Click here to switch to the map view.

The map label for this gene is aroA [H]

Identifier: 50085330

GI number: 50085330

Start: 2193227

End: 2195473

Strand: Reverse

Name: aroA [H]

Synonym: ACIAD2222

Alternate gene names: 50085330

Gene position: 2195473-2193227 (Counterclockwise)

Preceding gene: 50085331

Following gene: 50085329

Centisome position: 61.01

GC content: 44.1

Gene sequence:

>2247_bases
ATGGCCCAACCTTTATTTAAAAAAGTTGCCTTTATTGGTCTTGGATTAATAGGATCAAGTCTGGCGCGTGTTATTCAGGC
CGAAAAATTAGCAGGCTCAGTTGTGGCATCGACACGCTCTGCAAAAACACTTGAAGATGCAAAAGCACTGGGTTTGATCG
AAGAAGGCTTTCGTGATCCTGTAGAGGCAGTTCAAGGGGCCGATCTGGTGATACTCGCCTTGCCTGTGCGTGCAACCCAA
GCGGTTCTGGCGCAAATTCAACCCTATCTTGCACAGCATACTATCATCACCGATGTTGGGAGCACCAAAGGTAATGTGGT
TGATGCAGCTAAGGCTGTGTTTGGTGAAAATTTACCTGAAGGTTTTGTACCTGGCCATCCGATTGCAGGAAGTGAGCATA
CGGGTGTCCATGCAGGTAAAATTGATTTATTTGCAAATCACAAAGTAATTCTTACTCCTCTCAAGAGCAGTGCGCCTTGG
GCAGTTGAAAAGCTTATTCAGCTTTGGTCTGCTGCCAAGGCAGAAGTGATTTGTATGGATGTGACCAGACATGATGAAGT
GCTGGCACACACCAGTCATTTACCACATCTGATGGCATTTAATCTGGTCGAACAGCTTGCAAATCGTGAAGATAATCTGG
ATATTTTTAGGTATGCTGCTGGTGGATTCCGTGATTTTTCAAGGATCGCAGCGAGTGATCCACAAATGTGGCACGATATC
TTTTTTGCCAATAAAGCTGCAATACTCAATGCTGTAGATGGTTTTGAACACCAGCTTTCACAGATTCGACAGCTCATAGA
AAATGAAGACTCCCAAGCACTTATGGGATTGCTTGGTCATGCGCAGGCTGCACGACAACACTTTAATCACATGTTAGCAA
AGAAACCATTAATGGAGAAAAACAAGGTGACACAGCAATTTACGATTTCGCCAGGACCTAAAGCATTTAAAGGTAAATTC
ACCATACCTGGTGATAAATCAGTGTCACATCGTTCAATTATGTTTGGTGCGATTGCTGAAGGCACAACCCATGTAACGGG
CTTTCTTGAAGGTGAAGATGCGCTTGCCACTTTACAGGCATTTCGTGATATGGGTGTCAGCATCGAAGGACCGAAAAATG
GTGAAGTTACCATTCATGGTGTGGGTATGAATGGCTTGAAAGCGCCTGTTGGTGCTTTATATATGGGTAACTCTGGTACC
AGCATGCGCCTACTTTCAGGCATGCTTTCTGCGCAGAAATTTGATTCTGTAATGACAGGTGATGCTTCATTGTCAAAACG
ACCAATGGAACGTATTGCTAAGCCATTGCGTTTAATGGGCGCTCAGATTCAGACCACAGGAGAAAAGGGCACGCCTCCTG
TCAGTATTTCTGGTAGTCAGATGCTTAAAGGTATTCAGTATGATTTGCCAATGGCATCTGCTCAGGTGAAATCAGGTATT
TTACTTGCAGGTTTATGGGCGGAAGGCGAAACTTCTGTCACTGAACCAGAACCAACACGTGATCATACCGAGCGCATGTT
ACGAGCATTTGGCTATGACGTAAAAACAGAAGGCAACAAGATCACGTTGCAAGGTGGTGGTAAATTAGTGGGTACTCATA
TTCAGGTGCCTTCCGATATTTCATCTGCTGCTTTCTTTATGGTGGGTGCTGCGATTACAGAAAATGCTGATGTTGTGCTT
GAGGCTGTGGGAATCAACCCGACACGTACAGGTGTAATCGAAATCCTAAAACAAATGGGTGCGGATATTGCTGTTGAAAA
TGAACGCATTGCAGGCGGTGAACCAATTGCAGATATTCACATCAAGGGTTCGCGTACGCTAAAAGGTATTCATATTCCTG
AAGATCAAGTGCCATTGGCGATTGATGAATTCCCATCGTTGTTTATTGCGGCAGCATGTGCTGAAGGGCAAACTGTTTTA
ACAGGTGCAGCGGAGCTTCGTGTGAAAGAATCTGATCGTATTCAGGTGATGGCAGATGGTTTAAAGATCATGGGAATTGA
TTGTACGCCTACAAGCGATGGAATTATCATTGAAGGTAAAGGCAAATCAGGTGACTGGTCTCCTGTGTTTAATGGCGGAC
AGATTCAATCACATCATGATCATCGTATTGCAATGAGTTTTAGTATCGCTGGATTACGTACAGCAGGTGATATTGAGATT
ATTGGTACCGAAACTGTCGCTACTAGTTTTCCAACATTTACAGAGTTGGCAAATCGTGCAGGTTTAAGTATTACGGTCAG
TCAATGA

