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The map label for this gene is rnr [H]

Identifier: 50365025

GI number: 50365025

Start: 234224

End: 236338

Strand: Direct

Name: rnr [H]

Synonym: Mfl209

Alternate gene names: 50365025

Gene position: 234224-236338 (Clockwise)

Preceding gene: 50365024

Following gene: 50365026

Centisome position: 29.53

GC content: 25.91

Gene sequence:

>2115_bases
ATGAATAAAGAAATAATATTACAAATAGTTAAAGAAAATAATGAAATGATATCAATTAATAGTTTAGCAACGAAGCTAAA
CTATTTTGATTTACCAAAATTAGAAGATTACTTAAAAGAACTGAACGAAGAAAATATTCTTGCTTTCACTACTGAAAAAA
ATGTTTATTTATTGGGTGGTTCTTTTAAAAAAGGAAACTTGAGAATGAATCCAAAAGGATTTGGATTTGTAAACGACGTA
TTGCAACCTGAAGAAGAGGCTTATTTTGTTCCCCCTGTTAGTTTAAATGGATGTTTTGATAGTGATGAAGTTATTTTTAA
AGTTGTTAAAGACCAAGAAAAAACAAGAGCTGAAATTGTTGAATTATGTTTAAGGGTTAAAGAATTTTTAATAGGAGAAA
TAGTAAGAAGTTTTGATGGTAAGTTTTTAGATTTTATACCTAGTGATCAAGCATTTACAGGTTTTAGAATTAGGATATTA
AATAAAAAAGAATTTCCAATTCAAGAATACCAAATTGTCAAAGCTAAAATAATATCAGTTAAAGAAAGATTATTATTTGT
AAGACTTAAAAAAGTAATAGGTGATGCTAGAAAAGCTAGTGATAGAATTTTATCCATTGCTGAAGAATTCGAAATTAGAA
CAGAGTTTGAAAAAGCAACTTTAAAAGAGGCAGAAAGAGTAAATGTTCCTGTTGAGCATGAAGTTGATGAAATAAACAGA
AGAATGAAAAATTCATTATTAGATAAAATGGTTGTTACAATTGATGGAATTGACTCAAAAGATTTAGATGACGCAATATG
TGTTGAAAAATTAGAAAATGGTGAATTTAAATTATATGTTGCTATTGCTGATGTTAGTCATTATGTTGAACCAAAAACAC
CATTAGATAAAGAAGCATTAATAAGAGGTAACTCAACTTACTTAGCTAATAGAGTCTTACCTATGCTTCCAAAAATTTTA
AGTGATGATTTATGTTCATTAAATCCAAATACAAAAAAATTTGCATTAGCATGTGAAATGAAGTTTGATAAAAATGGAAT
TATGATTAGTAAAGAAGTTTATGAAACAATTATGATTTCAAAAGTAAGATTAAACTATAATGAAGTTAATGAATATATTG
CAAATAAAACATGAAATCATTGCGAAGAATCAAGAACAATGATTGATCAAGCAATTGAACTATTTAAATTAATTGAACAA
GTAAAAATTAAACGTGGAACAATTACTTTTGATGTTAGAGAACCAAAAGTAATAATGGATGAAAATAGTAACGTTATTGA
AATTAAAGCAAGACAAACTGGTGAATCTGAAAAGTTGATTGAACAATTTATGGTTAGTGCAAATGAAGCTGTTGCTGAAA
TAGTTTATGAAATGGAATTACCATTTATTTATAGAAATCATGATAAACCTGATGAAGAAGATTTAATTACATGATATCAA
TCATTGAAATCATTTGGGATTGATCCTAAATTAACACCATTGGAAATGTTAGATCCTATAAACATTAATAAAACATTAAA
AAGAATTAGTGAACAAACCAAAGATCCTATTGAAGAAGAATTATTAAACTTATCTCTTTTAAGATATATGGCAAAAGCTA
AATATGAATTAGAAAATATTGGGCATTTTGGTTTATCAAGTAAATGTTATACCCACTTCACTTCACCAATTAGAAGATAC
AGTGATTTAATTGTTCACAGATATTTAAAACAATACATCATTAATAAAGATTATGATCAAAAAGCATTAGAAATGAATGA
AGCATTTATCAAAAAAGCATCAGTAATAATTAATGAAACAGAAACAACTAGCGTAGACTGTGAACGAGAAGTAGTTAAAG
CTTGTACAGTTGAATATATGAGCGATAAAATAGGAAATATTTATGAAGGAACAATCTCTGTAGCATTAAAATTTGGTATT
TTTGTTCAACTTGAAAATATGGTAGAAGGTTTGGTTCATATTTCAAATCTTGAACCTAACATAGTTTATGATGAAACTAA
TAAAATACTAATTAAACATGATAATACATTTTATAGAATGGGACAAAAAGTTAAAATTAAAGTTATAAGCGCTGATATTA
GAAAAAGAAAAATTGACTTTATTTTAGTTAAATAA

Upstream 100 bases:

>100_bases
ACAATAGAAACCATAAGAGTACTTGAAATTATTGAAAATAATAACTAGGTTATTATAAAAGAAATGAGTAAAAAGCATTT
AATACTTTATAATTATTAGT

Downstream 100 bases:

>100_bases
AAGTAAGGAGGTTCTTGTTATGGGTGAACATGTTATTGCATTAAACAAAAAAGCAAAATTTAATTATGAAATACTTGAAA
CTTGAGAAGCAGGAATTGAA

Product: virulence associated protein, ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 704; Mature: 704

Protein sequence:

>704_residues
MNKEIILQIVKENNEMISINSLATKLNYFDLPKLEDYLKELNEENILAFTTEKNVYLLGGSFKKGNLRMNPKGFGFVNDV
LQPEEEAYFVPPVSLNGCFDSDEVIFKVVKDQEKTRAEIVELCLRVKEFLIGEIVRSFDGKFLDFIPSDQAFTGFRIRIL
NKKEFPIQEYQIVKAKIISVKERLLFVRLKKVIGDARKASDRILSIAEEFEIRTEFEKATLKEAERVNVPVEHEVDEINR
RMKNSLLDKMVVTIDGIDSKDLDDAICVEKLENGEFKLYVAIADVSHYVEPKTPLDKEALIRGNSTYLANRVLPMLPKIL
SDDLCSLNPNTKKFALACEMKFDKNGIMISKEVYETIMISKVRLNYNEVNEYIANKTWNHCEESRTMIDQAIELFKLIEQ
VKIKRGTITFDVREPKVIMDENSNVIEIKARQTGESEKLIEQFMVSANEAVAEIVYEMELPFIYRNHDKPDEEDLITWYQ
SLKSFGIDPKLTPLEMLDPININKTLKRISEQTKDPIEEELLNLSLLRYMAKAKYELENIGHFGLSSKCYTHFTSPIRRY
SDLIVHRYLKQYIINKDYDQKALEMNEAFIKKASVIINETETTSVDCEREVVKACTVEYMSDKIGNIYEGTISVALKFGI
FVQLENMVEGLVHISNLEPNIVYDETNKILIKHDNTFYRMGQKVKIKVISADIRKRKIDFILVK

Sequences:

>Translated_704_residues
MNKEIILQIVKENNEMISINSLATKLNYFDLPKLEDYLKELNEENILAFTTEKNVYLLGGSFKKGNLRMNPKGFGFVNDV
LQPEEEAYFVPPVSLNGCFDSDEVIFKVVKDQEKTRAEIVELCLRVKEFLIGEIVRSFDGKFLDFIPSDQAFTGFRIRIL
NKKEFPIQEYQIVKAKIISVKERLLFVRLKKVIGDARKASDRILSIAEEFEIRTEFEKATLKEAERVNVPVEHEVDEINR
RMKNSLLDKMVVTIDGIDSKDLDDAICVEKLENGEFKLYVAIADVSHYVEPKTPLDKEALIRGNSTYLANRVLPMLPKIL
SDDLCSLNPNTKKFALACEMKFDKNGIMISKEVYETIMISKVRLNYNEVNEYIANKT*NHCEESRTMIDQAIELFKLIEQ
VKIKRGTITFDVREPKVIMDENSNVIEIKARQTGESEKLIEQFMVSANEAVAEIVYEMELPFIYRNHDKPDEEDLIT*YQ
SLKSFGIDPKLTPLEMLDPININKTLKRISEQTKDPIEEELLNLSLLRYMAKAKYELENIGHFGLSSKCYTHFTSPIRRY
SDLIVHRYLKQYIINKDYDQKALEMNEAFIKKASVIINETETTSVDCEREVVKACTVEYMSDKIGNIYEGTISVALKFGI
FVQLENMVEGLVHISNLEPNIVYDETNKILIKHDNTFYRMGQKVKIKVISADIRKRKIDFILVK
>Mature_704_residues
MNKEIILQIVKENNEMISINSLATKLNYFDLPKLEDYLKELNEENILAFTTEKNVYLLGGSFKKGNLRMNPKGFGFVNDV
LQPEEEAYFVPPVSLNGCFDSDEVIFKVVKDQEKTRAEIVELCLRVKEFLIGEIVRSFDGKFLDFIPSDQAFTGFRIRIL
NKKEFPIQEYQIVKAKIISVKERLLFVRLKKVIGDARKASDRILSIAEEFEIRTEFEKATLKEAERVNVPVEHEVDEINR
RMKNSLLDKMVVTIDGIDSKDLDDAICVEKLENGEFKLYVAIADVSHYVEPKTPLDKEALIRGNSTYLANRVLPMLPKIL
SDDLCSLNPNTKKFALACEMKFDKNGIMISKEVYETIMISKVRLNYNEVNEYIANKT*NHCEESRTMIDQAIELFKLIEQ
VKIKRGTITFDVREPKVIMDENSNVIEIKARQTGESEKLIEQFMVSANEAVAEIVYEMELPFIYRNHDKPDEEDLIT*YQ
SLKSFGIDPKLTPLEMLDPININKTLKRISEQTKDPIEEELLNLSLLRYMAKAKYELENIGHFGLSSKCYTHFTSPIRRY
SDLIVHRYLKQYIINKDYDQKALEMNEAFIKKASVIINETETTSVDCEREVVKACTVEYMSDKIGNIYEGTISVALKFGI
FVQLENMVEGLVHISNLEPNIVYDETNKILIKHDNTFYRMGQKVKIKVISADIRKRKIDFILVK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=481, Percent_Identity=28.2744282744283, Blast_Score=157, Evalue=5e-38,
Organism=Homo sapiens, GI190014623, Length=338, Percent_Identity=30.4733727810651, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI219521928, Length=455, Percent_Identity=30.5494505494506, Blast_Score=146, Evalue=8e-35,
Organism=Homo sapiens, GI19115966, Length=455, Percent_Identity=30.5494505494506, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI134288890, Length=424, Percent_Identity=28.7735849056604, Blast_Score=142, Evalue=1e-33,
Organism=Escherichia coli, GI87082383, Length=729, Percent_Identity=29.4924554183813, Blast_Score=305, Evalue=7e-84,
Organism=Escherichia coli, GI1787542, Length=580, Percent_Identity=27.2413793103448, Blast_Score=149, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI212645896, Length=388, Percent_Identity=29.639175257732, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17553506, Length=428, Percent_Identity=28.2710280373832, Blast_Score=143, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324552, Length=337, Percent_Identity=30.5637982195846, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6320499, Length=424, Percent_Identity=24.0566037735849, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24649634, Length=337, Percent_Identity=30.5637982195846, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI19922976, Length=355, Percent_Identity=29.0140845070423, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24654597, Length=355, Percent_Identity=29.0140845070423, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24654592, Length=355, Percent_Identity=29.0140845070423, Blast_Score=140, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 81142; Mature: 81142

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEIILQIVKENNEMISINSLATKLNYFDLPKLEDYLKELNEENILAFTTEKNVYLLGG
CCHHHEEEEEECCCCEEEEHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEEC
SFKKGNLRMNPKGFGFVNDVLQPEEEAYFVPPVSLNGCFDSDEVIFKVVKDQEKTRAEIV
CCCCCCEEECCCCCCHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
ELCLRVKEFLIGEIVRSFDGKFLDFIPSDQAFTGFRIRILNKKEFPIQEYQIVKAKIISV
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
KERLLFVRLKKVIGDARKASDRILSIAEEFEIRTEFEKATLKEAERVNVPVEHEVDEINR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
RMKNSLLDKMVVTIDGIDSKDLDDAICVEKLENGEFKLYVAIADVSHYVEPKTPLDKEAL
HHHHHHHHHHEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEEECHHHHCCCCCCCCHHHH
IRGNSTYLANRVLPMLPKILSDDLCSLNPNTKKFALACEMKFDKNGIMISKEVYETIMIS
CCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEEEEEEECCCCEEEEHHHHHHHHHH
KVRLNYNEVNEYIANKTNHCEESRTMIDQAIELFKLIEQVKIKRGTITFDVREPKVIMDE
HEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEC
NSNVIEIKARQTGESEKLIEQFMVSANEAVAEIVYEMELPFIYRNHDKPDEEDLITYQSL
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHH
KSFGIDPKLTPLEMLDPININKTLKRISEQTKDPIEEELLNLSLLRYMAKAKYELENIGH
HHCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
FGLSSKCYTHFTSPIRRYSDLIVHRYLKQYIINKDYDQKALEMNEAFIKKASVIINETET
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEECCCC
TSVDCEREVVKACTVEYMSDKIGNIYEGTISVALKFGIFVQLENMVEGLVHISNLEPNIV
CCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCCCEE
YDETNKILIKHDNTFYRMGQKVKIKVISADIRKRKIDFILVK
EECCCEEEEEECCHHHHCCCEEEEEEEECHHHHCEEEEEEEC
>Mature Secondary Structure
MNKEIILQIVKENNEMISINSLATKLNYFDLPKLEDYLKELNEENILAFTTEKNVYLLGG
CCHHHEEEEEECCCCEEEEHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEEC
SFKKGNLRMNPKGFGFVNDVLQPEEEAYFVPPVSLNGCFDSDEVIFKVVKDQEKTRAEIV
CCCCCCEEECCCCCCHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
ELCLRVKEFLIGEIVRSFDGKFLDFIPSDQAFTGFRIRILNKKEFPIQEYQIVKAKIISV
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
KERLLFVRLKKVIGDARKASDRILSIAEEFEIRTEFEKATLKEAERVNVPVEHEVDEINR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
RMKNSLLDKMVVTIDGIDSKDLDDAICVEKLENGEFKLYVAIADVSHYVEPKTPLDKEAL
HHHHHHHHHHEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEEECHHHHCCCCCCCCHHHH
IRGNSTYLANRVLPMLPKILSDDLCSLNPNTKKFALACEMKFDKNGIMISKEVYETIMIS
CCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEEEEEEECCCCEEEEHHHHHHHHHH
KVRLNYNEVNEYIANKTNHCEESRTMIDQAIELFKLIEQVKIKRGTITFDVREPKVIMDE
HEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEC
NSNVIEIKARQTGESEKLIEQFMVSANEAVAEIVYEMELPFIYRNHDKPDEEDLITYQSL
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHH
KSFGIDPKLTPLEMLDPININKTLKRISEQTKDPIEEELLNLSLLRYMAKAKYELENIGH
HHCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
FGLSSKCYTHFTSPIRRYSDLIVHRYLKQYIINKDYDQKALEMNEAFIKKASVIINETET
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEECCCC
TSVDCEREVVKACTVEYMSDKIGNIYEGTISVALKFGIFVQLENMVEGLVHISNLEPNIV
CCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCCCEE
YDETNKILIKHDNTFYRMGQKVKIKVISADIRKRKIDFILVK
EECCCEEEEEECCHHHHCCCEEEEEEEECHHHHCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]