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The map label for this gene is apt

Identifier: 50365092

GI number: 50365092

Start: 319780

End: 320292

Strand: Direct

Name: apt

Synonym: Mfl276

Alternate gene names: 50365092

Gene position: 319780-320292 (Clockwise)

Preceding gene: 50365091

Following gene: 50365093

Centisome position: 40.31

GC content: 29.63

Gene sequence:

>513_bases
ATGGATTTAAAAAAACATATTTTAAATGTTAAGGATTTCCCAATTGATGGAATTGACTTTAAAGATGTAACACCATTATT
AAATGATGCTGATGCTTTTGCTTATGTAATTGATGAAATGGCAAAATTTGTTATTGAATGTGGAGCTAATGTTGTAGTTG
CTCCAGAAGCAAGAGGATTCTTATTTGCAAGTGCTGTAGCTTATAAATCACATACTAGATTTGTATTAGTTAGAAAACCT
GGTAAATTACCTCGTGAAGTTATCGATATTGAATATACTTTAGAGTATGGAACAAATCATCAACAAATGCACAAAGGTGA
TATTAAACCTGGTGATAAAGTAGTTATTATAGATGATGTACTAGCAACTGGTGGAACAATTGAAGCTATTGTTAAATTAG
TTGAAATGCAAGAAGGTAAAGTTGAGGGAGTTTCATTCTTAATTGATTTGCCAGCATTACATGATGAAAATCTATTACAA
GAATACAAAGTTCAAAAACTTGTTAAATATTAA

Upstream 100 bases:

>100_bases
TTTCAAACTATGGTAGAAAAGAATTTATCTCTCAAACTAATGTTTCTCAAGAAGAACAAATAGTTAAAGATATTAACGAT
TAATTAAAAGGAGTAAATAT

Downstream 100 bases:

>100_bases
GATTAACACCTATAATTAAAATAGGTGTTTTTTTATTTAAAACAGAAAGGTATATTTATGGAAGACAAACAAAGATGTGA
TTGATCATCAAATGCTATTT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MDLKKHILNVKDFPIDGIDFKDVTPLLNDADAFAYVIDEMAKFVIECGANVVVAPEARGFLFASAVAYKSHTRFVLVRKP
GKLPREVIDIEYTLEYGTNHQQMHKGDIKPGDKVVIIDDVLATGGTIEAIVKLVEMQEGKVEGVSFLIDLPALHDENLLQ
EYKVQKLVKY

Sequences:

>Translated_170_residues
MDLKKHILNVKDFPIDGIDFKDVTPLLNDADAFAYVIDEMAKFVIECGANVVVAPEARGFLFASAVAYKSHTRFVLVRKP
GKLPREVIDIEYTLEYGTNHQQMHKGDIKPGDKVVIIDDVLATGGTIEAIVKLVEMQEGKVEGVSFLIDLPALHDENLLQ
EYKVQKLVKY
>Mature_170_residues
MDLKKHILNVKDFPIDGIDFKDVTPLLNDADAFAYVIDEMAKFVIECGANVVVAPEARGFLFASAVAYKSHTRFVLVRKP
GKLPREVIDIEYTLEYGTNHQQMHKGDIKPGDKVVIIDDVLATGGTIEAIVKLVEMQEGKVEGVSFLIDLPALHDENLLQ
EYKVQKLVKY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=32.1637426900585, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=35.2, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1786675, Length=159, Percent_Identity=49.685534591195, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=39.4117647058824, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6323619, Length=153, Percent_Identity=35.2941176470588, Blast_Score=79, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17136334, Length=174, Percent_Identity=37.9310344827586, Blast_Score=100, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_MESFL (Q6F1J0)

Other databases:

- EMBL:   AE017263
- RefSeq:   YP_053517.1
- ProteinModelPortal:   Q6F1J0
- SMR:   Q6F1J0
- GeneID:   2897963
- GenomeReviews:   AE017263_GR
- KEGG:   mfl:Mfl276
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   MFLO265311:MFL276-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19014; Mature: 19014

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKKHILNVKDFPIDGIDFKDVTPLLNDADAFAYVIDEMAKFVIECGANVVVAPEARGF
CCHHHHHCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCE
LFASAVAYKSHTRFVLVRKPGKLPREVIDIEYTLEYGTNHQQMHKGDIKPGDKVVIIDDV
EHHHHHHHCCCCEEEEEECCCCCCHHHEEEEEEEECCCCHHHHCCCCCCCCCEEEEEECC
LATGGTIEAIVKLVEMQEGKVEGVSFLIDLPALHDENLLQEYKVQKLVKY
CCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLKKHILNVKDFPIDGIDFKDVTPLLNDADAFAYVIDEMAKFVIECGANVVVAPEARGF
CCHHHHHCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCE
LFASAVAYKSHTRFVLVRKPGKLPREVIDIEYTLEYGTNHQQMHKGDIKPGDKVVIIDDV
EHHHHHHHCCCCEEEEEECCCCCCHHHEEEEEEEECCCCHHHHCCCCCCCCCEEEEEECC
LATGGTIEAIVKLVEMQEGKVEGVSFLIDLPALHDENLLQEYKVQKLVKY
CCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA