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The map label for this gene is csd [H]

Identifier: 49187839

GI number: 49187839

Start: 4733956

End: 4735176

Strand: Reverse

Name: csd [H]

Synonym: BAS4849

Alternate gene names: 49187839

Gene position: 4735176-4733956 (Counterclockwise)

Preceding gene: 49187840

Following gene: 49187838

Centisome position: 90.56

GC content: 38.49

Gene sequence:

>1221_bases
ATGAATATTCATGAAATACGCAAACAGTTTCCAATTCTTGATCAAAAAGTGAACGGCAAACAACTTGTTTATTTCGATAG
TGCAGCAACTTCTCAAAAACCAATTCAAGTCATTGAAACGTTAGAACGTTACTATAAAGAATATAATTCTAACGTGCATC
GCGGTGTTCATACGCTCGGTACGAAAGCTACCGATGCGTATGAAGGTGCACGTGAGAAAGTTCGCAAGTTTATTAATGCG
AAATCAATGGAAGAGATTATTTTCACACGCGGAACGACAACTGCATTAAATACAGTAGCGGCTAGTTATGGTCTTGAAAA
TGTAAAAGAAGGCGATGAAATCGTTATTTCTTACATGGAGCATCATAGTAACATCATTCCGTGGCAACAAGTTGCGAAGA
AAACTGGTGCAACTTTAAAATATCTTCCGCTTCAACCAGATGGGACAATTTCAATAGAAGATGCTCGTCAAACAATTACA
CCGAATACAAAAATCGTTTCTATCATGTATGTATCTAACGTACTTGGAACGATTAACCCTGTAAAAGAAATCGGAGCAAT
CGCACACGAAAACGGTGCAATTATGGTCGTTGACGGTGCACAAAGTACACCTCATATGAAAGTGGATGTACAAGATTTAA
ATTGTGATTTCTACGCATTATCTGCTCATAAGATGTGCGGACCTACAGGTATCGGCGTATTATATGGTAAGAAAGAATTG
CTAAACAATATGGAGCCAATTGAATTTGGCGGTGAAATGATTGATTTCGTAGATTTACAAGAATCTACTTGGAAAGAGCT
TCCGTGGAAGTTTGAAGCAGGTACGCCGATTATCGGTAATGCAATCGGACTTGGTGCGGCAATTGATTTCCTAGAAGAAA
TCGGTCTTGATAATATTGAAAAGCATGAGCATGAATTAGCGCAATACGCTTTAGAAAGACTATCAGAAGTAGATGGCGTT
ACAATTTATGGTCCAAAGCATCGCGCTGGTCTTGTTACATTTAATATTGAAGATGTACATCCTCACGATGTAGCGACAGT
ATTAGATGTAGAAGGTATCGCGGTTCGCGCAGGACACCACTGTGCACAACCGCTTATGAAGTGGCTGAAAGCTTCTTCAA
CAGCACGTGCGAGCTTCTATTTATATAATACAAAAGAAGAAATTGATACATTTGTTGAATCGCTAATCAAGACAAAGGAG
TATTTCACAAATGTCATTTAA

Upstream 100 bases:

>100_bases
GTTTAGTCATCCATGGATTCTTAGCACCTGTAGTTAATGAGCTTCCAATTGAAGGAGTAAAAGCACAGCTTGTTGAGGTA
ATTGAAAGGAAAGTTCGCTA

Downstream 100 bases:

>100_bases
TAATTTAGATACGTTATATCGTCAAGTTATTATGGATCATTACAAAAATCCTCGTAACCATGGCGTGTTAGAAGATAGTG
TCACTGTTAACTTGAACAAT

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNIHEIRKQFPILDQKVNGKQLVYFDSAATSQKPIQVIETLERYYKEYNSNVHRGVHTLGTKATDAYEGAREKVRKFINA
KSMEEIIFTRGTTTALNTVAASYGLENVKEGDEIVISYMEHHSNIIPWQQVAKKTGATLKYLPLQPDGTISIEDARQTIT
PNTKIVSIMYVSNVLGTINPVKEIGAIAHENGAIMVVDGAQSTPHMKVDVQDLNCDFYALSAHKMCGPTGIGVLYGKKEL
LNNMEPIEFGGEMIDFVDLQESTWKELPWKFEAGTPIIGNAIGLGAAIDFLEEIGLDNIEKHEHELAQYALERLSEVDGV
TIYGPKHRAGLVTFNIEDVHPHDVATVLDVEGIAVRAGHHCAQPLMKWLKASSTARASFYLYNTKEEIDTFVESLIKTKE
YFTNVI

Sequences:

>Translated_406_residues
MNIHEIRKQFPILDQKVNGKQLVYFDSAATSQKPIQVIETLERYYKEYNSNVHRGVHTLGTKATDAYEGAREKVRKFINA
KSMEEIIFTRGTTTALNTVAASYGLENVKEGDEIVISYMEHHSNIIPWQQVAKKTGATLKYLPLQPDGTISIEDARQTIT
PNTKIVSIMYVSNVLGTINPVKEIGAIAHENGAIMVVDGAQSTPHMKVDVQDLNCDFYALSAHKMCGPTGIGVLYGKKEL
LNNMEPIEFGGEMIDFVDLQESTWKELPWKFEAGTPIIGNAIGLGAAIDFLEEIGLDNIEKHEHELAQYALERLSEVDGV
TIYGPKHRAGLVTFNIEDVHPHDVATVLDVEGIAVRAGHHCAQPLMKWLKASSTARASFYLYNTKEEIDTFVESLIKTKE
YFTNVI
>Mature_406_residues
MNIHEIRKQFPILDQKVNGKQLVYFDSAATSQKPIQVIETLERYYKEYNSNVHRGVHTLGTKATDAYEGAREKVRKFINA
KSMEEIIFTRGTTTALNTVAASYGLENVKEGDEIVISYMEHHSNIIPWQQVAKKTGATLKYLPLQPDGTISIEDARQTIT
PNTKIVSIMYVSNVLGTINPVKEIGAIAHENGAIMVVDGAQSTPHMKVDVQDLNCDFYALSAHKMCGPTGIGVLYGKKEL
LNNMEPIEFGGEMIDFVDLQESTWKELPWKFEAGTPIIGNAIGLGAAIDFLEEIGLDNIEKHEHELAQYALERLSEVDGV
TIYGPKHRAGLVTFNIEDVHPHDVATVLDVEGIAVRAGHHCAQPLMKWLKASSTARASFYLYNTKEEIDTFVESLIKTKE
YFTNVI

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=390, Percent_Identity=26.9230769230769, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI156713448, Length=322, Percent_Identity=28.8819875776398, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI1787970, Length=396, Percent_Identity=48.989898989899, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1789175, Length=404, Percent_Identity=40.0990099009901, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI48994898, Length=389, Percent_Identity=23.9074550128535, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25143064, Length=390, Percent_Identity=26.1538461538462, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI193211090, Length=414, Percent_Identity=24.1545893719807, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17533177, Length=334, Percent_Identity=24.251497005988, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319831, Length=390, Percent_Identity=27.9487179487179, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI20129463, Length=412, Percent_Identity=27.9126213592233, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45269; Mature: 45269

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIHEIRKQFPILDQKVNGKQLVYFDSAATSQKPIQVIETLERYYKEYNSNVHRGVHTLG
CCHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHC
TKATDAYEGAREKVRKFINAKSMEEIIFTRGTTTALNTVAASYGLENVKEGDEIVISYME
CCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHCHHHCCCCHHHHHHHHH
HHSNIIPWQQVAKKTGATLKYLPLQPDGTISIEDARQTITPNTKIVSIMYVSNVLGTINP
HCCCCCCHHHHHHHHCCEEEEEECCCCCCEEECCCHHHCCCCCEEEEEEEHHHHHHCCCH
VKEIGAIAHENGAIMVVDGAQSTPHMKVDVQDLNCDFYALSAHKMCGPTGIGVLYGKKEL
HHHHHHHEECCCEEEEEECCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCEEEECCHHH
LNNMEPIEFGGEMIDFVDLQESTWKELPWKFEAGTPIIGNAIGLGAAIDFLEEIGLDNIE
HCCCCCHHHCCCEEEEEECCHHHHHHCCEEECCCCCEECCHHHHHHHHHHHHHCCCCCHH
KHEHELAQYALERLSEVDGVTIYGPKHRAGLVTFNIEDVHPHDVATVLDVEGIAVRAGHH
HHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCCCHHEEEECCCEEEECCHH
CAQPLMKWLKASSTARASFYLYNTKEEIDTFVESLIKTKEYFTNVI
HHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIHEIRKQFPILDQKVNGKQLVYFDSAATSQKPIQVIETLERYYKEYNSNVHRGVHTLG
CCHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHC
TKATDAYEGAREKVRKFINAKSMEEIIFTRGTTTALNTVAASYGLENVKEGDEIVISYME
CCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHCHHHCCCCHHHHHHHHH
HHSNIIPWQQVAKKTGATLKYLPLQPDGTISIEDARQTITPNTKIVSIMYVSNVLGTINP
HCCCCCCHHHHHHHHCCEEEEEECCCCCCEEECCCHHHCCCCCEEEEEEEHHHHHHCCCH
VKEIGAIAHENGAIMVVDGAQSTPHMKVDVQDLNCDFYALSAHKMCGPTGIGVLYGKKEL
HHHHHHHEECCCEEEEEECCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCEEEECCHHH
LNNMEPIEFGGEMIDFVDLQESTWKELPWKFEAGTPIIGNAIGLGAAIDFLEEIGLDNIE
HCCCCCHHHCCCEEEEEECCHHHHHHCCEEECCCCCEECCHHHHHHHHHHHHHCCCCCHH
KHEHELAQYALERLSEVDGVTIYGPKHRAGLVTFNIEDVHPHDVATVLDVEGIAVRAGHH
HHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCCCHHEEEECCCEEEECCHH
CAQPLMKWLKASSTARASFYLYNTKEEIDTFVESLIKTKEYFTNVI
HHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]