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The map label for this gene is proC [H]

Identifier: 50841806

GI number: 50841806

Start: 370892

End: 371683

Strand: Direct

Name: proC [H]

Synonym: PPA0319

Alternate gene names: 50841806

Gene position: 370892-371683 (Clockwise)

Preceding gene: 50841805

Following gene: 50841807

Centisome position: 14.49

GC content: 61.74

Gene sequence:

>792_bases
ATGAGCGGGAAGATTGCCGTCCTGGGCTGTGGAACGATGGCTGGGGCGCTTGTTGGTGGACTCATTGACGCTGGACAAAT
GAAGGCCGAGGACGTCGTGGCAACCGCGCGATCGGCGTCCCATCGCGACGAAATCGCCAACACTTTGGGTGTAACTACGA
GCGGTGACAACACCACAGCTGTGCGGGACGCCGACCTCGTCATCCTCGGCGTCAAGCCTTACGCGGCCGTTGACGTGCTG
GAAGAAGTCTCGGGTGCTCTGAAAGCTGATGCGGTGGTTGTCTCCATTGCTGCCGGTGTCACTACTGAGAAGTTGCTCAT
GGCATGGCAGGGAAAGATCGTCCGTGTAATGCCAAACACCCCAGTTCGGGTGGGCAAAGGGGCGTTCATTGTGAGTTCCG
CTCCCGGCTCCGAGGATGCGGCTAAGAAGGTGGGTGACCTACTCGAATCGGTGGGAGTCGTCGTCACTGTGCCTGAGGAG
CTGCATAATGCTGCCACAGCCGTGTCGGGATCGGGTCCGGCGTACGTTTTCTTGGTAGCAGAGGCCATGATCGATGCTGC
CGTCGCGCTGGGTGTGCCGCGCGACCAGGCTAGCCAACTTACTGTAGCGACGTTAGCCGGTTCGGCTGAGTTGTTGGCAG
GAGGCGAGCACCCTGCGGTCCTGCGATCCAAGGTGACGAGCCCGGGTGGTACCACTGCGGCTGCCGTAGCCGCATTGGAG
GCCGGAGGTGTGCGCTCCGTTTTCGCCGATGCGATGACGGCATGTCGGGACCGCGCCGCTGGCCTGTCCTGA

Upstream 100 bases:

>100_bases
CACCGGCTGGCAAAGGTCTGGTGTTCTTCTGCGCTGCGGACAATTTGCGCAAGGGCGCGGCCCTCAACGCGGTGCAGCTC
GCTGAGCTGGTGGCTGCCGA

Downstream 100 bases:

>100_bases
TGAGTTGGTGCGGCGATTTTGGATCCCATGGTCGACACAGCGTAGAGTACCCCTCTGTCCGCCTTGTCGGTGGGCCAAGA
ACTTCGCACCTACCTGGGTG

Product: putative delta-1-pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSGKIAVLGCGTMAGALVGGLIDAGQMKAEDVVATARSASHRDEIANTLGVTTSGDNTTAVRDADLVILGVKPYAAVDVL
EEVSGALKADAVVVSIAAGVTTEKLLMAWQGKIVRVMPNTPVRVGKGAFIVSSAPGSEDAAKKVGDLLESVGVVVTVPEE
LHNAATAVSGSGPAYVFLVAEAMIDAAVALGVPRDQASQLTVATLAGSAELLAGGEHPAVLRSKVTSPGGTTAAAVAALE
AGGVRSVFADAMTACRDRAAGLS

Sequences:

>Translated_263_residues
MSGKIAVLGCGTMAGALVGGLIDAGQMKAEDVVATARSASHRDEIANTLGVTTSGDNTTAVRDADLVILGVKPYAAVDVL
EEVSGALKADAVVVSIAAGVTTEKLLMAWQGKIVRVMPNTPVRVGKGAFIVSSAPGSEDAAKKVGDLLESVGVVVTVPEE
LHNAATAVSGSGPAYVFLVAEAMIDAAVALGVPRDQASQLTVATLAGSAELLAGGEHPAVLRSKVTSPGGTTAAAVAALE
AGGVRSVFADAMTACRDRAAGLS
>Mature_262_residues
SGKIAVLGCGTMAGALVGGLIDAGQMKAEDVVATARSASHRDEIANTLGVTTSGDNTTAVRDADLVILGVKPYAAVDVLE
EVSGALKADAVVVSIAAGVTTEKLLMAWQGKIVRVMPNTPVRVGKGAFIVSSAPGSEDAAKKVGDLLESVGVVVTVPEEL
HNAATAVSGSGPAYVFLVAEAMIDAAVALGVPRDQASQLTVATLAGSAELLAGGEHPAVLRSKVTSPGGTTAAAVAALEA
GGVRSVFADAMTACRDRAAGLS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=259, Percent_Identity=37.8378378378378, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=37.3134328358209, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI24797095, Length=258, Percent_Identity=35.6589147286822, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI24797097, Length=258, Percent_Identity=35.6589147286822, Blast_Score=138, Evalue=6e-33,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=38.5185185185185, Blast_Score=164, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=41.1320754716981, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17540664, Length=282, Percent_Identity=28.7234042553192, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320861, Length=269, Percent_Identity=34.9442379182156, Blast_Score=144, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24648116, Length=274, Percent_Identity=36.8613138686131, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=37.1212121212121, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24647700, Length=141, Percent_Identity=42.5531914893617, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 26072; Mature: 25941

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKIAVLGCGTMAGALVGGLIDAGQMKAEDVVATARSASHRDEIANTLGVTTSGDNTTA
CCCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEE
VRDADLVILGVKPYAAVDVLEEVSGALKADAVVVSIAAGVTTEKLLMAWQGKIVRVMPNT
EECCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCEEEECCCC
PVRVGKGAFIVSSAPGSEDAAKKVGDLLESVGVVVTVPEELHNAATAVSGSGPAYVFLVA
CEEECCCEEEEECCCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCCCCCEEEEEHH
EAMIDAAVALGVPRDQASQLTVATLAGSAELLAGGEHPAVLRSKVTSPGGTTAAAVAALE
HHHHHHHHHHCCCCCCCCCEEEEEECCCHHEEECCCCCHHHHHHCCCCCCCHHHHHHHHH
AGGVRSVFADAMTACRDRAAGLS
CCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SGKIAVLGCGTMAGALVGGLIDAGQMKAEDVVATARSASHRDEIANTLGVTTSGDNTTA
CCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEE
VRDADLVILGVKPYAAVDVLEEVSGALKADAVVVSIAAGVTTEKLLMAWQGKIVRVMPNT
EECCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCEEEECCCC
PVRVGKGAFIVSSAPGSEDAAKKVGDLLESVGVVVTVPEELHNAATAVSGSGPAYVFLVA
CEEECCCEEEEECCCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCCCCCEEEEEHH
EAMIDAAVALGVPRDQASQLTVATLAGSAELLAGGEHPAVLRSKVTSPGGTTAAAVAALE
HHHHHHHHHHCCCCCCCCCEEEEEECCCHHEEECCCCCHHHHHHCCCCCCCHHHHHHHHH
AGGVRSVFADAMTACRDRAAGLS
CCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]