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The map label for this gene is serS [H]

Identifier: 50364832

GI number: 50364832

Start: 23458

End: 24726

Strand: Reverse

Name: serS [H]

Synonym: Mfl017

Alternate gene names: 50364832

Gene position: 24726-23458 (Counterclockwise)

Preceding gene: 50364846

Following gene: 50364831

Centisome position: 3.12

GC content: 28.84

Gene sequence:

>1269_bases
ATGTTAGACATAAATTTTATAGAGAGTAATTTAGTTAAAGTAAAAGAACAATTAAATAAAAGAAGCGGTGACTATTCATT
AATTATTGATGAGGCTGTTGAATTAAATGTTCAAAGAAAATCAATTTTAAAGGAAGTAGAAAATCTTAAAGCCAATAAAA
ATAATTTATCTAAACAAGTTGGTGAATTAATGCGAAACAAGCAAAGTGATGAAGCTAACAAAATTAAAGAAGAAGTTACT
TTAATAAATTCTAAAATAGAAAAATTAGATGATTCATTAAAATTGGTTCAAGAGCAATTAACAAGTAAATTGCAAAACAT
TCCAAATATTCCTAATGATAATATGCCAATTGGGAATGATGATAATGATAATGTCGAAGTTAGACAATGAGGTAATGAAT
TAATTAAAAAACACAATACTCCTCACTGAGATATTGCGGATAAATTAAAATTAGTTGATTTCGAAGCAGGTCCAAAATTA
AGTGGGTCAAGATTTGTTGTTTATACTGGTTTAGGAGCAAAATTAGTAAGAAGTTTATCTAACATATTATTAAATCTTCA
CACAAGCAAAGGTTATACAGAAATAACAGTTCCACTTCTTGTTAATCCTCAAGCAATGTATGGTACTGGTCAATTACCAA
AATTTAAAGAAGACGCTTATATAACAACAAACGATCAATATTTAATTCCAACAGGTGAAGTTCCACTAACTAATTTACAT
GCAGGGGAAATTTTAGACCTAAACCAATTACCAATTCACTATACAACTTATTCTCAATGTTTTAGACAAGAAGCTGGTAG
TGCTGGTAGGGATACAAAAGGTTTAATAAGATTACATCAATTTAATAAAGTTGAATTAGTAAAAATTACAAATCAAGAAT
CAAGTGAAGCAGAGCTTCAAGCAATGGTTAATGATGCAGAAGCTGTTCTTCAATTATTTAACTTGCCATATAGAGTTGTT
GAACTTTGTACTGGTGATGTTGGTTTTAGTTCAAGTAAAACATACGATCTAGAAGTTTGATTCCCAGAACAAAATAAATA
TCGTGAAATTTCAAGCTGTTCAAATTGTACAGATTTCCAAGCAAGAAATATGCAAACTAGATACAGAGATGCTAATGGTG
AAGTTAAATTAGCACATACTTTAAATGGTTCTGGAGTTGCTATAGACAGATTAATTGCTGCAATTTTAGAAAACTATTGA
GATGGGGAAAAATTAATTTTACCTACTGCTTTAAAGCCTTATTTTGATAACAAAGAATACATCGATTAA

Upstream 100 bases:

>100_bases
ATATTACATTATAGCTTTCTATCTAATAAGAATAGATTTTTTATAACTTAATTTGTATTATAATTTTAAATAGCAATCAC
ATAGTGATCTTGGAGGAAAA

Downstream 100 bases:

>100_bases
AACACTTAGAGTGTTTTTTTATTTTGTTTTCACTTTTAAAAATTTTATATTACAATTATTTTTAATCTTATAGAAAGTTA
AAACAATGAATACTAAAAAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLDINFIESNLVKVKEQLNKRSGDYSLIIDEAVELNVQRKSILKEVENLKANKNNLSKQVGELMRNKQSDEANKIKEEVT
LINSKIEKLDDSLKLVQEQLTSKLQNIPNIPNDNMPIGNDDNDNVEVRQWGNELIKKHNTPHWDIADKLKLVDFEAGPKL
SGSRFVVYTGLGAKLVRSLSNILLNLHTSKGYTEITVPLLVNPQAMYGTGQLPKFKEDAYITTNDQYLIPTGEVPLTNLH
AGEILDLNQLPIHYTTYSQCFRQEAGSAGRDTKGLIRLHQFNKVELVKITNQESSEAELQAMVNDAEAVLQLFNLPYRVV
ELCTGDVGFSSSKTYDLEVWFPEQNKYREISSCSNCTDFQARNMQTRYRDANGEVKLAHTLNGSGVAIDRLIAAILENYW
DGEKLILPTALKPYFDNKEYID

Sequences:

>Translated_422_residues
MLDINFIESNLVKVKEQLNKRSGDYSLIIDEAVELNVQRKSILKEVENLKANKNNLSKQVGELMRNKQSDEANKIKEEVT
LINSKIEKLDDSLKLVQEQLTSKLQNIPNIPNDNMPIGNDDNDNVEVRQ*GNELIKKHNTPH*DIADKLKLVDFEAGPKL
SGSRFVVYTGLGAKLVRSLSNILLNLHTSKGYTEITVPLLVNPQAMYGTGQLPKFKEDAYITTNDQYLIPTGEVPLTNLH
AGEILDLNQLPIHYTTYSQCFRQEAGSAGRDTKGLIRLHQFNKVELVKITNQESSEAELQAMVNDAEAVLQLFNLPYRVV
ELCTGDVGFSSSKTYDLEV*FPEQNKYREISSCSNCTDFQARNMQTRYRDANGEVKLAHTLNGSGVAIDRLIAAILENY*
DGEKLILPTALKPYFDNKEYID
>Mature_422_residues
MLDINFIESNLVKVKEQLNKRSGDYSLIIDEAVELNVQRKSILKEVENLKANKNNLSKQVGELMRNKQSDEANKIKEEVT
LINSKIEKLDDSLKLVQEQLTSKLQNIPNIPNDNMPIGNDDNDNVEVRQ*GNELIKKHNTPH*DIADKLKLVDFEAGPKL
SGSRFVVYTGLGAKLVRSLSNILLNLHTSKGYTEITVPLLVNPQAMYGTGQLPKFKEDAYITTNDQYLIPTGEVPLTNLH
AGEILDLNQLPIHYTTYSQCFRQEAGSAGRDTKGLIRLHQFNKVELVKITNQESSEAELQAMVNDAEAVLQLFNLPYRVV
ELCTGDVGFSSSKTYDLEV*FPEQNKYREISSCSNCTDFQARNMQTRYRDANGEVKLAHTLNGSGVAIDRLIAAILENY*
DGEKLILPTALKPYFDNKEYID

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=444, Percent_Identity=32.8828828828829, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI225579074, Length=413, Percent_Identity=26.634382566586, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI8923421, Length=411, Percent_Identity=26.7639902676399, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1787120, Length=437, Percent_Identity=45.3089244851259, Blast_Score=357, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI17539260, Length=429, Percent_Identity=29.8368298368298, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17542084, Length=299, Percent_Identity=28.7625418060201, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=437, Percent_Identity=33.1807780320366, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=406, Percent_Identity=29.064039408867, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24581334, Length=447, Percent_Identity=30.4250559284116, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI17737985, Length=372, Percent_Identity=31.989247311828, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 46978; Mature: 46978

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDINFIESNLVKVKEQLNKRSGDYSLIIDEAVELNVQRKSILKEVENLKANKNNLSKQV
CCEEEHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCHHHHHHHHHHHHHCCHHHHHHHH
GELMRNKQSDEANKIKEEVTLINSKIEKLDDSLKLVQEQLTSKLQNIPNIPNDNMPIGND
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DNDNVEVRQGNELIKKHNTPHDIADKLKLVDFEAGPKLSGSRFVVYTGLGAKLVRSLSNI
CCCCEEEECCHHHHHHCCCCHHHHHCEEEEEECCCCCCCCCEEEEEECCHHHHHHHHHHH
LLNLHTSKGYTEITVPLLVNPQAMYGTGQLPKFKEDAYITTNDQYLIPTGEVPLTNLHAG
HEEEECCCCCEEEEEEEEECCHHCCCCCCCCCCCCCCEEECCCCEEEECCCCCCCCCCCC
EILDLNQLPIHYTTYSQCFRQEAGSAGRDTKGLIRLHQFNKVELVKITNQESSEAELQAM
CEEECCCCCEEEHHHHHHHHHHCCCCCCCCHHHEEEECCCCEEEEEEECCCCHHHHHHHH
VNDAEAVLQLFNLPYRVVELCTGDVGFSSSKTYDLEVFPEQNKYREISSCSNCTDFQARN
HHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCHHHCC
MQTRYRDANGEVKLAHTLNGSGVAIDRLIAAILENYDGEKLILPTALKPYFDNKEYID
CHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDINFIESNLVKVKEQLNKRSGDYSLIIDEAVELNVQRKSILKEVENLKANKNNLSKQV
CCEEEHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCHHHHHHHHHHHHHCCHHHHHHHH
GELMRNKQSDEANKIKEEVTLINSKIEKLDDSLKLVQEQLTSKLQNIPNIPNDNMPIGND
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DNDNVEVRQGNELIKKHNTPHDIADKLKLVDFEAGPKLSGSRFVVYTGLGAKLVRSLSNI
CCCCEEEECCHHHHHHCCCCHHHHHCEEEEEECCCCCCCCCEEEEEECCHHHHHHHHHHH
LLNLHTSKGYTEITVPLLVNPQAMYGTGQLPKFKEDAYITTNDQYLIPTGEVPLTNLHAG
HEEEECCCCCEEEEEEEEECCHHCCCCCCCCCCCCCCEEECCCCEEEECCCCCCCCCCCC
EILDLNQLPIHYTTYSQCFRQEAGSAGRDTKGLIRLHQFNKVELVKITNQESSEAELQAM
CEEECCCCCEEEHHHHHHHHHHCCCCCCCCHHHEEEECCCCEEEEEEECCCCHHHHHHHH
VNDAEAVLQLFNLPYRVVELCTGDVGFSSSKTYDLEVFPEQNKYREISSCSNCTDFQARN
HHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCHHHCC
MQTRYRDANGEVKLAHTLNGSGVAIDRLIAAILENYDGEKLILPTALKPYFDNKEYID
CHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA