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The map label for this gene is cobQ

Identifier: 50841901

GI number: 50841901

Start: 462065

End: 463519

Strand: Direct

Name: cobQ

Synonym: PPA0419

Alternate gene names: 50841901

Gene position: 462065-463519 (Clockwise)

Preceding gene: 50841900

Following gene: 50841902

Centisome position: 18.05

GC content: 63.71

Gene sequence:

>1455_bases
ATGACCGGAATCCTCGTTGCCGGAACATCGTCGGACGCGGGTAAATCCCTCGTCGTTACCGCCTTGTGCCGGGTCGCCCG
ACGTCGCGGCGTCGACGTGGTGCCTTTCAAAGCCCAGAACATGTCAAACAACTCGATGGTGTGCGCAGACGGTTCCGAAA
TCGGCCGAGCCCAGTACCTCCAGGCCACTGCAGCCGGGGTCACACCAACATCTGCCATGAATCCGGTGTTGCTTAAACCG
GGCACTGATCGGCGCTCCTTCGTCGTGTTGCGGGGAAAGCCCGGTGGAGTGTTGGAGGCGGGGGAATACACCACCGGACG
GCGATACCTGGCCGAGGCCGCATGGGCTGCCTATGACGAGCTTGCCGCGTCCCACGACATGGTGATCTGTGAGGGAGCTG
GGTCTCCGGCCGAGATCAACCTGCGCCGAGGCGACTACACGAATATGGGGTTGGCTCGGGCCAAGAACCTGCCGGTCGTG
CTTGTCGGTGACATTGACCGCGGCGGGGTTCTGGCAAGTCTCTTTGGCACCTGGGCACTTCTCGACGATGACGACCGGGC
TCTGTTGGCCGGTTACATCGTCAACAAGTTCCGTGGTGACGATGCCATCCTCGCTCCCGGGCTTGAGGAGATCACCGATC
GTACCGGGATGCCGAGTTTCGGGGTGTTGCCCTGGGTCCCGGGGGTGTGGCTCGATGGCGAGGACGCCTTGGAAGTGGGG
CGGTGGCGTCACGAGGGAGACGCCGTCGACCCGTCATCCTTACGGGTTGCGGTGGTGCGGTTCCCGCGCATCTCCAACGC
CACCGACGTCGACGCCATGGCTGGCGAGACGGGGGTGGACGTCCAGGTGACGACAAACCCGGATACGTGTCAGGCCGCTG
ACGTTCTCGTTCTGCCGGGGTCGCGGTCCACAGTGTCCGACTTGGAATGGTTGCGACGCTCGGGCATCGCTGACGTCGTG
GCTCGCCGTGCCGAGCAGGGGCGCACCGTGGTGGGCATTTGTGGCGGGTACCAGATGCTGTGCCGGACTATCCTCGACCC
CGATGGTCAGGAGACGACTCCAGGAAGTGTCGTCGAAGGGCTTGGACTGCTGCCGGTCGAGGTGGACTTCGCCGCCACGA
AGACCCTTGCCTTGTCGCACGGGACATGGCGGGGGATCGAGGTTGGTGGCTATGAAATCCATCACGGCGTCTGTCGTTCG
CTTGAGGACGCTGAAGCCTTCCTCGACGGCGTACACGTCGGTCCGGTATGGGGGACGATGTGGCACGGGGCATTCGAGCA
CGACGAATTCCGTCGCACGTGGCTGGCTGACGCGGCCCGTCACGCTGGTTCATCCTGGCGTCCGCACTCTGACGAGCTGG
GTTATCAGGCTCGACGCGAGGCGATGATCGAAACCCTTGCCGACGCGTTAGAGGCTCACGTCGATGTCGATCGGATACTG
CACCTGGTGCGTTGA

Upstream 100 bases:

>100_bases
CAGGGCTGGCCAGTGTGGCCCATGTGCTGTTCTACGGCGGCCTGATTCCGCGCGGTCTTCTGCCGCACAGCACAAGGCGT
TGATGACAAGGAGACTCACC

Downstream 100 bases:

>100_bases
TCTGGCGGTTGAGGATTTTCCTACTCGGCGATGAACTCGGCCACCTTGTTCTCAGATGACCTGGTTCAGGCTGTGAGTGT
GCAAGAACACCACGGCGGCG

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MTGILVAGTSSDAGKSLVVTALCRVARRRGVDVVPFKAQNMSNNSMVCADGSEIGRAQYLQATAAGVTPTSAMNPVLLKP
GTDRRSFVVLRGKPGGVLEAGEYTTGRRYLAEAAWAAYDELAASHDMVICEGAGSPAEINLRRGDYTNMGLARAKNLPVV
LVGDIDRGGVLASLFGTWALLDDDDRALLAGYIVNKFRGDDAILAPGLEEITDRTGMPSFGVLPWVPGVWLDGEDALEVG
RWRHEGDAVDPSSLRVAVVRFPRISNATDVDAMAGETGVDVQVTTNPDTCQAADVLVLPGSRSTVSDLEWLRRSGIADVV
ARRAEQGRTVVGICGGYQMLCRTILDPDGQETTPGSVVEGLGLLPVEVDFAATKTLALSHGTWRGIEVGGYEIHHGVCRS
LEDAEAFLDGVHVGPVWGTMWHGAFEHDEFRRTWLADAARHAGSSWRPHSDELGYQARREAMIETLADALEAHVDVDRIL
HLVR

Sequences:

>Translated_484_residues
MTGILVAGTSSDAGKSLVVTALCRVARRRGVDVVPFKAQNMSNNSMVCADGSEIGRAQYLQATAAGVTPTSAMNPVLLKP
GTDRRSFVVLRGKPGGVLEAGEYTTGRRYLAEAAWAAYDELAASHDMVICEGAGSPAEINLRRGDYTNMGLARAKNLPVV
LVGDIDRGGVLASLFGTWALLDDDDRALLAGYIVNKFRGDDAILAPGLEEITDRTGMPSFGVLPWVPGVWLDGEDALEVG
RWRHEGDAVDPSSLRVAVVRFPRISNATDVDAMAGETGVDVQVTTNPDTCQAADVLVLPGSRSTVSDLEWLRRSGIADVV
ARRAEQGRTVVGICGGYQMLCRTILDPDGQETTPGSVVEGLGLLPVEVDFAATKTLALSHGTWRGIEVGGYEIHHGVCRS
LEDAEAFLDGVHVGPVWGTMWHGAFEHDEFRRTWLADAARHAGSSWRPHSDELGYQARREAMIETLADALEAHVDVDRIL
HLVR
>Mature_483_residues
TGILVAGTSSDAGKSLVVTALCRVARRRGVDVVPFKAQNMSNNSMVCADGSEIGRAQYLQATAAGVTPTSAMNPVLLKPG
TDRRSFVVLRGKPGGVLEAGEYTTGRRYLAEAAWAAYDELAASHDMVICEGAGSPAEINLRRGDYTNMGLARAKNLPVVL
VGDIDRGGVLASLFGTWALLDDDDRALLAGYIVNKFRGDDAILAPGLEEITDRTGMPSFGVLPWVPGVWLDGEDALEVGR
WRHEGDAVDPSSLRVAVVRFPRISNATDVDAMAGETGVDVQVTTNPDTCQAADVLVLPGSRSTVSDLEWLRRSGIADVVA
RRAEQGRTVVGICGGYQMLCRTILDPDGQETTPGSVVEGLGLLPVEVDFAATKTLALSHGTWRGIEVGGYEIHHGVCRSL
EDAEAFLDGVHVGPVWGTMWHGAFEHDEFRRTWLADAARHAGSSWRPHSDELGYQARREAMIETLADALEAHVDVDRILH
LVR

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_PROAC (Q6AAP6)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055128.1
- ProteinModelPortal:   Q6AAP6
- GeneID:   2932457
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0419
- NMPDR:   fig|267747.1.peg.405
- HOGENOM:   HBG302271
- OMA:   NGRAFAN
- ProtClustDB:   PRK00784
- BioCyc:   PACN267747:PPA0419-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 51933; Mature: 51802

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 334-334 ACT_SITE 422-422

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGILVAGTSSDAGKSLVVTALCRVARRRGVDVVPFKAQNMSNNSMVCADGSEIGRAQYL
CCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCHHHCHHHHH
QATAAGVTPTSAMNPVLLKPGTDRRSFVVLRGKPGGVLEAGEYTTGRRYLAEAAWAAYDE
HHHHCCCCCCCCCCCEEECCCCCCCEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHH
LAASHDMVICEGAGSPAEINLRRGDYTNMGLARAKNLPVVLVGDIDRGGVLASLFGTWAL
HHCCCCEEEEECCCCCCEEEEECCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHCEEE
LDDDDRALLAGYIVNKFRGDDAILAPGLEEITDRTGMPSFGVLPWVPGVWLDGEDALEVG
ECCCCCHHHHHHHHHHHCCCCCEECCCHHHHHHCCCCCCCCCCCCCCCEEECCHHHHHHH
RWRHEGDAVDPSSLRVAVVRFPRISNATDVDAMAGETGVDVQVTTNPDTCQAADVLVLPG
CEECCCCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCEEEEECCCCCCCCCCEEEECC
SRSTVSDLEWLRRSGIADVVARRAEQGRTVVGICGGYQMLCRTILDPDGQETTPGSVVEG
CCCHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHC
LGLLPVEVDFAATKTLALSHGTWRGIEVGGYEIHHGVCRSLEDAEAFLDGVHVGPVWGTM
CCCCEEEECCCCEEEEEECCCCCCCEEECCEEEHHHHHHCHHHHHHHHCCCEECCCHHHH
WHGAFEHDEFRRTWLADAARHAGSSWRPHSDELGYQARREAMIETLADALEAHVDVDRIL
HCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
HLVR
HHHC
>Mature Secondary Structure 
TGILVAGTSSDAGKSLVVTALCRVARRRGVDVVPFKAQNMSNNSMVCADGSEIGRAQYL
CCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCHHHCHHHHH
QATAAGVTPTSAMNPVLLKPGTDRRSFVVLRGKPGGVLEAGEYTTGRRYLAEAAWAAYDE
HHHHCCCCCCCCCCCEEECCCCCCCEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHH
LAASHDMVICEGAGSPAEINLRRGDYTNMGLARAKNLPVVLVGDIDRGGVLASLFGTWAL
HHCCCCEEEEECCCCCCEEEEECCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHCEEE
LDDDDRALLAGYIVNKFRGDDAILAPGLEEITDRTGMPSFGVLPWVPGVWLDGEDALEVG
ECCCCCHHHHHHHHHHHCCCCCEECCCHHHHHHCCCCCCCCCCCCCCCEEECCHHHHHHH
RWRHEGDAVDPSSLRVAVVRFPRISNATDVDAMAGETGVDVQVTTNPDTCQAADVLVLPG
CEECCCCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCEEEEECCCCCCCCCCEEEECC
SRSTVSDLEWLRRSGIADVVARRAEQGRTVVGICGGYQMLCRTILDPDGQETTPGSVVEG
CCCHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHC
LGLLPVEVDFAATKTLALSHGTWRGIEVGGYEIHHGVCRSLEDAEAFLDGVHVGPVWGTM
CCCCEEEECCCCEEEEEECCCCCCCEEECCEEEHHHHHHCHHHHHHHHCCCEECCCHHHH
WHGAFEHDEFRRTWLADAARHAGSSWRPHSDELGYQARREAMIETLADALEAHVDVDRIL
HCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
HLVR
HHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA