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The map label for this gene is yvcT [H]

Identifier: 49187763

GI number: 49187763

Start: 4665023

End: 4666015

Strand: Direct

Name: yvcT [H]

Synonym: BAS4773

Alternate gene names: 49187763

Gene position: 4665023-4666015 (Clockwise)

Preceding gene: 49187759

Following gene: 49187764

Centisome position: 89.22

GC content: 38.67

Gene sequence:

>993_bases
ATGCGTGATAAAGCGAAAGGGGATGGAACCGTGAAACCAAAAGTTTATATTGCTGAACCAGTTCCAACATTTGTAGAAAA
CTATTTATCAGAACACTGTGATTATGAAAAATGGGAGCAAAATGAGAAGGTACCTCGTGATGTTCTACTAGAGAAAATAC
AAGATAAAGATGGTTTATTAAATTTTGGATCTGCTATTAATGAAGAATTATTGGAGGCGGCTCCTAACTTAAAAGTAGTA
AGCAACATTTCTGTCGGTTACGATAACTTTGATTTACAAGCGATGGCAAAGCACAATGTCATCGGAACAAATACACCGTA
CGTACTAGATGATACAGTAGCTGACCTCGTTTTCGCTCTTATGTTATCTGCTGGTCGTCGTGTTTGTGAACTCGACTCCT
ACGTAAAAAATGGTGAATGGAATGCCGAAATTGGAAAAGAACACTTTGGTCTAGATGTACATCATAGTACAATCGGCATT
ATCGGTATGGGCCGAATTGGAGAAGCTGTTGCAAAACGAGCGAAATTCGGATTTGATATGGATGTTCTTTATTATAACCG
TCGCCGAAAAGAAGAAGCTGAACAAAAATTCGACGCTACATATTGTGATTTACAGACACTACTCAAACAGTCTGACTTTA
TTGTTCTTCTTACTCCATTAACAGATGAAACGTATCACCTTATCGGAGAAAAGGAATTTTCATTCATGAAAGAAACAGCT
ATCTTCATTAATGCTTCTCGCGGGAAAACAGTCGATGAAGAAGCGTTAATCGATGCGTTAACTGAAAAGAAAATCTTTGC
AGCAGGCATCGATACGTTTACACAAGAGCCGATTCAAAAAGACAATCCGCTCTTATCATTACAAAACGTTGTGACTTTAC
CACACATCGGATCTGCAACATTAAAAACTAGGCAGCAAATGGCTATGACCGCCGCTGAAAATTTAGTTGCAGGGTTACAA
GGAAAAACACCACCGAATATTGTTCGCGGGTAA

Upstream 100 bases:

>100_bases
TTCGTTTGTGTCTAAATTATACAAATACACTTTCCAGTTTGAAAAGAAGATTTTTTTAGTGAATTATGTCAAAATAAGGT
GAAACTTAATCAGTGGAAAA

Downstream 100 bases:

>100_bases
TATGGAATAAACGAAAGGCAAGATGACATCGTCATCTTGCCTTTTTTTGTTAACATATTTTCTTTTCTCTTGGAGATGAT
ATGAACAAAAATCAATGGAG

Product: gluconate 2-dehydrogenase

Products: NA

Alternate protein names: 2KR [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLLNFGSAINEELLEAAPNLKVV
SNISVGYDNFDLQAMAKHNVIGTNTPYVLDDTVADLVFALMLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGI
IGMGRIGEAVAKRAKFGFDMDVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSATLKTRQQMAMTAAENLVAGLQ
GKTPPNIVRG

Sequences:

>Translated_330_residues
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLLNFGSAINEELLEAAPNLKVV
SNISVGYDNFDLQAMAKHNVIGTNTPYVLDDTVADLVFALMLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGI
IGMGRIGEAVAKRAKFGFDMDVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSATLKTRQQMAMTAAENLVAGLQ
GKTPPNIVRG
>Mature_330_residues
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLLNFGSAINEELLEAAPNLKVV
SNISVGYDNFDLQAMAKHNVIGTNTPYVLDDTVADLVFALMLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGI
IGMGRIGEAVAKRAKFGFDMDVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSATLKTRQQMAMTAAENLVAGLQ
GKTPPNIVRG

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=318, Percent_Identity=40.8805031446541, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI23308577, Length=290, Percent_Identity=28.6206896551724, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI145580578, Length=266, Percent_Identity=30.4511278195489, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI4557499, Length=266, Percent_Identity=30.4511278195489, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI4557497, Length=266, Percent_Identity=29.3233082706767, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI61743967, Length=266, Percent_Identity=29.3233082706767, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI145580575, Length=266, Percent_Identity=30.4511278195489, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI87082289, Length=326, Percent_Identity=49.3865030674847, Blast_Score=318, Evalue=3e-88,
Organism=Escherichia coli, GI1789279, Length=273, Percent_Identity=31.5018315018315, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1787645, Length=263, Percent_Identity=29.277566539924, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87081824, Length=236, Percent_Identity=25.8474576271186, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=281, Percent_Identity=31.3167259786477, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=270, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=254, Percent_Identity=35.0393700787402, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322116, Length=294, Percent_Identity=28.9115646258503, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320925, Length=286, Percent_Identity=28.6713286713287, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=27.6679841897233, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=171, Percent_Identity=30.4093567251462, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=279, Percent_Identity=28.3154121863799, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574284, Length=314, Percent_Identity=41.0828025477707, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI45551003, Length=314, Percent_Identity=41.0828025477707, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24585514, Length=314, Percent_Identity=41.0828025477707, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI28574282, Length=314, Percent_Identity=41.0828025477707, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI45552429, Length=314, Percent_Identity=41.0828025477707, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI28574286, Length=319, Percent_Identity=38.5579937304075, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=37.620578778135, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=34.6153846153846, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI19921140, Length=286, Percent_Identity=28.6713286713287, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646446, Length=271, Percent_Identity=30.9963099630996, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646448, Length=271, Percent_Identity=30.9963099630996, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646452, Length=271, Percent_Identity=30.9963099630996, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646450, Length=271, Percent_Identity=30.9963099630996, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI62472511, Length=268, Percent_Identity=31.7164179104478, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.215 [H]

Molecular weight: Translated: 36862; Mature: 36862

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLL
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHCCCCCCC
NFGSAINEELLEAAPNLKVVSNISVGYDNFDLQAMAKHNVIGTNTPYVLDDTVADLVFAL
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHH
MLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGIIGMGRIGEAVAKRAKFGFDM
HHHCCCHHHHHHHHHHCCCCCCCCCHHHCCCEEECCEEEEEECCHHHHHHHHHHHCCCCC
DVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCHHHHHHHHEE
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSAT
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHEEECCCCCCHH
LKTRQQMAMTAAENLVAGLQGKTPPNIVRG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRDKAKGDGTVKPKVYIAEPVPTFVENYLSEHCDYEKWEQNEKVPRDVLLEKIQDKDGLL
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHCCCCCCC
NFGSAINEELLEAAPNLKVVSNISVGYDNFDLQAMAKHNVIGTNTPYVLDDTVADLVFAL
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHH
MLSAGRRVCELDSYVKNGEWNAEIGKEHFGLDVHHSTIGIIGMGRIGEAVAKRAKFGFDM
HHHCCCHHHHHHHHHHCCCCCCCCCHHHCCCEEECCEEEEEECCHHHHHHHHHHHCCCCC
DVLYYNRRRKEEAEQKFDATYCDLQTLLKQSDFIVLLTPLTDETYHLIGEKEFSFMKETA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCHHHHHHHHEE
IFINASRGKTVDEEALIDALTEKKIFAAGIDTFTQEPIQKDNPLLSLQNVVTLPHIGSAT
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHEEECCCCCCHH
LKTRQQMAMTAAENLVAGLQGKTPPNIVRG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]