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The map label for this gene is yccK [H]

Identifier: 50365068

GI number: 50365068

Start: 281158

End: 282144

Strand: Direct

Name: yccK [H]

Synonym: Mfl252

Alternate gene names: 50365068

Gene position: 281158-282144 (Clockwise)

Preceding gene: 50365067

Following gene: 50365069

Centisome position: 35.44

GC content: 29.69

Gene sequence:

>987_bases
ATGAAAACAAGAACATTAGGAAAAGATTTAATTGTTTCAGAAATGGGATTAGGTTGTATGGGTTTAAGTTACAGTCAACC
TCCATTTCCAACAAAAGAAGAAGCAATTAAATTTTTAAGAGAAGCATATGAACAAGGTGTAACATTTTTTGATACAGCTG
AAGTTTATGGTCCTTTTGATAATGAAGAATTATTAGGAGAAGCTTTCAAAGACATACGTGATAAAGTAGTTATTGCAACA
AAATTTGGTTTTTCATTTGATGGAAAAAATATAACTGGAGTTGATAGTAGCAGAGAAAATATAATGAGAGCTATTGAGGG
TTCATTAAATAGATTGCAAACTGATTACATTGACTTATATTATCAACATAGAGTTGATCCAAACACTTCAATTGAAGAAG
TTGCACAAGTGATGAAAGAATTAATGGAACAAGGAAAAATTAAACATTGAGGATTAAGTGAAGCTTCTGCTAAAACTATT
AGAAAAGCACATGCAATTTGTCCAGTTACAGCATTACAAAGTGAATACTCAATGTTTTGAAGAGAAGCTGAAACAAAAGT
TATGCCTACTTTAGAAGAATTGGGAATTGGTTTTGTACCATTTTCTCCGTTAGGAAGAGGATTCTTAACAGGAACAATTA
AACCAGGTCATATTTTTCCAGAAGGTGATTTTAGAAATTCTATCCCAAGATTTAATACACCAGAGTATCTAGAAAATAAT
TTTAAATTAGTTAAATATGTTGAAGAACTAGCTGAACAAAAAAATACAACTCCAGCTGCTGTTGCTTTAGGTTGATTGTT
AGCGCAAAAACCATGAATAGTTCCAATTCCAGGAACTAAAAAAATTGAAAGACTAAAAGAAAATAATTCAGGAACAAATG
TAATGTTTTCAAAAGAAGAATTAGAAAATATTAAAAAAATGTTAGATACTATTGAATTAGTTGGTCATAGATATAATGAT
GCTACTGAAAGTAGAGTAGATAAATAA

Upstream 100 bases:

>100_bases
AAAAAGAAACTTTACGAAAATAATTAATTTTTTTGCTTGCATTAAAGTAGGTTTAATGAAATATGATGATATTGAGTTCA
AAACTCAGAGGAGATAAAAT

Downstream 100 bases:

>100_bases
TAAGATATTTAAAAACCGTGATATTCATTTCGGTTTTTTTACTTTATAATTATTAAATAAATATAATCTTATTATCAGAA
AGGGAAAATATGACAAAATG

Product: putative aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKTRTLGKDLIVSEMGLGCMGLSYSQPPFPTKEEAIKFLREAYEQGVTFFDTAEVYGPFDNEELLGEAFKDIRDKVVIAT
KFGFSFDGKNITGVDSSRENIMRAIEGSLNRLQTDYIDLYYQHRVDPNTSIEEVAQVMKELMEQGKIKHWGLSEASAKTI
RKAHAICPVTALQSEYSMFWREAETKVMPTLEELGIGFVPFSPLGRGFLTGTIKPGHIFPEGDFRNSIPRFNTPEYLENN
FKLVKYVEELAEQKNTTPAAVALGWLLAQKPWIVPIPGTKKIERLKENNSGTNVMFSKEELENIKKMLDTIELVGHRYND
ATESRVDK

Sequences:

>Translated_328_residues
MKTRTLGKDLIVSEMGLGCMGLSYSQPPFPTKEEAIKFLREAYEQGVTFFDTAEVYGPFDNEELLGEAFKDIRDKVVIAT
KFGFSFDGKNITGVDSSRENIMRAIEGSLNRLQTDYIDLYYQHRVDPNTSIEEVAQVMKELMEQGKIKH*GLSEASAKTI
RKAHAICPVTALQSEYSMF*REAETKVMPTLEELGIGFVPFSPLGRGFLTGTIKPGHIFPEGDFRNSIPRFNTPEYLENN
FKLVKYVEELAEQKNTTPAAVALG*LLAQKP*IVPIPGTKKIERLKENNSGTNVMFSKEELENIKKMLDTIELVGHRYND
ATESRVDK
>Mature_328_residues
MKTRTLGKDLIVSEMGLGCMGLSYSQPPFPTKEEAIKFLREAYEQGVTFFDTAEVYGPFDNEELLGEAFKDIRDKVVIAT
KFGFSFDGKNITGVDSSRENIMRAIEGSLNRLQTDYIDLYYQHRVDPNTSIEEVAQVMKELMEQGKIKH*GLSEASAKTI
RKAHAICPVTALQSEYSMF*REAETKVMPTLEELGIGFVPFSPLGRGFLTGTIKPGHIFPEGDFRNSIPRFNTPEYLENN
FKLVKYVEELAEQKNTTPAAVALG*LLAQKP*IVPIPGTKKIERLKENNSGTNVMFSKEELENIKKMLDTIELVGHRYND
ATESRVDK

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436964, Length=232, Percent_Identity=36.2068965517241, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI27436962, Length=232, Percent_Identity=35.7758620689655, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI27436966, Length=232, Percent_Identity=35.7758620689655, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI27436969, Length=227, Percent_Identity=34.8017621145374, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4504825, Length=224, Percent_Identity=34.8214285714286, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI27436971, Length=221, Percent_Identity=35.2941176470588, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI223718702, Length=287, Percent_Identity=26.4808362369338, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI41327764, Length=281, Percent_Identity=27.7580071174377, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI41152114, Length=188, Percent_Identity=31.3829787234043, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI87081735, Length=320, Percent_Identity=31.5625, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789375, Length=314, Percent_Identity=29.9363057324841, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788070, Length=332, Percent_Identity=29.8192771084337, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787674, Length=312, Percent_Identity=28.8461538461538, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788081, Length=275, Percent_Identity=25.8181818181818, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI48994888, Length=284, Percent_Identity=26.7605633802817, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325384, Length=347, Percent_Identity=29.3948126801153, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323998, Length=292, Percent_Identity=27.7397260273973, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319958, Length=292, Percent_Identity=27.0547945205479, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6325169, Length=325, Percent_Identity=25.5384615384615, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6322615, Length=254, Percent_Identity=25.9842519685039, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319951, Length=274, Percent_Identity=27.007299270073, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321052, Length=124, Percent_Identity=34.6774193548387, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640980, Length=239, Percent_Identity=29.7071129707113, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45549126, Length=235, Percent_Identity=30.2127659574468, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24646159, Length=220, Percent_Identity=28.6363636363636, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36363; Mature: 36363

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRTLGKDLIVSEMGLGCMGLSYSQPPFPTKEEAIKFLREAYEQGVTFFDTAEVYGPFD
CCCCCCCHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHCCCCC
NEELLGEAFKDIRDKVVIATKFGFSFDGKNITGVDSSRENIMRAIEGSLNRLQTDYIDLY
CHHHHHHHHHHHHHCEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YQHRVDPNTSIEEVAQVMKELMEQGKIKHGLSEASAKTIRKAHAICPVTALQSEYSMFRE
HHHCCCCCCCHHHHHHHHHHHHHHCHHHHCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AETKVMPTLEELGIGFVPFSPLGRGFLTGTIKPGHIFPEGDFRNSIPRFNTPEYLENNFK
HHHHHCCCHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHCCCCCCCCHHHHHCCHH
LVKYVEELAEQKNTTPAAVALGLLAQKPIVPIPGTKKIERLKENNSGTNVMFSKEELENI
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEECHHHHHHH
KKMLDTIELVGHRYNDATESRVDK
HHHHHHHHHHHCCCCCHHHHHCCC
>Mature Secondary Structure
MKTRTLGKDLIVSEMGLGCMGLSYSQPPFPTKEEAIKFLREAYEQGVTFFDTAEVYGPFD
CCCCCCCHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHCCCCC
NEELLGEAFKDIRDKVVIATKFGFSFDGKNITGVDSSRENIMRAIEGSLNRLQTDYIDLY
CHHHHHHHHHHHHHCEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YQHRVDPNTSIEEVAQVMKELMEQGKIKHGLSEASAKTIRKAHAICPVTALQSEYSMFRE
HHHCCCCCCCHHHHHHHHHHHHHHCHHHHCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AETKVMPTLEELGIGFVPFSPLGRGFLTGTIKPGHIFPEGDFRNSIPRFNTPEYLENNFK
HHHHHCCCHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHCCCCCCCCHHHHHCCHH
LVKYVEELAEQKNTTPAAVALGLLAQKPIVPIPGTKKIERLKENNSGTNVMFSKEELENI
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEECHHHHHHH
KKMLDTIELVGHRYNDATESRVDK
HHHHHHHHHHHCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]