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The map label for this gene is ywqF [H]

Identifier: 49188035

GI number: 49188035

Start: 4922039

End: 4923427

Strand: Reverse

Name: ywqF [H]

Synonym: BAS5049

Alternate gene names: 49188035

Gene position: 4923427-4922039 (Counterclockwise)

Preceding gene: 49188039

Following gene: 49188034

Centisome position: 94.16

GC content: 35.64

Gene sequence:

>1389_bases
ATGCACAGGGAGAATTCTATGTATTCGTATATTTTCTATTGTATATTCCTGTGCGAAAAGGAAATGAAAATTACGATAAT
AGGTACCGGATATGTTGGATTGATTACTGGGGTAGGATTGGCAGTATTGGGACATTCGGTTACATGTTTTGATATAAATG
ATGAGAAAATTGAACGGATAAAACAAGGGGATCTGCCTATTTATGAAGCTGGCTTATATGAATTAATACATGATGCGTGT
GAGAATAATCGTTTAACTTTTACAACAAGTAAAGAGGAAGCATTTAAAGATGCAGAATTTATATTTATTGCAGTTGGAAC
GCCATCGTTATTAGATGGGACAGCGGATTTAACATATATTCAAAACGCATGTGTTGATATTGGGACATATGCGACTAAAG
ACATTATTGTTGTTACAAAAAGTACTGTTCCTGTAGGGACGAATGGTGCTATGAGGGGATGGATTGAGGAGACATTACAA
AACAGACATGAATTACATATTGTATCGAATCCTGAATTTTTACGGGAGGGTTCAGGGATTTACGATTTTTTTCAGGGAGA
TCGTATTGTAATTGGGGCCGATAATGAGGAAGCGGCACGAAAAGTGGAGAATTTATATAGTGAATTACACTTAAAAACAT
ATGTTACAGATATAAAAAGTGCAGAGATGATTAAATATGCATCGAATGCTTTTTTAGCGACAAAAATTAGTTTTATCAAT
GAAATTTCAAATATATGTGAGAAGGTAGGAGCAAATGTATTAGACGTCGCAAAAGGGATGGGAATGGATAAAAGAATTGG
AGCGTCTTTTTTAAATGCGGGCATTGGTTACGGGGGATCGTGTTTTCCGAAAGATACGAAAGCGCTTGTGCAAATTGCAG
GGAATGTGGCACATGATTTTCGCTTGTTAAAAGCCGTCATTGAAGTGAATAATAAACAACAGTTATTATTGATTGAGAAA
GCGAAGAAAGTAATAAATATGAACAAGAAGCGGATTGCGGTGCTGGGAGCGGCATTTAAACCGAATACAGATGATATAAG
AGATGCACCGTCCCTTATTATGATACAAGAGTTAATAAATCTAGGTGCGGACATAGTTCTATATGACCCGAAGGCGATTC
AAAATATGAAAAATATCTTTGGGGAGACTATACAATATAGTGAATGTATAGATGAATCGATTAGAGGAGCGAGTGCGGCT
TTTATCATGACAGAATGGGAAGATATCCGGACTTATCCGTTAGAAAATTACGTACAACTTATGAGAGAACCTATTTTATT
CGATGGAAGAAATTGCTATACTAATGAAGATGTCAAGAAGCAAGGAATAGATTATTATTCTGTTGGAAGAGAAAGTATTT
ATAAGAGGGATTTTTCCGTTATTCGTTAA

Upstream 100 bases:

>100_bases
GAAGAATATCTAATTTTACAAAAACTTAAAAAAGAATGAAGAAAGTAATTCATATAATAAAGAAGTAAAAGAGTTTTCTC
ATTTTTAAGGTGAGAGGAGG

Downstream 100 bases:

>100_bases
AAAGGTATGTATTCATGTATATTCTTATATGTCATAATAGGATTTGTAACTAGTGAAAGAAAAGAGGCAATGAAATGACT
GAACGTTTAAAAGTAATGAC

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MHRENSMYSYIFYCIFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERIKQGDLPIYEAGLYELIHDAC
ENNRLTFTTSKEEAFKDAEFIFIAVGTPSLLDGTADLTYIQNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQ
NRHELHIVSNPEFLREGSGIYDFFQGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFIN
EISNICEKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDFRLLKAVIEVNNKQQLLLIEK
AKKVINMNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELINLGADIVLYDPKAIQNMKNIFGETIQYSECIDESIRGASAA
FIMTEWEDIRTYPLENYVQLMREPILFDGRNCYTNEDVKKQGIDYYSVGRESIYKRDFSVIR

Sequences:

>Translated_462_residues
MHRENSMYSYIFYCIFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERIKQGDLPIYEAGLYELIHDAC
ENNRLTFTTSKEEAFKDAEFIFIAVGTPSLLDGTADLTYIQNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQ
NRHELHIVSNPEFLREGSGIYDFFQGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFIN
EISNICEKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDFRLLKAVIEVNNKQQLLLIEK
AKKVINMNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELINLGADIVLYDPKAIQNMKNIFGETIQYSECIDESIRGASAA
FIMTEWEDIRTYPLENYVQLMREPILFDGRNCYTNEDVKKQGIDYYSVGRESIYKRDFSVIR
>Mature_462_residues
MHRENSMYSYIFYCIFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERIKQGDLPIYEAGLYELIHDAC
ENNRLTFTTSKEEAFKDAEFIFIAVGTPSLLDGTADLTYIQNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQ
NRHELHIVSNPEFLREGSGIYDFFQGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFIN
EISNICEKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDFRLLKAVIEVNNKQQLLLIEK
AKKVINMNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELINLGADIVLYDPKAIQNMKNIFGETIQYSECIDESIRGASAA
FIMTEWEDIRTYPLENYVQLMREPILFDGRNCYTNEDVKKQGIDYYSVGRESIYKRDFSVIR

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=472, Percent_Identity=34.9576271186441, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI296040443, Length=467, Percent_Identity=31.2633832976445, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI296040438, Length=370, Percent_Identity=34.5945945945946, Blast_Score=179, Evalue=6e-45,
Organism=Escherichia coli, GI1788340, Length=360, Percent_Identity=30.5555555555556, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI48994968, Length=354, Percent_Identity=30.5084745762712, Blast_Score=151, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17560350, Length=469, Percent_Identity=33.6886993603412, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI17136908, Length=466, Percent_Identity=34.1201716738197, Blast_Score=239, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51761; Mature: 51761

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRENSMYSYIFYCIFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERI
CCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCHHHHHHH
KQGDLPIYEAGLYELIHDACENNRLTFTTSKEEAFKDAEFIFIAVGTPSLLDGTADLTYI
HCCCCCEEHHHHHHHHHHHHCCCCEEEEECHHHHCCCCCEEEEEECCCHHHCCCCHHHHH
QNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQNRHELHIVSNPEFLREGSGI
HHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCE
YDFFQGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFIN
EEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
EISNICEKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDF
HHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RLLKAVIEVNNKQQLLLIEKAKKVINMNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELIN
HHHHHHHHCCCCCEEEEHHHHHHHHCCCCCEEEEEEECCCCCCCHHHCCCHHHHHHHHHH
LGADIVLYDPKAIQNMKNIFGETIQYSECIDESIRGASAAFIMTEWEDIRTYPLENYVQL
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCHHHHHHH
MREPILFDGRNCYTNEDVKKQGIDYYSVGRESIYKRDFSVIR
HHCCCEECCCCCCCCCHHHHHCCCHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MHRENSMYSYIFYCIFLCEKEMKITIIGTGYVGLITGVGLAVLGHSVTCFDINDEKIERI
CCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCHHHHHHH
KQGDLPIYEAGLYELIHDACENNRLTFTTSKEEAFKDAEFIFIAVGTPSLLDGTADLTYI
HCCCCCEEHHHHHHHHHHHHCCCCEEEEECHHHHCCCCCEEEEEECCCHHHCCCCHHHHH
QNACVDIGTYATKDIIVVTKSTVPVGTNGAMRGWIEETLQNRHELHIVSNPEFLREGSGI
HHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCE
YDFFQGDRIVIGADNEEAARKVENLYSELHLKTYVTDIKSAEMIKYASNAFLATKISFIN
EEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
EISNICEKVGANVLDVAKGMGMDKRIGASFLNAGIGYGGSCFPKDTKALVQIAGNVAHDF
HHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RLLKAVIEVNNKQQLLLIEKAKKVINMNKKRIAVLGAAFKPNTDDIRDAPSLIMIQELIN
HHHHHHHHCCCCCEEEEHHHHHHHHCCCCCEEEEEEECCCCCCCHHHCCCHHHHHHHHHH
LGADIVLYDPKAIQNMKNIFGETIQYSECIDESIRGASAAFIMTEWEDIRTYPLENYVQL
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCHHHHHHH
MREPILFDGRNCYTNEDVKKQGIDYYSVGRESIYKRDFSVIR
HHCCCEECCCCCCCCCHHHHHCCCHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]