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The map label for this gene is ycbM [H]

Identifier: 49187427

GI number: 49187427

Start: 4341654

End: 4342589

Strand: Reverse

Name: ycbM [H]

Synonym: BAS4432

Alternate gene names: 49187427

Gene position: 4342589-4341654 (Counterclockwise)

Preceding gene: 49187428

Following gene: 49187426

Centisome position: 83.05

GC content: 30.24

Gene sequence:

>936_bases
ATGGTCAATTTGTTAATAAGTATTATTTTTATATTGTTATGTGTCATTTACATACAATATAAAATGAGAAAAAATAGTAG
TGAAAATTTAAGATACACATATGAAAAGTTAGAAAGTATTGTAAATGAAAAAACAGGCGAGAAGTTACTCGTTATGACAG
ATGATCTAGAATTGCAAAAATTATTAGTGGCAATTAATCAATTATTAGATGCAAAACAGAAAACAAATGCAGATCATGCG
AAAGTAGAAATTTCGATGAGAAAAATGCTTTCAAATATTTCACATGACTTGAAAACACCGCTAACAGTTATTCTTGGATA
TACAGAAATGTTAAATAAGGATAAAACGATGAGTAAAGAAGAACAACAAATATTACTTGAAAAGGTGCATGTGAAAACAC
TAGAAGTAATGGAACTAATTCATAAGTTTTTTGATTTAGCAAAATTAGAATCTGGTGACAAAGCAATCGAGATGACAAAA
GTGAATATGAATGAAGTTTGTCGTGAGAAGATTTTATCTTTTTATGATTTAGTGACGTCGAAAGGTTTTCATGTTCATAT
TGATATACCAGAAAGAAATATATATGCACTTGGAAATGTAGAAGTATTAGGTAGGGTATTGAACAATTTTATATCAAATG
CGATTACATATGGAGACGATGGAAAGACACTTGGTATGACGTTAAGAGATGATGAAACGAATGTGTATATAGACGTATGG
GATACAGGAAAAGGAATTGATGAATCGCATATTGATAAAGTGTTCGAGCGTATGTACACACTTGAAGATTCAAGAAATAG
ATTGTACCAAGGGAGCGGTTTAGGGTTAACGATTACAAAAAGACTTGTGGAAGCGATGGATGGAAAAATTCATCTTTCTA
GTAAGCCGTATGAAAAAACAATTTTTACAGTTGCATTAAAAAAGATGCAGTTTTAG

Upstream 100 bases:

>100_bases
CATATGAGAAGATTGCGTGAGAAAATCGAAAGTGATCCATCTAATCCAGAATACATTAAAACGTTATGGGGCATCGGTTA
TAAGTTGGAAGTGATGTAAT

Downstream 100 bases:

>100_bases
CTTGTAGAGAAGTAGATTCTACAAGCTTTTTTTCAGCGTAAGAAATTTGTAAGAAACGGGTAAGAAAAAAGAGATTTCCG
TTGTCTATTATAAAAATATA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MVNLLISIIFILLCVIYIQYKMRKNSSENLRYTYEKLESIVNEKTGEKLLVMTDDLELQKLLVAINQLLDAKQKTNADHA
KVEISMRKMLSNISHDLKTPLTVILGYTEMLNKDKTMSKEEQQILLEKVHVKTLEVMELIHKFFDLAKLESGDKAIEMTK
VNMNEVCREKILSFYDLVTSKGFHVHIDIPERNIYALGNVEVLGRVLNNFISNAITYGDDGKTLGMTLRDDETNVYIDVW
DTGKGIDESHIDKVFERMYTLEDSRNRLYQGSGLGLTITKRLVEAMDGKIHLSSKPYEKTIFTVALKKMQF

Sequences:

>Translated_311_residues
MVNLLISIIFILLCVIYIQYKMRKNSSENLRYTYEKLESIVNEKTGEKLLVMTDDLELQKLLVAINQLLDAKQKTNADHA
KVEISMRKMLSNISHDLKTPLTVILGYTEMLNKDKTMSKEEQQILLEKVHVKTLEVMELIHKFFDLAKLESGDKAIEMTK
VNMNEVCREKILSFYDLVTSKGFHVHIDIPERNIYALGNVEVLGRVLNNFISNAITYGDDGKTLGMTLRDDETNVYIDVW
DTGKGIDESHIDKVFERMYTLEDSRNRLYQGSGLGLTITKRLVEAMDGKIHLSSKPYEKTIFTVALKKMQF
>Mature_311_residues
MVNLLISIIFILLCVIYIQYKMRKNSSENLRYTYEKLESIVNEKTGEKLLVMTDDLELQKLLVAINQLLDAKQKTNADHA
KVEISMRKMLSNISHDLKTPLTVILGYTEMLNKDKTMSKEEQQILLEKVHVKTLEVMELIHKFFDLAKLESGDKAIEMTK
VNMNEVCREKILSFYDLVTSKGFHVHIDIPERNIYALGNVEVLGRVLNNFISNAITYGDDGKTLGMTLRDDETNVYIDVW
DTGKGIDESHIDKVFERMYTLEDSRNRLYQGSGLGLTITKRLVEAMDGKIHLSSKPYEKTIFTVALKKMQF

Specific function: Member of the two-component regulatory system ycbM/ycbL. Probably activates ycbL by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=256, Percent_Identity=28.515625, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI145693157, Length=255, Percent_Identity=28.6274509803922, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=26.4957264957265, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=254, Percent_Identity=26.3779527559055, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=24.5454545454545, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789149, Length=247, Percent_Identity=25.1012145748988, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87081816, Length=259, Percent_Identity=24.3243243243243, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786783, Length=293, Percent_Identity=24.2320819112628, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI48994928, Length=221, Percent_Identity=24.8868778280543, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790346, Length=212, Percent_Identity=23.5849056603774, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788549, Length=248, Percent_Identity=23.7903225806452, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790861, Length=200, Percent_Identity=24, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790551, Length=322, Percent_Identity=24.5341614906832, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787894, Length=233, Percent_Identity=25.3218884120172, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789403, Length=228, Percent_Identity=23.2456140350877, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 35811; Mature: 35811

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNLLISIIFILLCVIYIQYKMRKNSSENLRYTYEKLESIVNEKTGEKLLVMTDDLELQK
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHH
LLVAINQLLDAKQKTNADHAKVEISMRKMLSNISHDLKTPLTVILGYTEMLNKDKTMSKE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHH
EQQILLEKVHVKTLEVMELIHKFFDLAKLESGDKAIEMTKVNMNEVCREKILSFYDLVTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHC
KGFHVHIDIPERNIYALGNVEVLGRVLNNFISNAITYGDDGKTLGMTLRDDETNVYIDVW
CCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCEEECCCCCEEEEEEECCCCEEEEEEE
DTGKGIDESHIDKVFERMYTLEDSRNRLYQGSGLGLTITKRLVEAMDGKIHLSSKPYEKT
CCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCEEEECCCCHHHH
IFTVALKKMQF
HHHHHHHHHCC
>Mature Secondary Structure
MVNLLISIIFILLCVIYIQYKMRKNSSENLRYTYEKLESIVNEKTGEKLLVMTDDLELQK
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHH
LLVAINQLLDAKQKTNADHAKVEISMRKMLSNISHDLKTPLTVILGYTEMLNKDKTMSKE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHH
EQQILLEKVHVKTLEVMELIHKFFDLAKLESGDKAIEMTKVNMNEVCREKILSFYDLVTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHC
KGFHVHIDIPERNIYALGNVEVLGRVLNNFISNAITYGDDGKTLGMTLRDDETNVYIDVW
CCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCEEECCCCCEEEEEEECCCCEEEEEEE
DTGKGIDESHIDKVFERMYTLEDSRNRLYQGSGLGLTITKRLVEAMDGKIHLSSKPYEKT
CCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCEEEECCCCHHHH
IFTVALKKMQF
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]