BacMap

Definition	Bacillus anthracis str. Sterne chromosome, complete genome.
Accession	NC_005945
Length	5,228,663

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The map label for this gene is fadB [H]

Identifier: 49187415

GI number: 49187415

Start: 4329245

End: 4330021

Strand: Reverse

Name: fadB [H]

Synonym: BAS4420

Alternate gene names: 49187415

Gene position: 4330021-4329245 (Counterclockwise)

Preceding gene: 49187416

Following gene: 49187414

Centisome position: 82.81

GC content: 42.6

Gene sequence:

>777_bases
ATGTTGAAATTCCTATCTGTAAGAGTTGAAGATCATATCGCGGTGGCTACGTTAAATCATGCGCCAGCTAACGCGATGTC
TTCGCAAGTTATGCATGACGTTACTGAATTAATTGATCAAGTGGAGAAGGATGATAATATTCGTGTTGTTGTTATTCATG
GTGAAGGGCGCTTCTTCTCGGCGGGAGCAGATATTAAAGAATTTACATCTGTTACTGAAGCGAAGCAAGCGACTGAATTA
GCGCAGCTTGGACAAGTTACGTTTGAGCGCGTTGAAAAATGTTCAAAACCAGTTATCGCGGCAATTCATGGAGCGGCACT
TGGCGGCGGCCTTGAGTTTGCTATGTCTTGCCACATGCGCTTTGCAACTGAAAGCGCAAAACTTGGTTTACCTGAATTAA
CACTTGGATTAATTCCTGGATTTGCAGGTACACAGCGATTACCACGTTATGTTGGGAAAGCGAAAGCTTGTGAAATGATG
TTAACAAGTACACCGATTACTGGTGCAGAAGCATTAAAATGGGGACTAGTTAACGGAGTTTTTGCTGAAGAAACATTTTT
AGATGATACGCTTAAAGTTGCAAAACAGATTGCTGGAAAAAGCCCAGCGACGGCCCGTGCTGTACTAGAGTTATTGCAAA
CGACGAAATCGTCTCATTATTATGAGGGTGTACAACGCGAAGCTCAAATCTTTGGTGAAGTATTTACGAGTGAAGATGGA
AGAGAAGGTGTAGCAGCATTTTTAGAAAAGCGTAAGCCTTCATTTAGTGGCAGGTAG

Upstream 100 bases:

>100_bases
GGGTAATGAGCGATCATAAGTATGATCTGGTCGCACTTTCAAAAACGGTACACGGGCTACTTATTGCAGCTTGTGGTTAT
CGTCAATAATGGGAGGGATC

Downstream 100 bases:

>100_bases
TTCAATTATTTTTTTAATATAAATTAACAGAAAATTAAAATTGATAGAATCTTTCTGAAAAACAAGGGGGTAAATGGAAT
GAACATCTACGTACTCATGA

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MLKFLSVRVEDHIAVATLNHAPANAMSSQVMHDVTELIDQVEKDDNIRVVVIHGEGRFFSAGADIKEFTSVTEAKQATEL
AQLGQVTFERVEKCSKPVIAAIHGAALGGGLEFAMSCHMRFATESAKLGLPELTLGLIPGFAGTQRLPRYVGKAKACEMM
LTSTPITGAEALKWGLVNGVFAEETFLDDTLKVAKQIAGKSPATARAVLELLQTTKSSHYYEGVQREAQIFGEVFTSEDG
REGVAAFLEKRKPSFSGR

Sequences:

>Translated_258_residues
MLKFLSVRVEDHIAVATLNHAPANAMSSQVMHDVTELIDQVEKDDNIRVVVIHGEGRFFSAGADIKEFTSVTEAKQATEL
AQLGQVTFERVEKCSKPVIAAIHGAALGGGLEFAMSCHMRFATESAKLGLPELTLGLIPGFAGTQRLPRYVGKAKACEMM
LTSTPITGAEALKWGLVNGVFAEETFLDDTLKVAKQIAGKSPATARAVLELLQTTKSSHYYEGVQREAQIFGEVFTSEDG
REGVAAFLEKRKPSFSGR
>Mature_258_residues
MLKFLSVRVEDHIAVATLNHAPANAMSSQVMHDVTELIDQVEKDDNIRVVVIHGEGRFFSAGADIKEFTSVTEAKQATEL
AQLGQVTFERVEKCSKPVIAAIHGAALGGGLEFAMSCHMRFATESAKLGLPELTLGLIPGFAGTQRLPRYVGKAKACEMM
LTSTPITGAEALKWGLVNGVFAEETFLDDTLKVAKQIAGKSPATARAVLELLQTTKSSHYYEGVQREAQIFGEVFTSEDG
REGVAAFLEKRKPSFSGR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=252, Percent_Identity=34.5238095238095, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI20127408, Length=175, Percent_Identity=40.5714285714286, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI68989263, Length=207, Percent_Identity=35.7487922705314, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI70995211, Length=265, Percent_Identity=28.6792452830189, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI31542718, Length=251, Percent_Identity=29.4820717131474, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI4502327, Length=251, Percent_Identity=31.0756972111554, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI221136756, Length=256, Percent_Identity=25.390625, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI221136753, Length=256, Percent_Identity=25.390625, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI221307494, Length=256, Percent_Identity=25.390625, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI157694516, Length=246, Percent_Identity=25.2032520325203, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI213417737, Length=246, Percent_Identity=25.2032520325203, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI25453481, Length=235, Percent_Identity=23.4042553191489, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI51538573, Length=235, Percent_Identity=23.4042553191489, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI45643119, Length=252, Percent_Identity=25.3968253968254, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI260275230, Length=252, Percent_Identity=25.3968253968254, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI260274832, Length=252, Percent_Identity=25.3968253968254, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI150378541, Length=240, Percent_Identity=29.5833333333333, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4757966, Length=224, Percent_Identity=23.6607142857143, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI51538581, Length=224, Percent_Identity=23.6607142857143, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI4757968, Length=240, Percent_Identity=24.1666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI49355787, Length=240, Percent_Identity=24.1666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI157694520, Length=223, Percent_Identity=25.1121076233184, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI261878539, Length=109, Percent_Identity=36.697247706422, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI116235487, Length=243, Percent_Identity=23.8683127572016, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI37594469, Length=148, Percent_Identity=31.7567567567568, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI37594471, Length=148, Percent_Identity=31.7567567567568, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI62530384, Length=245, Percent_Identity=25.7142857142857, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787659, Length=255, Percent_Identity=37.6470588235294, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1788682, Length=271, Percent_Identity=35.0553505535055, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI221142681, Length=247, Percent_Identity=33.6032388663968, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI87082183, Length=265, Percent_Identity=30.188679245283, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1790281, Length=192, Percent_Identity=32.8125, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1787660, Length=263, Percent_Identity=30.4182509505703, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788597, Length=260, Percent_Identity=28.8461538461538, Blast_Score=97, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI25145438, Length=252, Percent_Identity=38.4920634920635, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17554946, Length=259, Percent_Identity=35.5212355212355, Blast_Score=160, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17540714, Length=227, Percent_Identity=33.4801762114537, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17558304, Length=181, Percent_Identity=36.4640883977901, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17534483, Length=274, Percent_Identity=29.1970802919708, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17508951, Length=181, Percent_Identity=37.5690607734807, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI25144276, Length=181, Percent_Identity=37.5690607734807, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17508953, Length=181, Percent_Identity=37.5690607734807, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17560910, Length=255, Percent_Identity=29.8039215686275, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17540306, Length=241, Percent_Identity=27.8008298755187, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17536985, Length=211, Percent_Identity=26.0663507109005, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17549921, Length=234, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17535521, Length=253, Percent_Identity=24.901185770751, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25141363, Length=226, Percent_Identity=23.8938053097345, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=195, Percent_Identity=27.1794871794872, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20129971, Length=246, Percent_Identity=38.6178861788618, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24653477, Length=246, Percent_Identity=38.6178861788618, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24653139, Length=251, Percent_Identity=37.0517928286853, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI19920382, Length=253, Percent_Identity=30.4347826086957, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24583077, Length=181, Percent_Identity=37.5690607734807, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24583079, Length=181, Percent_Identity=37.5690607734807, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19921000, Length=181, Percent_Identity=37.5690607734807, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19922422, Length=263, Percent_Identity=29.6577946768061, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357171, Length=266, Percent_Identity=30.8270676691729, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24650670, Length=196, Percent_Identity=34.1836734693878, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24654903, Length=184, Percent_Identity=26.0869565217391, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24583165, Length=138, Percent_Identity=30.4347826086957, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27901; Mature: 27901

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKFLSVRVEDHIAVATLNHAPANAMSSQVMHDVTELIDQVEKDDNIRVVVIHGEGRFFS
CCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEE
AGADIKEFTSVTEAKQATELAQLGQVTFERVEKCSKPVIAAIHGAALGGGLEFAMSCHMR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHH
FATESAKLGLPELTLGLIPGFAGTQRLPRYVGKAKACEMMLTSTPITGAEALKWGLVNGV
HHCCHHCCCCCHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCH
FAEETFLDDTLKVAKQIAGKSPATARAVLELLQTTKSSHYYEGVQREAQIFGEVFTSEDG
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
REGVAAFLEKRKPSFSGR
HHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLKFLSVRVEDHIAVATLNHAPANAMSSQVMHDVTELIDQVEKDDNIRVVVIHGEGRFFS
CCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEE
AGADIKEFTSVTEAKQATELAQLGQVTFERVEKCSKPVIAAIHGAALGGGLEFAMSCHMR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHH
FATESAKLGLPELTLGLIPGFAGTQRLPRYVGKAKACEMMLTSTPITGAEALKWGLVNGV
HHCCHHCCCCCHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCH
FAEETFLDDTLKVAKQIAGKSPATARAVLELLQTTKSSHYYEGVQREAQIFGEVFTSEDG
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
REGVAAFLEKRKPSFSGR
HHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]