAC
CTACGAGGCTCGTCTCCTCGACCAACTCGACCGCAGCCGTCTACCCCAGCACGTCGCAGTCCTGGCTGACGGCAACCGTC
GCTGGGCCCGCCTCAACGCTCCGGGAGAACCCTTGGTGGCTGGCTACGAGGCGGGGGCAGATCGCCTTAGAGAGTTTTGC
ACATGGTGCGACGCTGTTGGCATCCCAATCATCACCTTGTGGGTGCTGTCGACTGACAACCTACAACGAGCCGAAACCGG
CGAGCTCGGACCACTACTCAAGGTCATCGAGTCCCTCGTCGACTCGTTAGCAGATAATTCACGGTGGCGGGTCCAGGCCG
TTGGCGACCTTGATCTTCTCCCAGACGACATGGCCGAATCGCTGTGTCGGGCCGGTCGCACCTCCATCGGGCATGTCGGT
ATGCATATCAACGTCGCGGTAGCTTACGGAGGCCGTCATGAACTGCGTGACGCCTTCCGTTCCCTCCTGGCCGAAGAGGC
GGAGAAAGGCACCAGCCTGGCTGACTTAGCCCGAACCCTGGAAATCGACCAGATCGAGGACCACCTGTACACGCGGGGCC
AGCCTGACCCTGACCTCATTATCCGCACCTCAGGAGAGCAGCGTCTTTCCGGATTCCTCATGTGGCAAAGCGCCCATTCA
GAGTTCTACTTCTGCGAGGCGTTGTGGCCCGATTTTCGCAAGGTTGACTTCCTGCGGGCGCTGCGCTCCTTCACCCAGCG
GGAGCGGCGCTATGGTCGCTAA

Upstream 100 bases:

>100_bases
TTTCTTTTTCCAGCCTACCTTGCCCTATACCCACGACGCGATCTCGCCTCATAACGCGAGCTAGCAACCGTTTGTGCCAG
GCACTGACTAATCTGGACCT

Downstream 100 bases:

>100_bases
TCCGCTGCTGGGGCGACGACCTCAGGCTCGCCGCCAGAGCGGTTCTTTGAGGTCCAGGTAGTCGGTTACCGGCTCAAAGC
ACACCGCGCCGCGGCATACC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1 [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSSLDHRLSKVSETLDRMHPSGLLYTTYEARLLDQLDRSRLPQHVAVLADGNRRWARLNAPGEPLVAGYEAGADRLREFC
TWCDAVGIPIITLWVLSTDNLQRAETGELGPLLKVIESLVDSLADNSRWRVQAVGDLDLLPDDMAESLCRAGRTSIGHVG
MHINVAVAYGGRHELRDAFRSLLAEEAEKGTSLADLARTLEIDQIEDHLYTRGQPDPDLIIRTSGEQRLSGFLMWQSAHS
EFYFCEALWPDFRKVDFLRALRSFTQRERRYGR

Sequences:

>Translated_273_residues
MSSLDHRLSKVSETLDRMHPSGLLYTTYEARLLDQLDRSRLPQHVAVLADGNRRWARLNAPGEPLVAGYEAGADRLREFC
TWCDAVGIPIITLWVLSTDNLQRAETGELGPLLKVIESLVDSLADNSRWRVQAVGDLDLLPDDMAESLCRAGRTSIGHVG
MHINVAVAYGGRHELRDAFRSLLAEEAEKGTSLADLARTLEIDQIEDHLYTRGQPDPDLIIRTSGEQRLSGFLMWQSAHS
EFYFCEALWPDFRKVDFLRALRSFTQRERRYGR
>Mature_272_residues
SSLDHRLSKVSETLDRMHPSGLLYTTYEARLLDQLDRSRLPQHVAVLADGNRRWARLNAPGEPLVAGYEAGADRLREFCT
WCDAVGIPIITLWVLSTDNLQRAETGELGPLLKVIESLVDSLADNSRWRVQAVGDLDLLPDDMAESLCRAGRTSIGHVGM
HINVAVAYGGRHELRDAFRSLLAEEAEKGTSLADLARTLEIDQIEDHLYTRGQPDPDLIIRTSGEQRLSGFLMWQSAHSE
FYFCEALWPDFRKVDFLRALRSFTQRERRYGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=231, Percent_Identity=32.034632034632, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI45580742, Length=231, Percent_Identity=32.034632034632, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1786371, Length=234, Percent_Identity=33.7606837606838, Blast_Score=134, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=30, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319474, Length=220, Percent_Identity=29.0909090909091, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323748, Length=239, Percent_Identity=23.0125523012552, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI18857969, Length=234, Percent_Identity=32.4786324786325, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30921; Mature: 30790

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLDHRLSKVSETLDRMHPSGLLYTTYEARLLDQLDRSRLPQHVAVLADGNRRWARLNA
CCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECC
PGEPLVAGYEAGADRLREFCTWCDAVGIPIITLWVLSTDNLQRAETGELGPLLKVIESLV
CCCCEEECHHHHHHHHHHHHHHHHHCCCCEEEHEEECCCCCCCCCCCCHHHHHHHHHHHH
DSLADNSRWRVQAVGDLDLLPDDMAESLCRAGRTSIGHVGMHINVAVAYGGRHELRDAFR
HHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHH
SLLAEEAEKGTSLADLARTLEIDQIEDHLYTRGQPDPDLIIRTSGEQRLSGFLMWQSAHS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHEEECCCC
EFYFCEALWPDFRKVDFLRALRSFTQRERRYGR
CEEEHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSLDHRLSKVSETLDRMHPSGLLYTTYEARLLDQLDRSRLPQHVAVLADGNRRWARLNA
CHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECC
PGEPLVAGYEAGADRLREFCTWCDAVGIPIITLWVLSTDNLQRAETGELGPLLKVIESLV
CCCCEEECHHHHHHHHHHHHHHHHHCCCCEEEHEEECCCCCCCCCCCCHHHHHHHHHHHH
DSLADNSRWRVQAVGDLDLLPDDMAESLCRAGRTSIGHVGMHINVAVAYGGRHELRDAFR
HHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHH
SLLAEEAEKGTSLADLARTLEIDQIEDHLYTRGQPDPDLIIRTSGEQRLSGFLMWQSAHS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHEEECCCC
EFYFCEALWPDFRKVDFLRALRSFTQRERRYGR
CEEEHHHHCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]