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The map label for this gene is moeA [H]

Identifier: 49187611

GI number: 49187611

Start: 4514330

End: 4515619

Strand: Reverse

Name: moeA [H]

Synonym: BAS4618

Alternate gene names: 49187611

Gene position: 4515619-4514330 (Counterclockwise)

Preceding gene: 49187613

Following gene: 49187610

Centisome position: 86.36

GC content: 41.24

Gene sequence:

>1290_bases
ATGGTAGAAAAACGAATTCCGATTCAAGTTGCTGAGGCAGTAGAGAGAGTAATGGAATATGCGAAAATTGGTGAAGTAGA
AGAGGTTTCTATTACGGAAAGTTACGGGAGAATTCTTGGGGAGGATGTTGTCTCTGATCATGACGTTCCTCATTTTGATC
GTTCTCCTTACGATGGTTTCGCAATTCGAGCAGAAGATACGAAAGAAGCAAATCAAGAGAATGCAATTGAGTTTGAAGTA
ATAGGGGAAATCGGGGCTGGATCTGTTTTTACAGAAGAAGTAGGATCTTTTCAGGCGGTTCGTATTATGACAGGAGCAGC
TATTCCAGCAGATTGTAATGCAGTCGTAATGCTAGAATTGACGGAAGGTTTTGAGAAGAACGGAAAAACATATATGAAGT
TAAAGCGTCCTTTTCATAGTGGCGACAATGTGTCATTTAAAGGAGAAGATATAAAACAAAATCAAGTTCTCGTTAAGAAA
GGTGCTGTAATCAATCCAGGTGTTGCGGCCTTATTAGCGACGTTTGGATACAGTAATGTGAAGGTTGTAAAACAGCCAGT
TGTTGGTATTGTGACGACAGGAAGTGAATTGTTAGAAGTACATGAGTCATTACAGCCGGGGAAAATTAGAAATAGTAACT
CTTATATGATTGCCGCCCAAATTATGAAAGCTGGGGGTAAAGTCCGTTATTATGGTCAACTTGCCGACGAGTTAGATGCA
TGTTTTACAGCCGTTCAATCGGCGATAGAAGAGGTGGATATTTTAATTACGACAGGCGGTGTGTCGGTAGGAGATTATGA
CTACTTACCGGCTATTTATGAAAGGTTACAGGCGAATGTACTCTTTAATAAAATAGCGATGAGACCGGGCAGTGTAACGA
CAGTAGCTGAAGTGGATGGAAAGTTACTTTTCGGTTTATCAGGGAATCCGTCAGCTTGTTATGTAGGATTTGAGTTATTT
GTGCATCCGGTTATAAAAACTTATTTGTATGCGAAGGAACCACACGTATATAGAGCAGATGCTATTTTACAAAAAGATTT
TCCAAAACCAAATCCGTTTACTCGTTTTGTAAGAGCAAAGGTGACAATCGTGGACGGGGCATTACACGCGATGCCGGTCG
GTTTAGATAAATCGAGTGCGGTATCTTCACTTGCAGATGCGAATGCTTTTATTGTGTTGCCTGGAGGAACGAGAGGCTTT
GAGACAGGGATGAAAGTGTCTGTATTATTGTTAGAGCACGCTGAGGGATGTGATTGGCCGTGGGCAAAGCCCCTTCAATC
TTACAAATAG

Upstream 100 bases:

>100_bases
TGTGTGAATGAAGACATGGAATTCCTCCTTGAAGTAATTTTTATTCAATATATAAAGTTTAATCGAGATAAAAAAAATTG
CAAATATGGGGTGAGAAACG

Downstream 100 bases:

>100_bases
TAGGGTATCAAAATAGCGGGAAAACAACACTTGTTGAGAAAATTGTACATGTATTAACTGAAAGCGAAATGAAAGTTGCT
ACCATTAAACATCACGGACA

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGRILGEDVVSDHDVPHFDRSPYDGFAIRAEDTKEANQENAIEFEV
IGEIGAGSVFTEEVGSFQAVRIMTGAAIPADCNAVVMLELTEGFEKNGKTYMKLKRPFHSGDNVSFKGEDIKQNQVLVKK
GAVINPGVAALLATFGYSNVKVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIMKAGGKVRYYGQLADELDA
CFTAVQSAIEEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDGKLLFGLSGNPSACYVGFELF
VHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAKVTIVDGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGF
ETGMKVSVLLLEHAEGCDWPWAKPLQSYK

Sequences:

>Translated_429_residues
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGRILGEDVVSDHDVPHFDRSPYDGFAIRAEDTKEANQENAIEFEV
IGEIGAGSVFTEEVGSFQAVRIMTGAAIPADCNAVVMLELTEGFEKNGKTYMKLKRPFHSGDNVSFKGEDIKQNQVLVKK
GAVINPGVAALLATFGYSNVKVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIMKAGGKVRYYGQLADELDA
CFTAVQSAIEEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDGKLLFGLSGNPSACYVGFELF
VHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAKVTIVDGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGF
ETGMKVSVLLLEHAEGCDWPWAKPLQSYK
>Mature_429_residues
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGRILGEDVVSDHDVPHFDRSPYDGFAIRAEDTKEANQENAIEFEV
IGEIGAGSVFTEEVGSFQAVRIMTGAAIPADCNAVVMLELTEGFEKNGKTYMKLKRPFHSGDNVSFKGEDIKQNQVLVKK
GAVINPGVAALLATFGYSNVKVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIMKAGGKVRYYGQLADELDA
CFTAVQSAIEEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDGKLLFGLSGNPSACYVGFELF
VHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAKVTIVDGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGF
ETGMKVSVLLLEHAEGCDWPWAKPLQSYK

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=398, Percent_Identity=32.9145728643216, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI10880983, Length=398, Percent_Identity=32.9145728643216, Blast_Score=182, Evalue=7e-46,
Organism=Escherichia coli, GI1787049, Length=374, Percent_Identity=31.8181818181818, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25147659, Length=390, Percent_Identity=27.6923076923077, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=366, Percent_Identity=24.3169398907104, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI17136978, Length=360, Percent_Identity=30.2777777777778, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24638841, Length=360, Percent_Identity=30.2777777777778, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46681; Mature: 46681

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGRILGEDVVSDHDVPHFDRSPYDGF
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEANQENAIEFEVIGEIGAGSVFTEEVGSFQAVRIMTGAAIPADCNAVVMLEL
EEEECCCCCCCCCCCEEEEEEECCCCCCEEHHHHCCEEEEEEEECCCCCCCCCEEEEEEE
TEGFEKNGKTYMKLKRPFHSGDNVSFKGEDIKQNQVLVKKGAVINPGVAALLATFGYSNV
ECCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCEEEEECCCEECCCHHHHHHHHCCCCE
KVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIMKAGGKVRYYGQLADELDA
EEEECCCEEEEECCHHHHHHHHCCCCCCEECCCCEEEEEHHHHCCCCEEEEHHHHHHHHH
CFTAVQSAIEEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDG
HHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KLLFGLSGNPSACYVGFELFVHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAK
EEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCHHHHHHEEE
VTIVDGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGFETGMKVSVLLLEHAEGCDWP
EEEEECCHHHEECCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
WAKPLQSYK
CCCHHHCCC
>Mature Secondary Structure
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGRILGEDVVSDHDVPHFDRSPYDGF
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEANQENAIEFEVIGEIGAGSVFTEEVGSFQAVRIMTGAAIPADCNAVVMLEL
EEEECCCCCCCCCCCEEEEEEECCCCCCEEHHHHCCEEEEEEEECCCCCCCCCEEEEEEE
TEGFEKNGKTYMKLKRPFHSGDNVSFKGEDIKQNQVLVKKGAVINPGVAALLATFGYSNV
ECCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCEEEEECCCEECCCHHHHHHHHCCCCE
KVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIMKAGGKVRYYGQLADELDA
EEEECCCEEEEECCHHHHHHHHCCCCCCEECCCCEEEEEHHHHCCCCEEEEHHHHHHHHH
CFTAVQSAIEEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDG
HHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KLLFGLSGNPSACYVGFELFVHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAK
EEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCHHHHHHEEE
VTIVDGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGFETGMKVSVLLLEHAEGCDWP
EEEEECCHHHEECCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
WAKPLQSYK
CCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]