Upstream 100 bases:

>100_bases
ATGGGGTGGTCGAGTCTTTAAGATAAGACAACCTGTTTAGCGTTTGATGAACAACTTCATCAAAAATGACCTGATTAAAA
AGAGATGAAAGTTTAACGGT

Downstream 100 bases:

>100_bases
TTCATTAATGTACCGAATATATACTCAGTAACATAAATTAAAGACAGCAGTCAGCTTTTGCTTGGCTGCTGTTTGTTTAT
TGGCTATGCTGACATCATAG

Product: bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 748; Mature: 747

Protein sequence:

>748_residues
MAQPLFKKVAFIGLGLIGSSLARVIQAEKLAGSVVASTRSAKTLEDAKALGLIEEGFRDPVEAVQGADLVILALPVRATQ
AVLAQIQPYLAQHTIITDVGSTKGNVVDAAKAVFGENLPEGFVPGHPIAGSEHTGVHAGKIDLFANHKVILTPLKSSAPW
AVEKLIQLWSAAKAEVICMDVTRHDEVLAHTSHLPHLMAFNLVEQLANREDNLDIFRYAAGGFRDFSRIAASDPQMWHDI
FFANKAAILNAVDGFEHQLSQIRQLIENEDSQALMGLLGHAQAARQHFNHMLAKKPLMEKNKVTQQFTISPGPKAFKGKF
TIPGDKSVSHRSIMFGAIAEGTTHVTGFLEGEDALATLQAFRDMGVSIEGPKNGEVTIHGVGMNGLKAPVGALYMGNSGT
SMRLLSGMLSAQKFDSVMTGDASLSKRPMERIAKPLRLMGAQIQTTGEKGTPPVSISGSQMLKGIQYDLPMASAQVKSGI
LLAGLWAEGETSVTEPEPTRDHTERMLRAFGYDVKTEGNKITLQGGGKLVGTHIQVPSDISSAAFFMVGAAITENADVVL
EAVGINPTRTGVIEILKQMGADIAVENERIAGGEPIADIHIKGSRTLKGIHIPEDQVPLAIDEFPSLFIAAACAEGQTVL
TGAAELRVKESDRIQVMADGLKIMGIDCTPTSDGIIIEGKGKSGDWSPVFNGGQIQSHHDHRIAMSFSIAGLRTAGDIEI
IGTETVATSFPTFTELANRAGLSITVSQ

Sequences:

>Translated_748_residues
MAQPLFKKVAFIGLGLIGSSLARVIQAEKLAGSVVASTRSAKTLEDAKALGLIEEGFRDPVEAVQGADLVILALPVRATQ
AVLAQIQPYLAQHTIITDVGSTKGNVVDAAKAVFGENLPEGFVPGHPIAGSEHTGVHAGKIDLFANHKVILTPLKSSAPW
AVEKLIQLWSAAKAEVICMDVTRHDEVLAHTSHLPHLMAFNLVEQLANREDNLDIFRYAAGGFRDFSRIAASDPQMWHDI
FFANKAAILNAVDGFEHQLSQIRQLIENEDSQALMGLLGHAQAARQHFNHMLAKKPLMEKNKVTQQFTISPGPKAFKGKF
TIPGDKSVSHRSIMFGAIAEGTTHVTGFLEGEDALATLQAFRDMGVSIEGPKNGEVTIHGVGMNGLKAPVGALYMGNSGT
SMRLLSGMLSAQKFDSVMTGDASLSKRPMERIAKPLRLMGAQIQTTGEKGTPPVSISGSQMLKGIQYDLPMASAQVKSGI
LLAGLWAEGETSVTEPEPTRDHTERMLRAFGYDVKTEGNKITLQGGGKLVGTHIQVPSDISSAAFFMVGAAITENADVVL
EAVGINPTRTGVIEILKQMGADIAVENERIAGGEPIADIHIKGSRTLKGIHIPEDQVPLAIDEFPSLFIAAACAEGQTVL
TGAAELRVKESDRIQVMADGLKIMGIDCTPTSDGIIIEGKGKSGDWSPVFNGGQIQSHHDHRIAMSFSIAGLRTAGDIEI
IGTETVATSFPTFTELANRAGLSITVSQ
>Mature_747_residues
AQPLFKKVAFIGLGLIGSSLARVIQAEKLAGSVVASTRSAKTLEDAKALGLIEEGFRDPVEAVQGADLVILALPVRATQA
VLAQIQPYLAQHTIITDVGSTKGNVVDAAKAVFGENLPEGFVPGHPIAGSEHTGVHAGKIDLFANHKVILTPLKSSAPWA
VEKLIQLWSAAKAEVICMDVTRHDEVLAHTSHLPHLMAFNLVEQLANREDNLDIFRYAAGGFRDFSRIAASDPQMWHDIF
FANKAAILNAVDGFEHQLSQIRQLIENEDSQALMGLLGHAQAARQHFNHMLAKKPLMEKNKVTQQFTISPGPKAFKGKFT
IPGDKSVSHRSIMFGAIAEGTTHVTGFLEGEDALATLQAFRDMGVSIEGPKNGEVTIHGVGMNGLKAPVGALYMGNSGTS
MRLLSGMLSAQKFDSVMTGDASLSKRPMERIAKPLRLMGAQIQTTGEKGTPPVSISGSQMLKGIQYDLPMASAQVKSGIL
LAGLWAEGETSVTEPEPTRDHTERMLRAFGYDVKTEGNKITLQGGGKLVGTHIQVPSDISSAAFFMVGAAITENADVVLE
AVGINPTRTGVIEILKQMGADIAVENERIAGGEPIADIHIKGSRTLKGIHIPEDQVPLAIDEFPSLFIAAACAEGQTVLT
GAAELRVKESDRIQVMADGLKIMGIDCTPTSDGIIIEGKGKSGDWSPVFNGGQIQSHHDHRIAMSFSIAGLRTAGDIEII
GTETVATSFPTFTELANRAGLSITVSQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=444, Percent_Identity=27.9279279279279, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6320332, Length=420, Percent_Identity=29.0476190476191, Blast_Score=133, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 79684; Mature: 79553

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQPLFKKVAFIGLGLIGSSLARVIQAEKLAGSVVASTRSAKTLEDAKALGLIEEGFRDP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCH
VEAVQGADLVILALPVRATQAVLAQIQPYLAQHTIITDVGSTKGNVVDAAKAVFGENLPE
HHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHCCCCCC
GFVPGHPIAGSEHTGVHAGKIDLFANHKVILTPLKSSAPWAVEKLIQLWSAAKAEVICMD
CCCCCCCCCCCCCCCEECCEEEEEECCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEE
VTRHDEVLAHTSHLPHLMAFNLVEQLANREDNLDIFRYAAGGFRDFSRIAASDPQMWHDI
CCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHH
FFANKAAILNAVDGFEHQLSQIRQLIENEDSQALMGLLGHAQAARQHFNHMLAKKPLMEK
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
NKVTQQFTISPGPKAFKGKFTIPGDKSVSHRSIMFGAIAEGTTHVTGFLEGEDALATLQA
CCCCEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEECCCCEEEEEEECCCHHHHHHHH
FRDMGVSIEGPKNGEVTIHGVGMNGLKAPVGALYMGNSGTSMRLLSGMLSAQKFDSVMTG
HHHCCCEEECCCCCCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCC
DASLSKRPMERIAKPLRLMGAQIQTTGEKGTPPVSISGSQMLKGIQYDLPMASAQVKSGI
CCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEECHHHHHCCCCCCCCCCHHHHHCCE
LLAGLWAEGETSVTEPEPTRDHTERMLRAFGYDVKTEGNKITLQGGGKLVGTHIQVPSDI
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCEEEEECCCEEEEEEEECCCCC
SSAAFFMVGAAITENADVVLEAVGINPTRTGVIEILKQMGADIAVENERIAGGEPIADIH
HHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEE
IKGSRTLKGIHIPEDQVPLAIDEFPSLFIAAACAEGQTVLTGAAELRVKESDRIQVMADG
EECCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCEEEECCEEEEECCCCCEEEEECC
LKIMGIDCTPTSDGIIIEGKGKSGDWSPVFNGGQIQSHHDHRIAMSFSIAGLRTAGDIEI
EEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCEEEEEEEEECCCCCCCEEE
IGTETVATSFPTFTELANRAGLSITVSQ
EECCHHHCCCCHHHHHHHHCCCEEEECC
>Mature Secondary Structure 
AQPLFKKVAFIGLGLIGSSLARVIQAEKLAGSVVASTRSAKTLEDAKALGLIEEGFRDP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCH
VEAVQGADLVILALPVRATQAVLAQIQPYLAQHTIITDVGSTKGNVVDAAKAVFGENLPE
HHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHCCCCCC
GFVPGHPIAGSEHTGVHAGKIDLFANHKVILTPLKSSAPWAVEKLIQLWSAAKAEVICMD
CCCCCCCCCCCCCCCEECCEEEEEECCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEE
VTRHDEVLAHTSHLPHLMAFNLVEQLANREDNLDIFRYAAGGFRDFSRIAASDPQMWHDI
CCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHH
FFANKAAILNAVDGFEHQLSQIRQLIENEDSQALMGLLGHAQAARQHFNHMLAKKPLMEK
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
NKVTQQFTISPGPKAFKGKFTIPGDKSVSHRSIMFGAIAEGTTHVTGFLEGEDALATLQA
CCCCEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEECCCCEEEEEEECCCHHHHHHHH
FRDMGVSIEGPKNGEVTIHGVGMNGLKAPVGALYMGNSGTSMRLLSGMLSAQKFDSVMTG
HHHCCCEEECCCCCCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCC
DASLSKRPMERIAKPLRLMGAQIQTTGEKGTPPVSISGSQMLKGIQYDLPMASAQVKSGI
CCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEECHHHHHCCCCCCCCCCHHHHHCCE
LLAGLWAEGETSVTEPEPTRDHTERMLRAFGYDVKTEGNKITLQGGGKLVGTHIQVPSDI
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCEEEEECCCEEEEEEEECCCCC
SSAAFFMVGAAITENADVVLEAVGINPTRTGVIEILKQMGADIAVENERIAGGEPIADIH
HHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEE
IKGSRTLKGIHIPEDQVPLAIDEFPSLFIAAACAEGQTVLTGAAELRVKESDRIQVMADG
EECCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCEEEECCEEEEECCCCCEEEEECC
LKIMGIDCTPTSDGIIIEGKGKSGDWSPVFNGGQIQSHHDHRIAMSFSIAGLRTAGDIEI
EEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCEEEEEEEEECCCCCCCEEE
IGTETVATSFPTFTELANRAGLSITVSQ
EECCHHHCCCCHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA