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The map label for this gene is uvrB

Identifier: 49188002

GI number: 49188002

Start: 4888476

End: 4890452

Strand: Reverse

Name: uvrB

Synonym: BAS5016

Alternate gene names: 49188002

Gene position: 4890452-4888476 (Counterclockwise)

Preceding gene: 49188003

Following gene: 49188001

Centisome position: 93.53

GC content: 40.62

Gene sequence:

>1977_bases
TTGGAACGTCAATTTGAAATTGTCTCAGCGTATTCCCCGCAAGGTGATCAGCCGGTAGCTATAGAGAAGCTTGTAGAGGG
AATTAATAGTGGAAAGAAAAAGCAAGTGTTGCTTGGGGCGACAGGAACGGGTAAGACATTTACGATTTCAAATGTCATTA
AAGAAGTGCAAAAGCCAACGCTTGTCATGGCTCACAATAAAACGTTAGCAGGACAGTTATATAGTGAGTTGAAAGACTTT
TTCCCGAATAATGCAGTTGAATATTTTGTTAGTTATTACGATTATTATCAGCCAGAAGCGTATGTGCCACAAACAGATAC
GTTTATTGAAAAAGACGCGCAGATTAATGATGAAATCGATAAATTGCGTCACTCAGCAACGTCCGCATTATTTGAACGGG
ATGATGTAATTATTGTTGCGAGTGTTTCGTGTATATATGGTTTAGGTTCTCCAGAAGAATACCGCGAGTTAGTTGTTTCA
CTTCGAGTTGGTATGGAAAAGGACCGCAATCAATTGCTTCGTGAACTTGTTGATGTGCAGTATGGACGTAATGATATTGA
TTTCAAGCGTGGTACATTCCGCGTGCGCGGAGATGTAGTTGAAATCTTCCCGGCATCACTTGACGAGCATTGCATTCGAA
TTGAGTTTTTTGGCGATGAAATTGATCGTATTCGCGAAGTAAATGCTTTAACGGGAGAAGTATTAGCAGAACGTGATCAT
GTAGCAATCTTCCCAGCATCTCACTTCGTTACACGTGAAGAAAAGATGAAGGTCGCTATTGAAAATATCGAAAAAGAATT
AGAAGAGCGTTTAAAGGAATTAAATGATAACGGTAAGTTGTTAGAAGCGCAGCGTATAGAACAGCGTACACGTTATGATT
TAGAAATGATGCGCGAGATGGGCTTTTGTTCAGGGATTGAAAACTATTCCCGTCATTTAACACTTCGTCCAGCGGGTGCA
ACGCCGTATACGTTATTAGACTATTTCCCGAAAGATTTCTTAATCGTTATGGATGAGTCCCACGTATCAGTGCCGCAAGT
AAGAGCGATGTATAACGGGGACCAAGCGCGTAAACAAGTGCTTGTGGATCATGGATTCCGTCTGCCATCAGCTTTAGATA
ATAGACCGCTCACATTTGATGAGTTTGAAGAGAAAACGAATCAAGTTATTTACGTTTCAGCAACGCCAGGACCGTATGAA
TTAGAGCAGTCGCCAGAAGTAATAGAACAAATTATTCGTCCAACAGGGCTTTTAGATCCGCCAATTGATATACGACCAAT
TGAAGGGCAGATTGACGATCTATTAGGAGAGATTCAAGATCGCATTGCAAAAAATGAACGTGTATTAATTACAACTTTAA
CGAAGAAGATGTCAGAGGATTTAACAGACTACTTAAAAGATGTAGGAATTAAGGTGAATTATCTGCATTCTGAAGTGAAA
ACGTTAGAACGTATTGAAATTATACGAGATCTTCGCCTTGGTAAGTTTGATGTTCTCGTTGGTATTAACTTATTGCGAGA
AGGATTAGATATTCCAGAAGTATCCCTTGTAGCTATTTTAGATGCCGATAAGGAAGGATTCTTGCGTTCAGAGCGTTCGT
TAATTCAAACAATTGGCCGTGCAGCACGTAATGAAAACGGTCGCGTTATTATGTACGCAGATCGTATAACGAGATCGATG
GGGATTGCGATTGAAGAGACGAAGCGTCGTCGTAGTATACAAGAAGCTTACAATGAAGAGCATGGTATTACGCCGAAAAC
GATTCAAAAAGGTGTGCGTGATGTAATCCGTGCAACGACAGCTGCTGAAGAGCCGGAAACATATGAAGCGACGCCAGCTA
AGAAGATGACGAAAAAAGAGCGTGAAAAGACAATTGCGAAGATGGAAGCAGAAATGAAAGAAGCAGCAAAAGCATTAGAC
TTCGAGCGTGCAGCTGAATTAAGAGATTTACTATTAGAATTAAAAGCGGAAGGGTGA

Upstream 100 bases:

>100_bases
AAACTGTAGTAGCGAGTGGTTGGCAAGGCAGGACACGTAGAAGCAGGAACACTCTAAGAATATACATTTGTCTATATTTT
TTGTAGCAGGTCGGATTTTC

Downstream 100 bases:

>100_bases
AAAGAGTGAGTAAGAGCAAGGATTTTATCGTTGTAAAAGGTGCTAGAGCACATAACTTAAAAAATATTGATGTAACCATT
CCGAGAAATCAACTTGTCGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MERQFEIVSAYSPQGDQPVAIEKLVEGINSGKKKQVLLGATGTGKTFTISNVIKEVQKPTLVMAHNKTLAGQLYSELKDF
FPNNAVEYFVSYYDYYQPEAYVPQTDTFIEKDAQINDEIDKLRHSATSALFERDDVIIVASVSCIYGLGSPEEYRELVVS
LRVGMEKDRNQLLRELVDVQYGRNDIDFKRGTFRVRGDVVEIFPASLDEHCIRIEFFGDEIDRIREVNALTGEVLAERDH
VAIFPASHFVTREEKMKVAIENIEKELEERLKELNDNGKLLEAQRIEQRTRYDLEMMREMGFCSGIENYSRHLTLRPAGA
TPYTLLDYFPKDFLIVMDESHVSVPQVRAMYNGDQARKQVLVDHGFRLPSALDNRPLTFDEFEEKTNQVIYVSATPGPYE
LEQSPEVIEQIIRPTGLLDPPIDIRPIEGQIDDLLGEIQDRIAKNERVLITTLTKKMSEDLTDYLKDVGIKVNYLHSEVK
TLERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNENGRVIMYADRITRSM
GIAIEETKRRRSIQEAYNEEHGITPKTIQKGVRDVIRATTAAEEPETYEATPAKKMTKKEREKTIAKMEAEMKEAAKALD
FERAAELRDLLLELKAEG

Sequences:

>Translated_658_residues
MERQFEIVSAYSPQGDQPVAIEKLVEGINSGKKKQVLLGATGTGKTFTISNVIKEVQKPTLVMAHNKTLAGQLYSELKDF
FPNNAVEYFVSYYDYYQPEAYVPQTDTFIEKDAQINDEIDKLRHSATSALFERDDVIIVASVSCIYGLGSPEEYRELVVS
LRVGMEKDRNQLLRELVDVQYGRNDIDFKRGTFRVRGDVVEIFPASLDEHCIRIEFFGDEIDRIREVNALTGEVLAERDH
VAIFPASHFVTREEKMKVAIENIEKELEERLKELNDNGKLLEAQRIEQRTRYDLEMMREMGFCSGIENYSRHLTLRPAGA
TPYTLLDYFPKDFLIVMDESHVSVPQVRAMYNGDQARKQVLVDHGFRLPSALDNRPLTFDEFEEKTNQVIYVSATPGPYE
LEQSPEVIEQIIRPTGLLDPPIDIRPIEGQIDDLLGEIQDRIAKNERVLITTLTKKMSEDLTDYLKDVGIKVNYLHSEVK
TLERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNENGRVIMYADRITRSM
GIAIEETKRRRSIQEAYNEEHGITPKTIQKGVRDVIRATTAAEEPETYEATPAKKMTKKEREKTIAKMEAEMKEAAKALD
FERAAELRDLLLELKAEG
>Mature_658_residues
MERQFEIVSAYSPQGDQPVAIEKLVEGINSGKKKQVLLGATGTGKTFTISNVIKEVQKPTLVMAHNKTLAGQLYSELKDF
FPNNAVEYFVSYYDYYQPEAYVPQTDTFIEKDAQINDEIDKLRHSATSALFERDDVIIVASVSCIYGLGSPEEYRELVVS
LRVGMEKDRNQLLRELVDVQYGRNDIDFKRGTFRVRGDVVEIFPASLDEHCIRIEFFGDEIDRIREVNALTGEVLAERDH
VAIFPASHFVTREEKMKVAIENIEKELEERLKELNDNGKLLEAQRIEQRTRYDLEMMREMGFCSGIENYSRHLTLRPAGA
TPYTLLDYFPKDFLIVMDESHVSVPQVRAMYNGDQARKQVLVDHGFRLPSALDNRPLTFDEFEEKTNQVIYVSATPGPYE
LEQSPEVIEQIIRPTGLLDPPIDIRPIEGQIDDLLGEIQDRIAKNERVLITTLTKKMSEDLTDYLKDVGIKVNYLHSEVK
TLERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNENGRVIMYADRITRSM
GIAIEETKRRRSIQEAYNEEHGITPKTIQKGVRDVIRATTAAEEPETYEATPAKKMTKKEREKTIAKMEAEMKEAAKALD
FERAAELRDLLLELKAEG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=666, Percent_Identity=58.1081081081081, Blast_Score=768, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_BACAN (Q81X47)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_847569.1
- RefSeq:   YP_022057.1
- RefSeq:   YP_031255.1
- ProteinModelPortal:   Q81X47
- SMR:   Q81X47
- EnsemblBacteria:   EBBACT00000012448
- EnsemblBacteria:   EBBACT00000016092
- EnsemblBacteria:   EBBACT00000022019
- GeneID:   1084964
- GeneID:   2819248
- GeneID:   2852664
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_5396
- KEGG:   bar:GBAA_5396
- KEGG:   bat:BAS5016
- TIGR:   BA_5396
- TIGR:   GBAA_5396
- GeneTree:   EBGT00050000000887
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   BANT260799:BAS5016-MONOMER
- BioCyc:   BANT261594:GBAA5396-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 75164; Mature: 75164

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERQFEIVSAYSPQGDQPVAIEKLVEGINSGKKKQVLLGATGTGKTFTISNVIKEVQKPT
CCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEHHHHHHHHCCCE
LVMAHNKTLAGQLYSELKDFFPNNAVEYFVSYYDYYQPEAYVPQTDTFIEKDAQINDEID
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHH
KLRHSATSALFERDDVIIVASVSCIYGLGSPEEYRELVVSLRVGMEKDRNQLLRELVDVQ
HHHHHHHHHHHCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YGRNDIDFKRGTFRVRGDVVEIFPASLDEHCIRIEFFGDEIDRIREVNALTGEVLAERDH
CCCCCCCCCCCEEEEECCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCC
VAIFPASHFVTREEKMKVAIENIEKELEERLKELNDNGKLLEAQRIEQRTRYDLEMMREM
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHH
GFCSGIENYSRHLTLRPAGATPYTLLDYFPKDFLIVMDESHVSVPQVRAMYNGDQARKQV
HHHCCHHHHHCEEEEEECCCCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCHHHHHHH
LVDHGFRLPSALDNRPLTFDEFEEKTNQVIYVSATPGPYELEQSPEVIEQIIRPTGLLDP
HHHCCCCCCHHCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCC
PIDIRPIEGQIDDLLGEIQDRIAKNERVLITTLTKKMSEDLTDYLKDVGIKVNYLHSEVK
CCCCEECCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEHHHHHH
TLERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGR
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
AARNENGRVIMYADRITRSMGIAIEETKRRRSIQEAYNEEHGITPKTIQKGVRDVIRATT
HHCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AAEEPETYEATPAKKMTKKEREKTIAKMEAEMKEAAKALDFERAAELRDLLLELKAEG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERQFEIVSAYSPQGDQPVAIEKLVEGINSGKKKQVLLGATGTGKTFTISNVIKEVQKPT
CCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEHHHHHHHHCCCE
LVMAHNKTLAGQLYSELKDFFPNNAVEYFVSYYDYYQPEAYVPQTDTFIEKDAQINDEID
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHH
KLRHSATSALFERDDVIIVASVSCIYGLGSPEEYRELVVSLRVGMEKDRNQLLRELVDVQ
HHHHHHHHHHHCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YGRNDIDFKRGTFRVRGDVVEIFPASLDEHCIRIEFFGDEIDRIREVNALTGEVLAERDH
CCCCCCCCCCCEEEEECCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCC
VAIFPASHFVTREEKMKVAIENIEKELEERLKELNDNGKLLEAQRIEQRTRYDLEMMREM
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHH
GFCSGIENYSRHLTLRPAGATPYTLLDYFPKDFLIVMDESHVSVPQVRAMYNGDQARKQV
HHHCCHHHHHCEEEEEECCCCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCHHHHHHH
LVDHGFRLPSALDNRPLTFDEFEEKTNQVIYVSATPGPYELEQSPEVIEQIIRPTGLLDP
HHHCCCCCCHHCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCC
PIDIRPIEGQIDDLLGEIQDRIAKNERVLITTLTKKMSEDLTDYLKDVGIKVNYLHSEVK
CCCCEECCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEHHHHHH
TLERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGR
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
AARNENGRVIMYADRITRSMGIAIEETKRRRSIQEAYNEEHGITPKTIQKGVRDVIRATT
HHCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AAEEPETYEATPAKKMTKKEREKTIAKMEAEMKEAAKALDFERAAELRDLLLELKAEG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629