Definition | Mesoplasma florum L1, complete genome. |
---|---|
Accession | NC_006055 |
Length | 793,224 |
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The map label for this gene is parC [H]
Identifier: 50365126
GI number: 50365126
Start: 358031
End: 360757
Strand: Direct
Name: parC [H]
Synonym: Mfl310
Alternate gene names: 50365126
Gene position: 358031-360757 (Clockwise)
Preceding gene: 50365125
Following gene: 50365127
Centisome position: 45.14
GC content: 29.41
Gene sequence:
>2727_bases ATGGCAAAAAAAATAGATAATTCAAATATTGAATCTGAAAAAGGAATAATTAGTTATGCTTTAGAAGACTTAATGGGTGA ACGATTTGGTAGATATGCTAAATACATTATTCAAGAACGTGCATTACCAGATGCTAGAGATGGTTTAAAACCAGTTCAAA GACGTATTTTATATGCAATGAATGAATTAAATCTAACTTATGATAAACCATATAAAAAATCAGCTAGAGTAGTTGGAGAA GTTATTGGTAAGTACCACCCACATGGTGATACATCAATCTATGATGCAATGGTTCGTATGAGTCAATGATGAAAACTAGG AATGCCTTTAATTGACATGCAAGGTAATAATGGTTCTATTGATGGTGATAATGCAGCTGCAATGCGTTATACTGAAACTC GTTTAGCTAAAATTAGTGATTTAATGTTAGATGACTTAAATAAAAATACAGTTAAGTTTGCGCCTAACTTTGATGATAGT GAAAAAGAACCAACTGTTTTACCAAGTTATTTCCCTAACATTTTAGTTAATGGATCAACAGGGATTGCTGCTGGATATGC TACAAATATGCCTCCACACAACCTTGGTGAAATTATTGATGCAACAATTAAATTAATTAGAACTCCAAACACTAGAATAG ACACTATTTTAGAAATTGTTAAAGGACCAGATTTTCCAACTGGAGGAACTGTTCAAGGACGTAATGGAATTAAAGATGCA TTTACAACTGGTAAAGGTAAAGTTATTGTTAATTCAAAATGACATGAAGAAGATAATAATATCATTATTGATGAAATCCC ATATGAAGTTGTTAAACAAGATTTAGTTAAAAAAATTGGTGATGTTATTGATGCTAATCCCGGTTTAGGGATCTTAGAAG TAAGAGATGAAACTGATCGAAATGGATTAAGAATAGCAATTGATTTAAGTGATAAAGCTAATTTAGATACAGTTAGAAAA TTCTTATTCAAATCAACTCCATTAAGTATTTCATATAACTATAACAATGTGGCTATTGTTGATTTACAACCAAAACAATT AGGAATTATTGAATTAATTCATGCATATATTGCTCACTATAAAGAAGTATTTACATTTAGAACTCAATTTGATTTAAATA AAGCTGAAAAACGTTTAGAAATCATTTTAGGTTTAATTAAAGCAATGAGTATTTTGGATCAAGTTATCTCAGTAATTAGA AGTTCAACAAACAGAAGTGATGCTATTGAAAACTTAATTTCAAAATTTGTATTCTCTCAACCTCAAGCAGCAGCTATTGT TGATATGAGACTATATCGTTTAACTTCAACTGATGTGGTTAAACTACAAAATGAAAAAGAAGAATTAGATGTAAACATTG CTAAATTAAAAGCTATTTTAAATAGTGAAGAAGTAATGGATAATGAAATCATTAACCGTTTAAGAGAAGTTAAAAAACAA TTCCCAACTCCAAGAAGATCAATTGTTGAAGATAGTATTGAAAACTTAGATGTTGAGCAAAAAGAAGTATTAGTTGAACA TGAATATAACTTATGAATTTCAAAAGATGGATATTTAAAAGCTATTGAATCAAAACTAATTAGTAAAAACGATCCTGCTG TATTTGGAAGAAAACCAAATGATATGTGAATTGCAGCTGGTGAAGTAAGTAACTTACAACATTTAATCTTAGTTACTAAC AAAGGAACATATTATTCAATTCCTTTATATAAACTACCAATGAGTAAATGAAGAGACATGGGAGTTCATGTTAACACTAT TGCTACAATGGATCCTAGTGAACATATTGTTAGTGCATTTGTAGTTAAAGATTTTGCTGAAGCTTTACAACAAATCTTAA TCACAAGTAAAAATGGAAACATTAAACGTATACCAGTTAAAGATTTAGAAACAAAAATCTTTACACGTGCATTTAGAATA ATGAAATTAGATGCAGTTGATGAAATTGTTAGTGCTAGTCTAATTACTTCAAAAACTAGAACTTGTGGAATTATTACAAG AAATGGTTATGGAGTAAGATACCATATTGAAGATATTCCAGTTCAAGGAACTAATTCAAAAGGTGTTAAAGCAGCTAATC TAAAAGAAGATTACATAGTTGCTGGTTTAGGATTAACAAGTGAAGATACTATTATGTATTTAACTGAAAAAGACGGAGTT AAAAAATTCAGAAATGAAGATTTACCAATCTATATTAGACCAAAACGTGGAATAAGAGTATTACCAGAACGTAAACGTGG AACAGAATACATTACATTTGCATTTAACTTTAATGCAAATGAAGAAAACATTATTAAAGCAATTGATACTCAAGATATGT ATCAAGAAGTTAACGTTAATAAATATCGTCATATTGAATTAACTAGTGTAACTGGTGATTTTGATATTAAAGATGTTGCA TTCGCTAGTTTAAGTGAAATTAATAAGGTTAAACCAAACGATATGCCCCCAGGTGCTTTAAATGCTGATGATGATGCTGA AGGATATGTGTCTAAAGAAGAAATTAGAGCACGTCAAGAAGCTAACAAAGGTAAAGTGTCAGCTAAAGTAGTGGTAAGCA AAAATATTAAAGAAGAAAGCGAAAAACGTATTCAATCGTTAACTGGTGGTTTAAGTGATTTACTAGGAGATATTTCTTCA GTTTTAGGAACACCAAGCAAATCAAAACCTAAAAAAGAAGTTAAAGATGAATTTCAATTAGACTTAAGTGATCTATTAGA GGAATAA
Upstream 100 bases:
>100_bases AGTATGAATTCAAGAAAATGTTAAATTCACTTTAGAAGATAATGATGATGCAATCATCTTAAATGAGAAACAAGAAAATA ACTAGAAAGGAGAAATATAC
Downstream 100 bases:
>100_bases GGAGTTACTATGGAGTCTTTAATTCATAAAATTGAAAAATACAAGAATCATGATGATTCTAAAATTCAATCAATAATTTC TAAAGTTCTTTACCAAAATT
Product: DNA topoisomerase IV subunit A
Products: NA
Alternate protein names: Topoisomerase IV subunit A [H]
Number of amino acids: Translated: 908; Mature: 907
Protein sequence:
>908_residues MAKKIDNSNIESEKGIISYALEDLMGERFGRYAKYIIQERALPDARDGLKPVQRRILYAMNELNLTYDKPYKKSARVVGE VIGKYHPHGDTSIYDAMVRMSQWWKLGMPLIDMQGNNGSIDGDNAAAMRYTETRLAKISDLMLDDLNKNTVKFAPNFDDS EKEPTVLPSYFPNILVNGSTGIAAGYATNMPPHNLGEIIDATIKLIRTPNTRIDTILEIVKGPDFPTGGTVQGRNGIKDA FTTGKGKVIVNSKWHEEDNNIIIDEIPYEVVKQDLVKKIGDVIDANPGLGILEVRDETDRNGLRIAIDLSDKANLDTVRK FLFKSTPLSISYNYNNVAIVDLQPKQLGIIELIHAYIAHYKEVFTFRTQFDLNKAEKRLEIILGLIKAMSILDQVISVIR SSTNRSDAIENLISKFVFSQPQAAAIVDMRLYRLTSTDVVKLQNEKEELDVNIAKLKAILNSEEVMDNEIINRLREVKKQ FPTPRRSIVEDSIENLDVEQKEVLVEHEYNLWISKDGYLKAIESKLISKNDPAVFGRKPNDMWIAAGEVSNLQHLILVTN KGTYYSIPLYKLPMSKWRDMGVHVNTIATMDPSEHIVSAFVVKDFAEALQQILITSKNGNIKRIPVKDLETKIFTRAFRI MKLDAVDEIVSASLITSKTRTCGIITRNGYGVRYHIEDIPVQGTNSKGVKAANLKEDYIVAGLGLTSEDTIMYLTEKDGV KKFRNEDLPIYIRPKRGIRVLPERKRGTEYITFAFNFNANEENIIKAIDTQDMYQEVNVNKYRHIELTSVTGDFDIKDVA FASLSEINKVKPNDMPPGALNADDDAEGYVSKEEIRARQEANKGKVSAKVVVSKNIKEESEKRIQSLTGGLSDLLGDISS VLGTPSKSKPKKEVKDEFQLDLSDLLEE
Sequences:
>Translated_908_residues MAKKIDNSNIESEKGIISYALEDLMGERFGRYAKYIIQERALPDARDGLKPVQRRILYAMNELNLTYDKPYKKSARVVGE VIGKYHPHGDTSIYDAMVRMSQ**KLGMPLIDMQGNNGSIDGDNAAAMRYTETRLAKISDLMLDDLNKNTVKFAPNFDDS EKEPTVLPSYFPNILVNGSTGIAAGYATNMPPHNLGEIIDATIKLIRTPNTRIDTILEIVKGPDFPTGGTVQGRNGIKDA FTTGKGKVIVNSK*HEEDNNIIIDEIPYEVVKQDLVKKIGDVIDANPGLGILEVRDETDRNGLRIAIDLSDKANLDTVRK FLFKSTPLSISYNYNNVAIVDLQPKQLGIIELIHAYIAHYKEVFTFRTQFDLNKAEKRLEIILGLIKAMSILDQVISVIR SSTNRSDAIENLISKFVFSQPQAAAIVDMRLYRLTSTDVVKLQNEKEELDVNIAKLKAILNSEEVMDNEIINRLREVKKQ FPTPRRSIVEDSIENLDVEQKEVLVEHEYNL*ISKDGYLKAIESKLISKNDPAVFGRKPNDM*IAAGEVSNLQHLILVTN KGTYYSIPLYKLPMSK*RDMGVHVNTIATMDPSEHIVSAFVVKDFAEALQQILITSKNGNIKRIPVKDLETKIFTRAFRI MKLDAVDEIVSASLITSKTRTCGIITRNGYGVRYHIEDIPVQGTNSKGVKAANLKEDYIVAGLGLTSEDTIMYLTEKDGV KKFRNEDLPIYIRPKRGIRVLPERKRGTEYITFAFNFNANEENIIKAIDTQDMYQEVNVNKYRHIELTSVTGDFDIKDVA FASLSEINKVKPNDMPPGALNADDDAEGYVSKEEIRARQEANKGKVSAKVVVSKNIKEESEKRIQSLTGGLSDLLGDISS VLGTPSKSKPKKEVKDEFQLDLSDLLEE >Mature_907_residues AKKIDNSNIESEKGIISYALEDLMGERFGRYAKYIIQERALPDARDGLKPVQRRILYAMNELNLTYDKPYKKSARVVGEV IGKYHPHGDTSIYDAMVRMSQ**KLGMPLIDMQGNNGSIDGDNAAAMRYTETRLAKISDLMLDDLNKNTVKFAPNFDDSE KEPTVLPSYFPNILVNGSTGIAAGYATNMPPHNLGEIIDATIKLIRTPNTRIDTILEIVKGPDFPTGGTVQGRNGIKDAF TTGKGKVIVNSK*HEEDNNIIIDEIPYEVVKQDLVKKIGDVIDANPGLGILEVRDETDRNGLRIAIDLSDKANLDTVRKF LFKSTPLSISYNYNNVAIVDLQPKQLGIIELIHAYIAHYKEVFTFRTQFDLNKAEKRLEIILGLIKAMSILDQVISVIRS STNRSDAIENLISKFVFSQPQAAAIVDMRLYRLTSTDVVKLQNEKEELDVNIAKLKAILNSEEVMDNEIINRLREVKKQF PTPRRSIVEDSIENLDVEQKEVLVEHEYNL*ISKDGYLKAIESKLISKNDPAVFGRKPNDM*IAAGEVSNLQHLILVTNK GTYYSIPLYKLPMSK*RDMGVHVNTIATMDPSEHIVSAFVVKDFAEALQQILITSKNGNIKRIPVKDLETKIFTRAFRIM KLDAVDEIVSASLITSKTRTCGIITRNGYGVRYHIEDIPVQGTNSKGVKAANLKEDYIVAGLGLTSEDTIMYLTEKDGVK KFRNEDLPIYIRPKRGIRVLPERKRGTEYITFAFNFNANEENIIKAIDTQDMYQEVNVNKYRHIELTSVTGDFDIKDVAF ASLSEINKVKPNDMPPGALNADDDAEGYVSKEEIRARQEANKGKVSAKVVVSKNIKEESEKRIQSLTGGLSDLLGDISSV LGTPSKSKPKKEVKDEFQLDLSDLLEE
Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=424, Percent_Identity=23.1132075471698, Blast_Score=79, Evalue=2e-14, Organism=Homo sapiens, GI19913406, Length=175, Percent_Identity=29.7142857142857, Blast_Score=78, Evalue=5e-14, Organism=Escherichia coli, GI1788562, Length=787, Percent_Identity=34.4345616264295, Blast_Score=422, Evalue=1e-119, Organism=Escherichia coli, GI1789396, Length=736, Percent_Identity=32.3369565217391, Blast_Score=340, Evalue=3e-94, Organism=Caenorhabditis elegans, GI212645845, Length=312, Percent_Identity=26.9230769230769, Blast_Score=81, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17535065, Length=441, Percent_Identity=24.4897959183673, Blast_Score=77, Evalue=3e-14, Organism=Caenorhabditis elegans, GI115534553, Length=169, Percent_Identity=28.9940828402367, Blast_Score=73, Evalue=5e-13, Organism=Caenorhabditis elegans, GI212645657, Length=303, Percent_Identity=24.0924092409241, Blast_Score=67, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6324241, Length=168, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI17136538, Length=175, Percent_Identity=30.2857142857143, Blast_Score=71, Evalue=4e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013760 - InterPro: IPR005741 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: 5.99.1.-
Molecular weight: Translated: 100996; Mature: 100865
Theoretical pI: Translated: 6.30; Mature: 6.30
Prosite motif: PS00018 EF_HAND_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.1 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.1 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAKKIDNSNIESEKGIISYALEDLMGERFGRYAKYIIQERALPDARDGLKPVQRRILYAM CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHH NELNLTYDKPYKKSARVVGEVIGKYHPHGDTSIYDAMVRMSQKLGMPLIDMQGNNGSIDG HHCCCEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCC DNAAAMRYTETRLAKISDLMLDDLNKNTVKFAPNFDDSEKEPTVLPSYFPNILVNGSTGI CCCEEEEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCE AAGYATNMPPHNLGEIIDATIKLIRTPNTRIDTILEIVKGPDFPTGGTVQGRNGIKDAFT EECCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEECCCCCCHHHHC TGKGKVIVNSKHEEDNNIIIDEIPYEVVKQDLVKKIGDVIDANPGLGILEVRDETDRNGL CCCCEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCE RIAIDLSDKANLDTVRKFLFKSTPLSISYNYNNVAIVDLQPKQLGIIELIHAYIAHYKEV EEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHH FTFRTQFDLNKAEKRLEIILGLIKAMSILDQVISVIRSSTNRSDAIENLISKFVFSQPQA HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCH AAIVDMRLYRLTSTDVVKLQNEKEELDVNIAKLKAILNSEEVMDNEIINRLREVKKQFPT HHHHHHHHEEECCCCEEEECCCHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCC PRRSIVEDSIENLDVEQKEVLVEHEYNLISKDGYLKAIESKLISKNDPAVFGRKPNDMIA CHHHHHHHHHHHCCCHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCCCEEECCCCCCEEE AGEVSNLQHLILVTNKGTYYSIPLYKLPMSKRDMGVHVNTIATMDPSEHIVSAFVVKDFA CCCCCCCEEEEEEECCCCEEEECEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH EALQQILITSKNGNIKRIPVKDLETKIFTRAFRIMKLDAVDEIVSASLITSKTRTCGIIT HHHHHHHEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE RNGYGVRYHIEDIPVQGTNSKGVKAANLKEDYIVAGLGLTSEDTIMYLTEKDGVKKFRNE ECCCEEEEEEEECCCCCCCCCCCEECCCCCCEEEEECCCCCCCEEEEEECCCHHHHHCCC DLPIYIRPKRGIRVLPERKRGTEYITFAFNFNANEENIIKAIDTQDMYQEVNVNKYRHIE CCCEEEECCCCCEECCCCCCCCEEEEEEEEECCCCCHHEEECCHHHHHHHCCCCCEEEEE LTSVTGDFDIKDVAFASLSEINKVKPNDMPPGALNADDDAEGYVSKEEIRARQEANKGKV EEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCE SAKVVVSKNIKEESEKRIQSLTGGLSDLLGDISSVLGTPSKSKPKKEVKDEFQLDLSDLL EEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHH EE CC >Mature Secondary Structure AKKIDNSNIESEKGIISYALEDLMGERFGRYAKYIIQERALPDARDGLKPVQRRILYAM CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHH NELNLTYDKPYKKSARVVGEVIGKYHPHGDTSIYDAMVRMSQKLGMPLIDMQGNNGSIDG HHCCCEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCC DNAAAMRYTETRLAKISDLMLDDLNKNTVKFAPNFDDSEKEPTVLPSYFPNILVNGSTGI CCCEEEEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCE AAGYATNMPPHNLGEIIDATIKLIRTPNTRIDTILEIVKGPDFPTGGTVQGRNGIKDAFT EECCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEECCCCCCHHHHC TGKGKVIVNSKHEEDNNIIIDEIPYEVVKQDLVKKIGDVIDANPGLGILEVRDETDRNGL CCCCEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCE RIAIDLSDKANLDTVRKFLFKSTPLSISYNYNNVAIVDLQPKQLGIIELIHAYIAHYKEV EEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHH FTFRTQFDLNKAEKRLEIILGLIKAMSILDQVISVIRSSTNRSDAIENLISKFVFSQPQA HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCH AAIVDMRLYRLTSTDVVKLQNEKEELDVNIAKLKAILNSEEVMDNEIINRLREVKKQFPT HHHHHHHHEEECCCCEEEECCCHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCC PRRSIVEDSIENLDVEQKEVLVEHEYNLISKDGYLKAIESKLISKNDPAVFGRKPNDMIA CHHHHHHHHHHHCCCHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCCCEEECCCCCCEEE AGEVSNLQHLILVTNKGTYYSIPLYKLPMSKRDMGVHVNTIATMDPSEHIVSAFVVKDFA CCCCCCCEEEEEEECCCCEEEECEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH EALQQILITSKNGNIKRIPVKDLETKIFTRAFRIMKLDAVDEIVSASLITSKTRTCGIIT HHHHHHHEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE RNGYGVRYHIEDIPVQGTNSKGVKAANLKEDYIVAGLGLTSEDTIMYLTEKDGVKKFRNE ECCCEEEEEEEECCCCCCCCCCCEECCCCCCEEEEECCCCCCCEEEEEECCCHHHHHCCC DLPIYIRPKRGIRVLPERKRGTEYITFAFNFNANEENIIKAIDTQDMYQEVNVNKYRHIE CCCEEEECCCCCEECCCCCCCCEEEEEEEEECCCCCHHEEECCHHHHHHHCCCCCEEEEE LTSVTGDFDIKDVAFASLSEINKVKPNDMPPGALNADDDAEGYVSKEEIRARQEANKGKV EEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCE SAKVVVSKNIKEESEKRIQSLTGGLSDLLGDISSVLGTPSKSKPKKEVKDEFQLDLSDLL EEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHH EE CC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 8763932; 11463916; 8891124; 8913454 [H]