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The map label for this gene is ampC [C]

Identifier: 50085111

GI number: 50085111

Start: 1962406

End: 1963662

Strand: Reverse

Name: ampC [C]

Synonym: ACIAD1974

Alternate gene names: 50085111

Gene position: 1963662-1962406 (Counterclockwise)

Preceding gene: 50085112

Following gene: 50085109

Centisome position: 54.57

GC content: 42.08

Gene sequence:

>1257_bases
ATGAACGCTTTAACGGAAGTCTTATTTGGTGATACGCGTAACTATCATGGCTCCGTAGATGAGCGATTTATAGATTTGGC
CGAGCAATTCAGTCGTTTGCAGGATGCAAGAACTGAGCAGGGTGGCGCTGTACTTGTGGTTTATTTTCAAGGGCAAAAAG
TGCTTGATATTTTTACAGGAAAAAAATCAGAAACAGAACAATGGAATGATCAAACCCTGTCAGTTTGTTATTCTACAGGC
AAAGGTGTATTGGCGACACTGGCCCATATTTTGGTGAGTGACGGCTTGATTGAATATGATGTGCCTATTGCACATTACTG
GCCCGAATTTGCACAACATCAAAAACAAAAGATGACGCTAAGACATATTTTAAGTCATCAAAGCGGTTTATATGATATTC
GAAATATTATTAAAGATGCGCGTGAAATGCTGGACTGGCAGCATATGTTAGAAGTATTTGAAACGACCTCACCTCGATTT
GATATTGGTCAGAGCAATGCTTATCAGGCACTGACATTCGGTTGGCTGGTTGGAGGAGTGTTAGAGAAAGCGACGGGTCG
CCATTTATCCGAGCTGATGCAGACGTATTTAGTACAACCTTTACAATTGGATGGTGCTTATTTTGGTGTACCAAGTTCGG
AGTTGTCTCGAGTAGCAAGGCTTATTACGACAAGGAATGAAGCCAAAGCAGATCAGCAACAACCCAAAGCTAAAAAGACC
CATCAACCTTCATTCAAAGACAAATTGATTGCTTGGACAGGGCAGGATCCTCAAGATTTTCAAGATGCGATGATTCCCAA
AGGAATGCGTAATTTTAGTTTTTTTAGTGATGAAGGCTTGCAGGCCGTGATTCCTGCTGCAAATGGCGTTTTTACTGCAA
ATAGCCTAAGCAAAATCTATGCGATGCTGGCAAAGCAAGGACAATGGAACGGAAAGGTCATCATTAAACCTGAAATATTT
CAGGAGCTTTCCAAGATTCAAAGTTTTTCCCGAGACAAAGTCATGCCCATCCCGATGCATTGGCGTCTAGGTTATCATCG
TATTATTACTCTGGGAAAACGTGCCAAACATGGCTTTGGGCATATTGGCTATAACGGCTCTGGTGCATGGTGCGATCCTG
AACGCGATTTGAGCTTTGCATATACACATAATTTTCAAATTGGGTCGATCACAGGCGATTATCGGCTTTGGGGGTTAACT
CAAGAGACTTTGCGATGTGCAGACCAGATTATAAAAGGAGGTAAAGGTTGGTTCTAA

Upstream 100 bases:

>100_bases
CAGAAACCACACGTTTCTGGCGTGGTAAAAGCACTATAAATAAAAATCTTTAAAGCCCGATTCGTTGGGCTTTTTTACAT
AAAACAAAAAAGGAACGCAT

Downstream 100 bases:

>100_bases
CGCGTTTTAGGTCTCAACTCCATATCTAGCATGATCTCGACATGATGTTTGAAAGAATGCGCGTCGAGACCATTTAAACC
GAGTTGATAAATACCTTCCA

Product: esterase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: Esterase; Carboxylesterase; Esterase A; Esterase/Lipase LipP; Beta-Lactamase Class C; Lactone Hydrolase; Lipase LipE; Esterase/Lipase/Beta-Lactamase; Beta-Lactamase Protein; Esterase LipL; Lipase LipD; Lipase/Esterase/Beta-Lactamase; Beta-Lactamase Family Protein; Hydrolase; Esterase/Lipase; Carboxylesterase EstC; Serine Hydrolase; Beta-Lactamase Family

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MNALTEVLFGDTRNYHGSVDERFIDLAEQFSRLQDARTEQGGAVLVVYFQGQKVLDIFTGKKSETEQWNDQTLSVCYSTG
KGVLATLAHILVSDGLIEYDVPIAHYWPEFAQHQKQKMTLRHILSHQSGLYDIRNIIKDAREMLDWQHMLEVFETTSPRF
DIGQSNAYQALTFGWLVGGVLEKATGRHLSELMQTYLVQPLQLDGAYFGVPSSELSRVARLITTRNEAKADQQQPKAKKT
HQPSFKDKLIAWTGQDPQDFQDAMIPKGMRNFSFFSDEGLQAVIPAANGVFTANSLSKIYAMLAKQGQWNGKVIIKPEIF
QELSKIQSFSRDKVMPIPMHWRLGYHRIITLGKRAKHGFGHIGYNGSGAWCDPERDLSFAYTHNFQIGSITGDYRLWGLT
QETLRCADQIIKGGKGWF

Sequences:

>Translated_418_residues
MNALTEVLFGDTRNYHGSVDERFIDLAEQFSRLQDARTEQGGAVLVVYFQGQKVLDIFTGKKSETEQWNDQTLSVCYSTG
KGVLATLAHILVSDGLIEYDVPIAHYWPEFAQHQKQKMTLRHILSHQSGLYDIRNIIKDAREMLDWQHMLEVFETTSPRF
DIGQSNAYQALTFGWLVGGVLEKATGRHLSELMQTYLVQPLQLDGAYFGVPSSELSRVARLITTRNEAKADQQQPKAKKT
HQPSFKDKLIAWTGQDPQDFQDAMIPKGMRNFSFFSDEGLQAVIPAANGVFTANSLSKIYAMLAKQGQWNGKVIIKPEIF
QELSKIQSFSRDKVMPIPMHWRLGYHRIITLGKRAKHGFGHIGYNGSGAWCDPERDLSFAYTHNFQIGSITGDYRLWGLT
QETLRCADQIIKGGKGWF
>Mature_418_residues
MNALTEVLFGDTRNYHGSVDERFIDLAEQFSRLQDARTEQGGAVLVVYFQGQKVLDIFTGKKSETEQWNDQTLSVCYSTG
KGVLATLAHILVSDGLIEYDVPIAHYWPEFAQHQKQKMTLRHILSHQSGLYDIRNIIKDAREMLDWQHMLEVFETTSPRF
DIGQSNAYQALTFGWLVGGVLEKATGRHLSELMQTYLVQPLQLDGAYFGVPSSELSRVARLITTRNEAKADQQQPKAKKT
HQPSFKDKLIAWTGQDPQDFQDAMIPKGMRNFSFFSDEGLQAVIPAANGVFTANSLSKIYAMLAKQGQWNGKVIIKPEIF
QELSKIQSFSRDKVMPIPMHWRLGYHRIITLGKRAKHGFGHIGYNGSGAWCDPERDLSFAYTHNFQIGSITGDYRLWGLT
QETLRCADQIIKGGKGWF

Specific function: This Protein Is A Serine Beta-Lactamase With A Substrate Specificity For Cephalosporins. [C]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Caenorhabditis elegans, GI17538474, Length=419, Percent_Identity=27.4463007159904, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71983659, Length=388, Percent_Identity=26.5463917525773, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17538001, Length=374, Percent_Identity=27.0053475935829, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71983666, Length=303, Percent_Identity=26.4026402640264, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17535191, Length=407, Percent_Identity=26.2899262899263, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17535177, Length=407, Percent_Identity=24.5700245700246, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71990590, Length=355, Percent_Identity=20.8450704225352, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 47389; Mature: 47389

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALTEVLFGDTRNYHGSVDERFIDLAEQFSRLQDARTEQGGAVLVVYFQGQKVLDIFTG
CCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECC
KKSETEQWNDQTLSVCYSTGKGVLATLAHILVSDGLIEYDVPIAHYWPEFAQHQKQKMTL
CCCCCHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCHHHHCHHHHHHHHHHHHH
RHILSHQSGLYDIRNIIKDAREMLDWQHMLEVFETTSPRFDIGQSNAYQALTFGWLVGGV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
LEKATGRHLSELMQTYLVQPLQLDGAYFGVPSSELSRVARLITTRNEAKADQQQPKAKKT
HHHHHHHHHHHHHHHHCCCCEEECCEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCHHCC
HQPSFKDKLIAWTGQDPQDFQDAMIPKGMRNFSFFSDEGLQAVIPAANGVFTANSLSKIY
CCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCEEEHHHHHHHH
AMLAKQGQWNGKVIIKPEIFQELSKIQSFSRDKVMPIPMHWRLGYHRIITLGKRAKHGFG
HHHHHCCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHCCCCC
HIGYNGSGAWCDPERDLSFAYTHNFQIGSITGDYRLWGLTQETLRCADQIIKGGKGWF
CCCCCCCCCCCCCCCCCEEEEEECEEEECCCCCEEEECCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNALTEVLFGDTRNYHGSVDERFIDLAEQFSRLQDARTEQGGAVLVVYFQGQKVLDIFTG
CCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECC
KKSETEQWNDQTLSVCYSTGKGVLATLAHILVSDGLIEYDVPIAHYWPEFAQHQKQKMTL
CCCCCHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCHHHHCHHHHHHHHHHHHH
RHILSHQSGLYDIRNIIKDAREMLDWQHMLEVFETTSPRFDIGQSNAYQALTFGWLVGGV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
LEKATGRHLSELMQTYLVQPLQLDGAYFGVPSSELSRVARLITTRNEAKADQQQPKAKKT
HHHHHHHHHHHHHHHHCCCCEEECCEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCHHCC
HQPSFKDKLIAWTGQDPQDFQDAMIPKGMRNFSFFSDEGLQAVIPAANGVFTANSLSKIY
CCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCEEEHHHHHHHH
AMLAKQGQWNGKVIIKPEIFQELSKIQSFSRDKVMPIPMHWRLGYHRIITLGKRAKHGFG
HHHHHCCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHCCCCC
HIGYNGSGAWCDPERDLSFAYTHNFQIGSITGDYRLWGLTQETLRCADQIIKGGKGWF
CCCCCCCCCCCCCCCCCEEEEEECEEEECCCCCEEEECCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA