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The map label for this gene is yggV [C]

Identifier: 49187371

GI number: 49187371

Start: 4288778

End: 4289395

Strand: Reverse

Name: yggV [C]

Synonym: BAS4376

Alternate gene names: 49187371

Gene position: 4289395-4288778 (Counterclockwise)

Preceding gene: 49187372

Following gene: 49187370

Centisome position: 82.04

GC content: 38.19

Gene sequence:

>618_bases
GTGGAAAATATGAAACAAGTTGTTGTAGCGACAAAAAATATGGGGAAAGTACGTGAATTTGCTGAGTTATTTGAGCGATT
TGATTTAGAAGTAAAATCATTACACGATTTCCCTCATATTGAAGAAGTCGAAGAAACTGGTGAAACATTTGAAGAAAATG
CGATTTTAAAAGCGGATAGTTTGAGTAGACAGTTGAATGCAATCGTAATTGCGGATGATTCAGGTCTTATTGTAGATGCT
TTAAACGGAAAACCAGGTGTGTATTCAGCTCGTTTTGCTGGAGAGCCGAAAGATGATCAAGCGAATATCGATAAAGTTTT
ACAAGAATTAAATGAAGTAGCGTTTGAAAAGCGTAAAGCTCGTTTCTACTGTGCATTAGCAGTGGCTTTCCCTGAAGGGG
ATAAAAAGCCTGTCATTGTAAACGGGACATGTGAAGGATTTATTTTAGAACAACGCCGCGGGGAAAACGGCTTTGGATAT
GATCCAATCTTTTATGTGGAAGAATATAAAAAAGCGATGGCGGAACTAAGTTCAGATGAGAAAAATGCCATTAGCCACCG
CGGACGTGCTCTACGTAAGCTAGAAGAAAAAATCCCTGAATGGTTTTTAGGAGAATAA

Upstream 100 bases:

>100_bases
AGTTAAATGAATTACTTGATGCTGCGGAACAAGGCATTTTCCAACTGATTGATATTCAAAAAGAAGCGTTAGGTGACATC
GTATCTCATATAGAGTAGAG

Downstream 100 bases:

>100_bases
GGGAGAGAGATTGATGAAAGCTTTAATCGTAAGCGATAGTCATAGCTCTGTGAAGGAATTACAGCAGTTAAAAGAGAAGT
ATGAAGGAAAAGTAGATATC

Product: nucleoside-triphosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MENMKQVVVATKNMGKVREFAELFERFDLEVKSLHDFPHIEEVEETGETFEENAILKADSLSRQLNAIVIADDSGLIVDA
LNGKPGVYSARFAGEPKDDQANIDKVLQELNEVAFEKRKARFYCALAVAFPEGDKKPVIVNGTCEGFILEQRRGENGFGY
DPIFYVEEYKKAMAELSSDEKNAISHRGRALRKLEEKIPEWFLGE

Sequences:

>Translated_205_residues
MENMKQVVVATKNMGKVREFAELFERFDLEVKSLHDFPHIEEVEETGETFEENAILKADSLSRQLNAIVIADDSGLIVDA
LNGKPGVYSARFAGEPKDDQANIDKVLQELNEVAFEKRKARFYCALAVAFPEGDKKPVIVNGTCEGFILEQRRGENGFGY
DPIFYVEEYKKAMAELSSDEKNAISHRGRALRKLEEKIPEWFLGE
>Mature_205_residues
MENMKQVVVATKNMGKVREFAELFERFDLEVKSLHDFPHIEEVEETGETFEENAILKADSLSRQLNAIVIADDSGLIVDA
LNGKPGVYSARFAGEPKDDQANIDKVLQELNEVAFEKRKARFYCALAVAFPEGDKKPVIVNGTCEGFILEQRRGENGFGY
DPIFYVEEYKKAMAELSSDEKNAISHRGRALRKLEEKIPEWFLGE

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Homo sapiens, GI15626999, Length=194, Percent_Identity=30.9278350515464, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI31657144, Length=157, Percent_Identity=32.484076433121, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1789324, Length=195, Percent_Identity=46.1538461538462, Blast_Score=178, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17556833, Length=129, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19920712, Length=148, Percent_Identity=36.4864864864865, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 23223; Mature: 23223

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENMKQVVVATKNMGKVREFAELFERFDLEVKSLHDFPHIEEVEETGETFEENAILKADS
CCCHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCEECHHH
LSRQLNAIVIADDSGLIVDALNGKPGVYSARFAGEPKDDQANIDKVLQELNEVAFEKRKA
HHHHCCEEEEECCCCEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHC
RFYCALAVAFPEGDKKPVIVNGTCEGFILEQRRGENGFGYDPIFYVEEYKKAMAELSSDE
EEEEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCH
KNAISHRGRALRKLEEKIPEWFLGE
HHHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MENMKQVVVATKNMGKVREFAELFERFDLEVKSLHDFPHIEEVEETGETFEENAILKADS
CCCHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCEECHHH
LSRQLNAIVIADDSGLIVDALNGKPGVYSARFAGEPKDDQANIDKVLQELNEVAFEKRKA
HHHHCCEEEEECCCCEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHC
RFYCALAVAFPEGDKKPVIVNGTCEGFILEQRRGENGFGYDPIFYVEEYKKAMAELSSDE
EEEEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCH
KNAISHRGRALRKLEEKIPEWFLGE
HHHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]