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The map label for this gene is mez [H]

Identifier: 50841800

GI number: 50841800

Start: 364625

End: 366271

Strand: Reverse

Name: mez [H]

Synonym: PPA0313

Alternate gene names: 50841800

Gene position: 366271-364625 (Counterclockwise)

Preceding gene: 50841801

Following gene: 50841799

Centisome position: 14.31

GC content: 58.77

Gene sequence:

>1647_bases
GTGTCACGAAAACCTGAGCCCATGACCAACCCGATCACGAATCGGGGGACGGCCTTTACCCGAGCTGAACGGTTGGAGCA
CGGCATGATCGGACGCCTTCCGGCGGCCGTCGAAACCTTGGAGCAACAGGCCCAACGCTGTTACCGCCAGCTTCAGGGAT
TGGGCTGCAATATTGATCGCTACGTCTTCCTGGAGGAGCTCCAAAACCGTAACGAGACCCTCTACTACAAACTCCTCGTC
GATCACCTCGTCGAGCTGTTGCCGGTAATCTATGATCCCACCGTCGGTGAGGCTATTAAGAAGTGGAGCCACGCCTACCG
ACGCTCCCGGGCGGTCTATTTGTCAGTAGACCATATCGAGGACGTCCGCCCCTCCTTCGAGACTCTCGAGCTGGGGCCTG
ATGACGTCGACTTGCTCGTCGTTTCCGATTCCGAACAAATCCTGGGAATTGGAGACTGGGGCGTCAACGGAACCGATATC
TCCATCGGCAAGCTCGCCGTCTACACTGCGGCCGCCGGTATTCGGCCGGAACGCACTATCGCCGTCAATCTGGACGTCGG
CACCGACAACGCATATTTGCTCAACGACCCGTCTTATCTTGGCAATCGTCACGCCAGGGTGCGCGGGGAACGCTACGACG
AGTTGATCCACGAGTACCTCGAAGTTGCAAGCGAGCTGTACCCACACGCACTGTTACATTTCGAGGACTTCGGTGCTTCT
AATGCTCGCCGCATTCTGGTACAGAATGCCGCAAACCACCGCATCTTTAATGACGACATGCAAGGCACAGCAGCCATCGT
GTTGGCAGCCGTCATCTCCGGGCTTAAGGTGACCCGGCAATCCTTCGCTGATCAGCGCCTGATCGTATACGGGGCAGGTA
CCGCTGGCACCGGAATTGCTGACCAAATCCGCGCAGCCATGATCAGTGACGGGTTAAGCCAGCAGGAGGCAGTCGATCGG
ATTTGGCTCGTCGACCGCAATGGCCTGGTCACTGACGATATGAAGGGCCTACCCGACTACCAAGAGCCCTACGCTAAGCC
AGTTGAGAAAACTCGTCATTGGGCTCACACGAATCGACACATTGGTCTTACCGAGACGATCCGACGAATTCACCCGACGA
TCCTCATCGGGACCTCCACTGACCACGACGCTTTTACCCAGCAGGTCGTCGAGGAAATGTGCCGAGAAGTCGAGCGCCCC
ATCATCATGCCGCTGTCGAATCCGACTGAGAAGATCGAGGCGATGCCTGCCGACGTTATTGCGTGGTCAAAGGGGAAAGC
TCTGGTTTCCGTTGGAATTCCGGTAGCGCCCTTCCATTATGAAGGCACCCGTTACGAGATTGGGCAGGGCAATAACGCCC
TCCTCTACCCGGGCCTAGGACTAGGAGTTATCGTCTCGGGAGCCGAACGGGTGAGCGCCCGCATGATCCGTGCCGCCGCC
GAAGCGGTGGCCTCCCAAGTTGACCCGCGTCCGGCTGGGTCATCCCTGCTACCGGCGGTGGAGAACCTACGTGCCTCCTC
GGCCACCGTTGCAGTGGCGGTCGTGCAAGCTGCCATCGAGGAGGGCCTTGCCACCAAAAAGCCCAGCAACGTCGTCCAGG
CAGTGCAAGATGCCATGTGGTGGCCGCATTACCCGCCGGTGGGCTGA

Upstream 100 bases:

>100_bases
CTTCGACACCCCCTCACGCGGATGTGTTCGCATCTGACGTTTCAGCACTGACAGATCCTCCCGGTAGTGTGAGAAGAGAA
GCCACCACCGGGAGATAGCC

Downstream 100 bases:

