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The map label for this gene is pstP [H]

Identifier: 50841676

GI number: 50841676

Start: 228612

End: 230099

Strand: Reverse

Name: pstP [H]

Synonym: PPA0187

Alternate gene names: 50841676

Gene position: 230099-228612 (Counterclockwise)

Preceding gene: 50841677

Following gene: 50841675

Centisome position: 8.99

GC content: 60.15

Gene sequence:

>1488_bases
ATGGCCTTTTCCCTCGATATTCGATGCCACTCCGAAATCGGTCTGGTCCGACGCAATAATCAAGACTCGGGATACGTCTC
CCCGAGGATGCTCGTCGTCGCTGACGGCATGGGAGGCGCAGCCGCGGGTGACCTTGCCTCGACCGTCGCGGTACGCCATG
TTGCTAAGGCCGACCGAAGGTTCTCCGGCGAGGGCTCACCAGCTCGCCCCCAAGGTGAGGAGATGCTCACCGTTCTTTCC
GGTGCGGTAGCCGACGCCAACGACGAACTGGCGGATCTCGTCGCATGGGACTCCTCCCTTGAAGGGATGGGAACGACCTT
CTGTGGCGCGATGTTCTCTGGTACCCAGCTTGGCATCGTTCACATCGGCGACTCCCGTGGCTATTTGCTGCGTCAAGGCC
GGATGAAGCGGATGACTCACGATCATTCCTGGGTGCAGTCTCTTATTGACGATGGGCGGATTACTCCCGAGGAGGCCGCT
GTTCACCCGCACCGGTCCCTCCTGCTCAAGGTGCTTAATGGTCAGCCTCAGCACATCCCGGACACTCAGATCGTGGATCT
TCGTTTGGGTGACCGCATTCTCTTCTGCTCCGACGGACTATGCGGTCTGGTTAACGACGATACGATCGGCGAGCACCTCA
ACACCACCAACCTCGACGACGTCGTCGATCTGCTCACAACAGACGCCCATGCTGGCGGCGGCACTGACAACATCACCATC
GTCGTCGCCGAGGTCGTTGAGGCCGACCCCAACCTGGACGCTTCCGAACCACACATCATTGGCGCAGCAACGACCCGCAA
AGTACCCGAGCATGAGGTCACCGCCCCACTGCCCCTCGATCAACCGGCATCCGCGACAAACAATGACGGCAAGTCAACCG
TATTGTTCGACTCCGAGGCTGAAGAGTCGATGCGCTACGCCCCCGTTGACTCCATGACCCGTCACCGCCGCCATTGGTTG
TGGCCCGTCGTCATCTTGGCCTTCGTCGCTGTGGTAGTCGGCGGCATTTTTGGCGCTCGCGCCTACCTCAACACCCAGTA
CTACGTTGGTACCGACGACGACACAGTAGCCATCTACCAAGGATCACCCGACAATTTAGCCTGGATTCAGCTATCTCACG
TCACCGAGAAAACCAACATCAAAACTGCTGATCTTCCCCGCTATTACCGAGACCGCGTCTTGGGGAATATAAGGGTCTCG
TCCATGGATTCAGCCCACGCCACAGTTGCTGAACTGCGTACTGGGGCTCAACAGTGCAAGGTAATAAGGGAGGCTGCCAC
TGCGCCACCTCCTACTAAACCCGCGACGCCCCCCTCAACACCCCCGCAACCTTCCGCCAGCGGACCCACCGCGAACGCCC
ATCACACTCCCCAGCCGTCCGCTGTACCAACCCCGGCCATGCCGACGCCAACTTCCGCTATGCCCTCACCGAGCGCCGCA
GGCCATGAAGTCGACCTCCCGGCCGTCACTTCGGGGGATTGCCAATGA

Upstream 100 bases:

>100_bases
TGTCAACGGTGAGCGCATCGAGAATCCGACGCGCCTGTCGGTGGGGGACGAGGTGCGAATTGGCAGGACCACCATGACCG
TCACCGGTAGGCGATGAGCA

Downstream 100 bases:

>100_bases
GTATCGGACAGGAATTTGATGACGGCACCGTCGTCATCCAGGCCAAGAGGCGCTGGACGGAACTCTTCATGCTCCTCATC
GCCTGGGCTATCGGCTTCGG

Product: putative protein phosphatase

Products: NA

Alternate protein names: Mycobacterial Ser/Thr phosphatase; Mstp; Possible serine/threonine phosphatase Ppp [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MAFSLDIRCHSEIGLVRRNNQDSGYVSPRMLVVADGMGGAAAGDLASTVAVRHVAKADRRFSGEGSPARPQGEEMLTVLS
GAVADANDELADLVAWDSSLEGMGTTFCGAMFSGTQLGIVHIGDSRGYLLRQGRMKRMTHDHSWVQSLIDDGRITPEEAA
VHPHRSLLLKVLNGQPQHIPDTQIVDLRLGDRILFCSDGLCGLVNDDTIGEHLNTTNLDDVVDLLTTDAHAGGGTDNITI
VVAEVVEADPNLDASEPHIIGAATTRKVPEHEVTAPLPLDQPASATNNDGKSTVLFDSEAEESMRYAPVDSMTRHRRHWL
WPVVILAFVAVVVGGIFGARAYLNTQYYVGTDDDTVAIYQGSPDNLAWIQLSHVTEKTNIKTADLPRYYRDRVLGNIRVS
SMDSAHATVAELRTGAQQCKVIREAATAPPPTKPATPPSTPPQPSASGPTANAHHTPQPSAVPTPAMPTPTSAMPSPSAA
GHEVDLPAVTSGDCQ

Sequences:

>Translated_495_residues
MAFSLDIRCHSEIGLVRRNNQDSGYVSPRMLVVADGMGGAAAGDLASTVAVRHVAKADRRFSGEGSPARPQGEEMLTVLS
GAVADANDELADLVAWDSSLEGMGTTFCGAMFSGTQLGIVHIGDSRGYLLRQGRMKRMTHDHSWVQSLIDDGRITPEEAA
VHPHRSLLLKVLNGQPQHIPDTQIVDLRLGDRILFCSDGLCGLVNDDTIGEHLNTTNLDDVVDLLTTDAHAGGGTDNITI
VVAEVVEADPNLDASEPHIIGAATTRKVPEHEVTAPLPLDQPASATNNDGKSTVLFDSEAEESMRYAPVDSMTRHRRHWL
WPVVILAFVAVVVGGIFGARAYLNTQYYVGTDDDTVAIYQGSPDNLAWIQLSHVTEKTNIKTADLPRYYRDRVLGNIRVS
SMDSAHATVAELRTGAQQCKVIREAATAPPPTKPATPPSTPPQPSASGPTANAHHTPQPSAVPTPAMPTPTSAMPSPSAA
GHEVDLPAVTSGDCQ
>Mature_494_residues
AFSLDIRCHSEIGLVRRNNQDSGYVSPRMLVVADGMGGAAAGDLASTVAVRHVAKADRRFSGEGSPARPQGEEMLTVLSG
AVADANDELADLVAWDSSLEGMGTTFCGAMFSGTQLGIVHIGDSRGYLLRQGRMKRMTHDHSWVQSLIDDGRITPEEAAV
HPHRSLLLKVLNGQPQHIPDTQIVDLRLGDRILFCSDGLCGLVNDDTIGEHLNTTNLDDVVDLLTTDAHAGGGTDNITIV
VAEVVEADPNLDASEPHIIGAATTRKVPEHEVTAPLPLDQPASATNNDGKSTVLFDSEAEESMRYAPVDSMTRHRRHWLW
PVVILAFVAVVVGGIFGARAYLNTQYYVGTDDDTVAIYQGSPDNLAWIQLSHVTEKTNIKTADLPRYYRDRVLGNIRVSS
MDSAHATVAELRTGAQQCKVIREAATAPPPTKPATPPSTPPQPSASGPTANAHHTPQPSAVPTPAMPTPTSAMPSPSAAG
HEVDLPAVTSGDCQ

Specific function: The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (pknA, pknB, pknD, pknE and pknF) and the penicillin-binding protein PBPA [H]

COG id: COG0631

COG function: function code T; Serine/threonine protein phosphatase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential). Note=May be localized to the outside of the cell [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015655
- InterPro:   IPR001932
- InterPro:   IPR014045 [H]

Pfam domain/function: PF00481 PP2C [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 52760; Mature: 52628

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFSLDIRCHSEIGLVRRNNQDSGYVSPRMLVVADGMGGAAAGDLASTVAVRHVAKADRR
CEEEEEEEECCCCCEEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
FSGEGSPARPQGEEMLTVLSGAVADANDELADLVAWDSSLEGMGTTFCGAMFSGTQLGIV
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEE
HIGDSRGYLLRQGRMKRMTHDHSWVQSLIDDGRITPEEAAVHPHRSLLLKVLNGQPQHIP
EECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHCCCCCCCC
DTQIVDLRLGDRILFCSDGLCGLVNDDTIGEHLNTTNLDDVVDLLTTDAHAGGGTDNITI
CCEEEEEEECCEEEEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEE
VVAEVVEADPNLDASEPHIIGAATTRKVPEHEVTAPLPLDQPASATNNDGKSTVLFDSEA
EEEEEHHCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCH
EESMRYAPVDSMTRHRRHWLWPVVILAFVAVVVGGIFGARAYLNTQYYVGTDDDTVAIYQ
HHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECCCCEEEEEE
GSPDNLAWIQLSHVTEKTNIKTADLPRYYRDRVLGNIRVSSMDSAHATVAELRTGAQQCK
CCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHH
VIREAATAPPPTKPATPPSTPPQPSASGPTANAHHTPQPSAVPTPAMPTPTSAMPSPSAA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GHEVDLPAVTSGDCQ
CCEECCCCCCCCCCC
>Mature Secondary Structure 
AFSLDIRCHSEIGLVRRNNQDSGYVSPRMLVVADGMGGAAAGDLASTVAVRHVAKADRR
EEEEEEEECCCCCEEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
FSGEGSPARPQGEEMLTVLSGAVADANDELADLVAWDSSLEGMGTTFCGAMFSGTQLGIV
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEE
HIGDSRGYLLRQGRMKRMTHDHSWVQSLIDDGRITPEEAAVHPHRSLLLKVLNGQPQHIP
EECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHCCCCCCCC
DTQIVDLRLGDRILFCSDGLCGLVNDDTIGEHLNTTNLDDVVDLLTTDAHAGGGTDNITI
CCEEEEEEECCEEEEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEE
VVAEVVEADPNLDASEPHIIGAATTRKVPEHEVTAPLPLDQPASATNNDGKSTVLFDSEA
EEEEEHHCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCH
EESMRYAPVDSMTRHRRHWLWPVVILAFVAVVVGGIFGARAYLNTQYYVGTDDDTVAIYQ
HHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECCCCEEEEEE
GSPDNLAWIQLSHVTEKTNIKTADLPRYYRDRVLGNIRVSSMDSAHATVAELRTGAQQCK
CCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHH
VIREAATAPPPTKPATPPSTPPQPSASGPTANAHHTPQPSAVPTPAMPTPTSAMPSPSAA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GHEVDLPAVTSGDCQ
CCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]