Click here to switch to the map view.

The map label for this gene is msrA [H]

Identifier: 50364865

GI number: 50364865

Start: 64863

End: 65354

Strand: Reverse

Name: msrA [H]

Synonym: Mfl050

Alternate gene names: 50364865

Gene position: 65354-64863 (Counterclockwise)

Preceding gene: 50364866

Following gene: 50364861

Centisome position: 8.24

GC content: 24.8

Gene sequence:

>492_bases
ATGGAAAATAAAACTATATATTTAGCTGGGGGTTGTTTCTGAGGAGTTCAAGCTTTTTTTGATTATCAAAAAGGAATAAT
TAAAACAACTGTTGGTTATGCACAAGGCGATATAGATAACCCTACTTATGAAGAAGTTTGTACTGGAAAAACAAATCATA
CAGAAACTTTAAAAATTGAATTTAATGAAAAAGAAATATCTCTTAAAGAAATATTAGATTTATATTTTTCAATAATAAAT
CCATTTTTACTAAACCAACAGGGGAATGATAGGGGTACACAATATAGAACTGGTATATATTCAATAAATGAATTTGATTT
TACTTTTGTAAAAAAATATTTGGAAAACTTTCAAAAACAAACAACTCAAAAAGTTGTTGTTGAAAATGAAATATTAAAAA
ATTTCTTTGATGCTGAGGAATATCACCAAAAATATTTGGACAAAAATCCTAATGGTTATTGTCACATTGATTTATCAGAT
TATAAAAAATAA

Upstream 100 bases:

>100_bases
TACCCTGTTGTTCCACCAAAGGTTGAATACAGTTTAACAGATTTAGGTAAAAGCTTAAAACCAATACTAGATCAAATGAG
TGATTGAGGAGTCAAAAATT

Downstream 100 bases:

>100_bases
AAGCTCCTTAAAGCTTTTATTTTTTTATTATACAGTCTTCGCAAATTATGCACGCTGTTTTATTTTCTTTATTATTACAT
AAATACATTTGTTTTTTTGT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MENKTIYLAGGCFWGVQAFFDYQKGIIKTTVGYAQGDIDNPTYEEVCTGKTNHTETLKIEFNEKEISLKEILDLYFSIIN
PFLLNQQGNDRGTQYRTGIYSINEFDFTFVKKYLENFQKQTTQKVVVENEILKNFFDAEEYHQKYLDKNPNGYCHIDLSD
YKK

Sequences:

>Translated_163_residues
MENKTIYLAGGCF*GVQAFFDYQKGIIKTTVGYAQGDIDNPTYEEVCTGKTNHTETLKIEFNEKEISLKEILDLYFSIIN
PFLLNQQGNDRGTQYRTGIYSINEFDFTFVKKYLENFQKQTTQKVVVENEILKNFFDAEEYHQKYLDKNPNGYCHIDLSD
YKK
>Mature_163_residues
MENKTIYLAGGCF*GVQAFFDYQKGIIKTTVGYAQGDIDNPTYEEVCTGKTNHTETLKIEFNEKEISLKEILDLYFSIIN
PFLLNQQGNDRGTQYRTGIYSINEFDFTFVKKYLENFQKQTTQKVVVENEILKNFFDAEEYHQKYLDKNPNGYCHIDLSD
YKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=150, Percent_Identity=38, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI208609995, Length=150, Percent_Identity=38, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI208609993, Length=109, Percent_Identity=34.8623853211009, Blast_Score=78, Evalue=3e-15,
Organism=Escherichia coli, GI1790665, Length=147, Percent_Identity=36.734693877551, Blast_Score=101, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=41.25, Blast_Score=122, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=32.6241134751773, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=32.6241134751773, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24664631, Length=141, Percent_Identity=31.9148936170213, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18938; Mature: 18938

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKTIYLAGGCFGVQAFFDYQKGIIKTTVGYAQGDIDNPTYEEVCTGKTNHTETLKIEF
CCCCEEEEECCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEE
NEKEISLKEILDLYFSIINPFLLNQQGNDRGTQYRTGIYSINEFDFTFVKKYLENFQKQT
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEECCCCHHHHHHHHHHHHHHH
TQKVVVENEILKNFFDAEEYHQKYLDKNPNGYCHIDLSDYKK
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MENKTIYLAGGCFGVQAFFDYQKGIIKTTVGYAQGDIDNPTYEEVCTGKTNHTETLKIEF
CCCCEEEEECCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEE
NEKEISLKEILDLYFSIINPFLLNQQGNDRGTQYRTGIYSINEFDFTFVKKYLENFQKQT
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEECCCCHHHHHHHHHHHHHHH
TQKVVVENEILKNFFDAEEYHQKYLDKNPNGYCHIDLSDYKK
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA