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The map label for this gene is rnc [H]

Identifier: 50365047

GI number: 50365047

Start: 255374

End: 256069

Strand: Direct

Name: rnc [H]

Synonym: Mfl231

Alternate gene names: 50365047

Gene position: 255374-256069 (Clockwise)

Preceding gene: 50365046

Following gene: 50365048

Centisome position: 32.19

GC content: 26.44

Gene sequence:

>696_bases
ATGACAATGCATGAATTTTTTGAAAATTTTGGAATAAAAATTAATGATTCAAAAATATTTAGTACTGCTTTAACTCATAA
TTCATATGCTAATGAAACTAAAACAAAAGAAACATACCAAAGACTTGAATTTCTAGGTGATGCAGTTTTACAAATGTATG
TTTCTAAGTTTCTTTATTTAAATTTCACAAATGCACCAGAAGGTAAACTAACAAAAACAAGGTCTGATATTGTTAGACAA
GAAACATTAAGTGAAATTGCAAAGATGATAGATTTAGGAAAAATTATAAGATTAGGTCAGGGAGAAATAAAATCTAAAGG
TTATGAAAAACCTTCTATTTTATCTGACGTATATGAAGCTGTTACAGCTGCTATATATTTAGATCAAACCGAAGAAGTGC
TCATATCATGAATAAAGTCAACAATATTCAAATACATTGAAAAAAATGATTATAAAGAATTAAATCATGATTATAAATCA
GAATTACAAGAAATTATTCAAGCTGAAATAAGAAGTGATCTAGAATATAGGGTTGAAAGCCAAAAACACATCGAAAAAGA
TAATAAAATTGAGTACACTGTTAGCGTTAATTTAGATGGAAAAAAATACGGTATTGGAACTGGATTTTCTAAACAAGAAG
CATCACAAAATGCAGCAAAAGATTGCTTAAATAAACTTAAAAAATCAGCAAAATAA

Upstream 100 bases:

>100_bases
GGTTCAAGTGATGTTAAATCATTTGAAGCAACACTAAGAATGACTTGTGATGCAGTGGAAAATGACGTATTAAATAAAAT
TAAAAAGGAATTGAATTAAT

Downstream 100 bases:

>100_bases
AGAGCCAAAAGTGAGAATTTATCTCACTTTTTATTTCTTAAAATATAGCTTTTATACATAGTATAAAGAAAGAAAAAACT
AACACTTTTTCCAGTTTTTT

Product: ribonuclease III, dsRNA-specific ribonuclease

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MTMHEFFENFGIKINDSKIFSTALTHNSYANETKTKETYQRLEFLGDAVLQMYVSKFLYLNFTNAPEGKLTKTRSDIVRQ
ETLSEIAKMIDLGKIIRLGQGEIKSKGYEKPSILSDVYEAVTAAIYLDQTEEVLISWIKSTIFKYIEKNDYKELNHDYKS
ELQEIIQAEIRSDLEYRVESQKHIEKDNKIEYTVSVNLDGKKYGIGTGFSKQEASQNAAKDCLNKLKKSAK

Sequences:

>Translated_231_residues
MTMHEFFENFGIKINDSKIFSTALTHNSYANETKTKETYQRLEFLGDAVLQMYVSKFLYLNFTNAPEGKLTKTRSDIVRQ
ETLSEIAKMIDLGKIIRLGQGEIKSKGYEKPSILSDVYEAVTAAIYLDQTEEVLIS*IKSTIFKYIEKNDYKELNHDYKS
ELQEIIQAEIRSDLEYRVESQKHIEKDNKIEYTVSVNLDGKKYGIGTGFSKQEASQNAAKDCLNKLKKSAK
>Mature_230_residues
TMHEFFENFGIKINDSKIFSTALTHNSYANETKTKETYQRLEFLGDAVLQMYVSKFLYLNFTNAPEGKLTKTRSDIVRQE
TLSEIAKMIDLGKIIRLGQGEIKSKGYEKPSILSDVYEAVTAAIYLDQTEEVLIS*IKSTIFKYIEKNDYKELNHDYKSE
LQEIIQAEIRSDLEYRVESQKHIEKDNKIEYTVSVNLDGKKYGIGTGFSKQEASQNAAKDCLNKLKKSAK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=230, Percent_Identity=26.0869565217391, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI155030236, Length=230, Percent_Identity=26.0869565217391, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1788920, Length=225, Percent_Identity=32, Blast_Score=107, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI193202651, Length=175, Percent_Identity=31.4285714285714, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17506883, Length=175, Percent_Identity=31.4285714285714, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=27.0742358078603, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26398; Mature: 26267

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMHEFFENFGIKINDSKIFSTALTHNSYANETKTKETYQRLEFLGDAVLQMYVSKFLYL
CCHHHHHHHCCCEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
NFTNAPEGKLTKTRSDIVRQETLSEIAKMIDLGKIIRLGQGEIKSKGYEKPSILSDVYEA
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHH
VTAAIYLDQTEEVLISIKSTIFKYIEKNDYKELNHDYKSELQEIIQAEIRSDLEYRVESQ
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
KHIEKDNKIEYTVSVNLDGKKYGIGTGFSKQEASQNAAKDCLNKLKKSAK
HHCCCCCCEEEEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TMHEFFENFGIKINDSKIFSTALTHNSYANETKTKETYQRLEFLGDAVLQMYVSKFLYL
CHHHHHHHCCCEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
NFTNAPEGKLTKTRSDIVRQETLSEIAKMIDLGKIIRLGQGEIKSKGYEKPSILSDVYEA
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHH
VTAAIYLDQTEEVLISIKSTIFKYIEKNDYKELNHDYKSELQEIIQAEIRSDLEYRVESQ
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
KHIEKDNKIEYTVSVNLDGKKYGIGTGFSKQEASQNAAKDCLNKLKKSAK
HHCCCCCCEEEEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA