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The map label for this gene is fadE [H]

Identifier: 49187864

GI number: 49187864

Start: 4753280

End: 4755064

Strand: Reverse

Name: fadE [H]

Synonym: BAS4875

Alternate gene names: 49187864

Gene position: 4755064-4753280 (Counterclockwise)

Preceding gene: 49187865

Following gene: 49187863

Centisome position: 90.94

GC content: 38.71

Gene sequence:

>1785_bases
ATGGAAAAAACAGTAGGAAATGCGGTTAAAGGCGGTAGCTTTTTAGTAGATGAGATTACGATTGATCAAGTGTTTACGCC
AGAAGATTTTTCATCTGAGCATAAAATGATTGCAAAAACGACAGAGGACTTTATCGTAAATGAAGTTCTTCCAGAGCTTG
AATATTTAGAGCAACATGAGTTTGATCGTTCTGTTCGTCTTTTAAAAGAAGCTGGGGAACTTGGTTTATTAGGCGCTGAC
GTACCAGAAGAGTACGGCGGAATTGGTCTTGATAAAGTAAGCTCAGCGTTAATCGCAGAGAAATTCTCTCGCGCTGGTGG
TTTTGCAATTACTCACGGTGCTCACGTAGGTATCGGATCTTTACCAATCGTGTTATTCGGTAACGAAGAGCAAAAGAAAA
AGTATTTACCATTGCTTGCAACTGGTGAAAAATTAGCTGCATACGCATTAACAGAGCCAGGTTCAGGATCTGACGCACTA
GGTGCAAAAACAACAGCACGTTTAAATGCAGAAGGTACACATTACGTATTAAATGGTGAAAAACAGTGGATTACAAACTC
TGCATTCGCTGACGTATTTATCGTATACGCAAAAATTGATGGAGAGCACTTCTCAGCATTTATCGTAGAGAAAGACTACG
CTGGTGTATCTACAAGCCCAGAAGAAAAGAAAATGGGTATTAAATGTTCTTCAACTCGTACGTTAATTTTAGAAGATGCG
TTAGTACCGAAAGAAAACTTACTTGGTGAAATCGGTAAAGGGCATATTATCGCATTCAACATTTTAAATATCGGTCGTTA
TAAATTAGGTGTTGGTACAGTTGGATCTGCGAAACGTGCAGTAGAAATTTCAGCACAATATGCAAACCAACGTCAACAGT
TCAAACAACCAATCGCTCGCTTCCCATTAATTCAAGAGAAACTTGCGAATATGGCAGCGAAAACATATGCAGCTGAAAGC
TCTGTATATCGTACAGTAGGTTTATTCGAAAGCCGCATGAGCACATTATCTGAAGAAGAAGTAAAAGACGGTAAAGCAGT
TGCAGCTTCTATCGCTGAATATGCAATCGAGTGCTCTTTAAACAAAGTATTCGGTTCTGAAGTACTAGACTATACAGTAG
ATGAAGGTGTTCAAATCCACGGTGGTTACGGATTTATGGCAGAGTACGAGATTGAAAGAATGTATCGCGATTCTCGTATT
AACCGTATTTTCGAAGGAACGAATGAAATTAACCGCCTAATCGTACCAGGTACGTTCTTACGTAAAGCGATGAAAGGTGA
ATTACCACTTCTTCAAAAGGCACAAAAATTACAAGAAGAGTTAATGATGATGATGCCAGAAGAAGTAGGCGATGAGCCAT
TAGCACTTCAAAAATATTTAGTAAATAACGCGAAGAAAATCGGCTTAATGGTAGCTGGATTAGCTGCTCAAAAATACGGT
AAAGCATTAGATAAAGAGCAAGAAATTCTTGTGAATATCGCTGACATCGTAAGTAACCTATACGCAATGGAATCAGCTGT
TCTTCGTACAGAAAAAGCAATTAAAACAACTGGTCTTGAAAAGAATAAACAAAAAGTGTTATACACTGAAGTATTCTGCC
AAGAAGCGTTCAACGAAATCGAAGCACATGCGAAAGAAACACTTATCGCAGTTGAAAACGGCGACATGTTACGCATGATG
TTATCATCATTACGTAAATTAACTCGCCACACACCACTTAACGTAATTCCGAAGAAGCGTGAAATCGCTGCGAAAATTTT
AGAAGATGAGCGTTATACAGTTTAA

Upstream 100 bases:

>100_bases
AAGAATGGAAGCAACAAAGGTTTATAAAAAATAAACGGGAGAGCCAGCTTCTTTCAAAATGAGAGAAGCGGCTTATGAAA
ATATGAAGGAGGAAATTTTC

Downstream 100 bases:

>100_bases
TACCTTTAAAGAACAGTAGTCGTTTATACGGCTACTGTTCTTTTTTCTGAAAAAATGAAATTTTTAGTGGTATAAAACTA
ATACCATTAGTATAATAAAA

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MEKTVGNAVKGGSFLVDEITIDQVFTPEDFSSEHKMIAKTTEDFIVNEVLPELEYLEQHEFDRSVRLLKEAGELGLLGAD
VPEEYGGIGLDKVSSALIAEKFSRAGGFAITHGAHVGIGSLPIVLFGNEEQKKKYLPLLATGEKLAAYALTEPGSGSDAL
GAKTTARLNAEGTHYVLNGEKQWITNSAFADVFIVYAKIDGEHFSAFIVEKDYAGVSTSPEEKKMGIKCSSTRTLILEDA
LVPKENLLGEIGKGHIIAFNILNIGRYKLGVGTVGSAKRAVEISAQYANQRQQFKQPIARFPLIQEKLANMAAKTYAAES
SVYRTVGLFESRMSTLSEEEVKDGKAVAASIAEYAIECSLNKVFGSEVLDYTVDEGVQIHGGYGFMAEYEIERMYRDSRI
NRIFEGTNEINRLIVPGTFLRKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKYLVNNAKKIGLMVAGLAAQKYG
KALDKEQEILVNIADIVSNLYAMESAVLRTEKAIKTTGLEKNKQKVLYTEVFCQEAFNEIEAHAKETLIAVENGDMLRMM
LSSLRKLTRHTPLNVIPKKREIAAKILEDERYTV

Sequences:

>Translated_594_residues
MEKTVGNAVKGGSFLVDEITIDQVFTPEDFSSEHKMIAKTTEDFIVNEVLPELEYLEQHEFDRSVRLLKEAGELGLLGAD
VPEEYGGIGLDKVSSALIAEKFSRAGGFAITHGAHVGIGSLPIVLFGNEEQKKKYLPLLATGEKLAAYALTEPGSGSDAL
GAKTTARLNAEGTHYVLNGEKQWITNSAFADVFIVYAKIDGEHFSAFIVEKDYAGVSTSPEEKKMGIKCSSTRTLILEDA
LVPKENLLGEIGKGHIIAFNILNIGRYKLGVGTVGSAKRAVEISAQYANQRQQFKQPIARFPLIQEKLANMAAKTYAAES
SVYRTVGLFESRMSTLSEEEVKDGKAVAASIAEYAIECSLNKVFGSEVLDYTVDEGVQIHGGYGFMAEYEIERMYRDSRI
NRIFEGTNEINRLIVPGTFLRKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKYLVNNAKKIGLMVAGLAAQKYG
KALDKEQEILVNIADIVSNLYAMESAVLRTEKAIKTTGLEKNKQKVLYTEVFCQEAFNEIEAHAKETLIAVENGDMLRMM
LSSLRKLTRHTPLNVIPKKREIAAKILEDERYTV
>Mature_594_residues
MEKTVGNAVKGGSFLVDEITIDQVFTPEDFSSEHKMIAKTTEDFIVNEVLPELEYLEQHEFDRSVRLLKEAGELGLLGAD
VPEEYGGIGLDKVSSALIAEKFSRAGGFAITHGAHVGIGSLPIVLFGNEEQKKKYLPLLATGEKLAAYALTEPGSGSDAL
GAKTTARLNAEGTHYVLNGEKQWITNSAFADVFIVYAKIDGEHFSAFIVEKDYAGVSTSPEEKKMGIKCSSTRTLILEDA
LVPKENLLGEIGKGHIIAFNILNIGRYKLGVGTVGSAKRAVEISAQYANQRQQFKQPIARFPLIQEKLANMAAKTYAAES
SVYRTVGLFESRMSTLSEEEVKDGKAVAASIAEYAIECSLNKVFGSEVLDYTVDEGVQIHGGYGFMAEYEIERMYRDSRI
NRIFEGTNEINRLIVPGTFLRKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKYLVNNAKKIGLMVAGLAAQKYG
KALDKEQEILVNIADIVSNLYAMESAVLRTEKAIKTTGLEKNKQKVLYTEVFCQEAFNEIEAHAKETLIAVENGDMLRMM
LSSLRKLTRHTPLNVIPKKREIAAKILEDERYTV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=553, Percent_Identity=35.8047016274864, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI4557235, Length=596, Percent_Identity=32.5503355704698, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI76496475, Length=596, Percent_Identity=32.5503355704698, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI4557233, Length=410, Percent_Identity=35.1219512195122, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI7656849, Length=396, Percent_Identity=32.8282828282828, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI226958412, Length=398, Percent_Identity=33.9195979899498, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI187960098, Length=395, Percent_Identity=34.6835443037975, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI4557231, Length=396, Percent_Identity=34.5959595959596, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI226958414, Length=360, Percent_Identity=35.5555555555556, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI4501859, Length=393, Percent_Identity=30.5343511450382, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI4501857, Length=411, Percent_Identity=32.1167883211679, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI4503943, Length=397, Percent_Identity=31.4861460957179, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI7669494, Length=293, Percent_Identity=35.1535836177474, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI211971008, Length=423, Percent_Identity=23.8770685579196, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI48976061, Length=423, Percent_Identity=23.8770685579196, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1786223, Length=364, Percent_Identity=28.5714285714286, Blast_Score=132, Evalue=8e-32,
Organism=Escherichia coli, GI87081958, Length=355, Percent_Identity=31.5492957746479, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI87082384, Length=286, Percent_Identity=24.8251748251748, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71985184, Length=520, Percent_Identity=37.1153846153846, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=35.3403141361257, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71985192, Length=356, Percent_Identity=40.1685393258427, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17569725, Length=400, Percent_Identity=34, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=33.3333333333333, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17538396, Length=400, Percent_Identity=34, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17506239, Length=397, Percent_Identity=33.5012594458438, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17508101, Length=390, Percent_Identity=31.5384615384615, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=395, Percent_Identity=29.620253164557, Blast_Score=174, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=393, Percent_Identity=30.5343511450382, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=37.8378378378378, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=38.2352941176471, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71982178, Length=289, Percent_Identity=32.1799307958478, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17505929, Length=404, Percent_Identity=25.990099009901, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=27.7929155313352, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=27.4590163934426, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=342, Percent_Identity=26.0233918128655, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI86563383, Length=342, Percent_Identity=26.0233918128655, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540912, Length=319, Percent_Identity=23.8244514106583, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281363737, Length=471, Percent_Identity=37.1549893842887, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI21356377, Length=413, Percent_Identity=36.5617433414044, Blast_Score=252, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24646207, Length=402, Percent_Identity=34.0796019900498, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=35.4330708661417, Blast_Score=215, Evalue=7e-56,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=33.8582677165354, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24666513, Length=390, Percent_Identity=32.8205128205128, Blast_Score=192, Evalue=7e-49,
Organism=Drosophila melanogaster, GI19920834, Length=300, Percent_Identity=33, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI45550141, Length=357, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221473076, Length=357, Percent_Identity=23.8095238095238, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 65636; Mature: 65636

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTVGNAVKGGSFLVDEITIDQVFTPEDFSSEHKMIAKTTEDFIVNEVLPELEYLEQHE
CCCCCCCCCCCCCEEEEEEEECCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDRSVRLLKEAGELGLLGADVPEEYGGIGLDKVSSALIAEKFSRAGGFAITHGAHVGIGS
HHHHHHHHHHCCCCCEECCCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCEECCCC
LPIVLFGNEEQKKKYLPLLATGEKLAAYALTEPGSGSDALGAKTTARLNAEGTHYVLNGE
CEEEEECCCHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCEEEECCC
KQWITNSAFADVFIVYAKIDGEHFSAFIVEKDYAGVSTSPEEKKMGIKCSSTRTLILEDA
HHHHCCCHHEEEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHCCEEECCCCEEEEECC
LVPKENLLGEIGKGHIIAFNILNIGRYKLGVGTVGSAKRAVEISAQYANQRQQFKQPIAR
CCCHHHHHHHCCCCCEEEEEEEECCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
FPLIQEKLANMAAKTYAAESSVYRTVGLFESRMSTLSEEEVKDGKAVAASIAEYAIECSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
NKVFGSEVLDYTVDEGVQIHGGYGFMAEYEIERMYRDSRINRIFEGTNEINRLIVPGTFL
HHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCEEECCHHHH
RKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKYLVNNAKKIGLMVAGLAAQKYG
HHHHCCCCHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KALDKEQEILVNIADIVSNLYAMESAVLRTEKAIKTTGLEKNKQKVLYTEVFCQEAFNEI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
EAHAKETLIAVENGDMLRMMLSSLRKLTRHTPLNVIPKKREIAAKILEDERYTV
HHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEKTVGNAVKGGSFLVDEITIDQVFTPEDFSSEHKMIAKTTEDFIVNEVLPELEYLEQHE
CCCCCCCCCCCCCEEEEEEEECCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDRSVRLLKEAGELGLLGADVPEEYGGIGLDKVSSALIAEKFSRAGGFAITHGAHVGIGS
HHHHHHHHHHCCCCCEECCCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCEECCCC
LPIVLFGNEEQKKKYLPLLATGEKLAAYALTEPGSGSDALGAKTTARLNAEGTHYVLNGE
CEEEEECCCHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCEEEECCC
KQWITNSAFADVFIVYAKIDGEHFSAFIVEKDYAGVSTSPEEKKMGIKCSSTRTLILEDA
HHHHCCCHHEEEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHCCEEECCCCEEEEECC
LVPKENLLGEIGKGHIIAFNILNIGRYKLGVGTVGSAKRAVEISAQYANQRQQFKQPIAR
CCCHHHHHHHCCCCCEEEEEEEECCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
FPLIQEKLANMAAKTYAAESSVYRTVGLFESRMSTLSEEEVKDGKAVAASIAEYAIECSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
NKVFGSEVLDYTVDEGVQIHGGYGFMAEYEIERMYRDSRINRIFEGTNEINRLIVPGTFL
HHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCEEECCHHHH
RKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKYLVNNAKKIGLMVAGLAAQKYG
HHHHCCCCHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KALDKEQEILVNIADIVSNLYAMESAVLRTEKAIKTTGLEKNKQKVLYTEVFCQEAFNEI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
EAHAKETLIAVENGDMLRMMLSSLRKLTRHTPLNVIPKKREIAAKILEDERYTV
HHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]