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The map label for this gene is hemE [H]

Identifier: 50841794

GI number: 50841794

Start: 356696

End: 357976

Strand: Reverse

Name: hemE [H]

Synonym: PPA0306

Alternate gene names: 50841794

Gene position: 357976-356696 (Counterclockwise)

Preceding gene: 229259642

Following gene: 50841793

Centisome position: 13.98

GC content: 62.45

Gene sequence:

>1281_bases
ATGATCGGTCAATGCCAGGCCAAGTCCGTCAACCTGCGCGGCCGCCTCGGAAACGACGCCAAGCCCCTGCTCGGCATGAT
CCACGGTCAAGACACACAATCCCACGAAGCGTTATTCAACCATGCTGTAACGACGAACCCCAGTACATACGAAGCTCATA
ACTCGCCCAATAACCGTCCTGTGGGCGGCATCTGCACGTGGTGGGGCACAATCGGGGTGATGACTGAGACCACTACCTTC
ATGGCAGATTCACCGCTTCTGCAAGCCATGACTGGGCACCGCCCTACCGTCACCCCGGTGTGGTTTATGCGCCAGGCAGG
CCGTTCGCTACCGGAGTACCGCGAAGCCCGAGAGGGCACCACGATGCTCGAGTCTTGCCTCAACCCTGAGCTCGCCGCCG
AGATTACCTGCCAACCTGTGCGCCGCCACCACGTCGACGGGGCCGTTCTCTACTCCGACATCATGGTGCCGCTAGCTCTG
GCGGGGGCAGAGGTGCGCATTGAGCCAGGAGTCGGGCCCGTTCTCGACGAACCCGTCCGCACTGCCTCCGACGTTGACCG
CATTACTCGACGTCATGTCGAGGACCCCTCGGTTATCGAGGAGGCTGCACGCCTGGCGATCACCGAGTTAGGCGACGCCA
CACCGCTCATCGGTTTCGCGGGTGCCCCGTTTACTATCGCCGCCTACCTCGTCGAGGGCGGCCCTTCCCGCGACCATCTG
TCTGCCCGAGCGATGATGCACTCAGACCCACAGACCTGGGCAAGGCTGATGGAGTGGGTTGCCGACTTGGATGCTGCCTT
CCTGGCTGCTCAGCTGCGCGGCGGGGCGCGTGCCTTCCAGCTCTTTGATTCCTGGGCTGGGTCGCTGAGCGCAAGCGATT
ATAGAGCCAGCGTCGCACCGTTCTCTCAGCGGGCTCTGGCTACCGTCGATCCGAACATCCCGGTGGTTCACTTTGGCATC
AATGCCACCCATCTGCTATCTGAGTTTGCGCAGGTGGCAGCTACTGCGTCACGGTACCCAGTACTTGGTGTCGACCACCG
GATTAGCCTCGATGAGGCCTGCGCCACTCTTATGGTCTCCGGGATGGAGATGCCGGTTCAGGGCAACATCGATCCCGCCT
TGCTCTTCGCCGGATGGGAACCGCTGGAGTCCGCCACCCGCGATATCGTCGCGGCAGGACGTCAGGCCCCTGGACACGTC
GTCAATCTGGGTCACGGTGTGCCCTCCAACACCGACCCCAACGTCTTGACACGGCTGGTGGAGCTGGTGCACTCCCTGTG
A

Upstream 100 bases:

>100_bases
CGGCCTCGTCGAACCCTTGCGCGACGGCTTCAGGGGAGGTTTCAACGATCAGGCACACCCGGTTGCACGTTGACAGCACA
AGGGCGCCCCGGATCTGGGG

Downstream 100 bases:

>100_bases
GCCGAGTAGCGACGATGAACATTTCTGATCCGCAGCACGTCGACGCCGTCGTCATTGGCGGGGGCATGGCTGGCCTCGTG
GCCGCCTGGCAGTTCACCCA

Product: uroporphyrinogen decarboxylase, HemE

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MIGQCQAKSVNLRGRLGNDAKPLLGMIHGQDTQSHEALFNHAVTTNPSTYEAHNSPNNRPVGGICTWWGTIGVMTETTTF
MADSPLLQAMTGHRPTVTPVWFMRQAGRSLPEYREAREGTTMLESCLNPELAAEITCQPVRRHHVDGAVLYSDIMVPLAL
AGAEVRIEPGVGPVLDEPVRTASDVDRITRRHVEDPSVIEEAARLAITELGDATPLIGFAGAPFTIAAYLVEGGPSRDHL
SARAMMHSDPQTWARLMEWVADLDAAFLAAQLRGGARAFQLFDSWAGSLSASDYRASVAPFSQRALATVDPNIPVVHFGI
NATHLLSEFAQVAATASRYPVLGVDHRISLDEACATLMVSGMEMPVQGNIDPALLFAGWEPLESATRDIVAAGRQAPGHV
VNLGHGVPSNTDPNVLTRLVELVHSL

Sequences:

>Translated_426_residues
MIGQCQAKSVNLRGRLGNDAKPLLGMIHGQDTQSHEALFNHAVTTNPSTYEAHNSPNNRPVGGICTWWGTIGVMTETTTF
MADSPLLQAMTGHRPTVTPVWFMRQAGRSLPEYREAREGTTMLESCLNPELAAEITCQPVRRHHVDGAVLYSDIMVPLAL
AGAEVRIEPGVGPVLDEPVRTASDVDRITRRHVEDPSVIEEAARLAITELGDATPLIGFAGAPFTIAAYLVEGGPSRDHL
SARAMMHSDPQTWARLMEWVADLDAAFLAAQLRGGARAFQLFDSWAGSLSASDYRASVAPFSQRALATVDPNIPVVHFGI
NATHLLSEFAQVAATASRYPVLGVDHRISLDEACATLMVSGMEMPVQGNIDPALLFAGWEPLESATRDIVAAGRQAPGHV
VNLGHGVPSNTDPNVLTRLVELVHSL
>Mature_426_residues
MIGQCQAKSVNLRGRLGNDAKPLLGMIHGQDTQSHEALFNHAVTTNPSTYEAHNSPNNRPVGGICTWWGTIGVMTETTTF
MADSPLLQAMTGHRPTVTPVWFMRQAGRSLPEYREAREGTTMLESCLNPELAAEITCQPVRRHHVDGAVLYSDIMVPLAL
AGAEVRIEPGVGPVLDEPVRTASDVDRITRRHVEDPSVIEEAARLAITELGDATPLIGFAGAPFTIAAYLVEGGPSRDHL
SARAMMHSDPQTWARLMEWVADLDAAFLAAQLRGGARAFQLFDSWAGSLSASDYRASVAPFSQRALATVDPNIPVVHFGI
NATHLLSEFAQVAATASRYPVLGVDHRISLDEACATLMVSGMEMPVQGNIDPALLFAGWEPLESATRDIVAAGRQAPGHV
VNLGHGVPSNTDPNVLTRLVELVHSL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=363, Percent_Identity=32.7823691460055, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI2367337, Length=356, Percent_Identity=35.1123595505618, Blast_Score=199, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320252, Length=358, Percent_Identity=30.4469273743017, Blast_Score=179, Evalue=9e-46,
Organism=Drosophila melanogaster, GI221330099, Length=354, Percent_Identity=32.2033898305085, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI19921920, Length=354, Percent_Identity=32.2033898305085, Blast_Score=178, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 45848; Mature: 45848

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGQCQAKSVNLRGRLGNDAKPLLGMIHGQDTQSHEALFNHAVTTNPSTYEAHNSPNNRP
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCC
VGGICTWWGTIGVMTETTTFMADSPLLQAMTGHRPTVTPVWFMRQAGRSLPEYREAREGT
CCCEEEHHHHHHHHCCCHHHHCCCHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
TMLESCLNPELAAEITCQPVRRHHVDGAVLYSDIMVPLALAGAEVRIEPGVGPVLDEPVR
HHHHHHCCCCHHHHHEHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHH
TASDVDRITRRHVEDPSVIEEAARLAITELGDATPLIGFAGAPFTIAAYLVEGGPSRDHL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHH
SARAMMHSDPQTWARLMEWVADLDAAFLAAQLRGGARAFQLFDSWAGSLSASDYRASVAP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHCCC
FSQRALATVDPNIPVVHFGINATHLLSEFAQVAATASRYPVLGVDHRISLDEACATLMVS
CCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHH
GMEMPVQGNIDPALLFAGWEPLESATRDIVAAGRQAPGHVVNLGHGVPSNTDPNVLTRLV
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHHHHH
ELVHSL
HHHHCC
>Mature Secondary Structure
MIGQCQAKSVNLRGRLGNDAKPLLGMIHGQDTQSHEALFNHAVTTNPSTYEAHNSPNNRP
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCC
VGGICTWWGTIGVMTETTTFMADSPLLQAMTGHRPTVTPVWFMRQAGRSLPEYREAREGT
CCCEEEHHHHHHHHCCCHHHHCCCHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
TMLESCLNPELAAEITCQPVRRHHVDGAVLYSDIMVPLALAGAEVRIEPGVGPVLDEPVR
HHHHHHCCCCHHHHHEHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHH
TASDVDRITRRHVEDPSVIEEAARLAITELGDATPLIGFAGAPFTIAAYLVEGGPSRDHL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHH
SARAMMHSDPQTWARLMEWVADLDAAFLAAQLRGGARAFQLFDSWAGSLSASDYRASVAP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHCCC
FSQRALATVDPNIPVVHFGINATHLLSEFAQVAATASRYPVLGVDHRISLDEACATLMVS
CCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHH
GMEMPVQGNIDPALLFAGWEPLESATRDIVAAGRQAPGHVVNLGHGVPSNTDPNVLTRLV
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHHHHH
ELVHSL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA