Click here to switch to the map view.

The map label for this gene is vanR [H]

Identifier: 49187736

GI number: 49187736

Start: 4627399

End: 4628097

Strand: Reverse

Name: vanR [H]

Synonym: BAS4745

Alternate gene names: 49187736

Gene position: 4628097-4627399 (Counterclockwise)

Preceding gene: 49187737

Following gene: 49187735

Centisome position: 88.51

GC content: 38.34

Gene sequence:

>699_bases
ATGAAGCGCATTTCAATTTTAATAGCGGATGATGAGGCAGAAATTGCTGATTTAATTGAGATACATTTAGAAAAAGAAGG
GTACCACGTCGTGAAGGCAGCAGACGGGGAAGAAGCAATTCATATTATTGAAACGCAGCCAATCGACTTAGTGGTTTTAG
ATATTATGATGCCAAAAATGGATGGGTATGAGGTGACGCGCCAAATTCGAGCGAAGCATCATATGCCAATTATTTTCTTG
AGTGCGAAAACTTCGGACTTTGATAAGGTGACAGGTCTTGTATTAGGTGCAGATGATTATATGACGAAACCTTTTACGCC
GATTGAATTAGTTGCGCGTGTAAATGCACAATTACGCCGATTTCTTACATTAAATCAGCCGAAAGTAGCTGAGAATAAAT
CTGCTTTACAGGTAGGCGGAGTTACTATTGATCCTGAGCGAAGAACAGTGAACGTGTACGGAGAGCAAATTGAGTTAACA
CCGAAAGAGTTTGATATTTTATATTTATTAGCGAGTCATCCGAAGAAAGTGTACAATGTGGAAAATATTTTTCAGCAAGT
ATGGGCAGATGATTATTATGAAGGTGGAAATACAGTTATGGTACATATTCGTACGTTGCGGAAAAAGCTTGGGGAAGATA
AAAGAAAAGATAAGCTAATAAAAACAGTGTGGGGAGTAGGGTATACTTTCAATGGATAA

Upstream 100 bases:

>100_bases
TATAATTTTATTTACAAAGGTTACTCTAACGGGTAACCTTTTCGTATTGTACAAATTGGATAGACTAGTTTACAATCGAG
CGTATAAAAGGGGGAGTAAA

Downstream 100 bases:

>100_bases
CATGATGAAAAGCTTTCGATTTAAAATGATTGCCTTATTTGCGTTAAGTATGGTGCTCGCTGCAACTGTAACTTATATAA
TTTATAAAGGATTGCAGTTG

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MKRISILIADDEAEIADLIEIHLEKEGYHVVKAADGEEAIHIIETQPIDLVVLDIMMPKMDGYEVTRQIRAKHHMPIIFL
SAKTSDFDKVTGLVLGADDYMTKPFTPIELVARVNAQLRRFLTLNQPKVAENKSALQVGGVTIDPERRTVNVYGEQIELT
PKEFDILYLLASHPKKVYNVENIFQQVWADDYYEGGNTVMVHIRTLRKKLGEDKRKDKLIKTVWGVGYTFNG

Sequences:

>Translated_232_residues
MKRISILIADDEAEIADLIEIHLEKEGYHVVKAADGEEAIHIIETQPIDLVVLDIMMPKMDGYEVTRQIRAKHHMPIIFL
SAKTSDFDKVTGLVLGADDYMTKPFTPIELVARVNAQLRRFLTLNQPKVAENKSALQVGGVTIDPERRTVNVYGEQIELT
PKEFDILYLLASHPKKVYNVENIFQQVWADDYYEGGNTVMVHIRTLRKKLGEDKRKDKLIKTVWGVGYTFNG
>Mature_232_residues
MKRISILIADDEAEIADLIEIHLEKEGYHVVKAADGEEAIHIIETQPIDLVVLDIMMPKMDGYEVTRQIRAKHHMPIIFL
SAKTSDFDKVTGLVLGADDYMTKPFTPIELVARVNAQLRRFLTLNQPKVAENKSALQVGGVTIDPERRTVNVYGEQIELT
PKEFDILYLLASHPKKVYNVENIFQQVWADDYYEGGNTVMVHIRTLRKKLGEDKRKDKLIKTVWGVGYTFNG

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=36.2445414847162, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=40.1785714285714, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=35.6828193832599, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=32.7433628318584, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=35.3711790393013, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=33.0396475770925, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1790860, Length=233, Percent_Identity=31.7596566523605, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=36.7256637168142, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=32.3008849557522, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=31.7796610169492, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790552, Length=228, Percent_Identity=33.7719298245614, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=31.6964285714286, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=32.7586206896552, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=29.8245614035088, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788713, Length=106, Percent_Identity=37.7358490566038, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790299, Length=146, Percent_Identity=31.5068493150685, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788550, Length=124, Percent_Identity=32.258064516129, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790437, Length=103, Percent_Identity=33.0097087378641, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=106, Percent_Identity=34.9056603773585, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26451; Mature: 26451

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRISILIADDEAEIADLIEIHLEKEGYHVVKAADGEEAIHIIETQPIDLVVLDIMMPKM
CCEEEEEEECCCHHHHHHHHHEECCCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCC
DGYEVTRQIRAKHHMPIIFLSAKTSDFDKVTGLVLGADDYMTKPFTPIELVARVNAQLRR
CCHHHHHHHHHHCCCCEEEEECCCCCCHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
FLTLNQPKVAENKSALQVGGVTIDPERRTVNVYGEQIELTPKEFDILYLLASHPKKVYNV
HCCCCCCCCCCCCCEEEECCEEECCCCCEEEEECCEEEECCCCEEEEEEEECCCHHHHHH
ENIFQQVWADDYYEGGNTVMVHIRTLRKKLGEDKRKDKLIKTVWGVGYTFNG
HHHHHHHHCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MKRISILIADDEAEIADLIEIHLEKEGYHVVKAADGEEAIHIIETQPIDLVVLDIMMPKM
CCEEEEEEECCCHHHHHHHHHEECCCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCC
DGYEVTRQIRAKHHMPIIFLSAKTSDFDKVTGLVLGADDYMTKPFTPIELVARVNAQLRR
CCHHHHHHHHHHCCCCEEEEECCCCCCHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
FLTLNQPKVAENKSALQVGGVTIDPERRTVNVYGEQIELTPKEFDILYLLASHPKKVYNV
HCCCCCCCCCCCCCEEEECCEEECCCCCEEEEECCEEEECCCCEEEEEEEECCCHHHHHH
ENIFQQVWADDYYEGGNTVMVHIRTLRKKLGEDKRKDKLIKTVWGVGYTFNG
HHHHHHHHCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]