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The map label for this gene is pheA [H]

Identifier: 50085331

GI number: 50085331

Start: 2195579

End: 2196688

Strand: Reverse

Name: pheA [H]

Synonym: ACIAD2223

Alternate gene names: 50085331

Gene position: 2196688-2195579 (Counterclockwise)

Preceding gene: 50085334

Following gene: 50085330

Centisome position: 61.04

GC content: 43.06

Gene sequence:

>1110_bases
ATGATCCATGATGATCAGAAACCTTCATCTTCTCTCGACTTGCAAGAAATCCGGATTCAGATCGATAGCGTAGATCAACA
GATTCAGGAACTTATTAATCGCCGTGCAACTTTGGCAGAAGCTGTGGCAAAAGCCAAATTTGCTTCGGAAGAAAATCCAT
TGTTTTATCGGCCAGAGCGAGAAGCACAGGTTTTACGTAAGGTCATGGAGCGCAATCAAGGGCCTCTTTCAGATGTCACC
ATGGCACGTTTGTTTCGTGAAATCATGTCTGCTTGTCTGGCACTTGAAGCACCTCAAAGTATTGCATTTTTAGGGCCTGA
AGGAACCTTTACTCAGTCTGCTGCACTCAAGCACTTTGGGAAAGATGCGGTGGTACGCCCACTTCCGACGATTGATGAAG
TATTTCGTGAAGTTGAAGCAGGTAGTGCACACTATGGTGTGGTTCCTGTTGAAAACTCATCTGAAGGTGTCGTCAATCAT
ACACTCGACTGTTTTAGAACTTCTCAGTTAAATGTGATTGGTGAAGTTGAATTACGCATTCACCATCAATTTCTGGTGTC
TCACAATACCCGTAAAGACAGTATTAAACAGATTTATGCGCATCAGCAGGCCTTGGCTCAGTGCAGACAGTGGCTAGATA
CACACTATCCTGGTGTTGAGCGAGTTGCCTTGAGTTCTAATGCCGAGGCTGCACGCCGTATTCGTAATGAGTGGCATTCG
GCTGCCATTGCCTCTGATATTGCAGCATCTATGTATGATCTTGAAATTTTTCATAGCAATATCGAAGATAATCCAGAAAA
CACCACACGCTTTTTAGTCATTGGGCGTGAGAAAATTCCTCAAAGTGGTAATGATAAAACTTCATTACTGATTTCTGCAC
ATGATCGTGCTGGTGCTTTGCTTGAAATTCTAGCTCCTTTTGCAAAACACAAGATTAGCTTGACCAGTATCGAAACTCGT
CCAGCCTTACCTGAAAAATGGGCATATGTGTTCTTTATAGACCTAGAAGGACACATCGAACAGGAAAATGTTGCAGCAGC
AATTGATGATATTCGTCCACTTGTAAAAGAGTTGCGTATTTTAGGGTCTTATCCTGCTGCGGTATTGTAA

Upstream 100 bases:

>100_bases
AAAGCAAACTTTTATTGCGCGTTAAGTCCCTTGATGTACAACAAATTCAAAAGAAGTCTTGCTATACTGTTGCGAAATAA
TTTGCAGAGGCTGCATTGCA

Downstream 100 bases:

>100_bases
TGACAATGGGGTGGTCGAGTCTTTAAGATAAGACAACCTGTTTAGCGTTTGATGAACAACTTCATCAAAAATGACCTGAT
TAAAAAGAGATGAAAGTTTA

Product: bifuctional chorismate mutase P/prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MIHDDQKPSSSLDLQEIRIQIDSVDQQIQELINRRATLAEAVAKAKFASEENPLFYRPEREAQVLRKVMERNQGPLSDVT
MARLFREIMSACLALEAPQSIAFLGPEGTFTQSAALKHFGKDAVVRPLPTIDEVFREVEAGSAHYGVVPVENSSEGVVNH
TLDCFRTSQLNVIGEVELRIHHQFLVSHNTRKDSIKQIYAHQQALAQCRQWLDTHYPGVERVALSSNAEAARRIRNEWHS
AAIASDIAASMYDLEIFHSNIEDNPENTTRFLVIGREKIPQSGNDKTSLLISAHDRAGALLEILAPFAKHKISLTSIETR
PALPEKWAYVFFIDLEGHIEQENVAAAIDDIRPLVKELRILGSYPAAVL

Sequences:

>Translated_369_residues
MIHDDQKPSSSLDLQEIRIQIDSVDQQIQELINRRATLAEAVAKAKFASEENPLFYRPEREAQVLRKVMERNQGPLSDVT
MARLFREIMSACLALEAPQSIAFLGPEGTFTQSAALKHFGKDAVVRPLPTIDEVFREVEAGSAHYGVVPVENSSEGVVNH
TLDCFRTSQLNVIGEVELRIHHQFLVSHNTRKDSIKQIYAHQQALAQCRQWLDTHYPGVERVALSSNAEAARRIRNEWHS
AAIASDIAASMYDLEIFHSNIEDNPENTTRFLVIGREKIPQSGNDKTSLLISAHDRAGALLEILAPFAKHKISLTSIETR
PALPEKWAYVFFIDLEGHIEQENVAAAIDDIRPLVKELRILGSYPAAVL
>Mature_369_residues
MIHDDQKPSSSLDLQEIRIQIDSVDQQIQELINRRATLAEAVAKAKFASEENPLFYRPEREAQVLRKVMERNQGPLSDVT
MARLFREIMSACLALEAPQSIAFLGPEGTFTQSAALKHFGKDAVVRPLPTIDEVFREVEAGSAHYGVVPVENSSEGVVNH
TLDCFRTSQLNVIGEVELRIHHQFLVSHNTRKDSIKQIYAHQQALAQCRQWLDTHYPGVERVALSSNAEAARRIRNEWHS
AAIASDIAASMYDLEIFHSNIEDNPENTTRFLVIGREKIPQSGNDKTSLLISAHDRAGALLEILAPFAKHKISLTSIETR
PALPEKWAYVFFIDLEGHIEQENVAAAIDDIRPLVKELRILGSYPAAVL

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=379, Percent_Identity=29.8153034300792, Blast_Score=169, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324013, Length=322, Percent_Identity=28.8819875776398, Blast_Score=92, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 41353; Mature: 41353

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHDDQKPSSSLDLQEIRIQIDSVDQQIQELINRRATLAEAVAKAKFASEENPLFYRPER
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCH
EAQVLRKVMERNQGPLSDVTMARLFREIMSACLALEAPQSIAFLGPEGTFTQSAALKHFG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCC
KDAVVRPLPTIDEVFREVEAGSAHYGVVPVENSSEGVVNHTLDCFRTSQLNVIGEVELRI
CCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEEEE
HHQFLVSHNTRKDSIKQIYAHQQALAQCRQWLDTHYPGVERVALSSNAEAARRIRNEWHS
EHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHHHH
AAIASDIAASMYDLEIFHSNIEDNPENTTRFLVIGREKIPQSGNDKTSLLISAHDRAGAL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHCCCCCCCCEEEEEEECCCHHHH
LEILAPFAKHKISLTSIETRPALPEKWAYVFFIDLEGHIEQENVAAAIDDIRPLVKELRI
HHHHHHHHHCCEEEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LGSYPAAVL
HCCCCHHCC
>Mature Secondary Structure
MIHDDQKPSSSLDLQEIRIQIDSVDQQIQELINRRATLAEAVAKAKFASEENPLFYRPER
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCH
EAQVLRKVMERNQGPLSDVTMARLFREIMSACLALEAPQSIAFLGPEGTFTQSAALKHFG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCC
KDAVVRPLPTIDEVFREVEAGSAHYGVVPVENSSEGVVNHTLDCFRTSQLNVIGEVELRI
CCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEEEE
HHQFLVSHNTRKDSIKQIYAHQQALAQCRQWLDTHYPGVERVALSSNAEAARRIRNEWHS
EHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHHHH
AAIASDIAASMYDLEIFHSNIEDNPENTTRFLVIGREKIPQSGNDKTSLLISAHDRAGAL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHCCCCCCCCEEEEEEECCCHHHH
LEILAPFAKHKISLTSIETRPALPEKWAYVFFIDLEGHIEQENVAAAIDDIRPLVKELRI
HHHHHHHHHCCEEEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LGSYPAAVL
HCCCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]