>100_bases
CCGGGACACAGCGTGGAACACCGTCGTAGTCGAACCTGTCGGTTCCTGCTGGCAGGGTAAACGCCATGGCGAGGAAGACG
CAAACTCCGACGTGGGTATG

Product: malate dehydrogenase

Products: NA

Alternate protein names: Malic enzyme [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MSRKPEPMTNPITNRGTAFTRAERLEHGMIGRLPAAVETLEQQAQRCYRQLQGLGCNIDRYVFLEELQNRNETLYYKLLV
DHLVELLPVIYDPTVGEAIKKWSHAYRRSRAVYLSVDHIEDVRPSFETLELGPDDVDLLVVSDSEQILGIGDWGVNGTDI
SIGKLAVYTAAAGIRPERTIAVNLDVGTDNAYLLNDPSYLGNRHARVRGERYDELIHEYLEVASELYPHALLHFEDFGAS
NARRILVQNAANHRIFNDDMQGTAAIVLAAVISGLKVTRQSFADQRLIVYGAGTAGTGIADQIRAAMISDGLSQQEAVDR
IWLVDRNGLVTDDMKGLPDYQEPYAKPVEKTRHWAHTNRHIGLTETIRRIHPTILIGTSTDHDAFTQQVVEEMCREVERP
IIMPLSNPTEKIEAMPADVIAWSKGKALVSVGIPVAPFHYEGTRYEIGQGNNALLYPGLGLGVIVSGAERVSARMIRAAA
EAVASQVDPRPAGSSLLPAVENLRASSATVAVAVVQAAIEEGLATKKPSNVVQAVQDAMWWPHYPPVG

Sequences:

>Translated_548_residues
MSRKPEPMTNPITNRGTAFTRAERLEHGMIGRLPAAVETLEQQAQRCYRQLQGLGCNIDRYVFLEELQNRNETLYYKLLV
DHLVELLPVIYDPTVGEAIKKWSHAYRRSRAVYLSVDHIEDVRPSFETLELGPDDVDLLVVSDSEQILGIGDWGVNGTDI
SIGKLAVYTAAAGIRPERTIAVNLDVGTDNAYLLNDPSYLGNRHARVRGERYDELIHEYLEVASELYPHALLHFEDFGAS
NARRILVQNAANHRIFNDDMQGTAAIVLAAVISGLKVTRQSFADQRLIVYGAGTAGTGIADQIRAAMISDGLSQQEAVDR
IWLVDRNGLVTDDMKGLPDYQEPYAKPVEKTRHWAHTNRHIGLTETIRRIHPTILIGTSTDHDAFTQQVVEEMCREVERP
IIMPLSNPTEKIEAMPADVIAWSKGKALVSVGIPVAPFHYEGTRYEIGQGNNALLYPGLGLGVIVSGAERVSARMIRAAA
EAVASQVDPRPAGSSLLPAVENLRASSATVAVAVVQAAIEEGLATKKPSNVVQAVQDAMWWPHYPPVG
>Mature_547_residues
SRKPEPMTNPITNRGTAFTRAERLEHGMIGRLPAAVETLEQQAQRCYRQLQGLGCNIDRYVFLEELQNRNETLYYKLLVD
HLVELLPVIYDPTVGEAIKKWSHAYRRSRAVYLSVDHIEDVRPSFETLELGPDDVDLLVVSDSEQILGIGDWGVNGTDIS
IGKLAVYTAAAGIRPERTIAVNLDVGTDNAYLLNDPSYLGNRHARVRGERYDELIHEYLEVASELYPHALLHFEDFGASN
ARRILVQNAANHRIFNDDMQGTAAIVLAAVISGLKVTRQSFADQRLIVYGAGTAGTGIADQIRAAMISDGLSQQEAVDRI
WLVDRNGLVTDDMKGLPDYQEPYAKPVEKTRHWAHTNRHIGLTETIRRIHPTILIGTSTDHDAFTQQVVEEMCREVERPI
IMPLSNPTEKIEAMPADVIAWSKGKALVSVGIPVAPFHYEGTRYEIGQGNNALLYPGLGLGVIVSGAERVSARMIRAAAE
AVASQVDPRPAGSSLLPAVENLRASSATVAVAVVQAAIEEGLATKKPSNVVQAVQDAMWWPHYPPVG

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=544, Percent_Identity=36.2132352941176, Blast_Score=357, Evalue=2e-98,
Organism=Homo sapiens, GI4505145, Length=544, Percent_Identity=36.0294117647059, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI62420882, Length=543, Percent_Identity=33.3333333333333, Blast_Score=333, Evalue=4e-91,
Organism=Homo sapiens, GI62420880, Length=543, Percent_Identity=33.3333333333333, Blast_Score=333, Evalue=4e-91,
Organism=Homo sapiens, GI239049447, Length=543, Percent_Identity=33.3333333333333, Blast_Score=333, Evalue=4e-91,
Organism=Homo sapiens, GI270265879, Length=455, Percent_Identity=38.2417582417582, Blast_Score=317, Evalue=1e-86,
Organism=Escherichia coli, GI87081919, Length=544, Percent_Identity=39.3382352941176, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1788806, Length=413, Percent_Identity=23.9709443099274, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17537199, Length=548, Percent_Identity=36.8613138686131, Blast_Score=345, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6322823, Length=562, Percent_Identity=40.3914590747331, Blast_Score=412, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24646388, Length=541, Percent_Identity=35.8595194085028, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI24646386, Length=541, Percent_Identity=35.8595194085028, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI281362672, Length=539, Percent_Identity=36.5491651205937, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI281362674, Length=539, Percent_Identity=36.5491651205937, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI21356279, Length=539, Percent_Identity=36.5491651205937, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI281363505, Length=538, Percent_Identity=29.7397769516729, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI78707236, Length=538, Percent_Identity=29.7397769516729, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI281363503, Length=536, Percent_Identity=29.6641791044776, Blast_Score=292, Evalue=4e-79,
Organism=Drosophila melanogaster, GI78707232, Length=514, Percent_Identity=30.3501945525292, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI78707242, Length=539, Percent_Identity=30.4267161410019, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI78707238, Length=539, Percent_Identity=30.4267161410019, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI78707240, Length=515, Percent_Identity=31.0679611650485, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI19922384, Length=535, Percent_Identity=29.3457943925234, Blast_Score=241, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 60384; Mature: 60253

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKPEPMTNPITNRGTAFTRAERLEHGMIGRLPAAVETLEQQAQRCYRQLQGLGCNIDR
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
YVFLEELQNRNETLYYKLLVDHLVELLPVIYDPTVGEAIKKWSHAYRRSRAVYLSVDHIE
HHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEHHHH
DVRPSFETLELGPDDVDLLVVSDSEQILGIGDWGVNGTDISIGKLAVYTAAAGIRPERTI
HCCCCCCEEECCCCCEEEEEEECCCCEEEEECCCCCCCCEEHHHHEEHHHHCCCCCCCEE
AVNLDVGTDNAYLLNDPSYLGNRHARVRGERYDELIHEYLEVASELYPHALLHFEDFGAS
EEEEEECCCCEEEECCCHHHCCCCHHCCCHHHHHHHHHHHHHHHHHCHHHHEEEHHCCCC
NARRILVQNAANHRIFNDDMQGTAAIVLAAVISGLKVTRQSFADQRLIVYGAGTAGTGIA
CCCEEEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
DQIRAAMISDGLSQQEAVDRIWLVDRNGLVTDDMKGLPDYQEPYAKPVEKTRHWAHTNRH
HHHHHHHHHCCCCHHHHHCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
IGLTETIRRIHPTILIGTSTDHDAFTQQVVEEMCREVERPIIMPLSNPTEKIEAMPADVI
CCHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCHHE
AWSKGKALVSVGIPVAPFHYEGTRYEIGQGNNALLYPGLGLGVIVSGAERVSARMIRAAA
EECCCCEEEEECCCCCCEECCCCEEEECCCCCEEEECCCCCCCEECCHHHHHHHHHHHHH
EAVASQVDPRPAGSSLLPAVENLRASSATVAVAVVQAAIEEGLATKKPSNVVQAVQDAMW
HHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
WPHYPPVG
CCCCCCCC
>Mature Secondary Structure 
SRKPEPMTNPITNRGTAFTRAERLEHGMIGRLPAAVETLEQQAQRCYRQLQGLGCNIDR
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
YVFLEELQNRNETLYYKLLVDHLVELLPVIYDPTVGEAIKKWSHAYRRSRAVYLSVDHIE
HHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEHHHH
DVRPSFETLELGPDDVDLLVVSDSEQILGIGDWGVNGTDISIGKLAVYTAAAGIRPERTI
HCCCCCCEEECCCCCEEEEEEECCCCEEEEECCCCCCCCEEHHHHEEHHHHCCCCCCCEE
AVNLDVGTDNAYLLNDPSYLGNRHARVRGERYDELIHEYLEVASELYPHALLHFEDFGAS
EEEEEECCCCEEEECCCHHHCCCCHHCCCHHHHHHHHHHHHHHHHHCHHHHEEEHHCCCC
NARRILVQNAANHRIFNDDMQGTAAIVLAAVISGLKVTRQSFADQRLIVYGAGTAGTGIA
CCCEEEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
DQIRAAMISDGLSQQEAVDRIWLVDRNGLVTDDMKGLPDYQEPYAKPVEKTRHWAHTNRH
HHHHHHHHHCCCCHHHHHCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
IGLTETIRRIHPTILIGTSTDHDAFTQQVVEEMCREVERPIIMPLSNPTEKIEAMPADVI
CCHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCHHE
AWSKGKALVSVGIPVAPFHYEGTRYEIGQGNNALLYPGLGLGVIVSGAERVSARMIRAAA
EECCCCEEEEECCCCCCEECCCCEEEECCCCCEEEECCCCCCCEECCHHHHHHHHHHHHH
EAVASQVDPRPAGSSLLPAVENLRASSATVAVAVVQAAIEEGLATKKPSNVVQAVQDAMW
HHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
WPHYPPVG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]