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The map label for this gene is adk

Identifier: 50364959

GI number: 50364959

Start: 158217

End: 158855

Strand: Direct

Name: adk

Synonym: Mfl144

Alternate gene names: 50364959

Gene position: 158217-158855 (Clockwise)

Preceding gene: 50364958

Following gene: 50364960

Centisome position: 19.95

GC content: 29.26

Gene sequence:

>639_bases
ATGAATATTATGTTATTAGGAGCACCTGGTTCAGGTAAAGGAACTTTGGCAGAAAAATTAATCAAGAATCAAGGATTTAA
TCAAATGTCAACAGGAGATTTGATGCGTAAAGAAATCAATGATGAAACACCTTTAGGAATTGAATGTGCAAGATATATGA
ATGAAGGTAGATTAGTACCTGATGAAGTTACAATGGGTATTGTAAAAAACTTTTTACAAGATAATCATAATCAATTAATT
TTTGATGGAATTCCAAGAACATTAAATCAAGCTAAAATTTTAGAAGAAAACTTAATTGAACTAAATGCAAAAATAGATAA
AGTTATATACATTGATGTTCCAAGTGAAATTTTATTAAACAGAATAAGTGGAAGATTAATTTGTCCAAAATGCAAAGTTA
GTTACCATATCATTAGCAGAAAACCAAAATTAGAAGGAATTTGTGATAATGATGGAACTGAACTAGTTCGTAGACCAGAT
GATGCTCCAGAAAAAGTTAAAGTTAGACTTGAAGCATATGCAAATGAAACAGCACCATTAGTAGATTACTATAAAAATAA
ACCTGGATTTATTCATATTGTAGATAATGCGAACACAACTGCTGAAGAAGTTTATGCAGAAGTTTTAGGAGCTTTATAG

Upstream 100 bases:

>100_bases
ATTTACAACAAAAATGGGTTTCAATTAGAAACAAATATAAATGAGTTATTGCCGCATGCCTTTGAGCCTGCACAACTTAT
TAAATAAAAGGAGAGAAAAT

Downstream 100 bases:

>100_bases
ATGGCTGTTACAATAAAATCACCTCAAGAAATTGAAAAAATGCGTGTTGCTGGTCAAGTTTTGGCAGAAGCTATTGACAT
GTTAAAATCAATGATAAAAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MNIMLLGAPGSGKGTLAEKLIKNQGFNQMSTGDLMRKEINDETPLGIECARYMNEGRLVPDEVTMGIVKNFLQDNHNQLI
FDGIPRTLNQAKILEENLIELNAKIDKVIYIDVPSEILLNRISGRLICPKCKVSYHIISRKPKLEGICDNDGTELVRRPD
DAPEKVKVRLEAYANETAPLVDYYKNKPGFIHIVDNANTTAEEVYAEVLGAL

Sequences:

>Translated_212_residues
MNIMLLGAPGSGKGTLAEKLIKNQGFNQMSTGDLMRKEINDETPLGIECARYMNEGRLVPDEVTMGIVKNFLQDNHNQLI
FDGIPRTLNQAKILEENLIELNAKIDKVIYIDVPSEILLNRISGRLICPKCKVSYHIISRKPKLEGICDNDGTELVRRPD
DAPEKVKVRLEAYANETAPLVDYYKNKPGFIHIVDNANTTAEEVYAEVLGAL
>Mature_212_residues
MNIMLLGAPGSGKGTLAEKLIKNQGFNQMSTGDLMRKEINDETPLGIECARYMNEGRLVPDEVTMGIVKNFLQDNHNQLI
FDGIPRTLNQAKILEENLIELNAKIDKVIYIDVPSEILLNRISGRLICPKCKVSYHIISRKPKLEGICDNDGTELVRRPD
DAPEKVKVRLEAYANETAPLVDYYKNKPGFIHIVDNANTTAEEVYAEVLGAL

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=36.4485981308411, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=36.4485981308411, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI19923437, Length=188, Percent_Identity=35.1063829787234, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI310110345, Length=210, Percent_Identity=32.8571428571429, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI53832003, Length=210, Percent_Identity=32.8571428571429, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI8051579, Length=210, Percent_Identity=32.8571428571429, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI53832001, Length=210, Percent_Identity=32.8571428571429, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4502011, Length=209, Percent_Identity=27.7511961722488, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI28144899, Length=217, Percent_Identity=29.0322580645161, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI28144897, Length=217, Percent_Identity=29.0322580645161, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7706497, Length=215, Percent_Identity=26.9767441860465, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI22749187, Length=185, Percent_Identity=25.9459459459459, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1786680, Length=189, Percent_Identity=39.6825396825397, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17552384, Length=210, Percent_Identity=35.2380952380952, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17537943, Length=210, Percent_Identity=31.4285714285714, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17567503, Length=214, Percent_Identity=29.4392523364486, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=26.9767441860465, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=39.0697674418605, Blast_Score=142, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321018, Length=201, Percent_Identity=36.81592039801, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322828, Length=215, Percent_Identity=27.906976744186, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=37.1428571428571, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737899, Length=185, Percent_Identity=37.2972972972973, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24645822, Length=185, Percent_Identity=37.2972972972973, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI221459597, Length=210, Percent_Identity=27.1428571428571, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356893, Length=210, Percent_Identity=27.1428571428571, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24663208, Length=216, Percent_Identity=24.537037037037, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17647141, Length=216, Percent_Identity=24.537037037037, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_MESFL (Q6F1X3)

Other databases:

- EMBL:   AE017263
- RefSeq:   YP_053384.1
- ProteinModelPortal:   Q6F1X3
- SMR:   Q6F1X3
- GeneID:   2897839
- GenomeReviews:   AE017263_GR
- KEGG:   mfl:Mfl144
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   CLSK745872
- BioCyc:   MFLO265311:MFL144-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23696; Mature: 23696

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00113 ADENYLATE_KINASE; PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIMLLGAPGSGKGTLAEKLIKNQGFNQMSTGDLMRKEINDETPLGIECARYMNEGRLVP
CEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCCH
DEVTMGIVKNFLQDNHNQLIFDGIPRTLNQAKILEENLIELNAKIDKVIYIDVPSEILLN
HHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
RISGRLICPKCKVSYHIISRKPKLEGICDNDGTELVRRPDDAPEKVKVRLEAYANETAPL
HHCCCEECCCCCEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCHHHEEEEEHHCCCCCCH
VDYYKNKPGFIHIVDNANTTAEEVYAEVLGAL
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNIMLLGAPGSGKGTLAEKLIKNQGFNQMSTGDLMRKEINDETPLGIECARYMNEGRLVP
CEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCCH
DEVTMGIVKNFLQDNHNQLIFDGIPRTLNQAKILEENLIELNAKIDKVIYIDVPSEILLN
HHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
RISGRLICPKCKVSYHIISRKPKLEGICDNDGTELVRRPDDAPEKVKVRLEAYANETAPL
HHCCCEECCCCCEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCHHHEEEEEHHCCCCCCH
VDYYKNKPGFIHIVDNANTTAEEVYAEVLGAL
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA