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The map label for this gene is menA [H]

Identifier: 49187743

GI number: 49187743

Start: 4636149

End: 4637102

Strand: Direct

Name: menA [H]

Synonym: BAS4752

Alternate gene names: 49187743

Gene position: 4636149-4637102 (Clockwise)

Preceding gene: 49187724

Following gene: 49187744

Centisome position: 88.67

GC content: 40.67

Gene sequence:

>954_bases
ATGGAAATGAACGTCGAAACGAATTCCTCTCCTACGGCGCCAAAGCCAAGTAAGCAAACAGGCTGGCGCATTTGGTGGAG
TTTACTACGTCCCCATACATTAACAGCAGCTTTCGTTCCTGTTTTCATCGGAACAGCCTATGCAATGCAGGTCGGAGGTA
TAAATCAAATACATCTCCCTCTTTTCCTTATAATGCTTCTTGCTTGTCTTCTCATTCAGGCAGCAACAAACATGTTTAAT
GAATACTTTGATTATAAAAGAGGACTTGATCACGAAGGTTCAGTCGGTATCGGCGGCGCTATCGTTCGCGATGGCATTCA
GCCAAAAACAGTGCTTAACTTAGCATTTGGATTTTTCGGCATCGCAATACTATTAGGTGTTTATATTTGTATGAATTCTA
GCTGGTGGCTTGCTGCAATCGGTCTTGTTTGTATGGCCGTTGCTTACCTTTATACAGGCGGTCCACTTCCAATTGCATAT
ACACCATTTGGAGAGTTAACAGCCGGATTATTTATGGGTGTCATTATTATCGGGATTTCATTCTTTATTCAAACTGGAAC
TGTAACATCAGAAGTCGTGTTACTATCTATTCCAAGTTCCATTTTAATTGGTGCCATTTTACTAGCTAATAACATCCGTG
ACTTAGATGGCGATAAAGAAAATGGTCGTAAAACGTTAGCCATTCTCGTTGGACGTGAAAGAGCCGTTGGTGTACTTGCT
TCTATGTTCATCGTTTCCTACATTTGGACAATTGCTTTAATTATCGTGGGCATCGTATCACCATGGATGCTTATCGTATT
TTTAAGTGCACCGAAAGCATTTAAAGCGACGAAAGGCTTTATCGGCAAAAGCATTCCAATGGAAATGGTACCTGCGATGA
TAGCAACAGCAAAAACAAATACAATCTTCGGTCTCCTTATGGGAATCGGATTATTACTTGGATATTTCCTTTAA

Upstream 100 bases:

>100_bases
GAGAAATTCACCTTCTCTTCCTAGAAAATAAACGTTGACACTAAATGATGCTTTTTCTACACTTAGTTGTGTACAATATG
TGACCAAAGGAGGATTCAAC

Downstream 100 bases:

>100_bases
AAGGAGCTGCTAATGCGGCTCCTTTTTCATATACCAAATTCAGCTCATAATTCCTACTCGCAACGCTCATACTATGTAAA
GAAACTGAATTGTAGGAAGG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MEMNVETNSSPTAPKPSKQTGWRIWWSLLRPHTLTAAFVPVFIGTAYAMQVGGINQIHLPLFLIMLLACLLIQAATNMFN
EYFDYKRGLDHEGSVGIGGAIVRDGIQPKTVLNLAFGFFGIAILLGVYICMNSSWWLAAIGLVCMAVAYLYTGGPLPIAY
TPFGELTAGLFMGVIIIGISFFIQTGTVTSEVVLLSIPSSILIGAILLANNIRDLDGDKENGRKTLAILVGRERAVGVLA
SMFIVSYIWTIALIIVGIVSPWMLIVFLSAPKAFKATKGFIGKSIPMEMVPAMIATAKTNTIFGLLMGIGLLLGYFL

Sequences:

>Translated_317_residues
MEMNVETNSSPTAPKPSKQTGWRIWWSLLRPHTLTAAFVPVFIGTAYAMQVGGINQIHLPLFLIMLLACLLIQAATNMFN
EYFDYKRGLDHEGSVGIGGAIVRDGIQPKTVLNLAFGFFGIAILLGVYICMNSSWWLAAIGLVCMAVAYLYTGGPLPIAY
TPFGELTAGLFMGVIIIGISFFIQTGTVTSEVVLLSIPSSILIGAILLANNIRDLDGDKENGRKTLAILVGRERAVGVLA
SMFIVSYIWTIALIIVGIVSPWMLIVFLSAPKAFKATKGFIGKSIPMEMVPAMIATAKTNTIFGLLMGIGLLLGYFL
>Mature_317_residues
MEMNVETNSSPTAPKPSKQTGWRIWWSLLRPHTLTAAFVPVFIGTAYAMQVGGINQIHLPLFLIMLLACLLIQAATNMFN
EYFDYKRGLDHEGSVGIGGAIVRDGIQPKTVLNLAFGFFGIAILLGVYICMNSSWWLAAIGLVCMAVAYLYTGGPLPIAY
TPFGELTAGLFMGVIIIGISFFIQTGTVTSEVVLLSIPSSILIGAILLANNIRDLDGDKENGRKTLAILVGRERAVGVLA
SMFIVSYIWTIALIIVGIVSPWMLIVFLSAPKAFKATKGFIGKSIPMEMVPAMIATAKTNTIFGLLMGIGLLLGYFL

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=320, Percent_Identity=26.875, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1790365, Length=309, Percent_Identity=25.5663430420712, Blast_Score=93, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737429, Length=281, Percent_Identity=30.2491103202847, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34217; Mature: 34217

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMNVETNSSPTAPKPSKQTGWRIWWSLLRPHTLTAAFVPVFIGTAYAMQVGGINQIHLP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LFLIMLLACLLIQAATNMFNEYFDYKRGLDHEGSVGIGGAIVRDGIQPKTVLNLAFGFFG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHH
IAILLGVYICMNSSWWLAAIGLVCMAVAYLYTGGPLPIAYTPFGELTAGLFMGVIIIGIS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHH
FFIQTGTVTSEVVLLSIPSSILIGAILLANNIRDLDGDKENGRKTLAILVGRERAVGVLA
HHHHCCCCHHHEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCHHHHHHHH
SMFIVSYIWTIALIIVGIVSPWMLIVFLSAPKAFKATKGFIGKSIPMEMVPAMIATAKTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TIFGLLMGIGLLLGYFL
HHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MEMNVETNSSPTAPKPSKQTGWRIWWSLLRPHTLTAAFVPVFIGTAYAMQVGGINQIHLP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LFLIMLLACLLIQAATNMFNEYFDYKRGLDHEGSVGIGGAIVRDGIQPKTVLNLAFGFFG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHH
IAILLGVYICMNSSWWLAAIGLVCMAVAYLYTGGPLPIAYTPFGELTAGLFMGVIIIGIS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHH
FFIQTGTVTSEVVLLSIPSSILIGAILLANNIRDLDGDKENGRKTLAILVGRERAVGVLA
HHHHCCCCHHHEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCHHHHHHHH
SMFIVSYIWTIALIIVGIVSPWMLIVFLSAPKAFKATKGFIGKSIPMEMVPAMIATAKTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TIFGLLMGIGLLLGYFL
HHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]